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Cited by 44Neuroscience of respiration and sleepRespiratory and Cough-Related ResearchHeart Rate Variability and Autonomic Control

Diaphragmatic and external intercostal muscle control during vomiting: behavior of inspiratory bulbospinal neurons

Miller, A. D., Nonaka, S., Lakos, S. F., Tan, L. K.·1990·Journal of Neurophysiology
DOI 10.1152/jn.1990.63.1.31
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Abstract

1. The role of dorsal and ventral respiratory group (DRG and VRG) bulbospinal inspiratory (I) neurons in the control of diaphragmatic and external intercostal (inspiratory) muscle activity during vomiting was examined by recording from these neurons during fictive vomiting in decerebrate, paralyzed cats. Fictive vomiting was defined by a characteristic series of bursts of coactivation of phrenic and abdominal muscle nerves, elicited either by electrical stimulation of abdominal vagal afferents or by emetic drugs, which would be expected to produce vomiting if the animals were not paralyzed. 2. Data were recorded from 22 DRG and 29 VRG I neurons that were antidromically activated from the fourth cervical spinal segment (C4). Only 10% (5/51) of these neurons started to fire near the beginning of phrenic discharge during fictive vomiting and thus had the appropriate discharge pattern to contribute to the initial activation of the diaphragm and coactive external intercostal muscles during vomiting. The frequency of occurrence of these Active neurons was not significantly different in the DRG (3/22) and VRG (2/29) (chi 2 test). Most remaining neurons were either totally silent (n = 7) or had only sporadic, infrequent firing (n = 16) (Silent neurons, 23/51 = 45%), or else fired near the end of phrenic discharge during fictive vomiting (End neurons, 21/51 = 41%). Two neurons were categorized as having miscellaneous (Misc) behavior. 3. No differences were found among neurons having different response patterns during fictive vomiting in regard to the following: the manner in which fictive vomiting was elicited: cell location: conduction velocity; and neuronal firing onset, rate, and pattern during respiration.(ABSTRACT TRUNCATED AT 250 WORDS)

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  • Miller and colleagues identified neural circuits controlling respiratory and abdominal muscles during nausea and vomiting, and critical brain areas.

    “Miller and colleagues have identified the neural circuits controlling the respiratory and abdominal muscles during nausea and vomiting, and which brain areas are critical (Miller and Grelot 1996; Miller et al. 1990, 1994; Miller and Wilson 1983).”

    From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Miller et al. 1990

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Authors
Miller, A. D., Nonaka, S., Lakos, S. F., & Tan, L. K.
Affiliations
Rockefeller University (US)
ORCID
Venue
Journal of Neurophysiology
Publisher
American Physiological Society
Published
1990-01-01
Volume
63
Issue
1
Pages
31-36
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
DOI
10.1152/jn.1990.63.1.31
OpenAlex
W2339264054
Cited by
44
References
0
Citations by year
2019: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 3 · 2012: 4
FWCI
3.68
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurophysiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (NS20585)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory and Cough-Related Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
vomiting, diaphragm, external intercostal muscle, dorsal respiratory group, ventral respiratory group, phrenic nerve, antidromic activation, cervical spinal cord, respiratory control
MeSH terms
Animals, Brain Stem, Cats, Decerebrate State, Diaphragm, Intercostal Muscles, Motor Neurons, Spinal Cord, Vomiting

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