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Cited by 148Bone Metabolism and DiseasesBone health and osteoporosis researchOrthopaedic implants and arthroplasty

The DOI matches its Crossref record; 54 of the 55 references it cites were found in a registry or an index.

Fatigue Microdamage as an Essential Element of Bone Mechanics and Biology

Martin, R. Bruce·2003·Calcified Tissue International
DOI 10.1007/s00223-002-1059-9
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Abstract

The fossil record shows that bone remodeling has existed since the earliest large vertebrates became weight-bearing on land, but the functions of remodeling have long been debated. The principal protagonists in this debate have been those favoring a mechanical function and those asserting that remodeling serves to move calcium in and out of the skeleton. In recent years the arguments of the former school have included not only the adaptation of internal structure to specific kinds of stresses, but the need to remove fatigue damage. It has become clear that (1) physiologic strains continually produce fatigue damage in bone; (2) this damage weakens bone and is associated with both osteocyte apoptosis and the activation of remodeling; and (3) remodeling is the only means by which this damage can be removed. The significance of these observations is increased by the fact that fatigue failure is more likely in larger structures. This "volume effect," along with the advantages of enhanced mobility and metabolic efficiency, may have selected for bone remodeling as a means of controlling fatigue damage as it occurs, allowing larger vertebrates to maintain a relatively light skeleton over an extended lifetime. In this view, bone remodeling is not primarily a mechanism for calcium transport, but is intimately related to other inflammatory repair responses.

Overview

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Crossref · 10.1007/s00223-002-1059-9

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Metadata

Authors
Martin, R. B.
Affiliations
University of California Davis Medical Center (US)
Corresponding author
Martin, R. Bruce
Venue
Calcified Tissue International
Publisher
Springer Science and Business Media LLC
Published
2003-08-01
Volume
73
Issue
2
Pages
101-107
ISSN
  • 0171-967X (ISSN-L)
  • 1432-0827
DOI
10.1007/s00223-002-1059-9
OpenAlex
W2084566277
Cited by
148
References
55
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 11 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 11 · 2014: 12 · 2013: 5 · 2012: 7
FWCI
2.76
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Calcified Tissue International (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 41644)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
Keywords
bone remodeling, fatigue damage, bone mechanics, osteocyte apoptosis, volume effect, calcium transport, bone regeneration, fossil vertebrates
MeSH terms
Animals, Biomechanical Phenomena, Bone and Bones, Calcium, Biological Evolution, Humans, Fractures, Stress, Bone Remodeling

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