Cited by 172Memory and Neural MechanismsNeurotransmitter Receptor Influence on BehaviorMemory Processes and Influences

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Learning to forget: manipulating extinction and reconsolidation processes to treat addiction

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Torregrossa, Mary M., Taylor, Jane R.·2013·Psychopharmacology

DOI 10.1007/s00213-012-2750-9PMC PMC3466391

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Abstract

Finding effective long-lasting treatments for drug addiction has been an elusive goal. Consequently, researchers are beginning to investigate novel treatment strategies including manipulations of drug-associated memories. When environmental stimuli (cues) become associated with drug use, they become powerful motivators of continued drug use and relapse after abstinence. Reducing the strength of these cue-drug memories could decrease the number of factors that induce craving and relapse to aid in the treatment of addiction. Enhancing the consolidation of extinction learning and/or disrupting cue-drug memory reconsolidation are two strategies that have been proposed to reduce the strength of cues in motivating drug-seeking and drug-taking behavior. Here, we review the latest basic and clinical research elucidating the mechanisms underlying consolidation of extinction and reconsolidation of cue-drug memories in the hopes of developing pharmacological tools that exploit these signaling systems to treat addiction.

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Authors: Torregrossa, M. M., & Taylor, J. R.
Affiliations: Yale University (US)
Corresponding author: Torregrossa, Mary M.
ORCID: Torregrossa, Mary M.
Taylor, Jane R.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2012-05-26
Volume: 226
Issue: 4
Pages: 659-672
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-012-2750-9
PMC: PMC3466391
OpenAlex: W2043662856
Cited by: 172
References: 157
Citations by year: 2026: 7 · 2025: 9 · 2024: 12 · 2023: 11 · 2022: 5 · 2021: 13 · 2020: 23 · 2019: 18 · 2018: 11 · 2017: 8 · 2016: 17 · 2015: 12 · 2014: 13 · 2013: 11 · 2012: 2
FWCI: 0.96
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (K01DA031745, P20DA027844, R01DA011717, R01DA015222)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: drug addiction, extinction learning, memory reconsolidation, relapse, craving, memory consolidation, pharmacological treatment of addiction, drug-seeking behavior
MeSH terms: Animals, Cues, Extinction, Psychological, Humans, Memory, Motivation, Time Factors, Behavior, Addictive, Substance-Related Disorders, Secondary Prevention

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Learning to forget: manipulating extinction and reconsolidation processes to treat addiction

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