D-serine plasma concentration is a potential biomarker of (R,S)-ketamine antidepressant response in subjects with treatment-resistant depression
Open accessAbstract
Rationale (R,S)-ketamine is a rapid and effective antidepressant drug that produces a response in two thirds of patients with treatment-resistant depression (TRD). The underlying biochemical differences between a (R,S)-ketamine responder (KET-R) and non-responder (KET-NR) have not been definitively identified but may involve serine metabolism. Objectives The aim of the study was to examine the relationship between baseline plasma concentrations of D-serine and its precursor L-serine and antidepressant response to (R,S)-ketamine in TRD patients. Methods Plasma samples were obtained from 21 TRD patients at baseline, 60 min before initiation of the (R,S)-ketamine infusion. Patients were classified as KET-Rs (n = 8) or KET-NRs (n = 13) based upon the difference in Montgomery-Åsberg Depression Rating Scale (MADRS) scores at baseline and 230 min after infusion, with response defined as a ≥50 % decrease in MADRS score. The plasma concentrations of D-serine and L-serine were determined using liquid chromatography-mass spectrometry. Results Baseline D-serine plasma concentrations were significantly lower in KET-Rs (3.02 ± 0.21 μM) than in KET-NRs (4.68 ± 0.81 μM), p < 0.001. A significant relationship between baseline D-serine plasma concentrations and percent change in MADRS at 230 min was determined using a Pearson correlation, r = 0.77, p < 0.001, with baseline D-serine explaining 60 % of the variance in (R,S)-ketamine response. The baseline concentrations of L-serine (L-Ser) in KET-Rs were also significantly lower than those measured in KET-NRs (66.2 ± 9.6 μM vs 242.9 ± 5.6 μM, respectively; p < 0.0001). Conclusions The results demonstrate that the baseline D-serine plasma concentrations were significantly lower in KET-Rs than in KET-NRs and suggest that this variable can be used to predict an antidepressant response following (R,S)-ketamine administration.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Ketamine inhibits transport of D-serine, ketamine metabolites decrease intracellular concentrations of D-serine in PC-12 cells, and plasma D-serine levels predict a response to the antidepressant effects of ketamine.
“In this regard, it is interesting that ketamine inhibits transport of D-serine,124 ketamine metabolites decrease intracellular concentrations of D-serine in PC-12 cells,125 and that plasma D-serine levels predict a response to the antidepressant effects of ketamine.126,127”
From Ketamine as an antidepressant: Overview of its mechanisms of action and potential predictive biomarkers (2020) · cites this paper as [126]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(1978) · Biochemical Education · doi:10.1016/0307-4412(78)90049-3 · Cited by 5,073 · see citing works
Long-term potentiation depends on release of d-serine from astrocytes
Henneberger, C., Papouin, T., Oliet, S. H. R., & Rusakov, D. A. (2010) · Nature · doi:10.1038/nature08673 · Cited by 1,389 · see citing works
Murrough, J. W., Iosifescu, D. V., Chang, L. C., Al Jurdi, R. K., Green, C. E., Perez, A. M., Iqbal, S., Pillemer, S., Foulkes, A., Shah, A., et al. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13030392 · Cited by 1,205 · see citing works
(1994) · International Journal of Biochemistry · doi:10.1016/0020-711x(94)90020-5 · Cited by 941 · see citing works
Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists
Papouin, T., Ladépêche, L., Ruel, J., Sacchi, S., Labasque, M., Hanini, M., Groc, L., Pollegioni, L., Mothet, J., & Oliet, S. H. R. (2012) · Cell · doi:10.1016/j.cell.2012.06.029 · Cited by 752 · see citing works
Influence of body fat distribution on free fatty acid metabolism in obesity.
Jensen, M. D., Haymond, M. W., Rizza, R. A., Cryer, P. E., & Miles, J. M. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113997 · Cited by 683 · see citing works
Decreased Serum Levels of D-Serine in Patients With Schizophrenia
Hashimoto, K., Fukushima, T., Shimizu, E., Komatsu, N., Watanabe, H., 篠田, 直., Nakazato, M., Kumakiri, C., Okada, S.-I., Hasegawa, H., et al. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.6.572 · Cited by 489 · see citing works
Principles of Biochemistry (2nd edn)
Harris, D. (1993) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(93)90073-v · Cited by 405 · see citing works
Correlation between plasma levels of glutamate, alanine and serine with severity of depression
Mitani, H., Shirayama, Y., Yamada, T., Maeda, K., Ashby, C. R., & Kawahara, R. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.03.036 · Cited by 332 · see citing works
Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants
Browne, C. A., & Lucki, I. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00161 · Cited by 285 · see citing works
Do the dissociative side effects of ketamine mediate its antidepressant effects?
Luckenbaugh, D. A., Niciu, M. J., Ionescu, D. F., Nolan, N. M., Richards, E. M., Brutsche, N. E., Guevara, S., & Zarate, C. A. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.02.017 · Cited by 283 · see citing works
Self-citationZarate, C. A., Brutsche, N., Laje, G., Luckenbaugh, D. A., Venkata, S. L. V., Ramamoorthy, A., Moaddel, R., & Wainer, I. W. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.03.004 · Cited by 282 · see citing works
Self-citationHorrobin, D. F., & Bennett, C. N. (1999) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.1999.0037 · Cited by 222 · see citing works
Psychological effects of ketamine in healthy volunteers
Pomarol‐Clotet, E., Honey, G. D., Murray, G. K., Corlett, P. R., Absalom, A. R., Lee, M., McKenna, P. J., Bullmore, E. T., & Fletcher, P. C. (2006) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.105.015263 · Cited by 210 · see citing works
Identification and Validation of Urinary Metabolite Biomarkers for Major Depressive Disorder
Zheng, P., Wang, Y., Chen, L., Yang, D., Meng, H., Zhou, D., Zhong, J., Lei, Y., Melgiri, N. D., & Xie, P. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.021816 · Cited by 198 · see citing works
Machado-Vieira, R., Salvadore, G., Luckenbaugh, D. A., Manji, H. K., & Zarate, C. A. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0610 · Cited by 195 · cited 2× · see citing works
“…substantial number of patients with major depressive disorder (MDD) and bipolar depression (BD) do not respond to current antidepressant therapy and, for those who do respond, full antidepressant effects typically take 6 weeks or more (Machado-Vieira et al. 2008).”
BackgroundSelf-citationAltamura, C., Maes, M., Dai, J., & Meltzer, H. Y. (1995) · European Neuropsychopharmacology · doi:10.1016/0924-977x(95)00033-l · Cited by 193 · see citing works
L-serine synthesis in the central nervous system: a review on serine deficiency disorders.
Tabatabaie, L., Klomp, L., Berger, R., & de Koning, T. D. (2010) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2009.10.012 · Cited by 185 · see citing works
Maes, M. H. J., Verkerk, R. M., Vandoolaeghe, E., Lin, A., & Scharpé, S. (1998) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1998.tb10004.x · Cited by 179 · see citing works
Clinical Predictors of Ketamine Response in Treatment-Resistant Major Depression
Niciu, M. J., Luckenbaugh, D. A., Ionescu, D. F., Guevara, S., Machado-Vieira, R., Richards, E. M., Brutsche, N. E., Nolan, N. M., & Zarate, C. A. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13m08698 · Cited by 165 · see citing works
Self-citationNiciu, M. J., Henter, I. D., Luckenbaugh, D. A., Zarate, C. A., & Charney, D. S. (2014) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135950 · Cited by 161 · see citing works
Self-citationJi, Y., Hebbring, S. J., Zhu, H., Jenkins, G. D., Biernacka, J. M., Snyder, K., Drews, M., Fiehn, O., Zeng, Z., Schaid, D. J., et al. (2010) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2010.250 · Cited by 160 · see citing works
Yang, J. H., Wada, A., Yoshida, K., Miyoshi, Y., Sayano, T., Esaki, K., Kinoshita, M. O., Tomonaga, S., Azuma, N., Watanabe, M., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.187443 · Cited by 147 · see citing works
Labrie, V., & Roder, J. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.08.002 · Cited by 116 · see citing works
Paul, R. K., Singh, N. S., Khadeer, M., Moaddel, R., Sanghvi, M., Green, C. E., O’Loughlin, K., Torjman, M. C., Bernier, M., & Wainer, I. W. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000285 · Cited by 115 · see citing works
Self-citationMurrough, J. W., Wan, L.-B., Iacoviello, B. M., Collins, K. A., SOLON, C. A., Glicksberg, B. S., Perez, A. M., Mathew, S. J., Charney, D. S., Iosifescu, D. V., et al. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3255-x · Cited by 112 · see citing works
Plasma levels of D-serine in Brazilian individuals with schizophrenia
Calcia, M., Madeira, C., Alheira, F. V., da Silva, T. C. S., Tannos, F. M., Vargas-Lopes, C., Goldenstein, N., Brasil, M. A. A., Ferreira, S. T., & Panizzutti, R. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.09.014 · Cited by 83 · see citing works
Villaseñor, A., Ramamoorthy, A., Silva dos Santos, M., Lorenzo, M. P., Laje, G., Zarate, C., Barbas, C., & Wainer, I. W. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12494 · Cited by 71 · see citing works
Self-citationMetabolic control analysis of mammalian serine metabolism
Snell, K., & Fell, D. A. (1990) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(90)90006-n · Cited by 55 · see citing works
Inhibition of Human Serine Racemase, an Emerging Target for Medicinal Chemistry
Jirásková-Vaníčková, J., Ettrich, R. H., Vorlová, B., Hoffman, H. E., Lepšı́k, M., Jansa, P., & Konvalinka, J. (2011) · Current Drug Targets · doi:10.2174/138945011795677755 · Cited by 53 · see citing works
Genetic polymorphisms in fatty acid metabolism genes and colorectal cancer
Crous‐Bou, M., Rennert, G., Salazar, R., Rodríguez‐Moranta, F., Rennert, H. S., Lejbkowicz, F., Kopelovich, L., Lipkin, S. M., Gruber, S. B., & Moreno, V. R. (2012) · Mutagenesis · doi:10.1093/mutage/ger066 · Cited by 43 · see citing works
Plasma Amino Acids Changes in Complex Regional Pain Syndrome
Alexander, G. M., Reichenberger, E. R., Peterlin, B., Perreault, M., Grothusen, J. R., & Schwartzman, R. J. (2013) · Pain Research and Treatment · doi:10.1155/2013/742407 · Cited by 41 · see citing works
NMDA Receptor Activation: Two Targets for Two Co-Agonists
Henneberger, C., Bard, L., King, C., Jennings, A., & Rusakov, D. A. (2013) · Neurochemical Research · doi:10.1007/s11064-013-0987-2 · Cited by 35 · see citing works
Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo
Hopkins, S. C., Campbell, U. C., Heffernan, M. L. R., Spear, K. L., Jeggo, R. D., Spanswick, D. C., Varney, M. A., & Large, T. H. (2013) · Pharmacology Research & Perspectives · doi:10.1002/prp2.7 · Cited by 34 · see citing works
Xie, Y.-G., Alexander, G. M., Schwartzman, R. J., Singh, N., Torjman, M. C., Goldberg, M. E., Wainer, I. W., & Moaddel, R. (2013) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2013.10.028 · Cited by 31 · see citing works
Self-citationSingh, N., Paul, R. K., Ramamoorthy, A., Torjman, M. C., Moaddel, R., Bernier, M., & Wainer, I. W. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.08.025 · Cited by 30 · see citing works
Self-citationSingh, N., Paul, R. K., Sichler, M., Moaddel, R., Bernier, M., & Wainer, I. W. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2011.10.003 · Cited by 29 · see citing works
Self-citationD-Serine Production, Degradation, and Transport in ALS: Critical Role of Methodology
Crow, J. P., Marecki, J. C., & Thompson, M. M. (2012) · Neurology Research International · doi:10.1155/2012/625245 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms
Zanos, P., Moaddel, R., Morris, P. J., Riggs, L. M., Highland, J. N., Georgiou, P., Pereira, E. F. R., Albuquerque, E. X., Thomas, C. J., Zarate, C. A., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.015198 · Cited by 1,260 · see citing works
Self-citationA brief history of the development of antidepressant drugs: From monoamines to glutamate.
Hillhouse, T. M., & Porter, J. H. (2015) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0038550 · Cited by 618 · see citing works
Detection and analysis of chiral molecules as disease biomarkers
Liu, Y., Wu, Z., Armstrong, D. W., Wolosker, H., & Zheng, Y. (2023) · Nature Reviews Chemistry · doi:10.1038/s41570-023-00476-z · Cited by 257 · see citing works
Matveychuk, D., Thomas, R. K., Swainson, J., Khullar, A., MacKay, M.-A., Baker, G. B., & Dursun, S. M. (2020) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320916657 · Cited by 209 · see citing works
Iadarola, N. D., Niciu, M. J., Richards, E. M., Vande Voort, J. L., Ballard, E. D., Lundin, N. B., Nugent, A. C., Machado-Vieira, R., & Zarate, C. A. (2015) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622315579059 · Cited by 201 · see citing works
Self-citationNew targets for rapid antidepressant action
Machado‐Vieira, R., Henter, I. D., & Zarate, C. A. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.12.001 · Cited by 156 · see citing works
Self-citationMechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works
D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression?
MacKay, M.-A. B., Kravtsenyuk, M., Thomas, R. K., Mitchell, N., Dursun, S. M., & Baker, G. B. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00025 · Cited by 128 · see citing works
d -Amino Acid Levels in Perfused Mouse Brain Tissue and Blood: A Comparative Study
Weatherly, C. A., Du, S., Parpia, C., Santos, P. T., Hartman, A. L., & Armstrong, D. W. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00398 · Cited by 116 · see citing works
Ketamine and other potential glutamate antidepressants
Dutta, A., McKie, S., & Deakin, J. F. W. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.10.028 · Cited by 89 · see citing works
Réus, G. Z., Carlessi, A. S., Titus, S. E., Abelaira, H. M., Ignácio, Z. M., da Luz, J. R., Matias, B. I., Bruchchen, L., Florentino, D., Vieira, A. A. D. S., et al. (2015) · Developmental Neurobiology · doi:10.1002/dneu.22283 · Cited by 82 · see citing works
Pennybaker, S. J., Niciu, M. J., Luckenbaugh, D. A., & Zarate, C. A. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.10.026 · Cited by 77 · see citing works
Self-citationMedeiros, G. C., Gould, T. D., Prueitt, W. L., Nanavati, J., Grunebaum, M. F., Farber, N. B., Singh, B., Selvaraj, S., Machado-Vieira, R., Achtyes, E. D., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01652-1 · Cited by 75 · see citing works
Self-citationd ‐Amino acids in biological systems
Du, S., Wey, M., & Armstrong, D. W. (2023) · Chirality · doi:10.1002/chir.23562 · Cited by 73 · see citing works
The glycine site of NMDA receptors: A target for cognitive enhancement in psychiatric disorders
Peyrovian, B., Rosenblat, J. D., Pan, Z., Iacobucci, M., Brietzke, E. M., & McIntyre, R. S. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.02.001 · Cited by 70 · see citing works
Advances in D-Amino Acids in Neurological Research
Seckler, J. M., & Lewis, S. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197325 · Cited by 68 · see citing works
Pradhan, B., Mitrev, L. V., Moaddel, R., & Wainer, I. W. (2018) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2018.03.006 · Cited by 63 · see citing works
Self-citationIncreased serum levels of serine enantiomers in patients with depression
Hashimoto, K., Yoshida, T., Ishikawa, M., Fujita, Y., Niitsu, T., Nakazato, M., Watanabe, H., Sasaki, T. G., Shiina, A., Hashimoto, T., et al. (2015) · Acta Neuropsychiatrica · doi:10.1017/neu.2015.59 · Cited by 57 · see citing works
Grabski, M., Borissova, A., Marsh, B., Morgan, C. J. A., & Curran, H. V. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112629 · Cited by 55 · see citing works
de Bartolomeis, A., Manchia, M., Marmo, F., Vellucci, L., Iasevoli, F., & Barone, A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00369 · Cited by 43 · see citing works
d-Alanine: Distribution, origin, physiological relevance, and implications in disease
Lee, C. J., Qiu, T. A., & Sweedler, J. V. (2020) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2020.140482 · Cited by 56 · see citing works
N -Methyl-D-Aspartate (NMDA) receptor modulators: a patent review (2015-present)
Ahmed, H., Haider, A., & Ametamey, S. M. (2020) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2020.1811234 · Cited by 54 · see citing works
Guo, J., Qiu, D., Gu, H., Wang, X., Hashimoto, K., Zhang, G.-F., & Yang, J. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01945-z · Cited by 51 · see citing works
Pradhan, B., Wainer, I. W., Moaddel, R., Torjman, M. C., Goldberg, M., Sabia, M., Parikh, T., & Pumariega, A. (2017) · Asia Pacific Journal of Clinical Trials Nervous System Diseases · doi:10.4103/2542-3932.211589 · Cited by 49 · see citing works
Self-citationMechanisms of action and clinical efficacy of NMDA receptor modulators in mood disorders
Ghasemi, M., Phillips, C., Fahimi, A., McNerney, M. W., & Salehi, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.002 · Cited by 49 · see citing works
Douglas, S. R., Shenoda, B. B., Qureshi, R., Saçan, A., Alexander, G. M., Perreault, M. J., Barrett, J. E., Aradillas, E., Schwartzman, R. J., & Ajit, S. K. (2015) · Journal of Pain · doi:10.1016/j.jpain.2015.05.008 · Cited by 47 · see citing works
Du, S., Wang, Y., Weatherly, C. A., Holden, K. I., & Armstrong, D. W. (2018) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-018-0979-9 · Cited by 45 · see citing works
Medeiros, G. C., Matheson, M., Demo, I., Reid, M. J., Matheson, S., Twose, C., Smith, G. S., Gould, T. D., Zarate, C. A., Barrett, F. S., et al. (2023) · The Lancet Psychiatry · doi:10.1016/s2215-0366(23)00183-9 · Cited by 49 · see citing works
Self-citationWei, I., Chen, K.-T., Tsai, M., Wu, C.-H., Lane, H., & Huang, C. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b04217 · Cited by 43 · see citing works
Voegeli, G., Cléry-Melin, M.-L., Ramoz, N., & Gorwood, P. A. P. M. (2017) · Drugs · doi:10.1007/s40265-017-0819-9 · Cited by 37 · see citing works
Fortress, A. M., Smith, I. M., & Pang, K. C. H. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.05.009 · Cited by 37 · see citing works
Neurobiological biomarkers of response to ketamine
Kadriu, B., Ballard, E. D., Henter, I. D., Murata, S., Gerlus, N., & Zarate, C. A. (2020) · Advances in pharmacology · doi:10.1016/bs.apha.2020.05.003 · Cited by 36 · see citing works
Self-citationKetamine‐An Update on Its Clinical Uses and Abuses
Xu, J., & Lei, H. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12363 · Cited by 35 · see citing works
Metabolomics of Major Depressive Disorder: A Systematic Review of Clinical Studies
Costa, L. N. F. G., Carneiro, B. A., Alves, G. S., Silva, D. H. L., Guimaraes, D. F., Souza, L. S., Bandeira, I. D., Beanes, G., Scippa, Â. M., & Quarantini, L. C. (2022) · Cureus · doi:10.7759/cureus.23009 · Cited by 34 · see citing works
An Astroglial Basis of Major Depressive Disorder: Molecular, Cellular, and Circuit Features
Lu, C., Ren, J., & Cao, X. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.07.017 · Cited by 33 · see citing works
Ishiwata, S., Hattori, K., Sasayama, D., Teraishi, T., Miyakawa, T., Yokota, Y., Matsumura, R., Nishikawa, T., & Kunugi, H. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.09.035 · Cited by 31 · see citing works
Tricklebank, M. D., Robbins, T. W., Simmons, C., & Wong, E. H. F. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05787-x · Cited by 30 · see citing works
Kalíková, K., Šlechtová, T., & Tesařová, E. (2016) · Separations · doi:10.3390/separations3040030 · Cited by 25 · see citing works
Wang, C., Zeng, C., Zhang, X., & Pu, L. (2017) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.7b02456 · Cited by 24 · see citing works
Singh, N. S., Rutkowska, E., Plazinska, A., Khadeer, M., Moaddel, R., Jozwiak, K., Bernier, M., & Wainer, I. W. (2016) · PLOS ONE · doi:10.1371/journal.pone.0149499 · Cited by 23 · see citing works
Self-citationEnantioselectivity Effects in Clinical Metabolomics and Lipidomics
Oliveira, R. V., Simionato, A. V. C., & Cass, Q. B. (2021) · Molecules · doi:10.3390/molecules26175231 · Cited by 23 · see citing works
Zhao, F., Du, Y., Tian, J. J., Shi, D., Wang, Y., Hu, L., Yu, S., Yu, X., & Pu, L. (2018) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201701773 · Cited by 23 · see citing works
Aleksandrova, L. R., Wang, Y. T., & Phillips, A. G. (2017) · Chronic Stress · doi:10.1177/2470547017743511 · Cited by 21 · see citing works
Artigas, F., Celada, P., & Bortolozzi, A. A. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.01.005 · Cited by 20 · see citing works
Serine enantiomers as diagnostic biomarkers for schizophrenia and bipolar disorder
Hashimoto, K. (2015) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-015-0602-4 · Cited by 19 · see citing works
Gkesoglou, T., Bargiota, S. I., Iordanidou, E., Vasiliadis, M., Bozikas, V., & Agorastos, A. (2022) · Brain Sciences · doi:10.3390/brainsci12070940 · Cited by 18 · see citing works
Hashimoto, K. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3735-7 · Cited by 16 · see citing works
Plasma and cerebrospinal fluid G72 protein levels in schizophrenia and major depressive disorder
Ishiwata, S., Hattori, K., Sasayama, D., Teraishi, T., Miyakawa, T., Yokota, Y., Matsumura, R., Yoshida, F., Nishikawa, T., & Kunugi, H. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.04.060 · Cited by 14 · see citing works
Assessment of the rapid and sustained antidepressant-like effects of dextromethorphan in mice.
Saavedra, J. S., Garrett, P. I., Honeycutt, S. C., Peterson, A. M., White, J., & Hillhouse, T. M. (2020) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2020.173003 · Cited by 13 · see citing works
Pharmacokinetic, pharmacodynamic, and behavioural studies of deschloroketamine in Wistar rats
Štefková, K., Danda, H., Dehaen, W., Jurásek, B., Šíchová, K., Pinterová, N., Mazoch, V., Krausová, B. H., Kysilov, B., Smejkalová, T., et al. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15680 · Cited by 13 · see citing works
Roméo, B., Choucha, W., Fossati, P., & Rotgé, J. (2016) · L Encéphale · doi:10.1016/j.encep.2016.06.005 · Cited by 13 · see citing works
A Bibliometric Analysis of Research on Ketamine From 2001 to 2020
Miao, H., Yu, K., Gao, D., Lin, X., Cao, Y., Liu, X., Qiao, H., & Li, T. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.839198 · Cited by 11 · see citing works
Enantioselective inhibition of <scp>d</scp>‐serine transport by (<scp><i>S</i></scp>)‐ketamine
Singh, N. S., Bernier, M., Camandola, S., Khadeer, M. A., Moaddel, R., Mattson, M. P., & Wainer, I. W. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13239 · Cited by 11 · see citing works
Self-citationSLC1A4 and Serine Homeostasis: Implications for Neurodevelopmental and Neurodegenerative Disorders
Elazar, D., Alvarez, N., Drobeck, S., & Gunn, T. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052104 · Cited by 10 · see citing works
Rengasamy, M. L., McClain, L. L., Gandhi, P., Segreti, A. M., Brent, D. A., Peters, D. G., & Pan, L. A. (2018) · Neurology Psychiatry and Brain Research · doi:10.1016/j.npbr.2018.05.001 · Cited by 10 · see citing works
Ma, M., Ren, Q., Fujita, Y., Yang, C., Dong, C., Ohgi, Y., Futamura, T., & Hashimoto, K. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4700-z · Cited by 10 · see citing works
Energy metabolism in Trypanosoma cruzi : the validated and putative bioenergetic and carbon sources
Alencar, M. B., Marsiccobetre, S., Mengarda, A. C., Ballari, M. S., & Silber, A. M. (2025) · mBio · doi:10.1128/mbio.02215-24 · Cited by 8 · see citing works
Gonçalves, K. T. D. C., Tavares, V. D. D. O., Barros, M. L. D. M., de Brito, A. J. C., Cavalcanti-Ribeiro, P., Palhano-Fontes, F., Falchi-Carvalho, M., Arcoverde, E., SANTOS, R. G. D., Hallak, J. E. C., et al. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-024-01925-6 · Cited by 7 · see citing works
Zhang, W., Wang, W., Zhou, Y., & Wang, J. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116453 · Cited by 6 · see citing works
Gunduz‐Bruce, H., Kenney, J. G., Changlani, S., Peixoto, A. J., Gueorguieva, R. V., Leone, C. A., & Stachenfeld, N. S. (2017) · Experimental Physiology · doi:10.1113/ep086212 · Cited by 6 · see citing works
Doran, M. M., Bermingham, K. P., Tricklebank, M. D., & Lowry, J. P. (2024) · Talanta · doi:10.1016/j.talanta.2024.126458 · Cited by 5 · see citing works
Courtes, A. C., Jones, G. H., Henter, I. D., Shahani, L., Fries, G. R., Juruena, M. F., Soares, J. C., Zarate, C. A., & Machado‐Vieira, R. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120016 · Cited by 4 · see citing works
Self-citationKetamine's Altered States Meta-Analysis
Tavares, V. D. D. O., Gonçalves, K. T. D. C., Barros, M. L. D. M., de Brito, A. J. C., Cavalcanti-Ribeiro, P., Palhano-Fontes, F., Falchi-Carvalho, M., Nunes, E. A., Sarris, J. J., Perkins, D., et al. (2024) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001946 · Cited by 3 · see citing works
The significance of dysregulated serine metabolism in depression
Lu, Y., Lv, M., Zhao, C., Pei, J., & Zhou, M. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118458 · Cited by 3 · see citing works
Ketamine: An Update for Its Use in Complex Regional Pain Syndrome and Major Depressive Disorder
Bentley, W. E. (2015) · Clinical and Experimental Pharmacology · doi:10.4172/2161-1459.1000169 · Cited by 3 · see citing works
Laksono, R. M., Kalim, H., Rohman, M. S., Widodo, N., & Ahmad, M. R. (2022) · Journal of Advanced Pharmaceutical Technology amp Research · doi:10.4103/japtr.japtr_72_22 · Cited by 3 · see citing works
Oyaide, M., Akita, T., Ishii, C., Mita, M., & Hamase, K. (2025) · Journal of Pharmaceutical and Biomedical Analysis Open · doi:10.1016/j.jpbao.2025.100053 · Cited by 2 · see citing works
Talebi, M., Sharifi-Ardani, S. E., Ghannadzadeh, F. S., Sattarpour, M., Jahanseir, A., Hashemi, S., & Jahani, R. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-11207-6 · Cited by 2 · see citing works
A Pain Physician and Anesthesiologist’s Perspective on Ketamine for Treatment-Resistant Depression
Gatewood, L. E., Gorlin, A. W., Bailey, C. H., Barsoum, G., & Porter, S. B. (2023) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-023-01439-7 · Cited by 1 · see citing works
A chronobiological perspective on ketamine’s antidepressant efficacy
Schiena, G., Ostinelli, E. G., Gambini, O., & D’Agostino, A. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4035-6 · Cited by 1 · see citing works
Ketamine’s Mechanisms of Rapid Antidepressant Activity: Evidence from Preclinical Studies
Hermes, G., & Sanacora, G. (2016) · Springer eBooks · doi:10.1007/978-3-319-42925-0_6 · Cited by 1 · see citing works
Predictable Biomarkers for Rapid-Acting Antidepressant Response to Ketamine
Tan, Y., & Hashimoto, K. (2021) · Contemporary clinical neuroscience · doi:10.1007/978-3-030-79790-4_3 · Cited by 1 · see citing works
Peripheral prognostic biomarkers of response in treatment-resistant depression
Agorastos, A., Gkesoglou, T., Kleidonopoulos, A., & Bozikas, V. P. (2021) · Psychiatriki · doi:10.22365/jpsych.2021.049 · Cited by 1 · see citing works
Neuropharmacology and toxicology of novel amphetamine-type stimulants
den Hollander, B. (2015)
Comparative Efficacy of Ketamine in Treatment-Resistant Depression
Kurt, H. G., Altinay, M. I., & Anand, A. (2020) · Psychiatric Annals · doi:10.3928/00485713-20200113-01
Evaluation of Analytes Characterized with Potential Protective Action after Rat Exposure to Lead
Liakh, I., Harshkova, D., Pauliukavets, A. Y., Шейбак, В. М., Bączek, T., & Miękus, N. (2021) · Molecules · doi:10.3390/molecules26082163
Emergence of Ketamine as a Rapid Acting Antidepressant: Mechanistic Insights and Future Directions
Singh, A., & Bedi, P. M. S. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.99765
Pham, G. S., & Mathew, S. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18496-3.00014-8
Movahed, P., & Takamiya, A. (2025) · Neuromethods · doi:10.1007/978-1-0716-4599-4_16
Sympathetic activation but not dissociation linked to ketamine’s sustained antidepressant effect
Andrashko, V., Novak, T., Kopeček, M., Šuláková, A., Knop, V., & Horacek, J. (2026) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253261419636
Gubser, L. P., Trippel, A., Zoelch, N., Engeli, E., & Herdener, M. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.111842
Prise en charge médicamenteuse des patients souffrant de douleur chronique réfractaire
Corriger, A. (2019) · theses.fr (ABES) · doi:10.70675/668e4777zf8d0z4bdcz9780z0f91fedfe2b6
Murase, Y., Ogata, H., Shimamoto, Y., Funatsuki, T., Koshikawa, Y., Takekita, Y., Hashimoto, K., & Kato, M. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.122231
Dissociation and antidepressant response to subcutaneous esketamine: A clinical study
Gonçalves, K. T. D. C., Tavares, V. D. D. O., Palhano-Fontes, F., Cavalcanti-Ribeiro, P., de Almeida, V. R. N., Barbosa, D. C., Fernandes, T. U. G., Cardoso, E. I. T., Lima, N. B. D. M., de Brito, A. J. C., et al. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.07.016
Metelska, A., Ziemichód, W., & Karakuła‐Juchnowicz, H. (2026) · Journal of Personalized Medicine · doi:10.3390/jpm16100488
- Authors
- Moaddel, R., Luckenbaugh, D. A., Xie, Y., Villaseñor, A., Brutsche, N. E., Machado-Vieira, R., Ramamoorthy, A., Lorenzo, M. P., Garcia, A., Bernier, M., Torjman, M. C., Barbas, C., Zarate, C. A., & Wainer, I. W.
- Affiliations
- National Institutes of Health (US)
- Universidad San Pablo CEU (ES)
- Cooper Medical School of Rowan University (US)
- Corresponding author
- Wainer, Irving W.
- ORCID
- Venue
- Psychopharmacology
- Published
- 2014-07-24
- Volume
- 232
- Issue
- 2
- Pages
- 399-409
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC5990001
- OpenAlex
- W1972478979
- Cited by
- 86
- References
- 38
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 3 · 2018: 7 · 2017: 11 · 2016: 5 · 2015: 12 · 2014: 3
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CEU Repositorio Institucional (Fundación Universitaria San Pablo CEU) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (Z99 AG999999)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Keywords
- D-serine, L-serine, treatment-resistant depression, antidepressant response prediction, biomarkers, serine metabolism, plasma concentration, rapid-acting antidepressants
- MeSH terms
- Adult, Antidepressive Agents, Chromatography, Liquid, Female, Humans, Infusions, Intravenous, Ketamine, Male, Middle Aged, Serine, Biomarkers, Tandem Mass Spectrometry, Depressive Disorder, Treatment-Resistant
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
