Effects of extinction, pimozide, SCH 23390, and metoclopramide on food-rewarded operant responding of rats
Abstract
The similarity in the pattern of responding produced by extinction and dopamine (DA) receptor blockers has led to the suggestion that DA neurons may participate in the usual effects of reward on behaviour. The purpose of the present study was to evaluate the effect of receptor-subtype specific DA antagonists on food-rewarded operant responding. Rats were trained to lever press for food on a variable interval 30-s schedule. They then received one of the following treatments prior to testing on the next 5 days: saline, nonreinforcement, the DA receptor blocker pimozide (0.5 or 1.0 mg/kg), the D1 receptor blocker SCH 23390 (0.01, 0.05, 0.1 mg/kg), and the D2 receptor blocker metoclopramide (1.0, 5.0, 10.0 mg/kg). Nonreinforcement resulted in both intra- and intersession declines in responding. The drugs produced dose-dependent decreases in overall responding. Additionally, both doses of pimozide and the higher doses of SCH 23390 and metoclopramide altered intrasession patterns of responding when compared to saline, with their greatest effect being in the latter portion of the session. Intersession declines were seen with the highest doses of SCH 23390 and metoclopramide and control studies showed that these declines could not be attributed to a buildup of the drug with repeated dosing. It was concluded that both D1 and D2 receptors participate in the control of behaviour by reward.
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Cocaine primarily activates D1R-containing neurons, which are necessary for reward-related learning and maintenance of reward-related behaviors.
“Cocaine primarily activates D1R-containing neurons, which are necessary for reward-related learning and maintenance of reward-related behaviors (Nakajima 1986; Nakajima and Mckenzie 1986; Beninger et al 1987; Bertran-Gonzalez et al 2008).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Beninger et al 1987
Cites
Beaton, A. E., & Keppel, G. (1975) · American Educational Research Journal · doi:10.2307/1162588 · Cited by 5,857 · see citing works
Multiple receptors for dopamine
Kebabian, J. W., & Calne, D. B. (1979) · Nature · doi:10.1038/277093a0 · Cited by 3,742 · see citing works
The Psychology of Animal Learning
Hill, W. F., & Mackintosh, N. J. (1976) · The American Journal of Psychology · doi:10.2307/1421765 · Cited by 2,397 · see citing works
Design and Analysis: A Researcher's Handbook
Morgan, J. (2005) · Technometrics · doi:10.1198/tech.2005.s329 · Cited by 2,365 · see citing works
Book Review: Design and Analysis: A Researcher's Handbook
Aaker, D. A., & Keppel, G. (1976) · Journal of Marketing Research · doi:10.2307/3150757 · Cited by 2,033 · see citing works
SCH 23390, a potential benzazepine antipsychotic with unique interactions on dopaminergic systems.
Iorio, L. C., Barnett, A., Leitz, F. H., Houser, V. P., & Korduba, C. A. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21599-3 · Cited by 896 · see citing works
SCH 23390—The first selective dopamine D-1 antagonist
Hyttel, J. (1983) · European Journal of Pharmacology · doi:10.1016/0014-2999(83)90381-3 · Cited by 740 · see citing works
The central effects of a novel dopamine agonist
Setler, P. E., Sarau, H. M., Zirkle, C. L., & Saunders, H. L. (1978) · European Journal of Pharmacology · doi:10.1016/0014-2999(78)90148-6 · Cited by 640 · see citing works
Neuroleptic-Induced "Anhedonia" in Rats: Pimozide Blocks Reward Quality of Food
Wise, R. A., Spindler, J., de Wit, H., & Gerberg, G. J. (1978) · Science · doi:10.1126/science.566469 · Cited by 636 · see citing works
Harrington, R., Hamilton, C. W., Brogden, R. N., Linkewich, J. A., Romankiewicz, J. A., & Heel, R. C. (1983) · Drugs · doi:10.2165/00003495-198325050-00002 · Cited by 359 · see citing works
Neuroleptics : neurochemical, behavioral, and clinical perspectives
Coyle, J. T., & Enna, S. J. (1983) · Raven Press eBooks · Cited by 232 · see citing works
Intravenous self-administration of dopamine receptor agonists by rhesus monkeys.
Woolverton, W. L., Goldberg, L. I., & Ginos, J. Z. (1984) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21719-0 · Cited by 204 · see citing works
Phillips, A. G., & Fibiger, H. C. (1979) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(79)90328-9 · Cited by 166 · see citing works
Metoclopramide and dopamine receptor blockade
Peringer, E. (1976) · Neuropharmacology · doi:10.1016/0028-3908(76)90056-3 · Cited by 156 · see citing works
Substituted benzamides as cerebral dopamine antagonists in rodents
Elliott, P., Jenner, P. G., Huizing, G., MARSDEN, C. D., & Miller, R. J. (1977) · Neuropharmacology · doi:10.1016/0028-3908(77)90070-3 · Cited by 127 · see citing works
Tombaugh, T. N., Anisman, H., & Tombaugh, J. W. (1980) · Psychopharmacology · doi:10.1007/bf00432365 · Cited by 116 · see citing works
Schulz, D. W., Stanford, E. J., Wyrick, S. W., & Mailman, R. B. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb07233.x · Cited by 116 · see citing works
Pimozide-induced suppression of responding: Evidence against a block of food reward
Mason, S. T., Beninger, R. J., Fibiger, H. C., & Phillips, A. G. (1980) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(80)90453-0 · Cited by 115 · see citing works
Self-citationEffects of pimozide on lever pressing behavior maintained on an intermittent reinforcement schedule
Gray, T., & Wise, R. A. (1980) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(80)90455-4 · Cited by 107 · see citing works
Jenner, P. (1980) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.43.12.1150-b · Cited by 103 · see citing works
Different effects of haloperidol and extinction on instrumental behaviours
Salamone, J. D. (1986) · Psychopharmacology · doi:10.1007/bf00310507 · Cited by 95 · see citing works
The D1 dopamine receptor antagonist, SCH 23390 reduces locomotor activity and rearing in rats
Hoffman, D. C., & Beninger, R. J. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90401-0 · Cited by 93 · see citing works
Self-citationNakajima, S., & McKenzie, G. M. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90437-5 · Cited by 81 · see citing works
Jenner, P. G., Clow, A., Reavill, C. A., Theodorou, A., & MARSDEN, C. D. (1978) · Life Sciences · doi:10.1016/0024-3205(78)90032-2 · Cited by 78 · see citing works
Gallistel, C. R., & Davis, A. J. (1983) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(83)90095-3 · Cited by 76 · see citing works
Preferential inhibition of ligand binding to calf striatal dopamine D1 receptors by SCH 23390
Cross, A. J. (1983) · Neuropharmacology · doi:10.1016/0028-3908(83)90208-3 · Cited by 66 · see citing works
Symposium on: Receptors of dopamine antagonists: New biochemical approaches
Leysen, J. E., & Laduron, P. M. (1978) · Life Sciences · doi:10.1016/0024-3205(78)90145-5 · Cited by 59 · see citing works
Ferrer, J. M., Sanguinetti, A., Vives, F., & Mora, F. (1983) · Pharmacology, Biochemistry and Behavior · doi:10.1016/0091-3057(83)90041-2 · Cited by 45 · see citing works
Automating the measurement of locomotor activity.
Rj, B., Ta, C., & Ej, M. (1985) · PubMed · Cited by 45 · see citing works
Prior training and intermittent retraining attenuate pimozide-induced avoidance deficits
Beninger, R. J., Phillips, A. G., & Fibiger, H. C. (1983) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(83)90290-3 · Cited by 41 · see citing works
Self-citationBeninger, R. J. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90434-8 · Cited by 24 · see citing works
Self-citationJenner, P., Marsden, C. D., & Peringer, E. (1975) · PubMed · Cited by 11 · see citing works
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Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564 · see citing works
Tripp, G., & Wickens, J. R. (2008) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2007.01851.x · Cited by 346 · see citing works
Burkett, J. P., & Young, L. J. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2794-x · Cited by 307 · see citing works
“Cocaine primarily activates D1R-containing neurons, which are necessary for reward-related learning and maintenance of reward-related behaviors (Nakajima 1986; Nakajima and Mckenzie 1986; Beninger et al. 1987; Bertran-Gonzalez et al. 2008).”
Opiate reward: Sites and substrates
Wise, R. A. (1989) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(89)80021-1 · Cited by 286 · see citing works
Acquas, E., Carboni, E., Leone, P., & Di Chiara, G. (1989) · Psychopharmacology · doi:10.1007/bf00442800 · Cited by 207 · see citing works
Waddington, J. L., & O’Boyle, K. M. (1989) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(89)90046-6 · Cited by 203 · see citing works
Baldwin, A. E., Sadeghian, K., & Kelley, A. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-01063.2002 · Cited by 191 · see citing works
Aberman, J., Ward, S. J., & Salamone, J. D. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00112-9 · Cited by 190 · see citing works
THE BEHAVIORAL PHARMACOLOGY OF EFFORT‐RELATED CHOICE BEHAVIOR: DOPAMINE, ADENOSINE AND BEYOND
Salamone, J. D., Correa, M., Nunes, E. J., Randall, P. A., & Pardo, M. (2012) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.2012.97-125 · Cited by 151 · see citing works
EFFECTS OF MESOLIMBIC DOPAMINE DEPLETION ON RESPONDING MAINTAINED BY COCAINE AND FOOD
Caine, S. B., & Koob, G. F. (1994) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.1994.61-213 · Cited by 147 · see citing works
Salamone, J. D., Arizzi, M. N., Sandoval, M., Cervone, K., & Aberman, J. (2002) · Psychopharmacology · doi:10.1007/s00213-001-0994-x · Cited by 151 · see citing works
Cousins, M. S., Wei, W., & Salamone, J. D. (1994) · Psychopharmacology · doi:10.1007/bf02247489 · Cited by 141 · see citing works
Reversal of antidepressant action by dopamine antagonists in an animal model of depression
Sampson, D., Willner, P., & Muscat, R. (1991) · Psychopharmacology · doi:10.1007/bf02245655 · Cited by 115 · see citing works
Receptor subtype-specific dopaminergic agents and conditioned behavior
Beninger, R. J., Hoffman, D. C., & Mazurski, E. J. (1989) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(89)80019-3 · Cited by 109 · see citing works
Self-citationEffects of dopamine receptor antagonists on sucrose consumption and preference
Muscat, R., & Willner, P. (1989) · Psychopharmacology · doi:10.1007/bf00634461 · Cited by 101 · see citing works
Miller, R. J., Wickens, J. R., & Beninger, R. J. (1990) · Progress in Neurobiology · doi:10.1016/0301-0082(90)90005-2 · Cited by 100 · see citing works
Self-citationEvidence for involvement of both D1 and D2 receptors in maintaining cocaine self-administration
Britton, D. R., Curzon, P., MacKenzie, R. G., Kebabian, J. W., Williams, J. E., & Kerkman, D. J. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90052-4 · Cited by 98 · see citing works
Salamone, J. D., Cousins, M. S., Maio, C., Champion, M., Turski, T., & Kovach, J. (1996) · Psychopharmacology · doi:10.1007/bf02249408 · Cited by 93 · see citing works
The role of signaling molecules in reward-related incentive learning
Beninger, R. J., & Gerdjikov, T. V. (2004) · Neurotoxicity Research · doi:10.1007/bf03033301 · Cited by 79 · see citing works
Self-citationPharmacology of Flavor Preference Conditioning in Sham-Feeding Rats
Yu, W.-Z., Sclafani, A. J., Delamater, A. R., & Bodnar, R. J. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00124-0 · Cited by 77 · see citing works
Attenuation of sucrose reinforcement in dopamine D1 receptor deficient mice
El-Ghundi, M., O’Dowd, B. F., Erclik, M. S., & George, S. R. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02496.x · Cited by 76 · see citing works
Joel, D., & Doljansky, J. T. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300010 · Cited by 72 · see citing works
Trevitt, J. T., Carlson, B., Nowend, K. L., & Salamone, J. D. (2001) · Psychopharmacology · doi:10.1007/s002130100708 · Cited by 70 · see citing works
Effects of dopaminergic drugs on working and reference memory in rats
Bushnell, P. J., & Levin, E. D. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90119-e · Cited by 71 · see citing works
Feldon, J., Katz, Y., & Weiner, I. (1988) · Psychopharmacology · doi:10.1007/bf00172968 · Cited by 60 · see citing works
Beninger, R. J., & Ranaldi, R. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90116-8 · Cited by 59 · see citing works
Self-citationPharmacology of Flavor Preference Conditioning in Sham-Feeding Rats
Yu, W.-Z., Silva, R. M., Sclafani, A. J., Delamater, A. R., & Bodnar, R. J. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00239-7 · Cited by 58 · see citing works
Pruitt, D. L., Bolaños, C. A., & McDougall, S. A. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00309-9 · Cited by 56 · see citing works
Role of dopamine D₁ and D₂ receptors in novelty-maintained place preference.
Bardo, M. T., Bowling, S. L., Robinet, P. M., Rowlett, J. K., Lacy, M., & Mattingly, B. A. (1993) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.1.1-4.101 · Cited by 55 · see citing works
Wachtel, H. (1991) · Journal of Neural Transmission - Parkinsons Disease and Dementia Section · doi:10.1007/bf02259537 · Cited by 54 · see citing works
The dopamine receptor antagonist SCH 23390 attenuates feeding induced by Δ9-tetrahydrocannabinol
Verty, A. N. A., McGregor, I. S., & Mallet, P. E. (2004) · Brain Research · doi:10.1016/j.brainres.2004.06.033 · Cited by 47 · see citing works
Ranaldi, R., & Beninger, R. J. (1993) · Psychopharmacology · doi:10.1007/bf02244342 · Cited by 47 · see citing works
Self-citationBupropion attenuates methamphetamine self-administration in adult male rats
Reichel, C. M., Murray, J. E., Grant, K. M., & Bevins, R. A. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.09.006 · Cited by 46 · see citing works
Trevitt, J. T., Lyons, M., Aberman, J., Carriero, D. L., Finn, M., & Salamone, J. D. (1997) · Psychopharmacology · doi:10.1007/s002130050322 · Cited by 46 · see citing works
Ishiwari, K., Betz, A. J., Weber, S. M., Felsted, J., & Salamone, J. D. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.12.006 · Cited by 45 · see citing works
Anhedonia in Unipolar Major Depressive Disorder: A Review~!2009-10-26~!2010-02-18~!2010-04-08~!
Dichter, G. S. (2010) · The Open Psychiatry Journal · doi:10.2174/1874354401004010001 · Cited by 50 · see citing works
Harper, D. N., Wisnewski, R., Hunt, M. J., & Schenk, S. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.2.455 · Cited by 41 · see citing works
Anhedonia in Unipolar Major Depressive Disorder: A Review
Dichter, G. S. (2010) · The Open Psychiatry Journal · Cited by 36 · see citing works
Effects of quinpirole on operant conditioning: perseveration of behavioral components
Kurylo, D. D. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.04.015 · Cited by 35 · see citing works
Joel, D., Avisar, A., & Doljansky, J. T. (2001) · Behavioral Neuroscience · doi:10.1037//0735-7044.115.6.1291 · Cited by 35 · see citing works
Neuropeptide-Y alters VTA dopamine neuron activity through both pre- and postsynaptic mechanisms
West, K. S., & Roseberry, A. G. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00879.2016 · Cited by 32 · see citing works
Baker, R. W., Osman, J. L., & Bodnar, R. J. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00528-7 · Cited by 30 · see citing works
Behavioral Effects of Clozapine and Dopamine Receptor Subtypes
Josselyn, S. A., Miller, R. J., & Beninger, R. J. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00051-6 · Cited by 30 · see citing works
Self-citationMcGregor, I. S., Atrens, D. M., & Jackson, D. M. (1992) · Psychopharmacology · doi:10.1007/bf02801979 · Cited by 28 · see citing works
Hunt, G. E., Atrens, D. M., & Jackson, D. M. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90192-9 · Cited by 28 · see citing works
Involvement of central dopamine and D1 receptors in stress-induced colonie motor alterations in rats
Bueno, L. P., Gué, M., Fabre‐Nys, C., & Junien, J. (1992) · Brain Research Bulletin · doi:10.1016/0361-9230(92)90018-s · Cited by 28 · see citing works
Nutritional Controls of Food Reward
Fernandes, M. F., Sharma, S., Hryhorczuk, C., Auguste, S., & Fulton, S. E. (2013) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2013.04.004 · Cited by 27 · see citing works
Rostral-caudal differences in effects of nucleus accumbens amphetamine on VTA ICSS
Ranaldi, R., & Beninger, R. J. (1994) · Brain Research · doi:10.1016/0006-8993(94)90929-6 · Cited by 25 · see citing works
Self-citationBidirectional Effects of Dopamine D2 Receptor Antagonists on Responding for a Conditioned Reinforcer
Smith, J. K., Neill, J. C., & Costall, B. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00399-1 · Cited by 25 · see citing works
Disentangling the role of NAc D1 and D2 cells in hedonic eating
Guillaumin, M. C. C., Viskaitis, P., Bracey, E. F., Burdakov, D., & Peleg‐Raibstein, D. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02131-x · Cited by 24 · see citing works
Ljungberg, T. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90412-7 · Cited by 24 · see citing works
Beninger, R. J., D'Amico, C. M., & Ranaldi, R. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90249-s · Cited by 23 · see citing works
Self-citationPreferential stimulation of D1 or D2 receptors disrupts food-rewarded operant responding in rats
Hoffman, D. C., & Beninger, R. J. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90296-7 · Cited by 23 · see citing works
Self-citationTests of functional equivalence between pimozide pretreatment, extinction and free feeding
Willner, P., Chawla, K., Sampson, D., Sophokleous, S., & Muscat, R. (1988) · Psychopharmacology · doi:10.1007/bf00181960 · Cited by 23 · see citing works
Holahan, M. R., Clarke, M., & Hines, D. D. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1959-8 · Cited by 22 · see citing works
Yates, J. R., & Bardo, M. T. (2017) · Behavioral Neuroscience · doi:10.1037/bne0000214 · Cited by 22 · see citing works
Rewarding effects of nicotine self-administration increase over time in male and female rats.
Chellian, R., Behnood-Rod, A., Wilson, R., & Bruijnzeel, A. W. (2021) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntab097 · Cited by 18 · see citing works
Frick, L. R., Bernardez-Vidal, M., Höcht, C., Zanutto, B. S., & Rapanelli, M. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.06.025 · Cited by 21 · see citing works
Effects of quinpirole on behavioral extinction
Kurylo, D. D., & Tanguay, S. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00218-x · Cited by 21 · see citing works
A matching law analysis of the effects of dopamine receptor antagonists
Willner, P., Sampson, D., Phillips, G. D., & Muscat, R. (1990) · Psychopharmacology · doi:10.1007/bf02244238 · Cited by 21 · see citing works
Olarte‐Sánchez, C. M., Valencia-Torres, L., Cassaday, H. J., Bradshaw, C. M., & Szabadi, E. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3189-3 · Cited by 20 · see citing works
Ranaldi, R., & Beninger, R. J. (1995) · Psychopharmacology · doi:10.1007/bf02245944 · Cited by 19 · see citing works
Self-citationDopamine-Glutamate Interactions in Reward-Related Incentive Learning
Beninger, R. J., & Gerdjikov, T. V. (2005) · Humana Press eBooks · doi:10.1007/978-1-59259-852-6_14 · Cited by 17 · see citing works
Self-citationDifferentiation of haloperidol and clozapine using a complex operant schedule in the dog
Bruhwyler, J., Chleide, E. M. G., Houbeau, G., Waegeneer, N., & MERCIER, M. G. A. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90297-7 · Cited by 16 · see citing works
Does dopamine block the spawning of the acroporid coral Acropora tenuis?
Isomura, N., Yamauchi, C., Takeuchi, Y., & Takemura, A. (2013) · Scientific Reports · doi:10.1038/srep02649 · Cited by 15 · see citing works
Bruhwyler, J., & Chleide, E. M. G. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90424-z · Cited by 15 · see citing works
West, K. S., Lü, C., Olson, D. P., & Roseberry, A. G. (2019) · The Journal of Physiology · doi:10.1113/jp277193 · Cited by 14 · see citing works
Huang, A. C. W., Shyu, B., & Hsiao, S. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.02.003 · Cited by 14 · see citing works
Chellian, R., Behnood‐Rod, A., Wilson, R., Lin, K., King, G. W.-Y., Ruppert-Gomez, M., Teter, A. N., Febo, M., & Bruijnzeel, A. W. (2022) · Scientific Reports · doi:10.1038/s41598-022-18081-3 · Cited by 13 · see citing works
Martimiano, P. H. D. M., da Silva, G. R., Coimbra, V. F. D. S. A., de Matos, R. J. B., de Souza, B. F. P., da Silva, A. A. M., de Melo, D. D. C. B., de Souza, S. L., & de Freitas, M. F. L. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.04.008 · Cited by 13 · see citing works
Effects of SCH 23390 on motivational aspects of deprivation-induced feeding
Koechling, U. M., Colle, L. M., & Wise, R. A. (1988) · Psychobiology · doi:10.3758/bf03327308 · Cited by 13 · see citing works
Ljungberg, T. (1989) · Journal of Neural Transmission · doi:10.1007/bf01578748 · Cited by 11 · see citing works
McDougall, S. A., Crawford, C. A., & Nonneman, A. J. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90460-w · Cited by 11 · see citing works
Behavioural tests of the dopamine depletion hypothesis of neuroleptic-induced response decrement
Willner, P., Phillips, G. D., Muscat, R., & Hood, P. (1992) · Psychopharmacology · doi:10.1007/bf02244828 · Cited by 8 · see citing works
Vigorito, M., Kruse, C. B., & Carretta, J. C. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90153-8 · Cited by 7 · see citing works
Pimozide, like extinction, devalues stimuli associated with sucrose taking
Johnston, L. D., Beninger, R. J., & Olmstead, M. C. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00460-9 · Cited by 7 · see citing works
Self-citationClinical evaluation of the on-line Sensicath blood gas monitoring system.
Myklejord, D. J., PRITZKER, M. R., Nicoloff, D. M., Emery, A. M., & Emery, R. W. (1998) · PubMed · Cited by 7 · see citing works
Koerber, J., Goodman, D., Barnes, J. L., & Grimm, J. W. (2013) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000002 · Cited by 6 · see citing works
Ting‐A‐Kee, R. A., Heinmiller, A., & van der Kooy, D. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.06.016 · Cited by 5 · see citing works
I., R. M. M. (2005) · Frontiers in bioscience · doi:10.2741/1723 · Cited by 4 · see citing works
Vercammen, L., López-Moraga, A., Beckers, T., Vervliet, B., & Luyten, L. (2025) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2025.108039 · Cited by 3 · see citing works
Baker, T. W., Florczynski, M. M., & Beninger, R. J. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3789-6 · Cited by 4 · see citing works
Self-citationHolahan, M. R., & Goheen, K. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.134917 · Cited by 3 · see citing works
Coley, C., Woodward, R., Naylor, L. H., & Strange, P. G. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb17244.x · Cited by 3 · see citing works
The neurochemical consequences of aromatic L-amino acid decarboxylase deficiency
Allen, G. F. G. (2011) · UCL Discovery (University College London) · Cited by 1 · see citing works
Efeito da administração aguda e repetida de fencanfamina sobre o valor reforçado do estímulo
García‐Mijares, M. (2000) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.47.2000.tde-14092006-114120
Baker, T. W. (2013) · QSpace (Queen's University Library)
West, K. M. (2022) · Digital Archive @ GSU · doi:10.57709/12454585
Vercammen, L., López-Moraga, A., Beckers, T., Vervliet, B., & Luyten, L. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.29.626069
The Role of Dopamine in Resistance to Change of Operant Behavior
Quick, S. L. (2021) · Digital Commons - USU (Utah State University) · doi:10.26076/64c5-a6f4
- Authors
- Beninger, R. J., Cheng, M., Hahn, B. L., Hoffman, D. C., Mazurski, E. J., Morency, M. A., Ramm, P., & Stewart, R. J.
- Affiliations
- Queen's University (CA)
- Venue
- Psychopharmacology
- Published
- 1987-07
- Volume
- 92
- Issue
- 3
- Pages
- 343-349
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W1969401266
- Cited by
- 93
- References
- 32
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 2
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- extinction, pimozide, SCH 23390, metoclopramide, dopamine antagonists, dopamine D1 receptor, dopamine D2 receptor, reward, nonreinforcement, variable-interval schedules, lever pressing, rats
- MeSH terms
- Animals, Appetitive Behavior, Benzazepines, Brain, Conditioning, Operant, Extinction, Psychological, Male, Metoclopramide, Pimozide, Rats, Inbred Strains, Receptors, Dopamine, Reinforcement Schedule, Receptors, Dopamine D1, Receptors, Dopamine D2, Rats
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