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Effects of intranucleus accumbens shell administration of dopamine agonists and antagonists on cocaine-taking and cocaine-seeking behaviors in the rat
Abstract
Rationale Dopamine signaling in the nucleus accumbens (NAc) plays an important role in regulating drug-taking and drug-seeking behaviors, but the role of D(1)- and D(2)-like receptors in this regulation remains unclear.Objectives Our objective was to study the role of NAc D(1)- and D(2)-like receptors in the reinstatement of cocaine-seeking behavior and the regulation of stabilized cocaine intake in rats.Methods Using a within-session reinstatement procedure, whereby animals self-administer cocaine (90 min) and extinguish responding (150 min) in a single session, we assessed the ability of NAc microinfusions of the D(1) agonist SKF 81297 and the D(2) agonist 7-OH-DPAT to reinstate extinguished cocaine seeking. The effects of the D(1) antagonist SCH 23390 and the D(2) antagonist eticlopride pretreatment on agonist- and cocaine-primed reinstatement were also measured. Similar agonist and antagonist treatments were tested for their ability to modulate stabilized cocaine and sucrose self-administration.Results Intra-NAc infusions of either SKF 81297 (0.3-3.0 microg) or 7-OH-DPAT (1.0-10.0 microg) dose-dependently reinstated cocaine seeking with greater efficacy in the medial core than in the shell subregion and at doses that also stimulated locomotor behavior. Intra-NAc shell infusions of SCH 23390 (1.0 microg) and eticlopride (3.0-10.0 microg) blocked cocaine-primed reinstatement (2.0 mg/kg, i.v.) and indiscriminately blocked reinstatement induced by either intra-NAc D(1) or D(2) agonists. Doses of agonists that triggered reinstatement failed to alter stabilized cocaine intake, whereas doses of antagonists that blocked reinstatement increased cocaine intake in the shell.Conclusions Both D(1) and D(2) receptors in the NAc play a prominent, and perhaps cooperative, role in regulating cocaine-taking and cocaine-seeking behaviors.
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“Furthermore, if cocaine is administered with D2R-like antagonists, it loses its reinforcing effects (Woolverton and Virus 1989; Bachtell et al 2005; Claytor et al 2006; Peng et al 2009).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Bachtell et al 2005
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“For instance, in animals that have extinguished conditioned responding (lever-pressing), systemic administration of cocaine reinstates the conditioned responding, and this cocaine-induced reinstatement is blocked by the administration of dopamine receptor antagonists into the medial shell, but not the core (McFarland and Kalivas, 2001; Anderson et al., 2003; Bachtell et al., 2005; Anderson et al.,”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Bachtell et al., 2005
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Tol, H. H. M. V., Bunzow, J. R., Guan, H., Sunahara, R. K., Seeman, P. M., Niznik, H. B., & Civelli, O. (1991) · Nature · doi:10.1038/350610a0 · Cited by 2,015
Bunney, W. E., Hippius, H., Laakmann, G., & Schmauß, M. (1990) · Springer eBooks · doi:10.1007/978-3-642-74034-3 · Cited by 1,523
Specificity in the projection patterns of accumbal core and shell in the rat
Heimer, L., Zahm, D. S., Churchill, L., Kalivas, P. W., & Wohltmann, C. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90202-y · Cited by 1,219
Dopamine receptor pharmacology
Seeman, P. M., & Tol, H. H. M. V. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90323-9 · Cited by 969
The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior
McFarland, K., & Kalivas, P. W. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08655.2001 · Cited by 905
Bouthenet, M.-L., Souil, E., Martres, M., Sokoloff, P., Bruno Giros, A., & Schwartz, J. (1991) · Brain Research · doi:10.1016/0006-8993(91)91456-b · Cited by 868
Pontieri, F. E., Tanda, G., & Chiara, G. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.12304 · Cited by 868
Lévesque, D., Díaz, J., Pilon, C., Martres, M., Bruno Giros, A., Souil, E., Schott, D., Morgat, J. L., Schwartz, J., & Sokoloff, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.17.8155 · Cited by 674
Glutamate Transmission in the Nucleus Accumbens Mediates Relapse in Cocaine Addiction
Cornish, J. L., & Kalivas, P. W. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-j0006.2000 · Cited by 553
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Research works printed but not linked: 1
- Caine SB, Negus SS, Mello NK, Bergman J (1999) Effects of dopamine D(1-like) and D(2-like) agonists in rats that self-administer cocaine. J Pharmacol Exp Ther 291:353–360
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Items 101–154 of 154
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Li, J., Zhang, L., Chen, Z., Xie, M., Huang, L. H., Xue, J., Liu, Y., Liu, N., Guo, F., Zheng, Y., et al. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.12.031 · Cited by 19
Wu, B., Liang, Y., Dong, Z., Chen, Z., Zhang, G., Lin, W., Wang, S., Wang, B., Ge, R., & Lian, Q. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.04.029 · Cited by 20
Anderson, E. M., Tsvetkov, E., Galante, A., DeVries, D. M., McCue, L. M., Wood, D., Barry, S., Berto, S., Lavı́n, A., Taniguchi, M., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2210953120 · Cited by 19
Effect of saikosaponin A on maintenance of intravenous morphine self-administration
Yoon, S. S., Kim, H. S., Cho, H., Yun, J., Chung, E. Y., Jang, C., Kim, K. J., & Yang, C. H. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.08.075 · Cited by 19
Neural systems mediating the inhibition of cocaine-seeking behaviors
Ewald, V. A. M., & LaLumiere, R. T. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.07.006 · Cited by 20
Cue-induced reinstatement of ethanol seeking in Sardinian alcohol-preferring rats
Maccioni, P., Orrù, A., Korkosz, A., Gessa, G. L., Carai, M. A. M., Colombo, G., & Bieńkowski, P. (2007) · Alcohol · doi:10.1016/j.alcohol.2007.02.006 · Cited by 18
Farzinpour, Z., Mousavi, Z., Karimi‐Haghighi, S., & Haghparast, A. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.010 · Cited by 19
Blacktop, J. M., Vranjkovic, O., Mayer, M., Hoof, M. V., Baker, D. L., & Mantsch, J. R. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.11.013 · Cited by 17
Hobson, B. D., Merritt, K. E., & Bachtell, R. K. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.038 · Cited by 17
Self-citationSuzuki, H., & Lucas, L. (2015) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-015-0337-8 · Cited by 16
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Guercio, L. A., Hofmann, M. E., Swinford-Jackson, S. E., Sigman, J. S., Wimmer, M. E., Dell’Acqua, M. L., Schmidt, H. D., & Pierce, R. C. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.297 · Cited by 13
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Ciano, P. D. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.07.007 · Cited by 12
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Landa, L., Jurajda, M., & Šulcová, A. (2012) · PubMed · Cited by 11
Ingebretson, A. E., Hearing, M. C., Huffington, E. D., & Thomas, M. J. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.011 · Cited by 10
Larson, T. A., Winkler, M. C., Stafford, J., Levis, S. C., O’Neill, C. E., & Bachtell, R. K. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5126-y · Cited by 10
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Hobson, B. D. (2012) · CU Scholar (University of Colorado Boulder)
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Hollander, J. A. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/rp6g-4w20
Briand, L. A. (2007) · Deep Blue (University of Michigan)
Frank, G. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.725600541.793558805
Spanagel, R., & Sommer, W. H. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.7162956.7397054
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Graf, E. N. (2012) · e-Publications@Marquette (Marquette University)
Campos, R. C. (2017) · theses.fr (ABES) · doi:10.70675/03a75158z9d38z4e81zb3aczea487daa9f14
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Metadata
- Authors
- Bachtell, R. K., Whisler, K., Karanian, D., & Self, D. W.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Self, David W.
- Venue
- Psychopharmacology
- Published
- 2005-09-15
- Volume
- 183
- Issue
- 1
- Pages
- 41-53
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2130332398
- Cited by
- 154
- References
- 71
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 12 · 2016: 3 · 2015: 10 · 2014: 10 · 2013: 11 · 2012: 18
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA 08227, DA10460, F32DA018481, DA 18481, P01DA008227)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- nucleus accumbens shell, cocaine self-administration, cocaine-seeking behavior, reinstatement, dopamine D1 receptor, dopamine D2 receptor, dopamine agonists, dopamine antagonists, SKF 81297, 7-OH-DPAT, SCH 23390, eticlopride, sucrose self-administration, locomotor activity
- MeSH terms
- Animals, Benzazepines, Cocaine, Dose-Response Relationship, Drug, Male, Motor Activity, Nucleus Accumbens, Salicylamides, Self Administration, Tetrahydronaphthalenes, Time Factors, Rats, Sprague-Dawley, Receptors, Dopamine D1, Receptors, Dopamine D2, Dopamine Agonists, Dopamine Antagonists, Dopamine Uptake Inhibitors, Cocaine-Related Disorders, Rats
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