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Cited by 8Neurotransmitter Receptor Influence on BehaviorMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

AMPA receptor antagonists reverse effects of extended habit training on signaled food approach responding in rats

Bespalov, A. Y., Harich, S., Jongen-Rêlo, A.-L., van Gaalen, M. M., Gross, G.·2007·Psychopharmacology
DOI 10.1007/s00213-007-0875-z
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Abstract

Rationale Dopamine D1 receptor stimulation is critically involved in early appetitive phases of learning in various behavioral paradigms. However, extended habit training was previously shown to reduce the ability of dopamine D1 receptor antagonists such as R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH-23390) to disrupt behavioral performance. Objective The present study aimed to evaluate whether coadministration of glutamate alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor antagonists restores sensitivity to acute blockade of D1 receptors. Materials and methods Adult male Wistar rats were presented with 45-mg food pellets delivered to the food tray, which was immediately preceded by a 400-ms tone (2.8 kHz, 78 dB). During each training and test session, there were 28 food-tone presentations with an average intertrial interval of 70 s, and each head entry into the food tray was recorded. Drug tests were conducted on either day 3 or 9 of the training using independent groups of animals. The main dependent variable was the number of trials during which no head-entry response was made during the 10-s period immediately after the food delivery. Results Longer training duration enhanced the resistance of the signaled food approach behavior to extinction and to disrupting effects of supplementary food ration. Similarly, acute administration of SCH-23390 (0.04-0.16 mg/kg) dose-dependently reduced the number o…

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  • Blockade of D1 receptors strongly disrupts rats' performance of a simple Pavlovian approach response to a sensory cue during early stages of training but has little or no disruptive effect in rats that receive extended training prior to dopamine antagonist challenge.

    “As another example, blockade of D1 receptors strongly disrupts rats' performance of a simple Pavlovian approach response to a sensory cue during early stages of training, but has little or no disruptive effect in rats that receive extended training prior to dopamine antagonist challenge [46–47].”

    From Cortical and basal ganglia contributions to habit learning and automaticity (2010) · cites this paper as [47]

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Authors
Bespalov, A. Y., Harich, S., Jongen-Rêlo, A.-L., van Gaalen, M. M., & Gross, G.
Affiliations
Abbott (Germany) (DE)
Corresponding author
Bespalov, A. Y.
ORCID
Bespalov, A. Y.
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2007-07-19
Volume
195
Issue
1
Pages
11-18
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/s00213-007-0875-z
OpenAlex
W2031980307
Cited by
8
References
26
Citations by year
2022: 1 · 2019: 1 · 2017: 1 · 2013: 1
FWCI
0.53
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
AMPA receptor antagonists, dopamine D1 receptor antagonist, SCH 23390, habit learning, extinction, rations, NBQX, GYKI 52466, glutamate, dopamine, appetitive behavior, behavioral sensitization
MeSH terms
Animals, Appetitive Behavior, Behavior, Animal, Benzazepines, Benzodiazepines, Conditioning, Classical, Conditioning, Operant, Dose-Response Relationship, Drug, Food, Habits, Injections, Intraperitoneal, Quinoxalines, Sound, Time Factors, Rats, Wistar, Receptors, Dopamine D1, Receptors, AMPA, Excitatory Amino Acid Antagonists, Rats

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