The role of nicotinic receptor beta-2 subunits in nicotine discrimination and conditioned taste aversion
Open accessAbstract
The subtypes of nicotinic receptors at which the behavioural effects of nicotine originate are not fully understood. These experiments use mice lacking the beta2 subunit of nicotinic receptors to investigate its role in nicotine discrimination and conditioned taste aversion (CTA). Wild-type and mutant mice were trained either in a two-lever nicotine discrimination procedure using a tandem schedule of food reinforcement, or in a counterbalanced two-flavour CTA procedure. Rates of lever-pressing of wild-type and mutant mice did not differ. Wild-type mice acquired discrimination of nicotine (0.4 or 0.8 mg/kg) rapidly and exhibited steep dose-response curves. Mutant mice failed to acquire these nicotine discriminations and exhibited flat dose-response curves. Both wild-type and mutant mice acquired discrimination of nicotine (1.6 mg/kg) although discrimination performance was weak in the mutants. Nicotine initially reduced response rates in wild-type and mutant mice, and tolerance developed to this effect in each genotype. Both genotypes acquired discrimination of morphine (3 mg/kg) with similar degrees of accuracy, and dose-response curves for morphine discrimination in the two genotypes were indistinguishable. Nicotine produced dose-related CTA in both genotypes, but the magnitude of the effect was less in the mutants than in the wild-type controls. It is concluded that nicotinic receptors containing the beta2 subunit play a major role in the discriminative stimulus and taste a…
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β2*-nAChRs are a critical neural substrate mediating the effects of nicotine in brain.
“In recent years evidence has emerged that the β2*-nAChRs are a critical neural substrate mediating the effects of nicotine in brain.”
From β2-Nicotinic Acetylcholine Receptor Availability During Acute and Prolonged Abstinence From Tobacco Smoking (2009) · cites this paper as [24]
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- Authors
- Shoaib, M., Gommans, J., Morley, A., Stolerman, I. P., Grailhe, R., & Changeux, J.-P.
- Affiliations
- King's College London (GB)
- Institut Pasteur (FR)
- Corresponding author
- Stolerman, I.P.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2002-03
- Volume
- 42
- Issue
- 4
- Pages
- 530-539
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2040143361
- Cited by
- 110
- References
- 3
- Citations by year
- 2026: 1 · 2024: 2 · 2022: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 7 · 2015: 5 · 2014: 5 · 2013: 10 · 2012: 3
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Association pour la Recherche sur le Cancer
- European Commission
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- nicotinic acetylcholine receptors, beta2 subunit, nicotine discrimination, conditioned taste aversion, nicotine tolerance, dose-response relationship, tobacco dependence, discriminative stimulus, response rate
- MeSH terms
- Animals, Conditioning, Psychological, Discrimination, Psychological, Dose-Response Relationship, Drug, Male, Mice, Inbred C57BL, Nicotine, Receptors, Nicotinic, Taste, Mice, Knockout, Nicotinic Agonists, Mice
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