Mapping of neural pathways that influence diaphragm activity and project to the lumbar spinal cord in cats
Open accessAbstract
During breathing, the diaphragm and abdominal muscles contract out of phase. However, during other behaviors (including vomiting, postural adjustments, and locomotion) simultaneous contractions are required of the diaphragm and other muscle groups including abdominal muscles. Recent studies in cats using transneuronal tracing techniques showed that in addition to neurons in the respiratory groups, cells in the inferior and lateral vestibular nuclei (VN) and medial pontomedullary reticular formation (MRF) influence diaphragm activity. The goal of the present study was to determine whether neurons in these regions have collateralized projections to both diaphragm motoneurons and the lumbar spinal cord. For this purpose, the transneuronal tracer rabies virus was injected into the diaphragm, and the monosynaptic retrograde tracer Fluoro-Gold (FG) was injected into the Th13-L1 spinal segments. A large fraction of MRF and VN neurons (median of 72 and 91%, respectively) that were infected by rabies virus were dual-labeled by FG. These data show that many MRF and VN neurons that influence diaphragm activity also have a projection to the lumbar spinal cord and thus likely are involved in coordinating behaviors that require synchronized contractions of the diaphragm and other muscle groups.
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Cells in the inferior and lateral vestibular nuclei and in the medial pontomedullary reticular formation influence diaphragm activity and project to the lumbar spinal cord.
“Rice et al. (2010) have shown using rabies tracing techniques that cells in the inferior and lateral vestibular nuclei and in the medial pontomedullary reticular formation (MRF) influence diaphragm activity and project to the lumbar spinal cord.”
From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Rice et al. (2010)
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- Authors
- Rice, C. D., Weber, S. A., Waggoner, A. L., Jessell, M. E., & Yates, B. J.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Yates, B. J.
- ORCID
- Yates, B. J.
- Venue
- Experimental Brain Research
- Published
- 2010-02-26
- Volume
- 203
- Issue
- 1
- Pages
- 205-211
- ISSN
- 0014-4819 (ISSN-L)
- 1432-1106
- PMC
- PMC2864334
- OpenAlex
- W1990152863
- Cited by
- 19
- References
- 35
- Citations by year
- 2022: 3 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 2
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Experimental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Deafness and Other Communication Disorders (R01DC003732)
- National Center for Research Resources (P40RR018604)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- lumbar spinal cord, inferior vestibular nucleus, lateral vestibular nucleus, respiratory control, retrograde tracing, rabies virus, Fluoro-Gold, cats, neural pathways
- MeSH terms
- Animals, Cats, Vestibular Nucleus, Lateral, Diaphragm, Fluorescent Antibody Technique, Lumbar Vertebrae, Medulla Oblongata, Motor Neurons, Neural Pathways, Neurons, Photomicrography, Pons, Rabies virus, Reticular Formation, Spinal Cord, Thoracic Vertebrae, Neuronal Tract-Tracers
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