Administration of the D1-like dopamine receptor antagonist SCH-23390 into the medial nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug-seeking behavior in rats

Anderson, Sharon M.; Bari, Ausaf A.; Pierce, R. Christopher

doi:10.1007/s00213-002-1298-5

Cited by 178Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeural and Behavioral Psychology Studies

Administration of the D1-like dopamine receptor antagonist SCH-23390 into the medial nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug-seeking behavior in rats

Anderson, Sharon M., Bari, Ausaf A., Pierce, R. Christopher·2003·Psychopharmacology

DOI 10.1007/s00213-002-1298-5

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Abstract

Rationale A growing literature indicates that increased dopamine transmission in the nucleus accumbens contributes to priming-induced reinstatement of cocaine-seeking behavior.Objectives The present experiments were designed to assess the role of D(1)-like dopamine receptors in the nucleus accumbens core and shell subregions in cocaine priming-induced reinstatement of drug seeking.Methods Rats were trained to lever press for cocaine using a fixed ratio (FR) 5 schedule of reinforcement. Drug-seeking was measured by active lever presses during daily 2-h sessions. After approximately 30 days of cocaine self-administration, the animals underwent an extinction phase during which cocaine was replaced with saline. Daily extinction sessions were conducted until responding was consistently less than 10% of the response rate maintained by cocaine self-administration. After the extinction phase, priming-induced reinstatement of cocaine-seeking behavior was assessed.Results Cocaine dose-dependently reinstated cocaine seeking, with robust drug seeking at 10 mg/kg cocaine. Administration of the D(1)-like dopamine receptor antagonist, SCH-23390 (0.1-1.0 micro g), directly into the medial nucleus accumbens shell dose-dependently attenuated drug seeking induced by 10 mg/kg cocaine. Microinjection of 1.0 micro g SCH-23390 into either the nucleus accumbens core or lateral septum had no influence on cocaine-seeking behavior.Conclusions These results indicate that stimulation of D(1)-like dopamine receptors in the medial nucleus accumbens shell contributes to drug-induced reinstatement of cocaine-seeking behavior.

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In cocaine reinstatement models, systemic administration of cocaine reinstates conditioned responding, and this cocaine-induced reinstatement is blocked by administration of dopamine receptor antagonists into the medial shell, but not the core.
“For instance, in animals that have extinguished conditioned responding (lever-pressing), systemic administration of cocaine reinstates the conditioned responding, and this cocaine-induced reinstatement is blocked by the administration of dopamine receptor antagonists into the medial shell, but not the core (McFarland and Kalivas, 2001; Anderson et al., 2003; Bachtell et al., 2005; Anderson et al.,”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Anderson et al., 2003

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Psychopharmacology (2003) 168:132–138 DOI 10.1007/s00213-002-1298-5
Pierce, R. C. (2014)
Self-citation

Authors: Anderson, S. M., Bari, A. A., & Pierce, R. C.
Affiliations: Boston University (US)
Corresponding author: Pierce, R. Christopher
ORCID: Anderson, Sharon M.
Bari, Ausaf A.
Pierce, R. Christopher
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2002-12-19
Volume: 168
Issue: 1-2
Pages: 132-138
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-002-1298-5
OpenAlex: W1995006074
Cited by: 178
References: 33
Citations by year: 2026: 2 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 8 · 2018: 5 · 2017: 10 · 2016: 11 · 2015: 6 · 2014: 4 · 2013: 15 · 2012: 13
FWCI: 3.02
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
National Institutes of Health (1r01da012171-01a1, 5f31da015263-03)
National Institute on Drug Abuse (DA 15263, F30DA014205, F30 DA14205, R01 DA12171)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: cocaine priming, reinstatement of drug seeking, D1-like receptors, SCH 23390, nucleus accumbens core, lateral septum, cocaine self-administration, extinction, dopamine signaling, cocaine dependence
MeSH terms: Animals, Benzazepines, Cocaine, Dose-Response Relationship, Drug, Male, Nucleus Accumbens, Behavior, Addictive, Rats, Sprague-Dawley, Receptors, Dopamine D1, Dopamine Antagonists, Rats

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Administration of the D1-like dopamine receptor antagonist SCH-23390 into the medial nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug-seeking behavior in rats

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