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Cited by 15Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersNeuroendocrine regulation and behavior

Sociability development in mice with cell-specific deletion of the NMDA receptor NR1 subunit gene

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Ferri, Sarah L., Pallathra, Ashley A., Kim, Hyong, Dow, Holly C., Raje, Praachi, McMullen, Mary, Bilker, Warren B., Siegel, Steven J. +2 more·2020·Genes, Brain and Behavior
DOI 10.1111/gbb.12624PMC PMC7987227
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Abstract

Social affiliative behavior is an important component of everyday life in many species and is likely to be disrupted in disabling ways in various neurodevelopmental and neuropsychiatric disorders. Therefore, determining the mechanisms involved in these processes is crucial. A link between N‐methyl‐d‐aspartate (NMDA) receptor function and social behaviors has been clearly established. The cell types in which NMDA receptors are critical for social affiliative behavior, however, remain unclear. Here, we use mice carrying a conditional allele of the NMDA R1 subunit to address this question. Mice bearing a floxed NMDAR1 (NR1) allele were crossed with transgenic calcium/calmodulin‐dependent kinase IIα (CaMKIIα)‐Cre mice or parvalbumin (PV)‐Cre mice targeting postnatal excitatory forebrain or PV‐expressing interneurons, respectively, and assessed using the three‐chambered Social Approach Test. We found that deletion of NR1 in PV‐positive interneurons had no effect on social sniffing, but deletion of NR1 in glutamatergic pyramidal cells resulted in a significant increase in social approach behavior, regardless of age or sex. Therefore, forebrain excitatory neurons expressing NR1 play an important role in regulating social affiliative behavior.

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  • Vehicle-treated mice exhibited behavior statistically equivalent to historical never-injected control mice for social preference at ~PN30 and 24 hr fear memory at ~PN60.

    “veh-treated mice exhibited behavior statistically equivalent to historical data of ours with mice that were undisturbed as neonates (no neonatal injection)”

    From Excess Neonatal Testosterone Causes Male-Specific Social and Fear Memory Deficits in Wild-Type Mice (2025) · cites this paper as Ferri et al., 2020

    Materials and Methods (Behavior; page unavailable) describes social-approach testing at about 30 and 70 days, but not vehicle-treated or never-injected mice. The Discussion (page unavailable) compares 70-day sniffing with previously collected data from naïve mice; it does not report statistical equivalence after neonatal injections. Searches for vehicle treatment, neonatal injection, and 24-hour fear memory found no passage establishing the claimed comparison. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Ferri, S. L., Pallathra, A. A., Kim, H., Dow, H. C., Raje, P., McMullen, M., Bilker, W. B., Siegel, S. J., Abel, T., & Brodkin, E. S.
Affiliations
  • University of Iowa (US)
  • University of Pennsylvania (US)
  • University of Southern California (US)
Corresponding author
Brodkin, Edward S.
ORCID
Venue
Genes, Brain and Behavior
Publisher
Wiley
Published
2019-12-12
Volume
19
Issue
1
Pages
e12624-e12624
ISSN
  • 1601-183X (ISSN-L)
  • 1601-1848
DOI
10.1111/gbb.12624
PMC
PMC7987227
OpenAlex
W2983819633
Cited by
15
References
21
Citations by year
2026: 2 · 2025: 4 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1
FWCI
0.72
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Genes Brain & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (1P50MH096891)
  • Roy J. Carver Charitable Trust
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
NMDA receptor, NR1 subunit, social approach behavior, parvalbumin interneurons, conditional gene deletion, neuropsychiatric disorders
MeSH terms
Social Interaction, Animals, Female, Interneurons, Male, Mice, Inbred C57BL, Nerve Tissue Proteins, Parvalbumins, Receptors, N-Methyl-D-Aspartate, Prosencephalon, Gene Deletion, Pyramidal Cells, Mice

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