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Learning to forget: manipulating extinction and reconsolidation processes to treat addiction
Open accessAbstract
Finding effective long-lasting treatments for drug addiction has been an elusive goal. Consequently, researchers are beginning to investigate novel treatment strategies including manipulations of drug-associated memories. When environmental stimuli (cues) become associated with drug use, they become powerful motivators of continued drug use and relapse after abstinence. Reducing the strength of these cue-drug memories could decrease the number of factors that induce craving and relapse to aid in the treatment of addiction. Enhancing the consolidation of extinction learning and/or disrupting cue-drug memory reconsolidation are two strategies that have been proposed to reduce the strength of cues in motivating drug-seeking and drug-taking behavior. Here, we review the latest basic and clinical research elucidating the mechanisms underlying consolidation of extinction and reconsolidation of cue-drug memories in the hopes of developing pharmacological tools that exploit these signaling systems to treat addiction.
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From Are smoking cessation treatments associated with suicidality risk? An overview (2016) · cites this paper as [63]
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Cites
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Nader, K., Schafe, G. E., & Le Doux, J. E. (2000) · Nature · doi:10.1038/35021052 · Cited by 2,706
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647
Context and Behavioral Processes in Extinction: Table 1.
Bouton, M. E. (2004) · Learning & Memory · doi:10.1101/lm.78804 · Cited by 1,808
The Neurobiology of Consolidations, Or, How Stable is the Engram?
Dudai, Y. (2004) · Annual Review of Psychology · doi:10.1146/annurev.psych.55.090902.142050 · Cited by 1,671
Context, ambiguity, and unlearning: sources of relapse after behavioral extinction
Bouton, M. E. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01546-9 · Cited by 1,662
Meta‐analysis of cue‐reactivity in addiction research
Carter, B. L., & Tiffany, S. T. (1999) · Addiction · doi:10.1046/j.1360-0443.1999.9433273.x · Cited by 1,638 · cited 3×
“Environmental stimuli (cues) that are repeatedly associated with a drug are known to promote compulsive drug taking and craving and are a primary trigger of relapse (Carter and Tiffany 1999; Shalev et al. 2002; See 2002).”
The reinstatement model of drug relapse: history, methodology and major findings
Shaham, Y., Shalev, U., Lu, L., de Wit, H., & Stewart, J. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1224-x · Cited by 1,615
Jentsch, J. D., & Taylor, J. R. (1999) · Psychopharmacology · doi:10.1007/pl00005483 · Cited by 1,545
Self-citationTzschentke, T. M. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00070.x · Cited by 1,336
Preventing the return of fear in humans using reconsolidation update mechanisms
Schiller, D., Monfils, M.-H., Raio, C. M., Johnson, D. C., LeDoux, J. E., & Phelps, E. A. (2010) · Nature · doi:10.1038/nature08637 · Cited by 1,248
Cited by
Sorted by citations
Items 101–171 of 171
Wojciechowski, J., Draps, M., Kublik, E., Dubiejko, P., Wolak, T. P., & Gola, M. K. (2025) · Journal of Behavioral Addictions · doi:10.1556/2006.2025.00012 · Cited by 10
Detrimental Effects of a Retrieval-Extinction Procedure on Nicotine Seeking, but Not Cocaine Seeking
Struik, R. F., Vries, T. J. D., & Peters, J. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00243 · Cited by 9
Exogenous SO2 donor treatment impairs reconsolidation of drug reward memory in mice
Rulan, D., Yang, Z., Yipu, Z., Yuan, G., Galaj, E., Xiaorui, S., Li, W., Jiaqi, L., Yan, Z., Yang, C., et al. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173911 · Cited by 9
Moro, F., Giannotti, G., Caffino, L., Marzo, C. M., Clemente, A. D., Fumagalli, F., & Cervo, L. (2019) · Addiction Biology · doi:10.1111/adb.12771 · Cited by 10
Twisted memories: Addiction-related engrams are strengthened by desire thinking
Mattioni, L., Ferri, F., Nikčević, A. V., Spada, M. M., & Sestieri, C. (2023) · Addictive Behaviors · doi:10.1016/j.addbeh.2023.107782 · Cited by 8
Brain Neuroplasticity Mechanisms in Psychiatric Illnesses and in the Development of Novel Treatments
O’Donnell, P., Etkin, A., & Manji, H. K. (2026) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20251212 · Cited by 8
A review of the factors affecting the course and outcome of the treatment of substance use disorders
Flora, K. (2018) · Journal of Substance Use · doi:10.1080/14659891.2018.1549598 · Cited by 8
Amaral, V. C. S., Morais‐Silva, G., Laverde, C. F., & Marin, M. T. (2020) · Neuroscience Research · doi:10.1016/j.neures.2020.07.002 · Cited by 8
Xie, X., Huang, Y., Chen, R., Huang, Z., Gangal, H., Li, Z., Lu, J., Cruz, A. M., Chaiprasert, A., Yu, E., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.03.023 · Cited by 7
Laverde, C. F., Morais‐Silva, G., Amaral, V. C. S., & Marin, M. T. (2020) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000613 · Cited by 8
Are smoking cessation treatments associated with suicidality risk? An overview
Penberthy, J. K., Penberthy, J. M., Harris, M. R., Nanda, S., Ahn, J., Martinez, C. P., Osika, A. O., Slepian, Z. A., Forsyth, J. C., Starr, J. A., et al. (2016) · Substance Abuse: Research and Treatment · doi:10.4137/sart.s33389 · Cited by 6
Bender, B. N., Stringfield, S. J., & Torregrossa, M. M. (2024) · Addiction Neuroscience · doi:10.1016/j.addicn.2024.100149 · Cited by 6
Self-citationDrug‐Related Engrams and Their Role in the Persistence and Recurrence of Drug‐Related Behaviors
Cutler, M., Thati, A., & Grella, S. L. (2025) · Hippocampus · doi:10.1002/hipo.70040 · Cited by 10
Lewis, V., Laberge, F., & Heyland, A. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107502 · Cited by 5
Latagliata, E. C., Saccoccio, P., Milia, C., & Puglisi‐Allegra, S. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4177-6 · Cited by 7
Pintori, N., Piva, A., Guardiani, V., Decimo, I., & Chiamulera, C. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113556 · Cited by 6
A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Dimet‐Wiley, A., Cisneros, I. E., Fox, R. G., Stutz, S. J., Anastasio, N. C., Cunningham, K. A., & Dineley, K. T. (2018) · Journal of Visualized Experiments · doi:10.3791/55864 · Cited by 6
Maladaptive Memory Mechanisms in Addiction and Relapse
Rich, M. T., & Torregrossa, M. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812202-0.00008-7 · Cited by 7
Self-citationGuida, C. R., Maia, J. M., Ferreira, L. F. R., Rahdar, A., Branco, L. G. S., & Soriano, R. N. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111070 · Cited by 6
Where do we stand in the field of anti-abuse drug discovery?
Tzschentke, T. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.948415 · Cited by 5
Lay, B. P. P., & Khoo, S. Y. (2021) · Neuroanatomy and Behaviour · doi:10.35430/nab.2021.e18 · Cited by 4
Circuits that encode and predict alcohol associated preferencePreprint
Scaplen, K. M., Talay, M., Salamon, S., Nuñez, K. M., Waterman, A. G., Gang, S., Song, S. L., Barnea, G., & Kaun, K. R. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/578401 · Cited by 5
Lloret-Torres, M. E., & Barreto-Estrada, J. L. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115300 · Cited by 4
Conditioned place preferences for virtual alcohol cues
Sklenarik, S. M., Burrows, C. N., & Astur, R. S. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114176 · Cited by 5
Peeters, L. D., Wills, L. J., Cuozzo, A. M., Ivanich, K. L., & Brown, R. W. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06379-7 · Cited by 4
de Carvalho, C. R., Stern, C. A. J., Bertoglio, L. J., & Takahashi, R. N. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800213-1.00075-4 · Cited by 4
Das, R., Gale, G., Hennessy, V. E., & Kamboj, S. K. (2018) · Journal of Visualized Experiments · doi:10.3791/56097-v · Cited by 4
Smith, D. M., & Torregrossa, M. M. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110160 · Cited by 3
Self-citationKou, X., Tao, Y., Xian, J.-Y., Lin, Y., Cai, C.-Y., Wu, H., Chang, L., & Zhu, D. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.02.112 · Cited by 3
Kuiper, L. B., Lucas, K. A., Mai, V., & Coolen, L. M. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00087 · Cited by 3
Franco‐García, A., Gómez‐Murcia, V., & Núñez, C. (2025) · Behavioral and Brain Functions · doi:10.1186/s12993-025-00313-x · Cited by 2
Zacher, A., Dietiker, L., Häffner, V., Bavato, F., Kleim, B., & Quednow, B. B. (2026) · Addiction · doi:10.1111/add.70449 · Cited by 2
Young, C. C., Papini, S., Minami, H., Morikawa, H., Otto, M. W., Roache, J. D., & Smits, J. A. J. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01872-9 · Cited by 2
Bakhtazad, A., Kabbaj, M., Garmabi, B., & Joghataei, M. T. (2024) · Peptides · doi:10.1016/j.peptides.2024.171298 · Cited by 2
López-García, P., McGreevy, K. R., Vaquero, M. E., Suarez‐Rivero, J. M., Moreno-Rodríguez, A., Pérez‐Pulido, A. J., de Mingo, D. R., Pallé, A., Popiel, H. A., Santi, A., et al. (2026) · Advanced Science · doi:10.1101/2025.01.27.635080 · Cited by 3
Yue, J.-L., Wang, R., Chen, S., Lin, X., Fang, Q., Guo, X.-J., Sun, Y., Yuan, K., Bao, Y., Shi, J., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03474-5 · Cited by 3
Crisis, what crisis? Addiction neuroscience and the challenges of translation
McLean, S., & Rose, N. (2020) · Wellcome Open Research · doi:10.12688/wellcomeopenres.16265.1 · Cited by 15
Rose, T. R., de Velasco, E. M. F., Mitten, E. H., & Wickman, K. (2022) · Addiction Biology · doi:10.1111/adb.13256 · Cited by 1
Wu, H., Song, Z., Chen, Q., Yan, R., Zhao, H., & Li, H. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118037 · Cited by 1
A novel imagery-based retrieval-extinction training for intervention in nicotine addiction
Chen, B., Gan, H., Yang, L., Yan, X., Lv, X., Zhang, X., & Bu, J. (2025) · BMC Medicine · doi:10.1186/s12916-025-04386-3 · Cited by 1
Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats
Rich, M. T., Huang, Y. H., & Torregrossa, M. M. (2021) · Journal of Visualized Experiments · doi:10.3791/63185 · Cited by 1
Self-citationBlasco-Fontecilla, H. (2023) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780197611272.013.11 · Cited by 1
Interactions between memory and reward systems
Poh, J.-H., & Adcock, R. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15754-7.00049-3 · Cited by 1
Berro, L. F., Howell, L. L., Tufik, S. B., & Andersen, M. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800634-4.00006-8 · Cited by 1
Manipulating Reconsolidation to Weaken Drug Memory
Milton, A. L. (2021) · Neuromethods · doi:10.1007/978-1-0716-1748-9_13 · Cited by 1
Chang, H.-A., Dai, W., & Hu, S. S. (2022) · The Chinese Journal of Physiology · doi:10.4103/0304-4920.354804 · Cited by 1
Bender, B. N., Stringfield, S. J., & Torregrossa, M. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.24.550364 · Cited by 1
Self-citationNo effect of partial reinforcement on fear extinction learning and memory in C57BL/6J micePreprint
Su, A. C. J., Fukunaga, Y., Penna, S. R., & Cazares, V. A. (2025) · Learning & Memory · doi:10.1101/lm.054033.124 · Cited by 1
Manipulating maladaptive motivational memories via reconsolidation
Rk, D. (2015) · UCL Discovery (University College London) · Cited by 1
Hippocampal Neurogenesis Leads to the Erasure of a Cocaine Conditioned Place Preference
Vankampen, L. A. (2015) · TSpace (University of Toronto)
The Role of Environmental Context in Amphetamine Abuse
Fukushiro, D. F., Berro, L. F., Santos-Baldaia, R., Hollais, A. W., & Wuo‐Silva, R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800212-4.00027-3
Howes, M. B., & O’Shea, G. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-408087-4.00009-8
Chiamulera, C., Cibin, M., & Lugoboni, F. (2016) · RIVISTA SPERIMENTALE DI FRENIATRIA · doi:10.3280/rsf2016-002007
Зайченко, М. И., Markevich, V. A., & Grigoryan, G. A. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.11.787
Role of Estrogens in Addiction-Related Learning
Yousuf, H. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190645908.003.0027 · Cited by 1
Vicente‐Rodríguez, M., Pérez‐García, C., Gramage, E., & Herradón, G. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136156
Fulton, B. S. (2014) · Wiley eBooks · doi:10.1002/9781118943670.refs
(2014) · Elsevier eBooks · doi:10.1016/b978-0-12-408087-4.00020-7
Nik, Z. M., Nasehi, M. M., Tajeri, B., Hassani‐Abharian, P., & Kraskian, A. (2021) · Military Caring Sciences · doi:10.52547/mcs.8.2.156
Smith, D. M., & Torregrossa, M. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.22.554187
Self-citationEditorial: On the destabilization of maladaptive memory: updates and future perspectives
Radiske, A., Cahill, E., Milton, A. L., & Cammarota, M. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1351704
Transcriptional characterization of cocaine withdrawal versus extinction within nucleus accumbensPreprint
Martínez-Rivera, F. J., Holt, L. M., Minier-Toribio, A. M., Estill, M. S., Yeh, S.-Y., Tofani, S., Futamura, R., Browne, C. J., Mews, P., Shen, L., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.12.584637
No effect of partial reinforcement on fear extinction learning and memory in C57BL/6J micePreprint
Su, A. C. J., Fukunaga, Y., Penna, S., & Cazares, V. A. (2024) · doi:10.31234/osf.io/8udn5
Lloret-Torres, M. E., & Barreto-Estrada, J. L. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4921217
Verma, A. K., Chivukula, U., Garbusow, M., & Kumar, N. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.10.687519
L’impulsivité en toxicomanie : un regard sur les mécanismes neuronaux de la rechute à la nicotine
Bourque, J. (2013) · Papyrus : Institutional Repository (Université de Montréal) · doi:10.71781/28551
Procedural Memory Reconsolidation Following Multiple Reminders
Flint, R. W., Morehouse, J., Chown, A. E., Dickens, K. H., & Flint, E. (2026) · Psychological Reports · doi:10.1177/00332941261438074
MacKillop, E., McIntyre‐Wood, C., Vaughn, D. W., Sweet, L. H., & MacKillop, J. M. (2026) · The Clinical Neuropsychologist · doi:10.1080/13854046.2026.2651223
Xie, X., Wang, X., & Wang, J. C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.30.722024
Salience attribution in addiction and psychosis
Freeman, T. P. (2013) · UCL Discovery (University College London)
Metadata
- Authors
- Torregrossa, M. M., & Taylor, J. R.
- Affiliations
- Yale University (US)
- Corresponding author
- Torregrossa, Mary M.
- Venue
- Psychopharmacology
- Published
- 2012-05-26
- Volume
- 226
- Issue
- 4
- Pages
- 659-672
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC3466391
- OpenAlex
- W2043662856
- Cited by
- 172
- References
- 157
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 12 · 2023: 11 · 2022: 5 · 2021: 13 · 2020: 23 · 2019: 18 · 2018: 11 · 2017: 8 · 2016: 17 · 2015: 12 · 2014: 13 · 2013: 11 · 2012: 2
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (K01DA031745, P20DA027844, R01DA011717, R01DA015222)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- drug addiction, extinction learning, memory reconsolidation, relapse, craving, memory consolidation, pharmacological treatment of addiction, drug-seeking behavior
- MeSH terms
- Animals, Cues, Extinction, Psychological, Humans, Memory, Motivation, Time Factors, Behavior, Addictive, Substance-Related Disorders, Secondary Prevention
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