Cited by 170Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal PhysiologyMemory and Neural Mechanisms

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What and when to "want"? Amygdala-based focusing of incentive salience upon sugar and sex

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Mahler, Stephen V., Berridge, Kent C.·2012·Psychopharmacology

DOI 10.1007/s00213-011-2588-6PMC PMC3444284

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Abstract

Rationale Amygdala-related circuitry helps translate learned Pavlovian associations into appetitive and aversive motivation, especially upon subsequent encounters with cues. Objectives We asked whether μ-opioid stimulation via microinjections of the specific agonist D-Ala(2), N-MePhe(4), Gly-ol)-enkephalin (DAMGO) in central nucleus of amygdala (CeA), or the adjacent basolateral amygdala (BLA) would magnify sucrose or sex "wanting", guided by available cues. Materials and methods CeA or BLA DAMGO enhancement of cue-triggered "wanting" was assessed using Pavlovian to instrumental transfer (PIT). Unconditioned food "wanting" was measured via intake, and male sexual "wanting" for an estrous female was measured in a sexual approach test. Sucrose hedonic taste "liking" was measured in a taste reactivity test. Results CeA (but not BLA) DAMGO increased the intensity of phasic peaks in instrumental sucrose seeking stimulated by Pavlovian cues over precue levels in PIT, while suppressing seeking at other moments. CeA DAMGO also enhanced food intake, as well as sexual approach and investigation of an estrous female by males. DAMGO "wanting" enhancements were localized to CeA, as indicated by "Fos plume"-based anatomical maps for DAMGO causation of behavioral effects. Despite increasing "wanting", CeA DAMGO decreased the hedonic impact or "liking" for sucrose in a taste reactivity paradigm. Conclusions CeA μ-opioid stimulation specifically enhances incentive salience, which is dynamically guided to food or sex by available cues.

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Authors: Mahler, S. V., & Berridge, K. C.
Affiliations: Medical University of South Carolina (US)
University of Michigan (US)
Corresponding author: Mahler, Stephen V.
ORCID: Mahler, Stephen V.
Berridge, Kent C.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2011-12-14
Volume: 221
Issue: 3
Pages: 407-426
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-011-2588-6
PMC: PMC3444284
OpenAlex: W2147423572
Cited by: 170
References: 103
Citations by year: 2026: 6 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 49 · 2019: 14 · 2018: 14 · 2017: 9 · 2016: 18 · 2015: 12 · 2014: 11 · 2013: 6 · 2012: 8
FWCI: 3.13
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (1s15mh053649-01)
National Institute of Mental Health (MH053649, R01MH063649)
National Institute on Drug Abuse (DA021481, DA015188, R01DA015188, F31DA021481)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: central amygdala, basolateral amygdala, mu-opioid receptor, DAMGO, incentive salience, sexual motivation, Pavlovian-to-instrumental transfer, sucrose seeking, dietary intake
MeSH terms: Amygdala, Analgesics, Opioid, Animals, Behavior, Animal, Cues, Eating, Estrus, Female, Male, Sexual Behavior, Animal, Sucrose, Rats, Sprague-Dawley, Receptors, Opioid, mu, Enkephalin, Ala(2)-MePhe(4)-Gly(5)-, Rats

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What and when to "want"? Amygdala-based focusing of incentive salience upon sugar and sex

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