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What and when to "want"? Amygdala-based focusing of incentive salience upon sugar and sex
Open accessAbstract
Rationale Amygdala-related circuitry helps translate learned Pavlovian associations into appetitive and aversive motivation, especially upon subsequent encounters with cues. Objectives We asked whether μ-opioid stimulation via microinjections of the specific agonist D-Ala(2), N-MePhe(4), Gly-ol)-enkephalin (DAMGO) in central nucleus of amygdala (CeA), or the adjacent basolateral amygdala (BLA) would magnify sucrose or sex "wanting", guided by available cues. Materials and methods CeA or BLA DAMGO enhancement of cue-triggered "wanting" was assessed using Pavlovian to instrumental transfer (PIT). Unconditioned food "wanting" was measured via intake, and male sexual "wanting" for an estrous female was measured in a sexual approach test. Sucrose hedonic taste "liking" was measured in a taste reactivity test. Results CeA (but not BLA) DAMGO increased the intensity of phasic peaks in instrumental sucrose seeking stimulated by Pavlovian cues over precue levels in PIT, while suppressing seeking at other moments. CeA DAMGO also enhanced food intake, as well as sexual approach and investigation of an estrous female by males. DAMGO "wanting" enhancements were localized to CeA, as indicated by "Fos plume"-based anatomical maps for DAMGO causation of behavioral effects. Despite increasing "wanting", CeA DAMGO decreased the hedonic impact or "liking" for sucrose in a taste reactivity paradigm. Conclusions CeA μ-opioid stimulation specifically enhances incentive salience, which is dynamically guided to food or sex by available cues.
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“Evidence suggests that repeated excitation by sexual stimuli can have a similar effect (Lynch and Ryan, 2020;Mahler and Berridge, 2012).”
From A motivation model of sex addiction – Relevance to the controversy over the concept (2022) · cites this paper as Mahler and Berridge, 2012
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Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,514
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Self-citationIntegrative activity of the brain
Konorski, J. (1967) · University of Chicago Press eBooks · Cited by 2,043
The taste reactivity test. I. Mimetic responses to gustatory stimuli in neurologically normal rats
Grill, H. J., & Norgren, R. (1978) · Brain Research · doi:10.1016/0006-8993(78)90568-1 · Cited by 1,220
A selective role for dopamine in stimulus-reward learning
Flagel, S. B., Clark, J. J., Robinson, T. E., Mayo, L., Czuj, A., Willuhn, I., Akers, C. A., Clinton, S. M., Phillips, P. E. M., & Akil, H. (2011) · Nature · doi:10.1038/nature09588 · Cited by 1,026
The Amygdala: a functional analysis
Aggleton, J. P. (2000) · Cited by 966
Research works printed but not linked: 3
- Difeliceantonio AG, Berridge KC (2010) Neostriatal sites of mu opioid stimulation enhance CS motivational magnets. Society for Neuroscience, San Diego, CA
- Peciña S, Berridge KC (2008) Incentive salience mediation by opioid versus dopamine in nucleus accumbens shell and core: amplified cue-triggered ‘wanting’ for reward Society for Neuroscience. Society for Neuroscience, Washington, DC
- Toates F (1986) Motivational Systems. Cambridge University Press, Cambridge, UK
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Metadata
- Authors
- Mahler, S. V., & Berridge, K. C.
- Affiliations
- Medical University of South Carolina (US)
- University of Michigan (US)
- Corresponding author
- Mahler, Stephen V.
- Venue
- Psychopharmacology
- Published
- 2011-12-14
- Volume
- 221
- Issue
- 3
- Pages
- 407-426
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC3444284
- OpenAlex
- W2147423572
- Cited by
- 170
- References
- 103
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 49 · 2019: 14 · 2018: 14 · 2017: 9 · 2016: 18 · 2015: 12 · 2014: 11 · 2013: 6 · 2012: 8
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1s15mh053649-01)
- National Institute of Mental Health (MH053649, R01MH063649)
- National Institute on Drug Abuse (DA021481, DA015188, R01DA015188, F31DA021481)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- central amygdala, basolateral amygdala, mu-opioid receptor, DAMGO, incentive salience, sexual motivation, Pavlovian-to-instrumental transfer, sucrose seeking, dietary intake
- MeSH terms
- Amygdala, Analgesics, Opioid, Animals, Behavior, Animal, Cues, Eating, Estrus, Female, Male, Sexual Behavior, Animal, Sucrose, Rats, Sprague-Dawley, Receptors, Opioid, mu, Enkephalin, Ala(2)-MePhe(4)-Gly(5)-, Rats
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