Cellular and molecular mechanisms in the long-term action of antidepressants.

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene

Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321 · see citing works

Mammalian neural stem cells.

Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 3,949 · see citing works

Antidepressant effects of ketamine in depressed patients

Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856 · see citing works

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.

Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766 · see citing works

A Neurotrophic Model for Stress-Related Mood Disorders

Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works

Subgenual prefrontal cortex abnormalities in mood disorders

Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693 · see citing works

Transcriptional regulation by the phosphorylation-dependent factor CREB

Mayr, B., & Montminy, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085068 · Cited by 2,587 · see citing works

Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms

Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323 · see citing works

Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works

Function and regulation of CREB family transcription factors in the nervous system

Lonze, B. E., & Ginty, D. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00828-0 · Cited by 2,127 · see citing works

Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms

Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795 · see citing works

Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780 · see citing works

New approaches to antidepressant drug discovery: beyond monoamines

Berton, O., & Nestler, E. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1846 · Cited by 1,589 · see citing works

Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus

Cameron, H. A., & Mckay, R. D. G. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1040 · Cited by 1,585 · see citing works

The stressed hippocampus, synaptic plasticity and lost memories

Kim, J. J., & Diamond, D. M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn849 · Cited by 1,543 · see citing works

Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue.

Rajkowska, G., Miguel-Hidalgo, J. J., Wei, J., Dilley, G., Pittman, S. D., Meltzer, H. Y., Overholser, J. C., Roth, B. L., & Stockmeier, C. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00041-4 · Cited by 1,477 · see citing works

Depression Duration But Not Age Predicts Hippocampal Volume Loss in Medically Healthy Women with Recurrent Major Depression

Sheline, Y. I., Sanghavi, M., Mintun, M. A., & Gado, M. H. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-05034.1999 · Cited by 1,382 · see citing works

The many faces of CREB

Carlezon, W. A., Duman, R. S., & Nestler, E. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.005 · Cited by 1,351 · see citing works

Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior

Chen, Z.-Y., Jing, D., Bath, K. G., Ieraci, A., Khan, T., Siao, C.-J., Herrera, D. G., Toth, M., Yang, C., McEwen, B. S., et al. (2006) · Science · doi:10.1126/science.1129663 · Cited by 1,340 · see citing works

Neuroimaging studies of mood disorders

Drevets, W. C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01020-9 · Cited by 1,313 · see citing works

New insights into BDNF function in depression and anxiety

Martinowich, K., Manji, H., & Lu, B. (2007) · Nature Neuroscience · doi:10.1038/nn1971 · Cited by 1,221 · see citing works

Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons

Watanabe, Y., Gould, E., & McEwen, B. S. (1992) · Brain Research · doi:10.1016/0006-8993(92)91597-8 · Cited by 1,212 · see citing works

Adult hippocampal neurogenesis in depression

Sahay, A., & Hen, R. (2007) · Nature Neuroscience · doi:10.1038/nn1969 · Cited by 1,206 · see citing works

CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

Bito, H., Deisseroth, K. A., & Tsien, R. W. (1996) · Cell · doi:10.1016/s0092-8674(00)81816-4 · Cited by 1,123 · see citing works

Calcium regulation of neuronal gene expression

West, A. E., Chen, W. G., Dalva, M., Dolmetsch, R., Kornhauser, J., Shaywitz, A. J., Takasu, M., Tao, X., & Greenberg, M. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.191352298 · Cited by 1,115 · see citing works

Current advances and trends in the treatment of depression

Blier, P., & de Montigny, C. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90315-8 · Cited by 1,113 · see citing works

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

Maeng, S., Zarate, C. A., Du, J., Schloesser, R. J., McCammon, J., Chen, G., & Manji, H. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.028 · Cited by 1,103 · see citing works

Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine

Eisenhofer, G., Kopin, I. J., & Goldstein, D. S. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.3.1 · Cited by 1,072 · see citing works

Mouse and rat <i>BDNF</i> gene structure and expression revisited

Aid, T., Kazantseva, A., Piirsoo, M., Palm, K., & Timmusk, T. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21139 · Cited by 943 · see citing works

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

Sanacora, G., Zarate, C. A., Krystal, J. H., & Manji, H. K. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2462 · Cited by 894 · see citing works

The antidepressant fluoxetine restores plasticity in the adult visual cortex

Vetencourt, J. F. M., Sale, A., Viegi, A., Baroncelli, L., De Pasquale, R., F. O'Leary, O., Castrén, E., & Maffei, L. (2008) · Science · doi:10.1126/science.1150516 · Cited by 890 · see citing works

The role of the hippocampus in the pathophysiology of major depression

Campbell, S., & MacQUEEN, G. M. (2004) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0441 · Cited by 879 · see citing works

Hippocampal neurogenesis in adult Old World primates

Gould, E., Reeves, A. J., Fallah, M., Tanapat, P., Gross, C. G., & Fuchs, E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5263 · Cited by 815 · see citing works

Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression

Sanacora, G., Gueorguieva, R. V., Epperson, C. N., Wu, Y., Appel, M., Rothman, D. L., Krystal, J. H., & Mason, G. F. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.705 · Cited by 796 · see citing works

Development of β-adrenergic receptor subsensitivity by antidepressants

Banerjee, S. P., Kung, L. S., Riggi, S. J., & Chanda, S. K. (1977) · Nature · doi:10.1038/268455a0 · Cited by 722 · see citing works

The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death

Sapolsky, R. M. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00971-9 · Cited by 699 · see citing works

Depression: a case of neuronal life and death?

Duman, R. S. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.033 · Cited by 612 · see citing works

Increased Levels of Glutamate in Brains from Patients with Mood Disorders

Hashimoto, K., Sawa, A., & Iyo, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.017 · Cited by 609 · see citing works

Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

Swanson, C. J., Bures, M., Johnson, M. P., Linden, A.-M., Monn, J. A., & Schoepp, D. D. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1630 · Cited by 607 · see citing works

Regulation of transcription factors by neuronal activity

West, A. E., Griffith, E. C., & Greenberg, M. E. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn987 · Cited by 604 · see citing works

What turns CREB on?

Johannessen, M., Delghandi, M. P., & Moens, U. L. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.05.001 · Cited by 586 · see citing works

Stress Preferentially Increases Extraneuronal Levels of Excitatory Amino Acids in the Prefrontal Cortex: Comparison to Hippocampus and Basal Ganglia

Moghaddam, B. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb13387.x · Cited by 567 · see citing works

Preclinical models: status of basic research in depression

Nestler, E. J., Gould, E., & Manji, H. K. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01405-1 · Cited by 559 · see citing works

Impaired Spatial Learning after Saturation of Long-Term Potentiation

Moser, E. I., Krobert, K. A., Moser, M.-B., & Morris, R. G. M. (1998) · Science · doi:10.1126/science.281.5385.2038 · Cited by 505 · see citing works

Initiation and adaptation: a paradigm for understanding psychotropic drug action

(1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.2.151 · Cited by 490 · see citing works

Behavioral stress modifies hippocampal plasticity through N-methyl-D-aspartate receptor activation.

Kim, J. J., Foy, M. R., & Thompson, R. F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4750 · Cited by 435 · see citing works

Glutamate and Depression: Clinical and Preclinical Studies

PAUL, I. A., & SKOLNICK, P. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.016 · Cited by 408 · see citing works

Is it time to reassess the BDNF hypothesis of depression?

Groves, J. O. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002075 · Cited by 403 · see citing works

The Revised Monoamine Theory of Depression: A Modulatory Role for Monoamines, Based on New Findings From Monoamine Depletion Experiments in Humans

Heninger, G. R., Delgado, P. L., & Charney, D. S. (1996) · Pharmacopsychiatry · doi:10.1055/s-2007-979535 · Cited by 381 · see citing works

Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy

Adachi, M., Barrot, M., Autry, A. E., Theobald, D., & Monteggia, L. M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.09.019 · Cited by 380 · see citing works

Antidepressants for the new millennium.

Skolnick, P. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00330-1 · Cited by 372 · see citing works

Biological rhythm disturbances in mood disorders

Wirz‐Justice, A. (2006) · International Clinical Psychopharmacology · doi:10.1097/01.yic.0000195660.37267.cf · Cited by 356 · see citing works

Neuroplasticity Mediated by Altered Gene Expression

McClung, C. A., & Nestler, E. J. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301544 · Cited by 347 · see citing works

Local structural balance and functional interaction of excitatory and inhibitory synapses in hippocampal dendrites

Liu, G. (2004) · Nature Neuroscience · doi:10.1038/nn1206 · Cited by 339 · see citing works

The Australian Burden of Disease Study: measuring the loss of health from diseases, injuries and risk factors

Mathers, C. D., Stevenson, C., Vos, E. T., & Begg, S. J. (2000) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2000.tb124125.x · Cited by 339 · see citing works

Calcium regulation of gene expression in neuronal cells

Ghosh, A., Ginty, D. D., Bading, H., & Greenberg, M. E. (1994) · Journal of Neurobiology · doi:10.1002/neu.480250309 · Cited by 326 · see citing works

Postnatal repeated maternal deprivation produces age-dependent changes of brain-derived neurotrophic factor expression in selected rat brain regions

Roceri, M., Cirulli, F., Pessina, C., Peretto, P., Racagni, G., & Riva, M. A. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.12.011 · Cited by 317 · see citing works

Signaling routes to CREM and CREB: plasticity in transcriptional activation

Cesare, D. D., Fimia, G. M., & Sassone‐Corsi, P. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01414-0 · Cited by 311 · see citing works

Acute Stress-induced Changes in Hippocampal/Prefrontal Circuits in Rats: Effects of Antidepressants

Rocher, C. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhg122 · Cited by 307 · see citing works

Signaling Pathways Regulating Gene Expression, Neuroplasticity, and Neurotrophic Mechanisms in the Action of Antidepressants: A Critical Overview

Tardito, D., Perez, J., Tiraboschi, E., Musazzi, L., Racagni, G., & Popoli, M. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.1.7 · Cited by 303 · see citing works

Positive Modulation of AMPA Receptors Increases Neurotrophin Expression by Hippocampal and Cortical Neurons

Lauterborn, J. C., LYNCH, G. S., Vanderklish, P. W., Arai, A., & Gall, C. M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00008.2000 · Cited by 291 · see citing works

Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine

Svenningsson, P., Bateup, H. S., Qi, H., Takamiya, K., Huganir, R. L., Spedding, M., Roth, B. L., McEwen, B. S., & Greengard, P. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05952.x · Cited by 287 · see citing works

Rapid glucocorticoid effects on excitatory amino acid levels in the hippocampus: a microdialysis study in freely moving rats

Venero, C., & Borrell, J. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00668.x · Cited by 277 · see citing works

Basic psychopharmacology of antidepressants, part 1: Antidepressants have seven distinct mechanisms of action.

Stahl, S. M. (1998) · PubMed · Cited by 260 · see citing works

Efficacy of agomelatine, a MT1/MT2 receptor agonist with 5-HT2C antagonistic properties, in major depressive disorder

Olié, J., & Kasper, S. F. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707007766 · Cited by 257 · see citing works

Plasma and platelet excitatory amino acids in psychiatric disorders

(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.11.1731 · Cited by 243 · see citing works

How can drug discovery for psychiatric disorders be improved?

Agid, Y., Buzsáki, G., Diamond, D. M., Frackowiak, R., Giedd, J., Girault, J.-A., Grace, A., Lambert, J. J., Manji, H., Mayberg, H., et al. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2217 · Cited by 240 · see citing works

Learned helplessness in the rat: improvements in validity and reliability

Vollmayr, B., & Henn, F. A. (2001) · Brain Research Protocols · doi:10.1016/s1385-299x(01)00067-8 · Cited by 238 · see citing works

Chronic Antidepressants Reduce Depolarization-Evoked Glutamate Release and Protein Interactions Favoring Formation of SNARE Complex in Hippocampus

Bonanno, G., Giambelli, R., Raiteri, L., Tiraboschi, E., Zappettini, S., Musazzi, L., Raiteri, M., Racagni, G., & Popoli, M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5033-04.2005 · Cited by 234 · see citing works

Temporal dynamics of glutamate efflux in the prefrontal cortex and in the hippocampus following repeated stress: effects of pretreatment with saline or diazepam

Bagley, J., & Moghaddam, B. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00435-6 · Cited by 231 · see citing works

Clinical Applications of MAO-Inhibitors

Riederer, P. F., Lachenmayer, L., & Laux, G. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043364775 · Cited by 222 · see citing works

Improvement in Subjective Sleep in Major Depressive Disorder With a Novel Antidepressant, Agomelatine

Lemoine, P., & Guilleminault, C. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n1112 · Cited by 217 · see citing works

A Double-Blind Comparison of Sexual Functioning, Antidepressant Efficacy, and Tolerability Between Agomelatine and Venlafaxine XR

Kennedy, S. H., Rizvi, S. J., Fulton, K., & Rasmussen, J. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318172b48c · Cited by 211 · see citing works

Acute stress‐mediated increases in extracellular glutamate levels in the rat amygdala: differential effects of antidepressant treatment

Reznikov, L. R., Grillo, C. A., Piroli, G. G., Pasumarthi, R. K., Reagan, L. P., & Fadel, J. R. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05560.x · Cited by 201 · see citing works

Absence of discontinuation symptoms with agomelatine and occurrence of discontinuation symptoms with paroxetine: a randomized, double-blind, placebo-controlled discontinuation study

Montgomery, S. A., Kennedy, S. H., Burrows, G. D., Lejoyeux, M., & Hindmarch, I. (2004) · International Clinical Psychopharmacology · doi:10.1097/01.yic.0000137184.64610.c8 · Cited by 196 · see citing works

Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments

Balu, D. T., Hoshaw, B. A., Malberg, J. E., Rosenzweig-Lipson, S., Schechter, L. E., & Lucki, I. (2008) · Brain Research · doi:10.1016/j.brainres.2008.03.023 · Cited by 194 · see citing works

Antidepressant action: to the nucleus and beyond

Malberg, J. E., & Blendy, J. A. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.10.005 · Cited by 193 · see citing works

Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus

Nair, A., Vadodaria, K. C., Banerjee, S. B., Benekareddy, M., Dias, B. G., Duman, R. S., & Vaidya, V. A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301276 · Cited by 189 · see citing works

Distribution of dopamine ?-hydroxylase-like immunoreactive fibers within the shell subregion of the nucleus accumbens

Berridge, C. W., Stratford, T. R., Foote, S. L., & Kelley, A. E. (1997) · Synapse · doi:10.1002/(sici)1098-2396(199711)27:3 · Cited by 188 · see citing works

Selective Phosphorylation of Nuclear CREB by Fluoxetine is Linked to Activation of CaM Kinase IV and MAP Kinase Cascades

Tiraboschi, E., Tardito, D., Kasahara, J., Moraschi, S., Pruneri, P., Gennarelli, M., Racagni, G., & Popoli, M. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300488 · Cited by 186 · see citing works

The antidepressant tianeptine persistently modulates glutamate receptor currents of the hippocampal CA3 commissural associational synapse in chronically stressed rats

Kole, M. H. P., Swan, L., & Fuchs, E. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02136.x · Cited by 181 · see citing works

Overcoming the effects of stress on synaptic plasticity in the intact hippocampus: rapid actions of serotonergic and antidepressant agents

Shakesby, A. C., Anwyl, R., & Rowan, M. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03638.2002 · Cited by 173 · see citing works

Major depressive disorder, sleep EEG and agomelatine: an open-label study

Quera-Salva, M.-A., Vanier, B., Laredo, J., Hartley, S., Chapotot, F., Moulin, C., Lofaso, F., & Guilleminault, C. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707007754 · Cited by 170 · see citing works

Activity-Dependent Neuroprotection and cAMP Response Element-Binding Protein (CREB): Kinase Coupling, Stimulus Intensity, and Temporal Regulation of CREB Phosphorylation at Serine 133

Lee, B., Butcher, G. Q., Hoyt, K. R., Impey, S., & Obrietan, K. H. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4288-04.2005 · Cited by 165 · see citing works

Regulation of Cellular Plasticity Cascades in the Pathophysiology and Treatment of Mood Disorders

Zarate, C. A., Du, J., Quiroz, J. A., GRAY, N. A., Denicoff, K. D., Singh, J., Charney, D. S., & Manji, H. K. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.017 · Cited by 164 · see citing works

Chronic administration of imipramine and citalopram alters the expression of NMDA receptor subunit mRNAs in mouse brain

Boyer, P., Skolnick, P., & Fossom, L. H. (1998) · Journal of Molecular Neuroscience · doi:10.1007/bf02761776 · Cited by 157 · see citing works

Modulation of Synaptic Plasticity by Antimanic Agents: The Role of AMPA Glutamate Receptor Subunit 1 Synaptic Expression

Du, J., Gray, N. A., Falke, C. A., Chen, W., Yuan, P., Szabo, S. T., Einat, H., & Manji, H. K. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1258-04.2004 · Cited by 157 · see citing works

Repeated ECS and fluoxetine administration have equivalent effects on hippocampal synaptic plasticity

Stewart, C. A., & Reid, I. (2000) · Psychopharmacology · doi:10.1007/s002130050045 · Cited by 152 · see citing works

Brain-Derived Neurotrophic Factor and Antidepressant Activity

Russo‐Neustadt, A. A., & Chen, M. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053764788 · Cited by 152 · see citing works

Identifying Molecular Substrates in a Mouse Model of the Serotonin Transporter × Environment Risk Factor for Anxiety and Depression

Carola, V., Frazzetto, G., Pascucci, T., Audero, E., Puglisi‐Allegra, S., Cabib, S., Lesch, K., & Gross, C. T. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.08.013 · Cited by 141 · see citing works

Modulation of synaptic plasticity by stress and antidepressants

Popoli, M., Gennarelli, M., & Racagni, G. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.01159.x · Cited by 139 · see citing works

Neuronal activity regulates the developmental expression and subcellular localization of cortical BDNF mRNA isoforms in vivo

Pattabiraman, P. P., Tropea, D., Chiaruttini, C., Tongiorgi, E., Cattaneo, A., & Domenici, L. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.11.010 · Cited by 132 · see citing works

Dynamic Multiphosphorylation Passwords for Activity-Dependent Gene Expression

Deisseroth, K. A., & Tsien, R. W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00664-5 · Cited by 130 · see citing works

Stress, Metaplasticity, and Antidepressants

Garcia, R. (2002) · Current Molecular Medicine · doi:10.2174/1566524023362023 · Cited by 130 · see citing works

Strategies for producing faster acting antidepressants

Adell, A., Castro, E., Celada, P., Bortolozzi, A., Pazos, Á., & Artigas, F. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03398-2 · Cited by 129 · see citing works

Activation of Calcium/Calmodulin-dependent Protein Kinase IV in Long Term Potentiation in the Rat Hippocampal CA1 Region

Kasahara, J., Fukunaga, K., & Miyamoto, E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100247200 · Cited by 127 · see citing works

Chronic antidepressant treatment increases the membrane expression of AMPA receptors in rat hippocampus

Martínez-Turrillas, R. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00299-x · Cited by 122 · see citing works

Increased adult hippocampal brain‐derived neurotrophic factor and normal levels of neurogenesis in maternal separation rats

Greisen, M. H., Altar, C. A., Bolwig, T. G., Whitehead, R. E., & Wörtwein, G. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20418 · Cited by 120 · see citing works

Antidepressant medications and other treatments of depressive disorders: a CINP Task Force report based on a review of evidence

Sartorius, N., Baghai, T. C., Baldwin, D. S., Barrett, B. M., Brand, U., Fleischhacker, W., Goodwin, G. M., Grunze, H., Knapp, M. R. J., Leonard, B. E., et al. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707008255 · Cited by 98 · see citing works

Antidepressants reverse the attenuation of the neurotrophic MEK/MAPK cascade in frontal cortex by elevated platform stress; reversal of effects on LTP is associated with GluA1 phosphorylation

Qi, H., Mailliet, F., Spedding, M., Rocher, C., Zhang, X., Delagrange, P., McEwen, B. S., Jay, T. M., & Svenningsson, P. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.068 · Cited by 91 · see citing works

Remodelling by early-life stress of NMDA receptor-dependent synaptic plasticity in a gene–environment rat model of depression

Ryan, B. K., Musazzi, L., Mallei, A., Tardito, D., Gruber, S. H. M., Khoury, A. E., Anwyl, R., Racagni, G., Mathé, A. A., Rowan, M. J., et al. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009607 · Cited by 79 · see citing works

Antidepressant treatments and function of glutamate ionotropic receptors mediating amine release in hippocampus

Pittaluga, A., Raiteri, L., Longordo, F., Luccini, E., Barbiero, V. S., Racagni, G., Popoli, M., & Raiteri, M. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.04.006 · Cited by 76 · see citing works

Temporal expression of brain-derived neurotrophic factor (BDNF) mRNA in the rat hippocampus after treatment with selective and mixed monoaminergic antidepressants

Larsen, M. H., Hay‐Schmidt, A., Rønn, L. C. B., & Mikkelsen, J. D. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.08.050 · Cited by 75 · see citing works

Tianeptine increases brain-derived neurotrophic factor expression in the rat amygdala

Reagan, L. P., Hendry, R. M., Reznikov, L. R., Piroli, G. G., Wood, G. E., McEwen, B. S., & Grillo, C. A. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.02.023 · Cited by 69 · see citing works

Biphasic change in BDNF gene expression following antidepressant drug treatment explained by differential transcript regulation

Khundakar, A. A., & Zetterström, T. (2006) · Brain Research · doi:10.1016/j.brainres.2006.05.063 · Cited by 67 · see citing works

Early maternal separation alters the response to traumatization: resulting in increased levels of hippocampal neurotrophic factors

Faure, J., Uys, J. D. K., Marais, L., Stein, D. J., & Daniels, W. M. U. (2007) · Metabolic Brain Disease · doi:10.1007/s11011-007-9048-3 · Cited by 65 · see citing works

Enhancing AMPA to NMDA throughput as a convergent mechanism for antidepressant action

Du, J., Machado-Vieira, R., Maeng, S., Martinowich, K., Manji, H. K., & Zarate, C. A. (2006) · Drug Discovery Today: Therapeutic Strategies · doi:10.1016/j.ddstr.2006.11.012 · Cited by 64 · see citing works

Chronic imipramine treatment partially reverses the long-term changes of hippocampal synaptic plasticity in socially stressed rats

von Frijtag, J. C., Kamal, A., Reijmers, L. G. J. E., Schrama, L. H., van den Bos, R., & Spruijt, B. M. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02062-6 · Cited by 62 · see citing works

What Is the Biological Significance of BDNF mRNA Targeting in the Dendrites?: Clues From Epilepsy and Cortical Development

Tongiorgi, E., Domenici, L., & Simonato, M. (2005) · Molecular Neurobiology · doi:10.1385/mn:33:1:017 · Cited by 58 · see citing works

Excited by Glutamate

Holden, C. (2003) · Science · doi:10.1126/science.300.5627.1866 · Cited by 57 · see citing works

Fluvoxamine suppresses the long-term potentiation in the hippocampal CA1 field of anesthetized rats: an effect mediated via 5-HT1A receptors

Kojima, T., Matsumoto, M., Togashi, H., Tachibana, K., Kemmotsu, O., & Yoshioka, M. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03756-3 · Cited by 56 · see citing works

The When and Where of BDNF and the Antidepressant Response

Wang, J., Dranovsky, A., & Hen, R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.01.008 · Cited by 55 · see citing works

Changes in synaptic plasticity in the rat hippocampo-medial prefrontal cortex pathway induced by repeated treatments with fluvoxamine

Ohashi, S., Matsumoto, M., Otani, H., Mori, K., Togashi, H., Ueno, K.-I., Kaku, A., & Yoshioka, M. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02973-6 · Cited by 54 · see citing works

Acute application of the tricyclic antidepressant desipramine presynaptically stimulates the exocytosis of glutamate in the hippocampus

Bouron, A., & Chatton, J. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00480-1 · Cited by 50 · see citing works

Correction

BMJ Publishing Group Ltd (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.089540 · Cited by 47 · see citing works

Allosteric modulation of the effects of the 5-HT reuptake inhibitor escitalopram on the rat hippocampal synaptic plasticity

Mnie‐Filali, O., Mansari, M. E., Espana, A., Sánchez, C., & Haddjeri, N. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.10.044 · Cited by 45 · see citing works

Do Stress and Long-Term Potentiation Share the Same Molecular Mechanisms?

Huang, C., Yang, C., & Hsu, K. (2005) · Molecular Neurobiology · doi:10.1385/mn:32:3:223 · Cited by 44 · see citing works

New perspectives on the molecular pharmacology of affective disorders

Sulser, F. (1989) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf00449803 · Cited by 39 · see citing works

Milnacipran, a serotonin and noradrenaline reuptake inhibitor, suppresses long-term potentiation in the rat hippocampal CA1 field via 5-HT1A receptors and α1-adrenoceptors

Tachibana, K., Matsumoto, M., Togashi, H., Kojima, T., Morimoto, Y., Kemmotsu, O., & Yoshioka, M. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.11.016 · Cited by 37 · see citing works

Chronic treatment with milnacipran reverses the impairment of synaptic plasticity induced by conditioned fear stress

Matsumoto, M., Tachibana, K., Togashi, H., Tahara, K., Kojima, T., Yamaguchi, T., & Yoshioka, M. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2094-1 · Cited by 32 · see citing works

Time-dependent biphasic modulation of human BDNF by antidepressants in neuroblastoma cells

Donnici, L., Tiraboschi, E., Tardito, D., Musazzi, L., Racagni, G., & Popoli, M. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-61 · Cited by 32 · see citing works

The link between sleep and depression: The effects of antidepressants on EEG sleep

van Bemmel, A. L. (1997) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(97)00003-2 · Cited by 25 · see citing works

Reduced CREB phosphorylation after chronic lithium treatment is associated with down-regulation of CaM kinase IV in rat hippocampus

Tardito, D., Tiraboschi, E., Kasahara, J., Racagni, G., & Popoli, M. (2006) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145706007140 · Cited by 25 · see citing works

P.2.c.025 Long-term treatment with agomelatine: prevention of relapse in patients with Major Depressive Disorder over 10 months

Goodwin, G. M., Rouillon, F., & Emsley, R. A. (2008) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(08)70471-1 · Cited by 13 · see citing works

Towards a glutamate hypothesis of depression

Sanacora, G., Treccani, G., & Popoli, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.07.036 · Cited by 1,036 · see citing works

The Role of BDNF on Neural Plasticity in Depression

Yang, T., Nie, Z., Shu, H., Kuang, Y., Chen, X., Cheng, J., Yu, S., & Liu, H. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00082 · Cited by 435 · see citing works

Neural basis of major depressive disorder: Beyond monoamine hypothesis

Boku, S., Nakagawa, S., Toda, H., & Hishimoto, A. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12604 · Cited by 402 · see citing works

Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression

Golden, S. A., Christoffel, D. J., Heshmati, M., Hodes, G. E., Magida, J., Davis, K., Cahill, M. E., Dias, C., Ribeiro, E., Ables, J. L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3090 · Cited by 322 · see citing works

From Serotonin to Neuroplasticity: Evolvement of Theories for Major Depressive Disorder

Liu, B., Liu, J., Wang, M., Zhang, Y., & Li, L. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00305 · Cited by 249 · see citing works

Differences in excitatory and inhibitory neurotransmitter levels between depressed patients and healthy controls: A systematic review and meta-analysis

Godfrey, K. E. M., Gardner, A. C., Kwon, S., Chea, W., & Muthukumaraswamy, S. D. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.08.015 · Cited by 207 · see citing works

The Role of BDNF in the Neuroimmune Axis Regulation of Mood Disorders

Jin, Y., Sun, L., Yang, W., Cui, R., & Xu, S. B. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00515 · Cited by 200 · see citing works

Psychedelics and Other Psychoplastogens for Treating Mental Illness.

Vargas, M. V., Meyer, R., Avanes, A. A., Rus, M., & Olson, D. E. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.727117 · Cited by 166 · see citing works

MicroRNAs and exosomes in depression: Potential diagnostic biomarkers

Tavakolizadeh, J., Roshanaei, K., Salmaninejad, A., Yari, R., Nahand, J. S., Khoshdel‐Sarkarizi, H., Mousavi, S. M., Salarinia, R., Rahmati, M., Mousavi, S. F., et al. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26599 · Cited by 160 · see citing works

Psychiatric and Cognitive Aspects of Phenylketonuria: The Limitations of Diet and Promise of New Treatments

Ashe, K., Kelso, W. M., Farrand, S., Panetta, J., Fazio, T. N., Jong, G. D., & Walterfang, M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00561 · Cited by 156 · see citing works

GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response

Gunn, B. G., Cunningham, L., Mitchell, S. G., Swinny, J. D., Lambert, J. J., & Belelli, D. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.06.001 · Cited by 149 · see citing works

Subchronic Alpha-Linolenic Acid Treatment Enhances Brain Plasticity and Exerts an Antidepressant Effect: A Versatile Potential Therapy for Stroke

Blondeau, N., Nguemeni, C., Debruyne, D. N., Piens, M., Wu, X., Pan, H., Hu, X., Gandin, C., Lipsky, R. H., Plumier, J.-C., et al. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.84 · Cited by 148 · see citing works

Antidepressant‐like effect induced by systemic and intra‐hippocampal administration of DNA methylation inhibitors

Sales, A. J., Biojone, C., Terceti, M. S., Guimarães, F. S., Gomes, M. V., & Joca, S. R. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01489.x · Cited by 147 · see citing works

Sigma receptors: Potential targets for a new class of antidepressant drug

Fishback, J. A., Robson, M. J., Xu, Y., & Matsumoto, R. R. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.04.003 · Cited by 126 · see citing works

Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor

Fujimoto, M., Hayashi, T., Urfer, R., Mita, S., & Su, T.-P. (2012) · Synapse · doi:10.1002/syn.21549 · Cited by 124 · see citing works

Dual Role of Autophagy in Diseases of the Central Nervous System

Bar-Yosef, T., Damri, O., & Agam, G. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00196 · Cited by 126 · see citing works

The antidepressive effect of the physical exercise correlates with increased levels of mature BDNF, and proBDNF proteolytic cleavage-related genes, p11 and tPA

Sartori, C. R., Vieira, A. S., Ferrari, E. M., Langone, F., Tongiorgi, E., & Parada, C. A. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.055 · Cited by 118 · see citing works

A Systematic, Updated Review on the Antidepressant Agomelatine Focusing on its Melatonergic Modulation

Fornaro, M., Prestía, D., Colicchio, S., & Perugi, G. (2010) · Current Neuropharmacology · doi:10.2174/157015910792246227 · Cited by 119 · see citing works

Aromatherapy and the Central Nerve System (CNS): Therapeutic Mechanism and its Associated Genes

Lv, X., Liu, Z., Zhang, H., & Tzeng, C. S. (2013) · Current Drug Targets · doi:10.2174/1389450111314080007 · Cited by 123 · see citing works

Pharmacogenetics of antidepressants

Crisafulli, C., Fabbri, C., Porcelli, S., Drago, A., Spina, E., De Ronchi, D., & Serretti, A. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00006 · Cited by 113 · see citing works

Stress, glucocorticoids and glutamate release: Effects of antidepressant drugs

Musazzi, L., Racagni, G., & Popoli, M. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.05.002 · Cited by 113 · see citing works

Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter—a review of current understanding of its mechanism of action

Zhong, H., Haddjeri, N., & Sánchez, C. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2463-5 · Cited by 105 · see citing works

An epigenome-wide DNA methylation study of PTSD and depression in World Trade Center responders

Kuan, P.-F., Waszczuk, M. A., Kotov, R., Marsit, C. J., Guffanti, G., Gonzalez, A., Yang, X., Koenen, K., Bromet, E., & Luft, B. J. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.130 · Cited by 103 · see citing works

Roles of glutamate signaling in preclinical and/or mechanistic models of depression

Tokita, K., Yamaji, T., & Hashimoto, K. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.04.016 · Cited by 103 · see citing works

Triple reuptake inhibitors for treating subtypes of major depressive disorder: the monoamine hypothesis revisited

Prins, J., Olivier, B., & Korte, S. M. (2011) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2011.594039 · Cited by 98 · see citing works

Effect of antidepressants on circadian rhythms in fish: Insights and implications regarding the design of behavioural toxicity tests.

Melvin, S. D. (2016) · Aquatic Toxicology · doi:10.1016/j.aquatox.2016.11.007 · Cited by 94 · see citing works

Common mechanisms of pain and depression: are antidepressants also analgesics?

Nekovářová, T., Yamamotová, A., Valeš, K., Stuchlı́k, A., Fricová, J., & Rokyta, R. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00099 · Cited by 88 · see citing works

Serum levels of brain-derived neurotrophic factor in drug-naïve obsessive–compulsive patients: A case–control study

Maina, G., Rosso, G., Zanardini, R., Bogetto, F., Gennarelli, M., & Bocchio‐Chiavetto, L. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.07.009 · Cited by 89 · see citing works

Ketamine’s antidepressant effect is mediated by energy metabolism and antioxidant defense system

Weckmann, K., Deery, M. J., Howard, J. A., Feret, R., Asara, J. M., Dethloff, F., Filiou, M. D., Iannace, J., Labermaier, C., Maccarrone, G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-16183-x · Cited by 91 · see citing works

The role of the neuroendocrine and immune systems in the pathogenesis of depression

Ogłodek, E., Szota, A. M., Just, M. J., Moś, D., & Araszkiewicz, A. S. (2014) · Pharmacological Reports · doi:10.1016/j.pharep.2014.04.009 · Cited by 87 · see citing works

Onset, time course and trajectories of improvement with antidepressants

Lam, R. W. M. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.07.005 · Cited by 84 · see citing works

G protein-linked signaling pathways in bipolar and major depressive disorders

Tomita, H., Ziegler, M. E., Kim, H. B., Evans, S. J., Choudary, P. V., Li, J. Z., Meng, F., Dai, M., Myers, R., Neal, C. R., et al. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00297 · Cited by 81 · see citing works

Agomelatine, a novel intriguing antidepressant option enhancing neuroplasticity: A critical review

Pompili, M., Serafini, G., Innamorati, M., Venturini, P., Fusar‐Poli, P., Sher, L., Amore, M., & Girardi, P. (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.765593 · Cited by 78 · see citing works

Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain

Xue, W., Zhou, X., Yi, N., Jiang, L., Tao, W., Wu, R., Wang, D., Jiang, J., Ge, X., Wang, Y., et al. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/184367 · Cited by 77 · see citing works

New‐generation, non‐SSRI antidepressants: Drug‐drug interactions and therapeutic drug monitoring. Part 2: NaSSAs, NRIs, SNDRIs, MASSAs, NDRIs, and others

Protti, M., Mandrioli, R., Marasca, C., Cavalli, A., Serretti, A., & Mercolini, L. (2020) · Medicinal Research Reviews · doi:10.1002/med.21671 · Cited by 71 · see citing works

Trehalose induced antidepressant-like effects and autophagy enhancement in mice

Kara, N., Toker, L., Agam, G., Anderson, G. W., Belmaker, R. H., & Einat, H. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3119-4 · Cited by 73 · see citing works

Rhythms and blues: modulation of oscillatory synchrony and the mechanism of action of antidepressant treatments

Leuchter, A. F., Hunter, A. M., Krantz, D. E., & Cook, I. A. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12742 · Cited by 71 · see citing works

DNA methylation and clinical response to antidepressant medication in major depressive disorder: A review and recommendations

Lisoway, A. J., Zai, C. C. H., Tiwari, A. K., & Kennedy, J. L. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2016.12.071 · Cited by 66 · see citing works

Effects of DNA methylation inhibitors and conventional antidepressants on mice behaviour and brain DNA methylation levels

Sales, A. J., & Joca, S. R. L. (2016) · Acta Neuropsychiatrica · doi:10.1017/neu.2015.40 · Cited by 62 · see citing works

Molecular Neurobiology and Promising New Treatment in Depression

Jeon, S. R., & Kim, Y. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030381 · Cited by 61 · see citing works

Fluoxetine Exposure during Adolescence Alters Responses to Aversive Stimuli in Adulthood

Iñiguez, S. D., Parise, L. F., Warren, B. L., Riggs, L. M., Parise, E. M., Vialou, V., Wright, K. N., Dayrit, G., Nieto, S. J., Wilkinson, M. B., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5725-12.2014 · Cited by 59 · see citing works

Update on GPCR-based targets for the development of novel antidepressants

Mantas, I., Saarinen, M., Xu, Q., & Svenningsson, P. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01040-1 · Cited by 59 · see citing works

Antidepressants elevate GDNF expression and release from C6 glioma cells in a β-arrestin1-dependent, CREB interactive pathway

Golan, M., Schreiber, G., & Avissar, S. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001550 · Cited by 54 · see citing works

Position statement of the European Psychiatric Association (EPA) on the value of antidepressants in the treatment of unipolar depression

Möller, H. ‐., Bitter, I., Bobes, J., Fountoulakis, K. Ν., Höschl, C., & Kasper, S. F. (2011) · European Psychiatry · doi:10.1016/j.eurpsy.2011.08.002 · Cited by 53 · see citing works

Neuronal NOS Inhibitor and Conventional Antidepressant Drugs Attenuate Stress-induced Fos Expression in Overlapping Brain Regions

Silva, M., de Aguiar, D. C., Diniz, C. R. A. F., Guimarães, F. S., & Joca, S. R. L. (2011) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-011-9775-1 · Cited by 52 · see citing works

Effect of a novel 5-HT3 receptor antagonist 4i, in corticosterone-induced depression-like behavior and oxidative stress in mice

Gupta, D., Radhakrishnan, M., & Kurhe, Y. (2015) · Steroids · doi:10.1016/j.steroids.2015.01.021 · Cited by 52 · see citing works

The dose makes the poison: From glutamate-mediated neurogenesis to neuronal atrophy and depression

Rubio-Casillas, A., & Fernández-Guasti, A. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0066 · Cited by 49 · see citing works

The Stability of NR2B in the Nucleus Accumbens Controls Behavioral and Synaptic Adaptations to Chronic Stress

Jiang, B., Wang, W., Wang, F., Hu, Z., Xiao, J., Yang, S., Zhang, J., Peng, X., Wang, J., & Chen, J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.031 · Cited by 46 · see citing works

Zinc in depression: From development to treatment: A comparative/ dose response meta-analysis of observational studies and randomized controlled trials

Yosaee, S., Clark, C. C. T., Keshtkaran, Z., Ashourpour, M., Keshani, P., & Soltani, S. (2020) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2020.08.001 · Cited by 48 · see citing works

Brain-derived neurotrophic factor Val66Met polymorphism association with antidepressant efficacy: A systematic review and meta-analysis: BDNF Val66Met and antidepressant efficacy

Yan, T., Wang, L., Kuang, W., Xu, J., Li, S., Chen, J., & Yang, Y. (2014) · Asia-Pacific Psychiatry · doi:10.1111/appy.12148 · Cited by 46 · see citing works

Targeting astrocytes in bipolar disorder

Peng, L., Li, B., & Verkhratsky, A. (2016) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2016.1171144 · Cited by 46 · see citing works

Early induction of CREB activation and CREB-regulating signalling by antidepressants

Tardito, D., Musazzi, L., Tiraboschi, E., Mallei, A., Racagni, G., & Popoli, M. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709000376 · Cited by 42 · see citing works

PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway

Fabbri, C., Marsano, A., Albani, D., Chierchia, A., Calati, R., Drago, A., Crisafulli, C., Calabrò, M., Kasper, S. F., Lanzenberger, R. R., et al. (2014) · The Pharmacogenomics Journal · doi:10.1038/tpj.2014.15 · Cited by 41 · see citing works

Lasting effects of chronic fluoxetine treatment on the late developing rat brain: Age-dependent changes in the serotonergic neurotransmitter system assessed by pharmacological MRI

Klomp, A., Tremoleda, J. L., Wylezinska, M., Nederveen, A. J., Feenstra, M. G. P., Gsell, W., & Reneman, L. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.082 · Cited by 41 · see citing works

Pharmacological characterization of BDNF promoters I, II and IV reveals that serotonin and norepinephrine input is sufficient for transcription activation

Musazzi, L., Rimland, J. M., Ieraci, A., Racagni, G., Domenici, E., & Popoli, M. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713001685 · Cited by 39 · see citing works

Rare susceptibility variants for bipolar disorder suggest a role for G protein-coupled receptors

Cruceanu, C., Schmouth, J.-F., Torres-Platas, S. G., López, J. P., Ambalavanan, A., Darcq, E., Gross, F., Breton, B., Spiegelman, D., Rochefort, D. L., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.223 · Cited by 38 · see citing works

Isotretinoin has no negative effect on attention, executive function and mood

Ergun, T., Seçkin, D., Özaydın, A., Bakar, Ö., Cömert, A., Atsü, N., Demirçay, Z., Yöney, H., & Zaimoğlu, S. (2011) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2011.04089.x · Cited by 38 · see citing works

Atorvastatin and Fluoxetine Prevent Oxidative Stress and Mitochondrial Dysfunction Evoked by Glutamate Toxicity in Hippocampal Slices

Ludka, F. K., Dal-Cim, T. A., Binder, L. B., Constantino, L. C., Massari, C. M., & Tasca, C. I. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9882-6 · Cited by 38 · see citing works

Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future Prospects

Álvarez-Mon, M. Á., Ortega, M. A., Montero, C. G., Fraile‐Μartinez, O., Monserrat, J., Lahera, G., Mora, F., Rodríguez-Quiroga, A., Fernández-Rojo, S., Quintero, J., et al. (2021) · Pharmaceuticals · doi:10.3390/ph14080821 · Cited by 36 · see citing works

A novel peripheral biomarker for depression and antidepressant response

Targum, S. D., Schappi, J. M., Koutsouris, A., Bhaumik, R., Rapaport, M. H., Rasgon, N., & Rasenick, M. M. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01399-1 · Cited by 38 · see citing works

Clinical features and drug induced side effects in early versus late antidepressant responders

Fabbri, C., Marsano, A., Balestri, M., Ronchi, D. D., & Serretti, A. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.05.020 · Cited by 33 · see citing works

Advances in novel molecular targets for antidepressants

Wang, Q., & Dwivedi, Y. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110041 · Cited by 32 · see citing works

Fluoxetine elevates allopregnanolone in female rat brain but inhibits a steroid microsomal dehydrogenase rather than activating an aldo‐keto reductase

Fry, J. P., Li, K. Y., Devall, A., Cockcroft, S., Honour, J. W., & Lovick, T. A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12891 · Cited by 31 · see citing works

Antidepressants and type 2 diabetes: highways to knowns and unknowns

Alruwaili, N. S., Al-Kuraishy, H. M., Al-Gareeb, A. I., Albuhadily, A. K., Ragab, A. E., Alenazi, A. A., Alexiou, A. T., Papadakis, M., & Batiha, G. E. (2023) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-023-01149-z · Cited by 30 · see citing works

Neurochemical and behavioural effects of hypidone hydrochloride (YL‐0919): a novel combined selective 5‐HT reuptake inhibitor and partial 5‐HT1Aagonist

Zhang, L., Wang, X., Zhao, N., Wang, Y., Hu, X., Ran, Y., Liu, Y., Zhang, Y., Yang, R., & Li, Y. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13675 · Cited by 30 · see citing works

Neuroplasticity and Mechanisms of Action of Acute and Chronic Treatment with Antidepressants in Preclinical Studies

Rosas-Sánchez, G. U., Germán-Ponciano, L. J., Guillén-Ruiz, G., Cueto‐Escobedo, J., Limón-Vázquez, A. K., Rodríguez‐Landa, J. F., & Soria-Fregozo, C. (2024) · Biomedicines · doi:10.3390/biomedicines12122744 · Cited by 30 · see citing works

Psychiatric neural networks and neuropharmacology: Selected advances and novel implications

Ghanemi, A. (2013) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2013.01.008 · Cited by 27 · see citing works

The intersection of pharmacology, imaging, and genetics in the development of personalized medicine

Gerretsen, P., Müller, D. J., Tiwari, A. K., Mamo, D. C., & Pollock, B. G. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.4/pgerretsen · Cited by 27 · see citing works

Immediate and persistent antidepressant-like effects of Chaihu-jia-Longgu-Muli-tang are associated with instantly up-regulated BDNF in the hippocampus of mice

Wang, X., Chen, J., Zhang, H., Huang, Z., Zou, Z., Yin, C., Sheng, L., Xue, W., Tang, J., Wu, H., et al. (2018) · Bioscience Reports · doi:10.1042/bsr20181539 · Cited by 26 · see citing works

Participation of the Serotonergic System and Brain-Derived Neurotrophic Factor in the Antidepressant-like Effect of Flavonoids

Germán-Ponciano, L. J., Rosas-Sánchez, G. U., Cueto‐Escobedo, J., Fernández-Demeneghi, R., Guillén-Ruiz, G., Soria-Fregozo, C., Herrera-Huerta, E. V., & Rodríguez‐Landa, J. F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810896 · Cited by 26 · see citing works

Monoamine involvement in the antidepressant-like effect induced by P2 blockade

Diniz, C. R. A. F., Rodrigues, M., Casarotto, P. C., Pereira, V. S., Crestani, C. C., & Joca, S. R. L. (2017) · Brain Research · doi:10.1016/j.brainres.2017.09.011 · Cited by 25 · see citing works

The role of cytochromes P450 in the metabolism of selected antidepressants and anxiolytics under psychological stress

Zemanová, N., Anzenbacher, P., & Anzenbacherová, E. (2022) · Biomedical Papers · doi:10.5507/bp.2022.019 · Cited by 25 · see citing works

The Role of Beta-Adrenergic Receptors in Depression and Resilience

Zhang, H., Cui, M., Cao, J., & Han, M. (2022) · Biomedicines · doi:10.3390/biomedicines10102378 · Cited by 25 · see citing works

Chronic oral ketamine prevents anhedonia and alters neuronal activation in the lateral habenula and nucleus accumbens in rats under chronic unpredictable mild stress

Kingir, E., Sevinc, C., & Ünal, G. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109468 · Cited by 25 · see citing works

Antidepressants Increase β-Arrestin2 Ubiquitinylation and Degradation by the Proteasomal Pathway in C6 Rat Glioma Cells

Golan, M., Schreiber, G., & Avissar, S. (2010) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.160218 · Cited by 24 · see citing works

Neuronal life or death linked to depression treatment: the interplay between drugs and their stress-related outcomes relate to single or combined drug therapies

Sołek, P., Koszła, O., Mytych, J., Badura, J., Chelminiak, Z., Cuprys, M., Fraczek, J., Tabęcka-Łonczyńska, A., & Koziorowski, M. (2019) · APOPTOSIS · doi:10.1007/s10495-019-01557-5 · Cited by 24 · see citing works

Molecular and Cellular Aspects of Major Depressive Disorder

Chottekalapanda, R. U., Greengard, P., & Sagi, Y. (2019) · doi:10.1093/oso/9780190455132.003.0004 · Cited by 23 · see citing works

Extra-Virgin Olive Oil Improves Depression Symptoms Without Affecting Salivary Cortisol and Brain-Derived Neurotrophic Factor in Patients With Major Depression: A Double-Blind Randomized Controlled Trial

Foshati, S., Ghanizadeh, A. J., & Akhlaghi, M. (2021) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2021.07.016 · Cited by 23 · see citing works

All roads lead to glutamate: NMDA and AMPA receptors as targets for rapid-acting antidepressants

Freudenberg, F., Reif-Leonhard, C., Dawson, G. R., McKernan, R. M., & Reif, A. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107918 · Cited by 23 · see citing works

NMDA-NO signaling in the dorsal and ventral hippocampus time-dependently modulates the behavioral responses to forced swimming stress

Diniz, C. R. A. F., Casarotto, P. C., & Joca, S. R. L. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.03.037 · Cited by 22 · see citing works

New Therapeutic Strategy for Mood Disorders

Crupi, R., Marino, A., & Cuzzocrea, S. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711797200417 · Cited by 20 · see citing works

Licorisoflavan A Exerts Antidepressant-Like Effect in Mice: Involvement of BDNF-TrkB Pathway and AMPA Receptors

Dong, X. Y., Liu, L., Li, Y., Ruan, J., & Wang, H. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02840-2 · Cited by 22 · see citing works

Brain structure and synaptic protein expression alterations after antidepressant treatment in a Wistar–Kyoto rat model of depression

Li, Q., Gao, Y., Li, H., Liu, H., Wang, D., Pan, W. X., Liu, S., & Xu, Y. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.07.037 · Cited by 21 · see citing works

Multi-matrix assay of the first melatonergic antidepressant agomelatine by combined liquid chromatography-fluorimetric detection and microextraction by packed sorbent

Saracino, M. A., Mercolini, L., Carbini, G., Volterra, V., Quarta, A. L., Amore, M., & Raggi, M. A. (2014) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2014.02.005 · Cited by 21 · see citing works

Antidepressant-induced differential ubiquitination of β-arrestins 1 and 2 in mononuclear leucocytes of patients with depression

Golan, M., Schreiber, G., & Avissar, S. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000291 · Cited by 21 · see citing works

Yoga in major depressive disorder: molecular mechanisms and clinical utility

Tolahunase, M., Gautam, S., Sagar, R., Kumar, M., & Dada, R. (2021) · Frontiers in Bioscience-Scholar · doi:10.52586/s553 · Cited by 22 · see citing works

Research progress on vesicle cycle and neurological disorders

Zhang, C., Zhu, L., & Chen, C. (2021) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/jpps31458 · Cited by 20 · see citing works

Intersecting Relationships of Psychosocial and Structural Syndemic Problems Among People with HIV in South Africa: Using Network Analysis to Identify Influential Problems

Lee, J. S., Bainter, S. A., Tsai, A. C., Andersen, L. S., Stanton, A. M., Magidson, J. F., Kagee, A., Joska, J. A., O’Cleirigh, C. M., & Safren, S. A. (2022) · AIDS and Behavior · doi:10.1007/s10461-022-03906-z · Cited by 20 · see citing works

Chronic Fluoxetine Treatment of Socially Isolated Rats Modulates Prefrontal Cortex Proteome

Filipović, D., Novak, B., Xiao, J., Yan, Y., Yeoh, K., & Turck, C. W. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.08.011 · Cited by 20 · see citing works

Astroglia, Glutamatergic Transmission and Psychiatric Diseases

Verkhratsky, A., Steardo, L., Peng, L., & Parpura, V. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-45096-4_12 · Cited by 18 · see citing works

Hippocampal cAMP regulates HCN channel function on two time scales with differential effects on animal behavior

Lyman, K. A., Han, Y., Zhou, C., Renteria, I., Besing, G.-L., Kurz, J. E., & Chetkovich, D. M. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abl4580 · Cited by 17 · see citing works

Neuroimmune crosstalk through brain-derived neurotrophic factor and its precursor pro-BDNF: New insights into mood disorders

Zhao, X., Li, H., & Dai, R. (2022) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i3.379 · Cited by 17 · see citing works

BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder

Marcin, L. R., Warrier, J., Thangathirupathy, S., Shi, J., Karageorge, G. N., Pearce, B. C., Ng, A., Park, H., Kempson, J., Li, J., et al. (2018) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.8b00080 · Cited by 17 · see citing works

Accuracy in recognising happy facial expressions is associated with antidepressant response to a NOP receptor antagonist but not placebo treatment

Dawson, G. R., Post, A., Smart, T. S., Browning, M. D., & Harmer, C. J. (2021) · Journal of Psychopharmacology · doi:10.1177/02698811211044684 · Cited by 17 · see citing works

Wheatgrass extract imparts neuroprotective actions against scopolamine-induced amnesia in mice

Katiyar, P., Rathore, A. S., Banerjee, S., Nathani, S., Zahra, W., Singh, S. P., Sircar, D., & Roy, P. (2022) · Food & Function · doi:10.1039/d2fo00423b · Cited by 16 · see citing works

Propamocarb exposure decreases the secretion of neurotransmitters and causes behavioral impairments in mice

Zhang, Y., Jin, C., Wang, X., Shen, M., Zhou, J., Wu, S., Fu, Z., & Jin, Y. (2018) · Environmental Toxicology · doi:10.1002/tox.22653 · Cited by 16 · see citing works

Potential depression and antidepressant-response biomarkers in human lymphoblast cell lines from treatment-responsive and treatment-resistant subjects: roles of SSRIs and omega-3 polyunsaturated fatty acids

Chukaew, P., Leow, A., Saengsawang, W., & Rasenick, M. M. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0724-6 · Cited by 16 · see citing works

Effect of newly synthesized 1,2,4-triazino[5,6-b]indole-3-thione derivatives on olfactory bulbectomy induced depression in rats

Aswar, U. M., ., P. K., Shelke, S. M., Bhosale, S. H., & Bodhankar, S. L. (2012) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(13)60012-x · Cited by 16 · see citing works

Effect of Imipramine and Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Activity of Proline-Specific Peptidases in the Brain of Rats with Experimental Anxious-Depressive Syndrome

Khlebnikova, N. N., Krupina, N. A., Kushnareva, E. Y., Золотов, Н. Н., & Крыжановский, Г. Н. (2012) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-012-1540-z · Cited by 14 · see citing works

Fluoxetine Enhances Synaptic Vesicle Trafficking and Energy Metabolism in the Hippocampus of Socially Isolated Rats

Filipović, D., Costina, V., Findeisen, P., & Inta, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315351 · Cited by 13 · see citing works

New Strategies in the Development of Antidepressants: Towards the Modulation of Neuroplasticity Pathways

Vidal, R., Pilar-Cuéllar, F., Dos-Anjos, S., Linge, R., Treceño, B., Vargas, V. I., Rodríguez‐Gaztelumendi, A., Mostany, R., Castro, E., Díaz, Á., et al. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211795164086 · Cited by 55 · see citing works

Antidepressants and neuroplasticity

D'Sa, C. M., & Duman, R. S. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.01203.x · Cited by 516 · see citing works

Neurogenesis and Neuroplasticity in Major Depression: Its Therapeutic Implication

Bourin, M. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-33-6044-0_10 · Cited by 19 · see citing works

Molecular and Cellular Mechanisms of Antidepressant Action

Sharp, T. (2012) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2012_216 · Cited by 36 · see citing works

New views on antidepressant action

Baudry, A., Mouillet‐Richard, S., Launay, J., & Kellermann, O. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.03.005 · Cited by 32 · see citing works