The role of mitochondria in mood disorders: from physiology to pathophysiology and to treatment
Open accessAbstract
Mitochondria are cellular organelles involved in several biological processes, especially in energy production. Several studies have found a relationship between mitochondrial dysfunction and mood disorders, such as major depressive disorder and bipolar disorder. Impairments in energy production are found in these disorders together with higher levels of oxidative stress. Recently, many agents capable of enhancing antioxidant defenses or mitochondrial functioning have been studied for the treatment of mood disorders as adjuvant therapy to current pharmacological treatments. A better knowledge of mitochondrial physiology and pathophysiology might allow the identification of new therapeutic targets and the development and study of novel effective therapies to treat these specific mitochondrial impairments. This could be especially beneficial for treatment-resistant patients. In this article, we provide a focused narrative review of the currently available evidence supporting the involvement of mitochondrial dysfunction in mood disorders, the effects of current therapies on mitochondrial functions, and novel targeted therapies acting on mitochondrial pathways that might be useful for the treatment of mood disorders.
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Mitochondrial function is widely recognized as a factor in the pathophysiology of several psychiatric disorders, including MDD, and a variety of physical conditions, such as metabolic diseases, cardiovascular diseases, and neurodegenerative disorders.
“Mitochondrial function is widely recognized as a factor in the pathophysiology of several psychiatric disorders, including MDD216, and a variety of physical conditions, such as metabolic diseases217, cardiovascular diseases218, and neurodegenerative disorders219.”
From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [216]
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- Authors
- Giménez-Palomo, A., Dodd, S., Anmella, G., Carvalho, A. F., Scaini, G., Quevedo, J., Pacchiarotti, I., Vieta, E., & Berk, M.
- Affiliations
- Barwon Health (AU)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Centre for Addiction and Mental Health (CA)
- The University of Texas Health Science Center at Houston (US)
- Corresponding author
- Berk, Michael
- ORCID
- Venue
- Frontiers in Psychiatry
- Publisher
- Frontiers Media SA
- Published
- 2021-07-06
- Volume
- 12
- Pages
- 546801-546801
- ISSN
- 1664-0640 (ISSN-L)
- PMC
- PMC8291901
- OpenAlex
- W3182426097
- Cited by
- 140
- References
- 381
- Citations by year
- 2026: 21 · 2025: 28 · 2024: 33 · 2023: 36 · 2022: 21 · 2021: 1
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Funders
- John S. Dunn Foundation
- Centres de Recerca de Catalunya
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Generalitat de Catalunya (2017 SGR 1365, SLT006/17/00357, 2017-SGR, PI18/ 00805)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Ministerio de Ciencia e Innovación (PI15/00283, PI18/00805, PI15/00283,PI18/00805, PI19/00394, PI18/01001, PI15/, CPII19/00009, SLT006/17/00357, 2017 SGR 1365)
- Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina
- Centro de Investigación Biomédica en Red de Salud Mental (SLT006/17/00357, 2017 SGR 1365)
- Instituto Mente e Cérebro - Neurociência
- National Health and Medical Research Council (1059660 and 1156072, 1156072, 1059660)
- Instituto de Salud Carlos III (PI15/00283, (CPII19/00009), 2017 SGR 1365, PI18/01001, PI18/00805, PI19/00394, SLT006/17/00357)
- European Regional Development Fund (PI19/00394, SLT006/17/00357, CPII19/00009)
- National Institute of Mental Health (R21MH117636, 1059660, 1156072)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- mitochondria, mitochondrial dysfunction, mood disorders, major depressive disorder, bipolar disorder, oxidative stress, energy metabolism, antioxidant therapy, adjuvant therapy, treatment-resistant depression, mitochondrial-targeted therapy
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