The 5-HT7 receptor and disorders of the nervous system: an overview

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A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms

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Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors

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Binding of lurasidone, a novel antipsychotic, to rat 5-HT7 receptor: Analysis by [3H]SB-269970 autoradiography

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Low-basicity 5-HT7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol

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Synthesis and biological evaluation of potential 5-HT7 receptor PET radiotracers

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Structure–activity relationships and molecular studies of novel arylpiperazinylalkyl purine-2,4-diones and purine-2,4,8-triones with antidepressant and anxiolytic-like activity

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Protective effect of 5-HT7 receptor activation against glutamate-induced neurotoxicity in human neuroblastoma SH-SY5Y cells via antioxidative and antiapoptotic pathways

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Interactions between heavy metals and sleep duration among pre-and postmenopausal women: A current approach to molecular mechanisms involved

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The development and validation of a novel virtual screening cascade protocol to identify potential serotonin 5-HT7R antagonists

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Decision time and perseveration of adolescent rats in the T-maze are affected differentially by buspirone and independent of 5-HT-1A expression

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Aberrant Rho GTPases signaling and cognitive dysfunction: In vivo evidence for a compelling molecular relationship

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Serotonin and Depression: Scrutiny of New Targets for Future Anti- Depressant Drug Development

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Assessment of 5-HT7Receptor Agonists Selectivity Using Nociceptive and Thermoregulation Tests in Knockout versus Wild-Type Mice

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New advances in the treatment of generalized anxiety disorder: the multimodal antidepressant vortioxetine

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ADN ‐1184 a monoaminergic ligand with 5‐ HT 6/7receptor antagonist activity: pharmacological profile and potential therapeutic utility

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Neuroanatomical dichotomy of sexual behaviors in rodents

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Rational Design, Pharmacomodulation, and Synthesis of Dual 5-Hydroxytryptamine 7 (5-HT7)/5-Hydroxytryptamine 2A (5-HT2A) Receptor Antagonists and Evaluation by [18F]-PET Imaging in a Primate Brain

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Update on the development of lurasidone as a treatment for patients with acute schizophrenia

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Synthesis and biological evaluation of 2-fluoro and 3-trifluoromethyl-phenyl-piperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione as potential antidepressant agents

Zagórska, A., Bucki, A., Kołaczkowski, M., Siwek, A., Głuch‐Lutwin, M., Starowicz, G., Kazek, G., Partyka, A., Wesołowska, A., Słoczyńska, K., et al. (2016) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2016.1198902 · Cited by 23

Lurasidone for major depressive disorder with mixed features and anxiety: a post-hoc analysis of a randomized, placebo-controlled study

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Assessment of Infant Dose Through Milk in a Lactating Woman Taking Amisulpride and Desvenlafaxine for Treatment-Resistant Depression

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Serotonin Receptors as a Potential Target in the Treatment of Alzheimer’s Disease

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Effects of amisulpride on human resting cerebral perfusion

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The role of serotonin receptors in migraine headaches

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Acute and repeated treatment with the 5-HT7 receptor antagonist SB 269970 induces functional desensitization of 5-HT7 receptors in rat hippocampus

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Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5-HT7-Rs in naples high excitability rats

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The ERBB4 intracellular domain (4ICD) regulates NRG1-induced gene expression in hippocampal neurons

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The Extracellular Entrance Provides Selectivity to Serotonin 5-HT7Receptor Antagonists with Antidepressant-like Behavior in Vivo

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Concomitant medication of psychoses in a lifetime perspective

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The effects of a 5-HT7 receptor agonist and antagonist on morphine withdrawal syndrome in mice

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Effects of 5-HT7 receptor antagonists on behaviors of mice that detect drugs used in the treatment of anxiety, depression, or schizophrenia

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Autism-like behaviors regulated by the serotonin receptor 5-HT2B in the dorsal fan-shaped body neurons of Drosophila melanogaster

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Synthesis and pharmacological evaluation of a new series of radiolabeled ligands for 5-HT7 receptor PET neuroimaging

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Palmitoylation of serotonin receptors

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Long-Term Citalopram Treatment Alters the Stress Responses of the Cortical Dopamine and Noradrenaline Systems: the Role of Cortical 5-HT1AReceptors

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New 1-arylindoles based serotonin 5-HT7 antagonists. Synthesis and binding evaluation studies

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Effects of the selective 5-HT7 receptor antagonist SB-269970 on premature responding in the five-choice serial reaction time test in rats

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Migraine, epilepsy, and psychiatric comorbidity

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Receptor screening technologies in the evaluation of Amazonian ethnomedicines with potential applications to cognitive deficits

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Cognitive Impairment in Schizophrenia, Neurotransmitters and the New Atypical Antipsychotic Aripiprazole

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Changes in brain white matter structure are associated with urine proteins in urologic chronic pelvic pain syndrome (UCPPS): A MAPP Network study

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Serotonin Type 6 and 7 Receptors as a Novel Therapeutic Target for the Treatment of Schizophrenia

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LP‐211, a selective 5‐HT7 receptor agonist, increases novelty‐preference and promotes risk‐prone behavior in rats

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Remission and recovery associated with lurasidone in the treatment of major depressive disorder with subthreshold hypomanic symptoms (mixed features): post-hoc analysis of a randomized, placebo-controlled study with longer-term extension

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Maternal exercise increases but concurrent maternal fluoxetine prevents the increase in hippocampal neurogenesis of adult offspring

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Privileged scaffold-based design to identify a novel drug-like 5-HT7 receptor-preferring agonist to target Fragile X syndrome

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Xylazine as an emerging new psychoactive substance; focuses on both 5‐HT7 and κ‐opioid receptors' molecular interactions and isosteric replacement

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Serotonergic Agents in the Management of Cluster Headache

Lambru, G., & Matharu, M. S. (2011) · Current Pain and Headache Reports · doi:10.1007/s11916-011-0176-4 · Cited by 14

The effects of drug detection training on behavioral reactivity and blood neurotransmitter levels in drug detection dogs: A preliminary study

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Pharmacophore Comparison and Development of Recently Discovered Long Chain Arylpiperazine and Sulfonamide Based 5-HT7 Ligands

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Microinjection of the 5-HT7 receptor antagonist SB-269970 into the rat brainstem and basal forebrain: Site-dependent effects on REM sleep

Monti, J. M., Leopoldo, M., Jantos, H., & Lagos, P. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.05.012 · Cited by 14

Labeling and preliminary in vivo evaluation of the 5-HT7 receptor selective agonist [11C]E-55888

Hansen, H. D., Andersen, V. L., Lehel, S., Magnussen, J. H., Dyssegaard, A., Stroth, N., Kristensen, J. L., Knudsen, G. M., & Herth, M. M. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.03.039 · Cited by 13

5-HT7receptor modulators: a medicinal chemistry survey of recent patent literature (2004 – 2009)

Leopoldo, M., Lacivita, E., Berardi, F., & Perrone, R. (2010) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2010.484802 · Cited by 13

Asenapine reduces anxiety-related behaviours in rat conditioned fear stress model

Ohyama, M., Kondo, M., Yamauchi, M., Imanishi, T., & Koyama, T. (2016) · Acta Neuropsychiatrica · doi:10.1017/neu.2016.17 · Cited by 13

Aminotriazines with indole motif as novel, 5-HT7 receptor ligands with atypical binding mode

Kułaga, D., Jaśkowska, J., Satała, G., Latacz, G., & Śliwa, P. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.104254 · Cited by 13

Novel tricyclic[2,1-f]theophylline derivatives of LCAP with activity in mouse models of affective disorders

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Ultrasound assisted one-pot synthesis and preliminary in vitro studies of salicylamide arylpiperazines as dual 5-HT1A/5-HT7 ligands

Jaśkowska, J., Drabczyk, A. K., Śliwa, P., Jodłowski, P. J., Pindelska, E., Kułaga, D., Zaręba, P., Majka, Z., Siwek, A., Wolak, M., et al. (2022) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2022.134585 · Cited by 12

Novel insights into the potential involvement of 5-HT7 receptors in endocrine dysregulation in stress-related disorders

Terrón, J. A. (2014) · Reviews in the Neurosciences · doi:10.1515/revneuro-2014-0017 · Cited by 12

5-HT1A/5-HT7 receptor interplay: Chronic activation of 5-HT7 receptors decreases the functional activity of 5-HT1A receptor and its сontent in the mouse brain

Kondaurova, E. M., Базовкина, Д. В., & Naumenko, V. S. (2017) · Molecular Biology · doi:10.1134/s0026893316060108 · Cited by 12

Serotonin 5-HT7 receptor slows down the Gs protein: a single molecule perspective

Petelák, A., Lambert, N. A., & Bondar, A. (2023) · Molecular Biology of the Cell · doi:10.1091/mbc.e23-03-0117 · Cited by 11

Reversal of electrophysiological and behavioral deficits mediated by 5-HT7 receptor upregulation following LP-211 treatment in an autistic-like rat model induced by prenatal valproic acid exposure

Rahdar, M., Davoudi, S., Dehghan, S., Javan, M., Hosseinmardi, N., Behzadi, G., & Janahmadi, M. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110057 · Cited by 11

Asenapine in bipolar I disorder: evidence and place in patient management

Samalin, L., Charpeaud, T., & Llorca, P. (2012) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622312468933 · Cited by 11

A randomized, double-blind, placebo controlled, phase 1 study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of LB-102, a selective dopamine D2/3/5-HT7 inhibitor

Biernat, L., Grattan, V. T., Hixon, M. S., Prensky, Z., & Vaino, A. R. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06185-7 · Cited by 11

Effects of medial prefrontal cortex 5-HT7 receptor knockdown on cognitive control after acute heroin administration

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Novel antagonists of 5-HT6 and/or 5-HT7 receptors affect the brain monoamines metabolism and enhance the anti-immobility activity of different antidepressants in rats

Partyka, A., Jastrzębska‐Więsek, M., Antkiewicz‐Michaluk, L., Michaluk, J., Wąsik, A., Canale, V., Zajdel, P., Kołaczkowski, M., & Wesołowska, A. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.10.004 · Cited by 11

Prior Activation of 5-HT7 Receptors Modulates the Conditioned Place Preference With Methylphenidate

Carbone, C., Russo, S. L. M. L., Lacivita, E., Frank, A., Alleva, E., Stark, H., Saso, L., Leopoldo, M., & Adriani, W. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00208 · Cited by 11

The effect of second-generation antipsychotics on anxiety/depression in patients with schizophrenia: A systematic review and meta-analysis

Abdolizadeh, A., Kupaei, M. H., Kambari, Y., Amaev, A., Korann, V., Torres‐Carmona, E., Song, J., Ueno, F., KOIZUMI, M., Nakajima, S., et al. (2024) · Schizophrenia Research · doi:10.1016/j.schres.2024.05.020 · Cited by 10

Stress- and antidepressant treatment-induced modifications of 5-HT7 receptor functions in the rat brain

Tokarski, K., Bobula, B., Grzegorzewska-Hiczwa, M., Kusek, M., & Hess, G. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70928-3 · Cited by 10

Solid‐Supported Synthesis and 5‐ HT 7/5‐ HT 1A Receptor Affinity of Arylpiperazinylbutyl Derivatives of 4,5‐dihydro‐1,2,4‐triazine‐6‐(1H)‐one

Grychowska, K., Masurier, N., Verdié, P., Satała, G., Bojarski, A. J., Martínez, J., Pawłowski, M., Subra, G., & Zajdel, P. (2015) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12539 · Cited by 10

Intracerebral transplantation for neurological disorders. Lessons from developmental, experimental, and clinical studies

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Design, Synthesis and Biological Evaluation of Novel 1,3,5-Triazines: Effect of Aromatic Ring Decoration on Affinity to 5-HT7 Receptor

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Lurasidone in post-menopausal females with major depressive disorder with mixed features: Post-hoc analysis of a placebo-controlled trial

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