Effects of continuous glucocorticoid infusion on bone metabolism in the rat.
Abstract
The effects of continuous administration of supraphysiologic doses of dexamethasone (DEX) on bone metabolism were examined in rats. Adult, male, Sprague Dawley rats were infused with DEX at a constant rate of 16.25 microg/day for 19 days. Despite soft tissue catabolism, DEX treatment led to a significant increase in bone volume in all experiments. This was accompanied by a significant gain in femoral weight and calcium content. These findings were also observed in DEX-treated parathyroidectomized animals indicating that intact parathyroid function was not required for this effect. DEX treatment did not affect mean levels of serum calcium or phosphorus but led to significant declines in circulating levels of PTH and 1,25(OH)2D and in the urinary calcium/creatinine ratio. This latter finding was also observed in PTX animals in which 1,25(OH)2D levels did not change. Serum concentrations of osteocalcin and tartrate-resistant acid phosphatase both declined in a time-dependent manner with DEX treatment suggesting a slowing of bone turnover with the net effect favoring formation. However, histomorphometric findings were variable. Two of three experiments demonstrated a decrease in cellular parameters of formation and resorption and in one experiment, these indices increased. Mineralized surface increased with DEX treatment. We conclude that, in marked contrast to the findings in man and certain other species, DEX treatment increases bone mass in rats. This may in part relate to a relatively greater suppression of resorption vis à vis formation.
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In another rat study, prednisolone infusion reduced biochemical markers of bone resorption and formation and paradoxically increased cancellous bone volume.
“In another rat study, prednisolone infusion led to reductions in biochemical markers of bone resorption and bone formation and a paradoxical increase in cancellous bone volume (265).”
From Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease (2008) · cites this paper as [265]
Cites
THE COLORIMETRIC DETERMINATION OF PHOSPHORUS
Fiske, C. H., & Subbarow, Y. (1925) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)84756-1 · Cited by 19,155 · see citing works
PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650020617 · Cited by 5,015 · see citing works
Bone Histomorphometry : Standardization of Nomenclature, Symbols, and Units
PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · Cited by 3,258 · see citing works
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Management
Lukert, B. P., & Raisz, L. G. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-5-352 · Cited by 1,063 · see citing works
Hock, J. M., & Gera, I. (1992) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650070110 · Cited by 371 · see citing works
Suzuki, Y., Ichikawa, Y., Saito, E., & Homma, M. (1983) · Metabolism · doi:10.1016/0026-0495(83)90221-4 · Cited by 363 · see citing works
Osteocalcin: Isolation, characterization, and detection
Gundberg, C. M., Hauschka, P. V., Lian, J. B., & Gallop, P. M. (1984) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(84)07036-1 · Cited by 333 · see citing works
Self-citationPerspectives bone histomorphometry in glucocorticoid-induced osteoporosis
Dempster, D. W. (1989) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650040202 · Cited by 319 · see citing works
CANALIS, E. M. (1983) · Endocrinology · doi:10.1210/endo-112-3-931 · Cited by 241 · see citing works
Huo, M. H., Troiano, N. W., Pelker, R. R., Gundberg, C. M., & Friedlaender, G. E. (1991) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100090310 · Cited by 241 · see citing works
Self-citationThe Course of Biochemical Parameters of Bone Turnover during Treatment with Corticosteroids
Prummel, M. F., Wiersinga, W. M., Lips, P. T. A. M., Sanders, G. T., & Sauerwein, H. P. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-2-382 · Cited by 202 · see citing works
Temporal Changes in Cancellous Bone Structure of Rats Immediately After Ovariectomy
Dempster, D. W., Birchman, R., Xu, R., Lindsay, R., & Shen, V. (1995) · Bone · doi:10.1016/8756-3282(95)80027-n · Cited by 162 · see citing works
Application of Atomic Absorption Spectrophotometry in the Determination of Calcium in Serum
Zettner, A., & Seligson, D. (1964) · Clinical Chemistry · doi:10.1093/clinchem/10.10.869 · Cited by 161 · see citing works
Effect of short-term glucocorticoids on serum osteocalcin in healthy young men
Godschalk, M., & Downs, R. W. (1988) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650030117 · Cited by 135 · see citing works
Peck, W. A., Brandt, J., & Miller, I. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.57.6.1599 · Cited by 128 · see citing works
McCulloch, C. A. G., & Tenenbaum, H. C. (1986) · The Anatomical Record · doi:10.1002/ar.1092150410 · Cited by 117 · see citing works
Long-term effects of physiologic concentrations of dexamethasone on human bone-derived cells
Wong, M.-M., Rao, L. G., Ly, H., Hamilton, L., Tong, J., Sturtridge, W. C., McBroom, R., Aubin, J. E., & Murray, T. M. (1990) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650050803 · Cited by 114 · see citing works
Goulding, A., & Gold, E. (1988) · Endocrinology · doi:10.1210/endo-122-2-482 · Cited by 90 · see citing works
Effect of Cortisone on Growing Bones of the Rat
Follis, R. H. (1951) · Experimental Biology and Medicine · doi:10.3181/00379727-76-18607 · Cited by 87 · see citing works
Stanton, B. A., Giebisch, G., Klein-Robbenhaar, G., Wade, J. B., & DeFronzo, R. A. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111832 · Cited by 80 · see citing works
Insogna, K. L., Mitnick, M., Stewart, A. F., Burtis, W. J., Mallette, L. E., & Broadus, A. E. (1985) · New England Journal of Medicine · doi:10.1056/nejm198510313131805 · Cited by 78 · see citing works
Self-citationThe influence of cortisone on the structure and growth of bone.
SISSONS, H. A., & Hadfield, G. J. (1955) · PubMed · Cited by 57 · see citing works
Reduced strength of rat cortical bone after glucocorticoid treatment
Ørtoft, G., & Oxlund, H. (1988) · Calcified Tissue International · doi:10.1007/bf02553282 · Cited by 50 · see citing works
22 The Influence of Adrenal Cortical Hormones on Bone Formation and Resorption
Storey, E. (1963) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-196300300-00023 · Cited by 48 · see citing works
Evidence for bidirectional net movement of creatinine in the rat kidney
NAMNUM, P. A., Insogna, K. L., Baggish, D., & Hayslett, J. P. (1983) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1983.244.6.f719 · Cited by 46 · see citing works
Self-citationStudies of Bone Tissue in Rats Treated by Prednisolone and 1,25-(OH)2D3
Lindgren, J., Johnell, O., & DeLuca, H. F. (1983) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198312000-00041 · Cited by 40 · see citing works
Biphasic dose-response curves of cortisol effects on rat diaphyseal bone biomechanics
Ferretti, J. L., V�zquez, S. O., Delgado, C. J., Capozza, R. F., & Cointry, G. R. (1992) · Calcified Tissue International · doi:10.1007/bf00297297 · Cited by 39 · see citing works
Mechanisms of Glucocorticoid-Induced Osteopenia: Role of Parathyroid Glands
Kukreja, S. C., Bowser, E. N., HARGIS, G. K., HENDERSON, W. J., & WILLIAMS, G. A. (1976) · Experimental Biology and Medicine · doi:10.3181/00379727-152-39396 · Cited by 36 · see citing works
Synthetic parathyroid hormone-like protein (1?74) is anabolic for bone in vivo
Weir, E. C., Terwilliger, G. A., Sartori, L., & Insogna, K. L. (1992) · Calcified Tissue International · doi:10.1007/bf00296214 · Cited by 35 · see citing works
Self-citationEffect of adrenal steroids on bone resorption in rats
Yasumura, S. (1976) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1976.230.1.90 · Cited by 24 · see citing works
Glucocorticoids and bone matrix formation.
RAISZ, L. G., & Chyun, Y. S. (1984) · PubMed · Cited by 11 · see citing works
Broulik, P. D., & Pacovský, V. (1991) · Calcified Tissue International · doi:10.1007/bf02555902 · Cited by 7 · see citing works
Homologous amino-terminal radioimmunoassay for rat parathyroid hormone
Calvo, M. S., Gundberg, C. M., Heath, H., & Fox, J. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.261.2.e262 · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Weinstein, R. S., Jilka, R. L., Parfitt, A. M., & Manolagas, S. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2799 · Cited by 1,753 · see citing works
Melatonin: Nature’s most versatile biological signal?
Pandi‐Perumal, S. R., Srinivasan, V., Maestroni, G. J. M., Cardinali, D. P., Poeggeler, B., & Hardeland, R. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05322.x · Cited by 875 · see citing works
Ohlsson, C., Bengtsson, B., Isaksson, O. G. P., Andreassen, T. T., & Slootweg, M. C. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.1.0324 · Cited by 863 · see citing works
Kearns, A. E., Khosla, S., & Kostenuik, P. J. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0014 · Cited by 824 · see citing works
Animal models for osteoporosis
Komori, T. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.028 · Cited by 314 · see citing works
Animal Models For Osteoporosis
Turner, R. T., Maran, A., Lotinun, S., Hefferan, T. E., Evans, G. L., Zhang, M., & Sibonga, J. D. (2001) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/a:1010067326811 · Cited by 198 · see citing works
Glucocorticoids inhibit bone resorption by isolated rat osteoclasts by enhancing apoptosis
Dempster, D., Moonga, B., Stein, L., Horbert, W., & Antakly, T. (1997) · Journal of Endocrinology · doi:10.1677/joe.0.1540397 · Cited by 180 · see citing works
Disorders Associated With Acute Rapid and Severe Bone Loss
Epstein, S., Inzerillo, A. M., Caminis, J. N., & Zaidi, M. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.12.2083 · Cited by 110 · see citing works
Biochemical markers of bone remodeling
Seibel, M. J. (2003) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(02)00077-4 · Cited by 106 · see citing works
Seibel, M. J. (2006) · PubMed Central · Cited by 98 · see citing works
Immunosuppressant Use Without Bone Loss—Implications for Bone Loss After Transplantation
Goodman, G. R., Dissanayake, I. R., Sodam, B. R., Gorodetsky, E., Lü, J., F., Y., Jee, W. S. S., & Epstein, S. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.1.72 · Cited by 55 · see citing works
Animal models to explore the effects of glucocorticoids on skeletal growth and structure.
Wood, C., Souček, O., Wong, S. C., Zaman, F., Farquharson, C., Savendahl, L., & Ahmed, S. F. (2018) · Journal of Endocrinology · doi:10.1530/joe-17-0361 · Cited by 53 · see citing works
Gunson, D. E., Gropp, K. E., & Varela, A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415759-0.00063-7 · Cited by 53 · see citing works
Hulley, P. A., Conradie, M., Langeveldt, C., & Hough, F. S. (2002) · Bone · doi:10.1016/s8756-3282(02)00807-4 · Cited by 52 · see citing works
Brent, M. B. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108383 · Cited by 50 · see citing works
Ørtoft, G., Andreassen, T. T., & Oxlund, H. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.5.710 · Cited by 49 · see citing works
Animal models for glucocorticoid-induced postmenopausal osteoporosis: An updated review
Zhang, Z., Ren, H., Shen, G., Qiu, T., Liang, D., Yang, Z., Yao, Z., Tang, J., Jiang, X., & Wei, Q. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.09.045 · Cited by 48 · see citing works
Glucocorticoid-induced osteoporosis: pathophysiological data and recent treatments
Lafage‐Proust, M., Boudignon, B. M., & Thomas, T. (2003) · Joint Bone Spine · doi:10.1016/s1297-319x(03)00016-2 · Cited by 47 · see citing works
Clinical application of biochemical markers of bone turnover
Seibel, M. J. (2006) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302006000400006 · Cited by 46 · see citing works
Shen, V., Birchman, R., Liang, X. G., Wu, D. D., Lindsay, R. S., & Dempster, D. W. (1997) · Bone · doi:10.1016/s8756-3282(97)00153-1 · Cited by 45 · see citing works
Scholz-Ahrens, K. E., Delling, G., Stampa, B., Helfenstein, A., Hahne, H. ‐., Açil, Y., Timm, W., Barkmann, R., Hassenpflug, J., Schrezenmeir, J., et al. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00627.2006 · Cited by 42 · see citing works
“The rat seems to have limitations as model for GIO, since there was no bone loss after intravenous GC administration (28).”
BackgroundEffects of Methylprednisolone on Bone Formation and Resorption in Rats
Wang, Y., Ohtsuka‐Isoya, M., Shao, P., Sakamoto, S., & Hisashi, S. (2002) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.90.236 · Cited by 42 · see citing works
Mukherjee, D., Srinivasan, B., Anbu, J., Azamthulla, M., Banala, V. T., & Ramachandra, S. G. (2018) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2018.1503297 · Cited by 38 · see citing works
“The glucocorticoid-induced decrease in the total body bone mineral content resulting in a decrease in bone mineral density has been demonstrated previously [44, 45].”
BackgroundRen, H., Liang, D., Jiang, X., Tang, J., Cui, J., Wei, Q., Zhang, S., Yao, Z., Shen, G., & Lin, S. (2015) · Steroids · doi:10.1016/j.steroids.2015.07.006 · Cited by 36 · see citing works
Surve, V. V., Andersson, N., Lehto-Axtelius, D., & Håkanson, R. (2001) · Acta Orthopaedica Scandinavica · doi:10.1080/000164701753532880 · Cited by 36 · see citing works
Mechanical vibration preserves bone structure in rats treated with glucocorticoids
de Oliveira, M. L., Bergamaschi, C. T., da Silva, O. L., Nonaka, K. O., Wang, C. C., Carvalho, A. B., Jorgetti, V., Campos, R. R., & Lazaretti‐Castro, M. (2010) · Bone · doi:10.1016/j.bone.2010.02.009 · Cited by 35 · see citing works
“On the other hand, other studies have reported controversial results, varying with the type of glucocorticoid, dose, age of animals, skeletal site, and duration of the experiment [33–36].”
ResultTakano, R., Tokunaga, K., Kondo, N., Ito, T., Kitahara, H., Ito, M., & Endo, N. (2009) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.217.51 · Cited by 35 · see citing works
High-turnover osteoporosis is induced by cyclosporin A in rats
Wada, C., Kataoka, M., Seto, H., Hayashi, N., Kido, J., Shinohara, Y., & Nagata, T. (2006) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-005-0672-x · Cited by 30 · see citing works
Ogoshi, T., Hagino, H., Fukata, S., Tanishima, S., Okano, T., & Teshima, R. (2008) · Modern Rheumatology · doi:10.1007/s10165-008-0096-2 · Cited by 32 · see citing works
Fridoni, M., Farahani, R. M., Nejati, H., Salimi, M., Gharavi, S. M., Bayat, M., Amini, A., Torkaman, G., & Bayat, S. (2015) · Lasers in Medical Science · doi:10.1007/s10103-014-1706-1 · Cited by 31 · see citing works
Jilka, R. L., Bellido, T., Almeida, M., Plotkin, L. I., O’Brien, C. A., Weinstein, R. S., & Manolagas, S. C. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373884-4.00032-x · Cited by 29 · see citing works
Melatonin effect on bone metabolism in rats treated with methylprednisolone
Ladizesky, M. G., Boggio, V., Cutrera, R. A., Mondelo, N., Mastaglia, S. R., Somoza, J., & Cardinali, D. P. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00316.x · Cited by 28 · see citing works
Vanadate prevents glucocorticoid-induced apoptosis of osteoblasts in vitro and osteocytes in vivo
Conradie, M., de Wet, H., Kotze, D., Burrin, J. M., Hough, F. S., & Hulley, P. A. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0217 · Cited by 28 · see citing works
New Concepts in Bone Remodeling
Dempster, D., & Zhou, H. (2006) · Elsevier eBooks · doi:10.1016/b9-78-012088-5/62650-0236 · Cited by 28 · see citing works
Wang, X., Hua, B., Jiang, C., Yuan, H., Zhu, L., Fan, W., Ji, Z., Wang, Z., & Yan, Z. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24400 · Cited by 27 · see citing works
Possible role of lymphocytes in glucocorticoid-induced increase in trabecular bone mineral density
Grahnemo, L., Jochéms, C., Andersson, A., Engdahl, C., Ohlsson, C., Islander, U., & Carlsten, H. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0508 · Cited by 24 · see citing works
“…mice and human rheumatoid arthritis patients maintained their BMD (Svensson et al. 2005, Islander et al. 2011a), there are studies showing improvements in trabecular and/or total bone in intact male rats treated with glucocorticoids (Binz et al. 1994, King et al. 1996, Ogoshi et al. 2008).”
BackgroundResultGlüer, C.-C., Scholz-Ahrens, K. E., Helfenstein, A., Delling, G., Timm, W., Açil, Y., Barkmann, R., Hassenpflug, J., Stampa, B., Bauss, F., et al. (2006) · Bone · doi:10.1016/j.bone.2006.10.019 · Cited by 24 · see citing works
“As noted in the introduction, rat models are of limited use because of the difference in response to GC compared to humans [34,59].”
BackgroundNoa, M., Mendoza, S., s, R. M., Mendoza, N., & Le??n, F. (2004) · Drugs in R&D · doi:10.2165/00126839-200405050-00004 · Cited by 23 · see citing works
Short-term glucocorticoid treatment causes spinal osteoporosis in ovariectomized rats
Böcker, W., Khassawna, T. E., Bauer, N. B., Brodsky, K., Weisweiler, D., Govindarajan, P., Schlewitz, G., Kampschulte, M., Dürselen, L., Thormann, U., et al. (2014) · European Spine Journal · doi:10.1007/s00586-014-3463-z · Cited by 22 · see citing works
“Previous studies reported contradictory results on glucocorticoid exposure to rats and showed either increased BMD or decreased BMD [34, 35].”
Shidara, K., Mohan, G., Lay, Y.-A. E., Jepsen, K. J., Yao, W., & Lane, N. E. (2018) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2018.07.001 · Cited by 22 · see citing works
“Previously described GC-induced animal models of ON have reported inconsistent results on the incidence of ON [16,17] and GC effects on bone [18,19].”
ResultEffect of atorvastatin with or without prednisolone on Freund's adjuvant induced-arthritis in rats
Abdin, A. A., El-Halim, M. S. A., Hedeya, S. E., & Saadany, A. A. E. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.11.052 · Cited by 22 · see citing works
Sun, P., Cai, D. H., Li, Q., Chen, H., Deng, W., He, L., & Yang, L. (2010) · Calcified Tissue International · doi:10.1007/s00223-010-9363-2 · Cited by 22 · see citing works
Huyut, Z., Bakan, N., Yıldırım, S., & Hakan, H. (2018) · Medical science monitor basic research/Medical science monitor. Basic research · doi:10.12659/msmbr.908504 · Cited by 20 · see citing works
Animal Models in Osteoporosis Research
Kimmel, D. B. (2002) · Elsevier eBooks · doi:10.1016/b978-012098652-1.50197-9 · Cited by 20 · see citing works
Okazaki, Y., Tsurukami, H., Nishida, S., Okimoto, N., Aota, S., Takeda, S., & Nakamura, T. (1998) · Bone · doi:10.1016/s8756-3282(98)00116-1 · Cited by 19 · see citing works
蕨, 信., Tachibana, Y., Kumegawa, M., & Hakeda, Y. (2001) · Cytotechnology · doi:10.1023/a:1008159332152 · Cited by 14 · see citing works
Dosing-time dependent effect of dexamethasone on bone density in rats
Takahashi, M., Ushijima, K., Hayashi, Y., Maekawa, T., Ando, H., Tsuruoka, S., & Fujimura, A. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.10.020 · Cited by 14 · see citing works
“However, King et al reported the opposite observation that Dex treatment increased the trabecular bone volume both in intact and parathyroidectomized rats (King et al. 1996).”
BackgroundEvaluating Glucocorticoid Administration on Biomechanical Properties of Rats’ Tibial Diaphysis
Freidouni, M., Nejati, H., Salimi, M., Bayat, M., Amini, A., Noruzian, M., Asgharie, M. A., & Rezaian, M. (2015) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.19389 · Cited by 14 · see citing works
“concluded that unlike the effects observed in humans treated with GCs, treatment of rats with prednisolone not only did not result in bone loss but might also exert a protective effect on the skeleton through the inhibition of bone resorption (9).”
BackgroundResultOcclusal disharmony-induced stress causes osteopenia of the lumbar vertebrae and long bones in mice
Shimizu, Y., Khan, M., Kato, G., Aoki, K., & Ono, T. (2018) · Scientific Reports · doi:10.1038/s41598-017-18037-y · Cited by 14 · see citing works
McHugh, N. A., Vercesi, H. M., Egan, R. W., & Hey, J. A. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00102.2002 · Cited by 14 · see citing works
Animal Models for Osteoporosis
Iwaniec, U. T., & Turner, R. T. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415853-5.00039-x · Cited by 13 · see citing works
Zammel, N., Amri, N., Chaabane, R., Rebaï, T., & Badraoui, R. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.04.159 · Cited by 12 · see citing works
High dose glucocorticoid hampers bone formation and resorption after bone marrow ablation in rat
Kondo, N., Tokunaga, K., Ito, T., Arai, K., Amizuka, N., Li, M., Kitahara, H., Ito, M., Naito, M., Shu‐Ying, J., et al. (2006) · Microscopy Research and Technique · doi:10.1002/jemt.20355 · Cited by 11 · see citing works
Animal Models for Osteoporosis
Iwaniec, U. T., & Turner, R. T. (2008) · Elsevier eBooks · doi:10.1016/b978-012370544-0.50041-0 · Cited by 9 · see citing works
Ahmed, H. H., Morcos, N. Y. S., Eskander, E. F., Seoudi, D. M., & Shalby, A. B. (2011) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2011.01.004 · Cited by 9 · see citing works
Animal Models in Bone Research
Kimmel, D. B. (2017) · Molecular and integrative toxicology · doi:10.1007/978-3-319-56192-9_4 · Cited by 8 · see citing works
Huumonen, S., & Larmas, M. (1999) · Calcified Tissue International · doi:10.1007/s002239900687 · Cited by 6 · see citing works
Kashani, I. R., Moradi, F., Pasbakhsh, P., Sobhani, A., Nikzad, H., & Sobhani, A. (2009) · Cited by 3 · see citing works
Brent, M. B., Brüel, A., & Thomsen, J. S. (2021) · Endocrine and Metabolic Science · doi:10.1016/j.endmts.2021.100114 · Cited by 3 · see citing works
THE EFFECT OF IMPAIRED DENTIN FORMATION ON DENTAL CARIES
Huumonen, S. (1999) · Cited by 3 · see citing works
Gropp, K. E., & Varela, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-821046-8.00009-8 · Cited by 2 · see citing works
Methods in Bone Biology in Animals: Biochemical Markers
Herrmann, M. (2011) · Springer eBooks · doi:10.1007/978-0-85729-293-3_6 · Cited by 2 · see citing works
Anti-osteoporosis Potential of Ananas comosus: An Herbal Phyto-Shield for the Silent Thief
Mahadik, S., Shastri, A., & Chavan, D. M. J. (2026) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-025-10356-2 · Cited by 1 · see citing works
“Group 1, a control group (NC); Group 2, negative control-received only dexamethasone; Group 3, a positive control-treated with sodium alendronate (0.2 mg/animal/day, orally) as a standard drug; and Groups 4,5, and 6 treated with 200, 400, and 800 mg/kg/day of HA extract [ 35, 36].”
InfluentialTherapeutic patenting for glucocorticoid-induced osteoporosis
Cooper, M. S., & Stewart, P. M. (2000) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.10.6.847 · Cited by 1 · see citing works
Seibel, M. J., Robins, S. P., & Gundberg, C. M. (1999) · Elsevier eBooks · doi:10.1016/b978-012098655-2/50027-2 · Cited by 1 · see citing works
Self-citationOstéoporose cortico-induite : données physiopathologiques et thérapeutiques récentes
Lafage‐Proust, M., Boudignon, B. M., & Thomas, T. (2003) · Revue du Rhumatisme · doi:10.1016/s1169-8330(03)00059-0
- Authors
- King, C. S., Weir, E. C., Gundberg, C. W., Fox, J., & Insogna, K. L.
- Affiliations
- Yale University (US)
- Tulane University (US)
- ORCID
- Insogna, K. L.
- Venue
- Calcified Tissue International
- Published
- 1996-09
- Volume
- 59
- Issue
- 3
- Pages
- 184-191
- ISSN
- 0171-967X (ISSN-L)
- 1432-0827
- OpenAlex
- W2094340185
- Cited by
- 68
- References
- 33
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 2 · 2013: 2
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Calcified Tissue International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Keywords
- dexamethasone, glucocorticoids, bone metabolism, bone mass, bone formation, bone resorption, parathyroidectomy, parathyroid hormone, 1,25-dihydroxyvitamin D, osteocalcin, tartrate-resistant acid phosphatase, calcium content, urinary calcium/creatinine ratio, histomorphometry, rats
- MeSH terms
- Animals, Body Weight, Bone and Bones, Calcium, Dexamethasone, Dihydroxycholecalciferols, Disease Models, Animal, Femur, Glucocorticoids, Male, Osteoporosis, Parathyroid Hormone, Biomarkers, Bone Density, Osteocalcin, Infusion Pumps, Implantable, Parathyroidectomy, Rats, Sprague-Dawley, Rats
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