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Trehalose induced antidepressant-like effects and autophagy enhancement in mice

Kara, N. Z., Toker, L., Agam, G., Anderson, G. W., Belmaker, R. H., Einat, H.·2013·Psychopharmacology
DOI 10.1007/s00213-013-3119-4
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Abstract

Rationale The disaccharide trehalose protects cells from hypoxic and anoxic injury and suppresses protein aggregation. In vivo studies with trehalose show cellular and behavioral beneficial effects in animal models of neurodegenerative diseases. Moreover, trehalose was shown to enhance autophagy, a process that had been recently suggested to be involved in the therapeutic action of antidepressant and mood-stabilizing drugs. Objective The present study was therefore designed to explore antidepressant and mood-stabilizing activity of trehalose in animal models for depression and mania. Methods Trehalose 1 or 2% was administered for 3 weeks as a drinking solution to Black Swiss mice (a model of manic-like behaviors) or 2% to ICR mice and their behavior evaluated in a number of tests related to depression or mania. The effects of trehalose were compared with similar chronic administration of the disaccharide maltose as well as with a vehicle (water) control. Results Chronic administration of trehalose resulted in a reduction of frontal cortex p62/beclin-1 ratio suggesting enhancement of autophagy. Trehalose had no mood-stabilizing effects on manic-like behavior in Black Swiss mice but instead augmented amphetamine-induced hyperactivity, an effect similar to antidepressant drugs. In ICR mice, trehalose did not alter spontaneous activity or amphetamine-induced hyperactivity but in two separate experiments had a significant effect to reduce immobility in the forced swim test, a stan…

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Metadata

Authors
Kara, N. Z., Toker, L., Agam, G., Anderson, G. W., Belmaker, R. H., & Einat, H.
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2013-05-05
Volume
229
Issue
2
Pages
367-375
ISSN
  • 0033-3158
  • 1432-2072
DOI
10.1007/s00213-013-3119-4
Cited by
64
References
5
Language
en
Licence
www.springer.com/tdm (tdm)

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