Stimulation of D1-like or D2 dopamine receptors in the shell, but not the core, of the nucleus accumbens reinstates cocaine-seeking behaviour in the rat

Schmidt, Heath D.; Anderson, Sharon M.; Pierce, R. Christopher

doi:10.1111/j.1460-9568.2005.04524.x

Cited by 119Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesSubstance Abuse Treatment and Outcomes

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Stimulation of D1-like or D2 dopamine receptors in the shell, but not the core, of the nucleus accumbens reinstates cocaine-seeking behaviour in the rat

Schmidt, Heath D., Anderson, Sharon M., Pierce, R. Christopher·2006·European Journal of Neuroscience

DOI 10.1111/j.1460-9568.2005.04524.x

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Abstract

Although increases in dopamine transmission in the brain are clearly involved in the reinstatement of cocaine seeking, the role of nucleus accumbens dopamine in cocaine priming-induced reinstatement remains controversial. The goal of these experiments was to evaluate the relative contributions of D1-like and D2-like dopamine receptors in the nucleus accumbens core and shell in the reinstatement of cocaine-seeking behaviour. Initially, rats were trained to press a lever for cocaine (0.25 mg, i.v.) using a fixed-ratio 5 (FR5) schedule of reinforcement. Responding was then extinguished by substituting saline for cocaine. During the reinstatement phase, subtype-specific dopamine receptor agonists were microinjected into the nucleus accumbens core or medial shell in order to assess their ability to induce cocaine seeking. Administration of the D1/D5 dopamine receptor agonist SKF-81297 (1.0 microg) into the nucleus accumbens shell, but not core, reinstated drug-seeking behaviour. Similarly, microinjection of quinpirole (3.0 microg), a D2/D3 dopamine receptor agonist, into the nucleus accumbens shell and not core reinstated drug-seeking behaviour. In contrast, administration of the D3- or D4-preferring dopamine receptor agonists PD 128,907 (1.5 and 3.0 microg) and PD 168,077 (0.3 and 3.0 microg), respectively, did not promote reinstatement when administered into either the core or the shell. Taken together, these results indicate that activation of D1/D5 or D2 dopamine receptors, in the limbic shell subregion of the nucleus accumbens but not the basal ganglia-orientated accumbens core, promotes the reinstatement of cocaine-seeking behaviour.

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Microinjections of cocaine or dopamine receptor agonists directly into the medial shell, but not the core, reinstate lever-pressing.
“Furthermore, microinjections of cocaine or dopamine receptor agonists directly into the medial shell, but not the core, reinstate lever-pressing (Schmidt et al., 2006).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Schmidt et al., 2006

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Kostrzewa, R. M., Nowak, P. G., Brus, R., & Brown, R. W. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1757-0 · Cited by 23

Authors: Schmidt, H. D., Anderson, S. M., & Pierce, R. C.
Affiliations: Boston University (US)
Corresponding author: Pierce, R. Christopher
ORCID: Schmidt, Heath D.
Anderson, Sharon M.
Pierce, R. Christopher
Venue: European Journal of Neuroscience
Publisher: Wiley
Published: 2006-01
Volume: 23
Issue: 1
Pages: 219-228
ISSN: 0953-816X (ISSN-L)
1460-9568
DOI: 10.1111/j.1460-9568.2005.04524.x
OpenAlex: W2095219741
Cited by: 119
References: 79
Citations by year: 2026: 2 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 9 · 2017: 7 · 2016: 4 · 2015: 6 · 2014: 2 · 2013: 7 · 2012: 8
FWCI: 4.68
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 17 d)
Locations: European Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5f31da015263-03)
National Institute on Drug Abuse (R01DA015214, DA 15214, DA 16824, F31DA016824, DA 15263)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: cocaine seeking, reinstatement, nucleus accumbens shell, nucleus accumbens core, dopamine D1 receptor, dopamine D2 receptor, dopamine D3 receptor, dopamine D4 receptor, SKF 81297, quinpirole, dopamine agonists, cocaine priming, extinction
MeSH terms: Animals, Behavior, Animal, Cocaine, Dose-Response Relationship, Drug, Drug Interactions, Male, Nucleus Accumbens, Rats, Sprague-Dawley, Receptors, Dopamine D1, Receptors, Dopamine D2, Dopamine Agonists, Dopamine Uptake Inhibitors, Cocaine-Related Disorders, Rats

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Stimulation of D1-like or D2 dopamine receptors in the shell, but not the core, of the nucleus accumbens reinstates cocaine-seeking behaviour in the rat

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