The DOI matches its Crossref record; 161 of the 161 references it cites were found in a registry or an index.
Learning to forget: manipulating extinction and reconsolidation processes to treat addiction
Open accessAbstract
Finding effective long-lasting treatments for drug addiction has been an elusive goal. Consequently, researchers are beginning to investigate novel treatment strategies including manipulations of drug-associated memories. When environmental stimuli (cues) become associated with drug use, they become powerful motivators of continued drug use and relapse after abstinence. Reducing the strength of these cue-drug memories could decrease the number of factors that induce craving and relapse to aid in the treatment of addiction. Enhancing the consolidation of extinction learning and/or disrupting cue-drug memory reconsolidation are two strategies that have been proposed to reduce the strength of cues in motivating drug-seeking and drug-taking behavior. Here, we review the latest basic and clinical research elucidating the mechanisms underlying consolidation of extinction and reconsolidation of cue-drug memories in the hopes of developing pharmacological tools that exploit these signaling systems to treat addiction.
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“Research supports that CBT is effective for a wide range of individuals who are trying to quit smoking, including PTSD patients,63 people living with HIV,66 individuals with mental illness,67 low socioeconomic smokers,57 adults with chronic pain,68 overweight and disadvantaged smokers,61 and youth.65”
From Are smoking cessation treatments associated with suicidality risk? An overview (2016) · cites this paper as [63]
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Cites
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“Environmental stimuli (cues) that are repeatedly associated with a drug are known to promote compulsive drug taking and craving and are a primary trigger of relapse (Carter and Tiffany 1999; Shalev et al. 2002; See 2002).”
The reinstatement model of drug relapse: history, methodology and major findings
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Bossert, J. M., Marchant, N. J., Calu, D. J., & Shaham, Y. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3120-y · Cited by 453
Everitt, B. J. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12644 · Cited by 318
Drug-Induced Conditioned Place Preference and Its Practical Use in Substance Use Disorder Research
McKendrick, G., & Graziane, N. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.582147 · Cited by 218
Reconsolidation of memory: A decade of debate
Besnard, A., Caboche, J., & Laroche, S. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.07.002 · Cited by 187
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Metadata
- Authors
- Torregrossa, M. M., & Taylor, J. R.
- Affiliations
- Yale University (US)
- Corresponding author
- Torregrossa, Mary M.
- Venue
- Psychopharmacology
- Published
- 2012-05-26
- Volume
- 226
- Issue
- 4
- Pages
- 659-672
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC3466391
- OpenAlex
- W2043662856
- Cited by
- 172
- References
- 157
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 12 · 2023: 11 · 2022: 5 · 2021: 13 · 2020: 23 · 2019: 18 · 2018: 11 · 2017: 8 · 2016: 17 · 2015: 12 · 2014: 13 · 2013: 11 · 2012: 2
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (K01DA031745, P20DA027844, R01DA011717, R01DA015222)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- drug addiction, extinction learning, memory reconsolidation, relapse, craving, memory consolidation, pharmacological treatment of addiction, drug-seeking behavior
- MeSH terms
- Animals, Cues, Extinction, Psychological, Humans, Memory, Motivation, Time Factors, Behavior, Addictive, Substance-Related Disorders, Secondary Prevention
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