The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
A classically conditioned cocaine cue acquires greater control over motivated behavior in rats prone to attribute incentive salience to a food cue
Open accessAbstract
Rationale Cues associated with rewards bias attention towards them and can motivate drug-seeking and drug-taking behavior. There is, however, considerable individual variation in the extent to which cues associated with rewards acquire motivational properties. For example, only in some rats does a localizable food cue become attractive, eliciting approach towards it, and "wanted", in the sense that it serves as an effective conditioned reinforcer.Objectives We asked whether the propensity of animals to attribute incentive salience to a food cue predicts the extent to which a classically conditioned cocaine cue acquires incentive motivational properties.Methods First, a Pavlovian conditioned approach procedure was used to identify rats prone to attribute incentive salience to a food cue. We then measured the extent to which a classically conditioned cocaine cue acquired two properties of an incentive stimulus: (1) the ability to elicit approach towards it, and (2) the ability to reinstate drug-seeking behavior, using an extinction-reinstatement procedure (i.e., to act as a conditioned reinforcer).Results We found that a classically conditioned cocaine cue became more attractive, in that it elicited greater approach toward it, and more desired, in that it supported more drug-seeking behavior under extinction conditions, in individuals prone to attribute incentive salience to a food cue.Conclusions We conclude that rats vary in their propensity to attribute incentive salience to both food and cocaine cues, and it is possible to predict, prior to any drug experience, in which rats a cocaine cue will acquire the strongest motivational control over behavior.
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“In particular, specific individuals may be more vulnerable to addictive spectrum disorders due to a naturally heightened sensitivity to reward cues (T. E. Robinson, Yager, Cogan, & Saunders, 2014b; Yager & Robinson, 2013).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Yager & Robinson, 2013
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Metadata
- Authors
- Yager, L. M., & Robinson, T. E.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Robinson, Terry E.
- ORCID
- Robinson, Terry E.
- Venue
- Psychopharmacology
- Published
- 2012-10-24
- Volume
- 226
- Issue
- 2
- Pages
- 217-228
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC3570662
- OpenAlex
- W2083414260
- Cited by
- 123
- References
- 51
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 8 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 11 · 2019: 7 · 2018: 8 · 2017: 11 · 2016: 13 · 2015: 12 · 2014: 18 · 2013: 9
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute for Health and Care Research
- National Institutes of Health (4p01da031656-05)
- National Institute on Drug Abuse (P01-DA-031656, F31DA030799, R37DA004294)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- cocaine cues, incentive salience, Pavlovian conditioned approach, conditioned reinforcer, drug-seeking behavior, individual differences, motivation, rats
- MeSH terms
- Animals, Behavior, Cocaine, Conditioning, Classical, Cues, Dose-Response Relationship, Drug, Food, Male, Motivation, Reward, Behavior, Addictive, Rats, Sprague-Dawley, Rats, Drug-Seeking Behavior
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