Metabonomics studies of intact hepatic and renal cortical tissues from diabetic db/db mice using high-resolution magic-angle spinning 1H NMR spectroscopy

Role of Insulin Resistance in Human Disease

Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154 · see citing works

Modified Spin-Echo Method for Measuring Nuclear Relaxation Times

Meiboom, S., & Gill, D. (1958) · Review of Scientific Instruments · doi:10.1063/1.1716296 · Cited by 6,001 · see citing works

Global and societal implications of the diabetes epidemic

Zimmet, P., Alberti, K. G. M. M., & Shaw, J. (2001) · Nature · doi:10.1038/414782a · Cited by 5,883 · see citing works

Centering, scaling, and transformations: improving the biological information content of metabolomics data

van den Berg, R. A., Hoefsloot, H. C., Westerhuis, J. A., Smilde, A. K., & van der Werf, M. J. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-142 · Cited by 2,450 · see citing works

Free Induction Decays of Rotating Solids

Lowe, I. J. (1959) · Physical Review Letters · doi:10.1103/physrevlett.2.285 · Cited by 1,172 · see citing works

Diabetes, a New Mutation in the Mouse

Hummel, K. P., Dickie, M. M., & Coleman, D. L. (1966) · Science · doi:10.1126/science.153.3740.1127 · Cited by 990 · see citing works

Experimental Pulse NMR

Fukushima, E., & Roeder, S. B. W. (2018) · CRC Press eBooks · doi:10.1201/9780429493867 · Cited by 914 · see citing works

WET, a T1- and B1-Insensitive Water-Suppression Method for in Vivo Localized 1H NMR Spectroscopy

Ogg, R. J., Kingsley, R. B., & Taylor, J. S. (1994) · Journal of Magnetic Resonance Series B · doi:10.1006/jmrb.1994.1048 · Cited by 734 · see citing works

WET Solvent Suppression and Its Applications to LC NMR and High-Resolution NMR Spectroscopy

Smallcombe, S. H., Patt, S. L., & Keifer, P. A. (1995) · Journal of Magnetic Resonance Series A · doi:10.1006/jmra.1995.0759 · Cited by 581 · see citing works

Improved WATERGATE Pulse Sequences for Solvent Suppression in NMR Spectroscopy

Liu, M., Mao, X., Ye, C., et al. (1998) · Journal of Magnetic Resonance · doi:10.1006/jmre.1998.1405 · Cited by 548 · see citing works

Experimental pulse NMR: A nuts and bolts approach

Boden, N. (1982) · Biochemical Education · doi:10.1016/0307-4412(82)90186-8 · Cited by 465 · see citing works

Metabonomics: Metabolic processes studied by NMR spectroscopy of biofluids

Lindon, J. C., Nicholson, J. K., Holmes, E. C., & Everett, J. R. (2000) · Concepts in Magnetic Resonance · doi:10.1002/1099-0534(2000)12:5 · Cited by 463 · see citing works

Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes

Koya, D., Haneda, M., Nakagawa, H., Isshiki, K., Sato, H., Maeda, S., Sugimoto, T., Yasuda, H., Kashiwagi, A., Ways, D. K., et al. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.3.439 · Cited by 426 · see citing works

Molecular basis of osmotic regulation

Burg, M. B. (1995) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1995.268.6.f983 · Cited by 369 · see citing works

An NMR‐based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse

Gavaghan, C. L., Holmes, E. C., Lenz, E. M., Wilson, I. D., & Nicholson, J. K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02147-5 · Cited by 321 · see citing works

Metabonomic Studies of Human Hepatocellular Carcinoma Using High-Resolution Magic-Angle Spinning 1H NMR Spectroscopy in Conjunction with Multivariate Data Analysis

Yang, Y., Li, C., Nie, X., et al. (2007) · Journal of Proteome Research · doi:10.1021/pr070063h · Cited by 235 · see citing works

Comparison of HR MAS MR spectroscopic profiles of breast cancer tissue with clinical parameters

Sitter, B., Lundgren, S., Bathen, T. F., Halgunset, J., Fjøsne, H. E., & Gribbestad, I. S. (2005) · NMR in Biomedicine · doi:10.1002/nbm.992 · Cited by 234 · see citing works

Solvent peak saturation with single phase and quadrature fourier transformation

Hoult, D. I. (1976) · Journal of Magnetic Resonance (1969) · doi:10.1016/0022-2364(76)90081-0 · Cited by 227 · see citing works

Increased Glomerular and Tubular Expression of Transforming Growth Factor-β1, Its Type II Receptor, and Activation of the Smad Signaling Pathway in the db/db Mouse

Hong, S. W., Isono, M., Chen, S., de la Cruz, M. D. C. I., Han, D. C., & Ziyadeh, F. N. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64121-1 · Cited by 194 · see citing works

Investigations into Biochemical Changes Due to Diurnal Variation and Estrus Cycle in Female Rats Using High-Resolution 1H NMR Spectroscopy of Urine and Pattern Recognition

Bollard, M. E., Holmes, E. C., Lindon, J. C., Mitchell, S. C., Branstetter, D. G., Zhang, W., & Nicholson, J. K. (2001) · Analytical Biochemistry · doi:10.1006/abio.2001.5211 · Cited by 175 · see citing works

Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning 1H nuclear magnetic resonance spectroscopy of liver tissues

Wang, Y., Bollard, M. E., Keun, H. C., Antti, H., Beckonert, O. P., Ebbels, T. M. D., Lindon, J. C., Holmes, E. C., Tang, H., & Nicholson, J. K. (2003) · Analytical Biochemistry · doi:10.1016/j.ab.2003.07.026 · Cited by 161 · see citing works

1H NMR metabonomics approach to the disease continuum of diabetic complications and premature death

Mäkinen, V., Soininen, P., Forsblom, C. M., Parkkonen, M., Ingman, P., Kaski, K. K., Groop, P., & Ala‐Korpela, M. (2008) · Molecular Systems Biology · doi:10.1038/msb4100205 · Cited by 158 · see citing works

NMR and pattern recognition studies on liver extracts and intact livers from rats treated with α-naphthylisothiocyanate

Waters, N. J., Holmes, E. C., Waterfield, C. J., et al. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01016-x · Cited by 149 · see citing works

Prevention of diabetic nephropathy in db/db mice with glycated albumin antagonists. A novel treatment strategy.

Cohen, M. P., Sharma, K., Jin, Y. S., Hud, E., Wu, V.-Y., Tomaszewski, J., & Ziyadeh, F. N. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117926 · Cited by 148 · see citing works

Prevention of Diabetic Nephropathy by Diet Control in the db/db Mouse

Lee, S. M., & BRESSLER, R. C. (1981) · Diabetes · doi:10.2337/diab.30.2.106 · Cited by 147 · see citing works

Metabolomics as a Functional Genomic Tool for Understanding Lipid Dysfunction in Diabetes, Obesity and Related Disorders

Griffin, J. L., & Nicholls, A. W. (2006) · Pharmacogenomics · doi:10.2217/14622416.7.7.1095 · Cited by 134 · see citing works

A combined 1H NMR and HPLC–MS-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats

Williams, R. E., Lenz, E. M., Evans, J. A., Wilson, I. D., Granger, J. H., Plumb, R. S., & Stumpf, C. L. (2005) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2005.01.013 · Cited by 109 · see citing works

Multi-component apparent diffusion coefficients in human brain: Relationship to spin-lattice relaxation

Mulkern, R. V., Zengingönül, H. P., Robertson, R. L., Bogner, P., Zou, K. H., Guðbjartsson, H., Guttmann, C. R. G., Holtzman, D. H., Kyriakos, W. E., Jolesz, F. A., et al. (2000) · Magnetic Resonance in Medicine · doi:10.1002/1522-2594(200008)44:2 · Cited by 109 · see citing works

Metabolic Phenotypes, Vascular Complications, and Premature Deaths in a Population of 4,197 Patients With Type 1 Diabetes

Mäkinen, V., Forsblom, C. M., Thorn, L. M., Wadén, J., Gordin, D., Heikkilä, O., Hietala, K., Kyllönen, L., Kytö, J., Rosengård‐Bärlund, M., et al. (2008) · Diabetes · doi:10.2337/db08-0332 · Cited by 92 · see citing works

Cervical cancer tissue characterized by high-resolution magic angle spinning MR spectroscopy

Sitter, B., Bathen, T. F., Hagen, B. �., et al. (2004) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/s10334-003-0025-5 · Cited by 90 · see citing works

Quantitative high resolution 1H NMR urinalysis studies on the biochemical effects of cadmium in the rat.

Nicholson, J. K., Higham, D. P., Timbrell, J. A., et al. (1989) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09335-6 · Cited by 90 · see citing works

Metabolite identification in human liver needle biopsies by high‐resolution magic angle spinning 1H NMR spectroscopy

Martínez-Granados, B., Monleón, D., Martínez‐Bisbal, M. C., et al. (2006) · NMR in Biomedicine · doi:10.1002/nbm.1005 · Cited by 86 · see citing works

Magnetic resonance imaging of progressive cardiomyopathic changes in the <i>db/db</i> mouse

Yue, P., Arai, T., Terashima, M., Sheikh, A. Y., Cao, F., Charo, D., Hoyt, G., Robbins, R. C., Ashley, E. A., Wu, J., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00856.2006 · Cited by 81 · see citing works

NMR of biofluids and pattern recognition: assessing the impact of NMR parameters on the principal component analysis of urine from rat and mouse

Potts, B. C. M., Deese, A. J., Stevens, G. J., Reily, M. D., Robertson, D. G., & Theiss, J. C. (2001) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(01)00430-7 · Cited by 80 · see citing works

Increased urinary type IV collagen marks the development of glomerular pathology in diabetic d/db mice

Cohen, M. P., Lautenslager, G. T., & Shearman, C. W. (2001) · Metabolism · doi:10.1053/meta.2001.28074 · Cited by 75 · see citing works

Diagnosing diabetic nephropathy by 1H NMR metabonomics of serum

Mäkinen, V., Soininen, P., Forsblom, C., Parkkonen, M., Ingman, P., Kaski, K., Groop, P., & Ala-Korpela, M. (2007) · Magnetic Resonance Materials in Physics, Biology and Medicine · doi:10.1007/s10334-006-0054-y · Cited by 70 · see citing works

Metabolomics in Lung Inflammation:A High-Resolution1H NMR Study of Mice Exposedto Silica Dust

Hu, J. Z., Rommereim, D. N., Minard, K. R., Woodstock, A., Harrer, B. J., Wind, R. A., Phipps, R. P., & Sime, P. J. (2008) · Toxicology Mechanisms and Methods · doi:10.1080/15376510701611032 · Cited by 67 · see citing works

The comparative metabonomics of age-related changes in the urinary composition of male Wistar-derived and Zucker (fa/fa) obese rats

Williams, R. E., Lenz, E. M., Rantalainen, M., & Wilson, I. D. (2006) · Molecular BioSystems · doi:10.1039/b517195d · Cited by 58 · see citing works

In vivo and ex vivo high-resolution 1H NMR in biological systems using low-speed magic angle spinning

Wind, R. A., & Hu, J. Z. (2006) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2006.05.003 · Cited by 57 · see citing works

Magic Angle Spinning NMR and 1H−31P Heteronuclear Statistical Total Correlation Spectroscopy of Intact Human Gut Biopsies

Wang, Y., Cloarec, O., Tang, H., Lindon, J. C., Holmes, E. C., Kochhar, S., & Nicholson, J. K. (2008) · Analytical Chemistry · doi:10.1021/ac701988a · Cited by 52 · see citing works

Acute biochemical effects of La(NO3)3 on liver and kidney tissues by magic-angle spinning 1H nuclear magnetic resonance spectroscopy and pattern recognition

Wu, H., Zhang, X., Li, X., et al. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2005.01.021 · Cited by 47 · see citing works

Beyond blood sugar: the potential of NMR-based metabonomics for type 2 human diabetes, and the horse as a possible model

Hodavance, M. S., Ralston, S. L., & Pelczer, I. (2006) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-006-0979-z · Cited by 45 · see citing works

Proton magnetic resonance spectroscopy in primary and secondary progressive multiple sclerosis

Cucurella, M., Rovira, À., Ro, J., Pedraza, S., Tintor�, M.-M., Montalbán, X., & Alonso, J. (2000) · NMR in Biomedicine · doi:10.1002/(sici)1099-1492(200004)13:2 · Cited by 42 · see citing works

NMR spectroscopic-based metabonomic investigation on the acute biochemical effects induced by Ce(NO3)3 in rats

Wu, H., Zhang, X., Liao, P., Li, Z., Li, W., Li, X., Wu, Y., & Pei, F. (2005) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2005.07.014 · Cited by 36 · see citing works

Water suppression without signal loss in HR-MAS 1H NMR of cells and tissues

Chen, J., Sambol, E. B., Kennealey, P. T., et al. (2004) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2004.08.009 · Cited by 31 · see citing works

Metabolic profiling of normal and hypertensive rat kidney tissues by hrMAS-NMR spectroscopy

Huhn, S. D., Szabo, C. M., Gass, J. H., et al. (2004) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-003-2477-x · Cited by 20 · see citing works

1H relaxation times of metabolites in biological samples obtained with nondestructive ex‐vivo slow‐MAS NMR

Hu, J. Z., Wind, R. A., & Rommereim, D. N. (2006) · Magnetic Resonance in Chemistry · doi:10.1002/mrc.1764 · Cited by 10 · see citing works

Strategies for data analyses in a high resolution 1H NMR based metabolomics study of a mouse model of Batten disease

Pears, M. R., Rubtsov, D. V., Mitchison, H. M., et al. (2007) · Metabolomics · doi:10.1007/s11306-007-0051-9 · Cited by 10 · see citing works

Data Normalization for Diabetes II Metabonomics Analysis

Wen, J., Xiao, X., Dong, J., et al. (2007) · International Conference on Bioinformatics and Biomedical Engineering · doi:10.1109/icbbe.2007.178 · Cited by 10 · see citing works

Trimethylamine <i>N</i> -Oxide, the Microbiome, and Heart and Kidney Disease

Zeisel, S. H., & Warrier, M. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064732 · Cited by 475 · see citing works

Trimethylamine N‐oxide: breathe new life

Subramaniam, S., & Fletcher, C. (2018) · British Journal of Pharmacology · doi:10.1111/bph.13959 · Cited by 171 · see citing works

Identification of biochemical changes in lactovegetarian urine using 1H NMR spectroscopy and pattern recognition

Xu, J., Yang, S., Cai, S., Dong, J., Li, X., & Chen, Z. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-009-3338-z · Cited by 85 · see citing works

High‐resolution nuclear magnetic resonance spectroscopy of biological tissues using projected magic angle spinning

Martin, R. W., Jachmann, R. C., Sakellariou, D., Nielsen, U. G., & Pines, A. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20585 · Cited by 11 · see citing works

Magic Angle Spinning

Andrew, E. R. (1996) · doi:10.1002/9780470034590.emrstm0283 · Cited by 14 · see citing works

High-resolution NMR of anisotropic samples with spinning away from the magic angle

Sakellariou, D., Meriles, C. A., Martin, R. W., et al. (2003) · Chemical Physics Letters · doi:10.1016/s0009-2614(03)01149-7 · Cited by 9 · see citing works

Two-dimensional resolution of isotropic and anisotropic chemical shifts in magic angle spinning NMR

Kolbert, A. C., & Griffin, R. G. (1990) · Chemical Physics Letters · doi:10.1016/0009-2614(90)87055-v · Cited by 92 · see citing works

Aligned deuterochloroform in cross‐linked polystyrene as a new sample for adjusting the magic angle in HR‐MAS

Leutzsch, M., Findeisen, M., & Berger, S. T. A. (2012) · Magnetic Resonance in Chemistry · doi:10.1002/mrc.3789