The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
The role of GABAA receptors in the acute and chronic effects of ethanol: a decade of progress
Open accessAbstract
The past decade has brought many advances in our understanding of GABAA receptor-mediated ethanol action in the central nervous system. We now know that specific GABAA receptor subtypes are sensitive to ethanol at doses attained during social drinking while other subtypes respond to ethanol at doses attained by severe intoxication. Furthermore, ethanol increases GABAergic neurotransmission through indirect effects, including the elevation of endogenous GABAergic neuroactive steroids, presynaptic release of GABA, and dephosphorylation of GABAA receptors promoting increases in GABA sensitivity. Ethanol’s effects on intracellular signaling also influence GABAergic transmission in multiple ways that vary across brain regions and cell types. The effects of chronic ethanol administration are influenced by adaptations in GABAA receptor function, expression, trafficking, and subcellular localization that contribute to ethanol tolerance, dependence, and withdrawal hyperexcitability. Adolescents exhibit altered sensitivity to ethanol actions, the tendency for higher drinking and longer lasting GABAergic adaptations to chronic ethanol administration. The elucidation of the mechanisms that underlie adaptations to ethanol exposure are leading to a better understanding of the regulation of inhibitory transmission and new targets for therapies to support recovery from ethanol withdrawal and alcoholism.
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Citations
Cites
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Cited by
A DNA methylation biomarker of alcohol consumption
Liu, C., Marioni, R. E., Hedman, Å. K., Pfeiffer, L., Tsai, P.-C., Reynolds, L. M., Just, A. C., Duan, Q., Boer, C. G., Tanaka, T., et al. (2018) · Molecular Psychiatry · doi:10.1038/mp.2016.192 · Cited by 402
Steroidogenesis: Unanswered Questions
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Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148
Synaptic targets: chronic alcohol actions
Roberto, M., & Varodayan, F. P. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.013 · Cited by 149
The Role of the Central Amygdala in Alcohol Dependence
Roberto, M., Kirson, D., & Khom, S. (2021) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039339 · Cited by 112
Metadata
- Authors
- Kumar, S., Porcu, P., Werner, D. F., Matthews, D. B., Diaz-Granados, J. L., Helfand, R. S., & Morrow, A. L.
- Venue
- Psychopharmacology
- Published
- 2009-05-20
- Volume
- 205
- Issue
- 4
- Pages
- 529-564
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W1980478962
- Cited by
- 431
- References
- 18
- FWCI
- 14.43
- Type
- journal article
- Language
- en
- Open access
- green
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