Melatonin: Nature’s most versatile biological signal?

Pandi‐Perumal, S. R.; Srinivasan, V.; Maestroni, G. J. M.; Cardinali, D. P.; Poeggeler, B.; Hardeland, R.

doi:10.1111/j.1742-4658.2006.05322.x

Cited by 883Circadian rhythm and melatoninmelanin and skin pigmentationImpact of Light on Environment and Health

Melatonin: Nature’s most versatile biological signal?

Open access

Pandi‐Perumal, S. R., Srinivasan, V., Maestroni, G. J. M., Cardinali, D. P., Poeggeler, B., Hardeland, R.·2006·The FEBS Journal

DOI 10.1111/j.1742-4658.2006.05322.x

Open this paper in CoChat — free account Open PDF

Abstract

Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity occurring in unicellular organisms, plants, fungi and animals. In most vertebrates, including humans, melatonin is synthesized primarily in the pineal gland and is regulated by the environmental light/dark cycle via the suprachiasmatic nucleus. Pinealocytes function as 'neuroendocrine transducers' to secrete melatonin during the dark phase of the light/dark cycle and, consequently, melatonin is often called the 'hormone of darkness'. Melatonin is principally secreted at night and is centrally involved in sleep regulation, as well as in a number of other cyclical bodily activities. Melatonin is exclusively involved in signaling the 'time of day' and 'time of year' (hence considered to help both clock and calendar functions) to all tissues and is thus considered to be the body's chronological pacemaker or 'Zeitgeber'. Synthesis of melatonin also occurs in other areas of the body, including the retina, the gastrointestinal tract, skin, bone marrow and in lymphocytes, from which it may influence other physiological functions through paracrine signaling. Melatonin has also been extracted from the seeds and leaves of a number of plants and its concentration in some of this material is several orders of magnitude higher than its night-time plasma value in humans. Melatonin participates in diverse physiological functions. In addition to its timekeeping functions, melatonin is an effective antioxidant which scavenges free radicals and up-regulates several antioxidant enzymes. It also has a strong antiapoptotic signaling function, an effect which it exerts even during ischemia. Melatonin's cytoprotective properties have practical implications in the treatment of neurodegenerative diseases. Melatonin also has immune-enhancing and oncostatic properties. Its 'chronobiotic' properties have been shown to have value in treating various circadian rhythm sleep disorders, such as jet lag or shift-work sleep disorder. Melatonin acting as an 'internal sleep facilitator' promotes sleep, and melatonin's sleep-facilitating properties have been found to be useful for treating insomnia symptoms in elderly and depressive patients. A recently introduced melatonin analog, agomelatine, is also efficient for the treatment of major depressive disorder and bipolar affective disorder. Melatonin's role as a 'photoperiodic molecule' in seasonal reproduction has been established in photoperiodic species, although its regulatory influence in humans remains under investigation. Taken together, this evidence implicates melatonin in a broad range of effects with a significant regulatory influence over many of the body's physiological functions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1742-4658.2006.05322.x

Cites

293 of 293 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Children typically produce more melatonin than adults.
“Children typically produce more melatonin than adults, which may infer that their need for dietary supplementation may require further scrutiny and be limited to specific disease states [4,11].”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [4]
Melatonin production gradually declines as people age, starting in the late twenties to the fifties, with production leveling at approximately 30 pg/mL.
“Production gradually declines as people age, starting in the late twenties to the fifties, with production leveling at approximately 30 pg/mL [4,11] (see Figure 1).”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [4]
Melatonin production can be influenced by illness, diet, environmental factors like bright light at night, medication use, and lifestyle.
“Aside from aging, production of melatonin can be influenced by illness [12], diet [4], environmental factors like bright light at night [13], medication use [14], and lifestyle [15].”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [4]
Melatonin is produced in response to darkness, as perceived by the eye's retina.
“Melatonin is colloquially referred to as the “hormone of darkness” since it is produced in response to darkness, as perceived by the eye’s retina [4].”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [4]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Phototransduction by retinal ganglion cells that set the circadian clock
Berson, D. M., Dunn, F. A., & Takao, M. (2002) · Science · doi:10.1126/science.1067262 · Cited by 3,629 · see citing works
Regulation of antioxidant enzymes: a significant role for melatonin
Rodrı́guez, C., Mayo, J. C., Sainz, R. M., Antolı́n, I., Herrera, F., Martı́n, V., & Reiter, R. J. (2003) · Journal of Pineal Research · doi:10.1046/j.1600-079x.2003.00092.x · Cited by 1,990 · see citing works
Neurotrophin signal transduction in the nervous system
Kaplan, D. R., & Miller, F. D. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00092-1 · Cited by 1,944 · see citing works
Action Spectrum for Melatonin Regulation in Humans: Evidence for a Novel Circadian Photoreceptor
Brainard, G. C., Hanifin, J. P., Greeson, J. M., Byrne, B., Glickman, G., Gerner, E., & Rollag, M. D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06405.2001 · Cited by 1,930 · see citing works
Mortality Associated With Sleep Duration and Insomnia
Kripke, D. F., Garfinkel, L., Wingard, D. L., Klauber, M. R., & Marler, M. R. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.2.131 · Cited by 1,614 · see citing works
The Pineal and Its Hormones in the Control of Reproduction in Mammals*
Reiter, R. J. (1980) · Endocrine Reviews · doi:10.1210/edrv-1-2-109 · Cited by 1,254 · see citing works
Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses
Reppert, S. M., Weaver, D. R., & Ebisawa, T. (1994) · Neuron · doi:10.1016/0896-6273(94)90055-8 · Cited by 1,096 · see citing works
Chemical and Physical Properties and Potential Mechanisms: Melatonin as a Broad Spectrum Antioxidant and Free Radical Scavenger
Tan, D., Reiter, R. J., Manchester, L. C., Yan, M.-T., El-Sawi, M. R., Sainz, R. M., Mayo, J. C., Kohen, R., Allegra, M., & Hardelan, R. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023394443 · Cited by 1,065 · see citing works
The melatonin rhythm: both a clock and a calendar
Reiter, R. J. (1993) · Cellular and Molecular Life Sciences · doi:10.1007/bf01923947 · Cited by 997 · see citing works
The basic physiology and pathophysiology of melatonin
Claustrat, B., Brun, J., & Chazot, G. (2004) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.08.001 · Cited by 951 · see citing works
The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
Fahn, S., & Cohen, G. (1992) · Annals of Neurology · doi:10.1002/ana.410320616 · Cited by 927 · see citing works
Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor.
Reppert, S. M., Godson, C., Mahle, C. D., Weaver, D. R., Slaugenhaupt, S. A., & Gusella, J. F. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8734 · Cited by 882 · see citing works
The Pineal Gland: A Neurochemical Transducer
Axelrod, J. (1974) · Science · doi:10.1126/science.184.4144.1341 · Cited by 875 · see citing works
Oxidative damage in the central nervous system: protection by melatonin
Reiter, R. J. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00052-5 · Cited by 836 · see citing works
Identification of melatonin in plants and its effects on plasma melatonin levels and binding to melatonin receptors in vertebrates.
Hattori, A., Migitaka, H., Iigo, M., Itoh, M., Yamamoto, K., Ohtani‐Kaneko, R., Hara, M., Suzuki, T., & Reiter, R. J. (1995) · PubMed · Cited by 827 · see citing works
Functional MT1 and MT2 Melatonin Receptors in Mammals
Dubocovich, M. L., & Markowska, M. (2005) · Endocrine · doi:10.1385/endo:27:2:101 · Cited by 816 · see citing works
Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress and levels of cortisol, dehydroepiandrosterone sulfate (DHEAS) and melatonin in breast and prostate cancer outpatients
Carlson, L. E., Speca, M., Patel, K. D., & Goodey, E. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00054-4 · Cited by 737 · see citing works
Molecular Dissection of Two Distinct Actions of Melatonin on the Suprachiasmatic Circadian Clock
Liu, C., Weaver, D. R., Jin, X., Shearman, L. P., Pieschl, R. L., Gribkoff, V. K., & Reppert, S. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80350-5 · Cited by 723 · see citing works
Biochemical Reactivity of Melatonin with Reactive Oxygen and Nitrogen Species: A Review of the Evidence
Reiter, R. J., Tan, D., Manchester, L. C., & Qi, W. (2001) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:34:2:237 · Cited by 697 · see citing works
Melatonin Shifts Human Orcadian Rhythms According to a Phase-Response Curve
Lewy, A. J., Ahmed, S., Jackson, J. M. L., & Sack, R. L. (1992) · Chronobiology International · doi:10.3109/07420529209064550 · Cited by 693 · see citing works
Steroid-Induced Fractures and Bone Loss in Patients with Asthma
Adinoff, A., & Hollister, J. R. (1983) · New England Journal of Medicine · doi:10.1056/nejm198308043090502 · Cited by 676 · see citing works
Antioxidative Protection by Melatonin: Multiplicity of Mechanisms from Radical Detoxification to Radical Avoidance
Hardeland, R. (2005) · Endocrine · doi:10.1385/endo:27:2:119 · Cited by 670 · see citing works
Self-citation
A Review of the Multiple Actions of Melatonin on the Immune System
Carrillo‐Vico, A., Guerrero, J. M., Lardone, P. J., & Reiter, R. J. (2005) · Endocrine · doi:10.1385/endo:27:2:189 · Cited by 664 · see citing works
REVIEW: Gastrointestinal Melatonin: Localization, Function, and Clinical Relevance
Bubenik, G. A. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1020107915919 · Cited by 655 · see citing works
Melatonin: A Coordinating Signal for Mammalian Reproduction?
Tamarkin, L., Baird, C. J., & Almeida, O. F. X. (1985) · Science · doi:10.1126/science.3881822 · Cited by 630 · see citing works
Melatonin as a chronobiotic
Arendt, J., & Skene, D. J. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.05.002 · Cited by 629 · see citing works
Identification of the Melatonin-binding SiteMT 3 as the Quinone Reductase 2
Nosjean, O., Ferro, M., Cogé, F., Beauverger, P., Henlin, J., Lefoulon, F., Fauchère, J., Delagrange, P., Canet, E., & Boutin, J. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005141200 · Cited by 604 · see citing works
Neuroendocrine Basis of Seasonal Reproduction
Karsch, F. J., Bittman, E. L., Foster, D. L., Goodman, R. L., Legan, S. J., & Robinson, J. E. (1984) · Elsevier eBooks · doi:10.1016/b978-0-12-571140-1.50010-4 · Cited by 602 · see citing works
Effect of inducing nocturnal serum melatoninconcentrations in daytime on sleep, mood, body temperature, andperformance.
Dollins, A. B., Zhdanova, I. V., Wurtman, R. J., Lynch, H. J., & Deng, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.5.1824 · Cited by 578 · see citing works
Sick and tired: does sleep have a vital role in the immune system?
Bryant, P. A., Trinder, J., & Curtis, N. (2004) · Nature Reviews Immunology · doi:10.1038/nri1369 · Cited by 551 · see citing works
Melatonin stimulates brain glutathione peroxidase activity
Barlow‐Walden, L., Reiter, R. J., Abe, M., Pablos, M. I., Menéndez-Peláez, A., CHEN, L., & Pöeggeler, B. (1995) · Neurochemistry International · doi:10.1016/0197-0186(94)00154-m · Cited by 549 · see citing works
Human pineal physiology and functional significance of melatonin
Macchi, M. M., & Bruce, J. N. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.08.001 · Cited by 545 · see citing works
Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin
Tan, D., Manchester, L. C., Hardeland, R., López‐Burillo, S., Mayo, J. C., Sainz, R. M., & Reiter, R. J. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.02111.x · Cited by 541 · see citing works
Self-citation
Effects of exogenous melatonin on sleep: a meta-analysis
Brzezinski, A., Vangel, M. G., Wurtman, R. J., Norrie, G., Zhdanova, I., Ben-Shushan, A., & Ford, I. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.06.004 · Cited by 541 · see citing works
The role of oxidative stress in chemical carcinogenesis.
Klaunig, J. E., Xu, Y., Isenberg, J. S., Bachowski, S., Kolaja, K. L., Jiang, J., Stevenson, D. E., & Walborg, E. F. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106s1289 · Cited by 515 · see citing works
Melatonin mitigates mitochondrial malfunction
León, J., Acuña-Castroviejo, D., Escames, G., Tan, D. X., & Reiter, R. J. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00181.x · Cited by 515 · see citing works
Entrainment of free-running circadian rhythms by melatonin in blind people
Sack, R. L., Brandes, R. W., Kendall, A. R., & Lewy, A. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200010123431503 · Cited by 490 · see citing works
Melatonin-Immune System Relationships
Guerrero, J. M., & Reiter, R. J. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023394335 · Cited by 476 · see citing works
Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance
Carrillo‐Vico, A., Calvo, J. R., Abreu, P. M., Lardone, P. J., García‐Mauriño, S., Reiter, R. J., & Guerrero, J. M. (2004) · The FASEB Journal · doi:10.1096/fj.03-0694fje · Cited by 457 · see citing works
Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: Meta-analysis
Buscemi, N., Vandermeer, B., Hooton, N., Pandya, R., Tjosvold, L., Hartling, L., Vohra, S., Klassen, T. P., & Baker, G. (2006) · BMJ · doi:10.1136/bmj.38731.532766.f6 · Cited by 454 · see citing works
Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension
Scheer, F. A. J. L., Van Montfrans, G. A., van Someren, E. J. W., Mairuhu, G., & Buijs, R. M. (2004) · Hypertension · doi:10.1161/01.hyp.0000113293.15186.3b · Cited by 451 · see citing works
Melatonin-Depleted Blood from Premenopausal Women Exposed to Light at Night Stimulates Growth of Human Breast Cancer Xenografts in Nude Rats
Blask, D. E., Brainard, G. C., Dauchy, R. T., Hanifin, J. P., Davidson, L. K., Krause, J. A., Sauer, L. A., Rivera-Bermudez, M. A., Dubocovich, M. L., Jasser, S. A., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1945 · Cited by 431 · see citing works
Melatonin for the prevention and treatment of jet lag
Herxheimer, A., & Petrie, K. J. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001520 · Cited by 428 · see citing works
Delayed sleep phase syndrome response to melatonin
Dahlitz, M., Álvarez, B., Parkes, J. D., English, J., Arendt, J., & Vignau, J. (1991) · The Lancet · doi:10.1016/0140-6736(91)92787-3 · Cited by 427 · see citing works
The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances
Hardeland, R., Reiter, R. J., Pöeggeler, B., & Tan, D. X. (1993) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80016-8 · Cited by 424 · see citing works
Self-citation
Molecular Basis of the Neurodegenerative Disorders
Martin, J. B. (1999) · New England Journal of Medicine · doi:10.1056/nejm199906243402507 · Cited by 416 · see citing works
Role of the pineal gland in immunity
Maestroni, G. J. M., Conti, A., & Pierpaoli, W. (1986) · Journal of Neuroimmunology · doi:10.1016/0165-5728(86)90047-0 · Cited by 410 · see citing works
Self-citation
Potent Neuroprotective Properties against the Alzheimer β-Amyloid by an Endogenous Melatonin-related Indole Structure, Indole-3-propionic Acid
Chyan, Y., Pöeggeler, B., Omar, R., Chain, D. G., Frangione, B., Ghiso, J. A., & Pappolla, M. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.31.21937 · Cited by 409 · see citing works
The cutaneous serotoninergic/melatoninergic system: securing a place under the sun
Slominski, A., Wortsman, J., & Tobin, D. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2079rev · Cited by 402 · see citing works
Non‐vertebrate melatonin
Hardeland, R., & Pöeggeler, B. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00040.x · Cited by 400 · see citing works
Self-citation
CIRCADIAN RHYTHMS: Basic Neurobiology and Clinical Applications
Moore MD, R. Y. (1997) · Annual Review of Medicine · doi:10.1146/annurev.med.48.1.253 · Cited by 400 · see citing works
Circadian rhythms in depression and recovery: evidence for blunted amplitude as the main chronobiological abnormality
Souêtre, E., Salvati, E., Belugou, J.-L., Pringuey, D., Candito, M., Krebs, B., Ardisson, J.-L., & Darcourt, G. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90207-2 · Cited by 396 · see citing works
Melatonin
Hardeland, R., Pandi-Perumal, S. R., & Cardinali, D. P. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.08.020 · Cited by 393 · see citing works
Self-citation
Age-Dependent Reduction in Serum Melatonin Concentrations in Healthy Human Subjects
Iguchi, H., Kato, K., & Ibayashi, H. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-55-1-27 · Cited by 381 · see citing works
Evidence for melatonin synthesis in mouse and human bone marrow cells
Conti, A., Conconi, S., Hertens, E., Skwarło‐Sońta, K., Markowska, M., & Maestroni, G. J. M. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.280401.x · Cited by 381 · see citing works
Self-citation
Melatonin enhances IL-2, IL-6, and IFN-gamma production by human circulating CD4+ cells: a possible nuclear receptor-mediated mechanism involving T helper type 1 lymphocytes and monocytes
García‐Mauriño, S., González-Haba, M. G., Calvo, J. R., Rafii-El-Idrissi, M., Sánchez‐Margalet, V., Goberna, R., & Guerrero, J. M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.2.574 · Cited by 380 · see citing works
Melatonin and sleep in aging population
Pandi-Perumal, S. R., Zisapel, N., Srinivasan, V. J., & Cardinali, D. P. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.08.009 · Cited by 367 · see citing works
Self-citation
Circadian Rhythms, Oxidative Stress, and Antioxidative Defense Mechanisms
Hardeland, R., Coto‐Montes, A. M., & Pöeggeler, B. (2003) · Chronobiology International · doi:10.1081/cbi-120025245 · Cited by 358 · see citing works
Self-citation
Melatonin: From Basic Research to Cancer Treatment Clinics
Vijayalaxmi, V., Thomas, C. R., Reiter, R. J., & Herman, T. S. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.11.004 · Cited by 358 · see citing works
Melatonin—A Highly Potent Endogenous Radical Scavenger and Electron Donor: New Aspects of the Oxidation Chemistry of this Indole Accessed in vitroa
Pöeggeler, B., Saarela, S. Y. O., Reiter, R. J., Tan, D. X., CHEN, L., Manchester, L. C., & Barlow‐Walden, L. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb21831.x · Cited by 351 · see citing works
Melatonin Promotes Osteoblast Differentiation and Bone Formation
Roth, J. A., Kim, B., Lin, W., & Cho, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.31.22041 · Cited by 343 · see citing works
Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina
Iuvone, P. M., Tosini, G., Pozdeyev, N. V., Haque, R., Klein, D. C., & Chaurasia, S. S. (2005) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2005.01.003 · Cited by 342 · see citing works
Melatonin induces γ-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells
Urata, Y., Honma, S., Goto, S., Todoroki, S., Iida, T., Cho, S., Honma, K., & Kondo, T. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00131-8 · Cited by 333 · see citing works
Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease
Matsubara, E., Bryant‐Thomas, T., Pacheco Quinto, J., Henry, T. L., Poeggeler, B., Herbert, D., Cruz‐Sanchez, F., Chyan, Y., Smith, M. A., Perry, G., et al. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01654.x · Cited by 332 · see citing works
Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages
Mayo, J. C., Sainz, R. M., Tan, D., Hardeland, R., León, J., Rodrı́guez, C., & Reiter, R. J. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.05.002 · Cited by 332 · see citing works
Self-citation
A Novel Melatonin Metabolite, Cyclic 3-Hydroxymelatonin: A Biomarker ofin VivoHydroxyl Radical Generation
Tan, D., Manchester, L. C., Reiter, R. J., Plummer, B. F., Hardies, L. J., Weintraub, S. T., Vijayalaxmi, V., & Shepherd, A. M. M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9826 · Cited by 319 · see citing works
Metabolism of melatonin by human cytochromes p450
Ma, X., Idle, J. R., Krausz, K. W., & Gonzalez, F. J. (2005) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.002410 · Cited by 319 · see citing works
Melatonin is a scavenger of peroxynitrite
Gilad, E., Cuzzocrea, S., Zingarelli, B., Salzman, A. L., & Szabó, C. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00008-8 · Cited by 317 · see citing works
Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti‐apoptotic effects of melatonin
Andrabi, S. A., Sayeed, I., Siemen, D., Wolf, G. L., & Horn, T. F. W. (2004) · The FASEB Journal · doi:10.1096/fj.03-1031fje · Cited by 311 · see citing works
Melatonin regulation of antioxidant enzyme gene expression
Mayo, J. C., Sainz, R. M., Antolı́n, I., Herrera, F., Martı́n, V., & Rodrı́guez, C. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/pl00012498 · Cited by 308 · see citing works
Melatonin in Chinese medicinal herbs
Chen, G., Huo, Y., Tan, D., Liang, Z., Zhang, W., & Zhang, Y. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00252-2 · Cited by 306 · see citing works
In vitro and in vivo formation of two new metabolites of melatonin.
Hirata, F., Hayaishi, O., Tokuyama, T., & Senoh, S. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42976-1 · Cited by 302 · see citing works
Melatonin‐induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo
Martı́n, M., Macías, M., Escames, G., Reiter, R. J., Agapito, M. T., Ortíz, G. G., & Acuña-Castroviejo, D. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.280407.x · Cited by 295 · see citing works
Melatonin in mood disorders
Srinivasan, V., Smits, M., Spence, W., Lowe, A. D., Kayumov, L., Pandi-Perumal, S. R., Parry, B., & Cardinali, D. P. (2006) · The World Journal of Biological Psychiatry · doi:10.1080/15622970600571822 · Cited by 292 · see citing works
Self-citation
Reaction of Melatonin and Related Indoles With Hydroxyl Radicals: EPR and Spin Trapping Investigations
Matuszak, Z., Reszka, K. J., & Chignell, C. F. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00614-4 · Cited by 288 · see citing works
Melatonin in higher plants: occurrence and possible functions
Kolář, J., & Macháčková, I. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00276.x · Cited by 285 · see citing works
Melatonin administration can entrain the free-running circadian system of blind subjects
Lockley, S. W., Skene, D. J., James, K., Thapan, K., Wright, J., & Arendt, J. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.164r001 · Cited by 284 · see citing works
Melatonin Reduces Body Weight Gain in Sprague Dawley Rats with Diet-Induced Obesity
Prunet‐Marcassus, B., Desbazeille, M., Bros, A., Louche, K., Delagrange, P., Renard, P., Casteilla, L., & Pénicaud, L. (2003) · Endocrinology · doi:10.1210/en.2003-0693 · Cited by 281 · see citing works
Evaluation of factors associated with glucocorticoid‐induced osteopenia in patients with rheumatic diseases
Dykman, T. R., Gluck, O. S., Murphy, W. A., Hahn, T. J., & Hahn, B. H. (1985) · Arthritis & Rheumatism · doi:10.1002/art.1780280402 · Cited by 281 · see citing works
Melatonin at Pharmacologic Doses Increases Bone Mass by Suppressing Resorption Through Down-Regulation of the RANKL-Mediated Osteoclast Formation and Activation
Koyama, H., Nakade, O., Takada, Y., Kaku, T., & Lau, K. ‐. W. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.7.1219 · Cited by 269 · see citing works
On the Role of Melatonin in Skin Physiology and Pathology
Slominski, A. T., Fischer, T. W., Zmijewski, M. A., Wortsman, J., Semak, I. V., Zbytek, B., Slominski, R. M., & Tobin, D. J. (2005) · Endocrine · doi:10.1385/endo:27:2:137 · Cited by 265 · see citing works
Melatonin for sleep disturbances in Parkinson's disease
Dowling, G. A., Mastick, J., Colling, E., Carter, J. H., Singer, C. M., & Aminoff, M. J. (2005) · Sleep Medicine · doi:10.1016/j.sleep.2005.04.004 · Cited by 264 · see citing works
Melatonin, a potent agent in antioxidative defense: Actions as a natural food constituent, gastrointestinal factor, drug and prodrug
Hardeland, R., & Pandi-Perumal, S. R. (2005) · Nutrition & Metabolism · doi:10.1186/1743-7075-2-22 · Cited by 263 · see citing works
Self-citation
Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria
Martı́n, M., Macías, M. J., León, J., Escames, G., Khaldy, H., & Acuña-Castroviejo, D. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00138-8 · Cited by 261 · see citing works
The immunotherapeutic potential of melatonin
Maestroni, G. J. M. (2001) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.10.3.467 · Cited by 254 · see citing works
Self-citation
N 1 ‐acetyl‐ N 2 ‐formyl‐5‐methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant
Tan, D. X., Manchester, L. C., Burkhardt, S., Sainz, R. M., Mayo, J. C., Kohen, R., Shohami, E., Huo, Y., Hardeland, R., & Reiter, R. J. (2001) · The FASEB Journal · doi:10.1096/fj.01-0309fje · Cited by 253 · see citing works
Self-citation
Melatonin inhibits expression of the inducible isoform of nitric oxide synthase in murine macrophages: role of inhibition of NFκB activation
Gilad, E., Wong, H. R., Zingarelli, B., Virág, L., O'connor, M., Salzman, A. L., & Szabó, C. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.9.685 · Cited by 252 · see citing works
Daily Melatonin Administration at Middle Age Suppresses Male Rate Visceral Fat, Plasma Leptin, and Plasma Insulin to Youthful Levels
Rasmussen, D. D., Boldt, B. M., Wilkinson, C. W., Yellon, S. M., & Matsumoto, A. M. (1999) · Endocrinology · doi:10.1210/endo.140.2.6674 · Cited by 250 · see citing works
Transcriptional activation of the nuclear receptor RZRα by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand
Wiesenberg, I., Missbach, M., Kahlen, J.-P., Schräder, M., & Carlberg, C. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.3.327 · Cited by 250 · see citing works
Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum
Pozo, D., Reiter, R. J., Calvo, J. R., & Guerrero, J. M. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00532-x · Cited by 245 · see citing works
Double Blind Study of Melatonin Effects on the Sleep-wake Rhythm, Cognitive and Non-cognitive Functions in Alzheimer Type Dementia
Asayama, K., Yamadera, H., Ito, T., Suzuki, H., Kudo, Y., & Endo, S. (2003) · Journal of Nippon Medical School · doi:10.1272/jnms.70.334 · Cited by 242 · see citing works
Melatonin, immune function and aging
Srinivasan, V. J., Gj, M., Cardinali, D. P., Esquifino, A. I., Pandi-Perumal, S. R., & Miller, S. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-17 · Cited by 239 · see citing works
Self-citation
An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease
Pappolla, M. A., Chyan, Y., Pöeggeler, B., Frangione, B., Wilson, G. L., Ghiso, J. A., & Reiter, R. J. (2000) · Journal of Neural Transmission · doi:10.1007/s007020050018 · Cited by 239 · see citing works
Melatonin effects on bone: experimental facts and clinical perspectives
Cardinali, D. P., Ladizesky, M. G., Boggio, V., Cutrera, R. A., & Mautalén, C. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00028.x · Cited by 239 · see citing works
Self-citation
Putting Cancer to Sleep at Night: The Neuroendocrine/Circadian Melatonin Signal
Blask, D. E., Dauchy, R. T., & Sauer, L. A. (2005) · Endocrine · doi:10.1385/endo:27:2:179 · Cited by 238 · see citing works
Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction
Ressmeyer, A., Mayo, J. C., Zelosko, V., Sainz, R. M., Tan, D., Pöeggeler, B., Antolı́n, I., Zsizsik, B. K., Reiter, R. J., & Hardeland, R. (2003) · Redox Report · doi:10.1179/135100003225002709 · Cited by 238 · see citing works
Self-citation
Melatonin stimulates proliferation and type I collagen synthesis in human bone cells in vitro
Nakade, O., Koyama, H., Ariji, H., Yajima, A., & Kaku, T. (1999) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1999.tb00603.x · Cited by 238 · see citing works
Melatonin and circadian control in mammals
Armstrong, S. M. (1989) · Cellular and Molecular Life Sciences · doi:10.1007/bf01953050 · Cited by 235 · see citing works
The Mitochondrial Production of Reactive Oxygen Species in Relation to Aging and Pathology
Genova, M. L., Pich, M. M., Bernacchia, A., Bianchi, C., Biondi, A., Bovina, C., Falasca, A. I., Formiggini, G., Castelli, G. P., & Lenaz, G. (2004) · Springer eBooks · doi:10.1007/978-3-662-41088-2_10 · Cited by 233 · see citing works
Melatonin as an antioxidant: physiology versus pharmacology
Reiter, R. J., Tan, D. X., & y Aibar, M. D. M. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00261.x · Cited by 232 · see citing works
Role of melatonin in neurodegenerative diseases
Srinivasan, V. J., Pandi-Perumal, S. R., Maestroni, G. J. M., Esquifino, A. I., Hardeland, R., & Cardinali, D. P. (2005) · Neurotoxicity Research · doi:10.1007/bf03033887 · Cited by 232 · see citing works
Self-citation
Melatonin mediates two distinct responses in vascular smooth muscle
Doolen, S., Krause, D. N., Dubocovich, M. L., & Duckles, S. P. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00064-8 · Cited by 229 · see citing works
Melatonin and the Circadian Regulation of Sleep Initiation, Consolidation, Structure, and the Sleep EEG
Dijk, D., & Cajochen, C. (1997) · Journal of Biological Rhythms · doi:10.1177/074873049701200618 · Cited by 229 · see citing works
Melatonin as a cytoskeletal modulator: implications for cell physiology and disease
Benítez‐King, G. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00282.x · Cited by 224 · see citing works
The clock in the mouse retina: melatonin synthesis and photoreceptor degeneration
Tosini, G., & Menaker, M. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01446-7 · Cited by 223 · see citing works
Seasonal Changes in Adiposity: the Roles of the Photoperiod, Melatonin and Other Hormones, and Sympathetic Nervous System
Bartness, T. J., Demas, G. E., & Song, C. K. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222700601 · Cited by 221 · see citing works
Delayed sleep phase syndrome: A placebo‐controlled cross‐over study on the effects of melatonin administered five hours before the individual dim light melatonin onset
Nagtegaal, J. E., KERKHOF, G. A., Smits, M. G., Swart, & van der Meer, Y. G. (1998) · Journal of Sleep Research · doi:10.1046/j.1365-2869.1998.00102.x · Cited by 221 · see citing works
Diminished Melatonin Secretion in the Elderly Caused by Insufficient Environmental Illumination1
Mishima, K., Okawa, M., Shimizu, T., & Hishikawa, Y. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.1.7097 · Cited by 218 · see citing works
Serum melatonin in relation to clinical variables in patients with major depressive disorder and a hypothesis of a low melatonin syndrome
Beck-Friis, J., Kjellman, B., Apéria, B., Undén, F., von Rosen, D., Ljunggren, J. ‐., & Wetterberg, L. (1985) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1985.tb02531.x · Cited by 217 · see citing works
Impaired nocturnal secretion of melatonin in coronary heart disease
Brugger, P., Marktl, W., & Herold, M. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92600-3 · Cited by 216 · see citing works
Mechanistic and comparative studies of melatonin and classic antioxidants in terms of their interactions with the ABTS cation radical
Tan, D. X., Hardeland, R., Manchester, L. C., Pöeggeler, B., López‐Burillo, S., Mayo, J. C., Sainz, R. M., & Reiter, R. J. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00037.x · Cited by 212 · see citing works
Self-citation
Circadian Rhythm Sleep Disorders
Zisapel, N. (2001) · CNS Drugs · doi:10.2165/00023210-200115040-00005 · Cited by 212 · see citing works
Basic aspects of melatonin action
Cardinali, D. P., & Pévet, P. (1998) · Sleep Medicine Reviews · doi:10.1016/s1087-0792(98)90020-x · Cited by 212 · see citing works
Self-citation
Five years survival in metastatic non‐small cell lung cancer patients treated with chemotherapy alone or chemotherapy and melatonin: a randomized trial
Lissoni, P., Chilelli, M. G., Villa, S., Cerizza, L., & Tancini, G. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00032.x · Cited by 212 · see citing works
Functional Melatonin Receptors in Rat Ovaries at Various Stages of the Estrous Cycle
Soares, J. M., Masana, M. I., Erşahin, Ç. H., & Dubocovich, M. L. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.049916 · Cited by 210 · see citing works
Rhythms of glutathione peroxidase and glutathione reductase in brain of chick and their inhibition by light
Pablos, M. I., Reiter, R. J., Ortíz, G. G., Guerrero, J. M., Agapito, M. T., Chuang, J.-I., & Sewerynek, E. (1998) · Neurochemistry International · doi:10.1016/s0197-0186(97)00043-0 · Cited by 210 · see citing works
Melatonin as a hypnotic: Pro
Zhdanova, I. V. (2004) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.04.003 · Cited by 208 · see citing works
Melatonin reduces nitric oxide synthase activity in rat hypothalamus
Bettahi, I., Pozo, D., Osuna, C., Reiter, R. J., Acuña-Castroviejo, D., & Guerrero, J. M. (1996) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1996.tb00260.x · Cited by 207 · see citing works
The role of melatonin in immuno‐enhancement: potential application in cancer
Miller, S. C., Pandi, P. S. R., Esquifino, A. I., Cardinali, D. P., & Maestroni, G. J. M. (2006) · International Journal of Experimental Pathology · doi:10.1111/j.0959-9673.2006.00474.x · Cited by 206 · see citing works
Self-citation
Sleep-Promoting Effects of Melatonin: At What Dose, in Whom, Under What Conditions, and by What Mechanisms?
Sack, R. L., Hughes, R. J., Edgar, D. M., & Lewy, A. J. (1997) · SLEEP · doi:10.1093/sleep/20.10.908 · Cited by 205 · see citing works
Melatonin-induced temperature suppression and its acute phase-shifting effects correlate in a dose-dependent manner in humans
Deacon, S., & Arendt, J. (1995) · Brain Research · doi:10.1016/0006-8993(95)96872-i · Cited by 203 · see citing works
Inverse Seasonal Relationship Between Melatonin and Ovarian Activity in Humans in a Region With a Strong Seasonal Contrast in Luminosity*
Kauppila, A., Kivelä, A., Pakarinen, A., & Vakkuri, O. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-5-823 · Cited by 202 · see citing works
Effects of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy men
Arangino, S., Cagnacci, A., Angiolucci, M., Vacca, A. M. B., Longu, G., Volpe, A., & Melis, G. B. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00112-5 · Cited by 200 · see citing works
The Mitochondrial Production of Reactive Oxygen Species in Relation to Aging and Pathology
Genova, M. L., Pich, M. M., Bernacchia, A., BIANCHI, C., Biondi, A., Bovina, C., Falasca, A. I., Formiggini, G., Castelli, G. P., & Lenaz, G. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1293.010 · Cited by 198 · see citing works
Melatonin's unique radical scavenging properties – roles of its functional substituents as revealed by a comparison with its structural analogs
Pöeggeler, B., Thuermann, S., Dose, A., Schoenke, M., Burkhardt, S., & Hardeland, R. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2002.01873.x · Cited by 196 · see citing works
Self-citation
Reactive Oxygen Intermediates, Molecular Damage, and Aging: Relation to Melatonin
Reiter, R. J., Guerrero, J. M., García, J. J., & Acuña-Castroviejo, D. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09920.x · Cited by 196 · see citing works
Melatonin: Role in Gating Nocturnal Rise in Sleep Propensity
Lavie, P. (1997) · Journal of Biological Rhythms · doi:10.1177/074873049701200622 · Cited by 190 · see citing works
Functional Expression of MT2 (Mel1b) Melatonin Receptors in Human PAZ6 Adipocytes
Brydon, L., Petit, L., Delagrange, P., Strosberg, A. D., & Jockers, R. (2001) · Endocrinology · doi:10.1210/endo.142.10.8423 · Cited by 190 · see citing works
Glucocorticoid-Induced Osteoporosis
Weinstein, R. S. (2001) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/a:1010007108155 · Cited by 189 · see citing works
The use of melatonin in Alzheimer's disease.
Cardinali, D. P., Brusco, L. I., Liberczuk, C., & Furio, A. M. (2002) · PubMed · Cited by 189 · see citing works
Self-citation
Melatonin and its precursors scavenge nitric oxide
Noda, Y., Mori, A., Liburdy, R. P., & Packer, L. (1999) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1999.tb00611.x · Cited by 185 · see citing works
AMPLIFICATION OF NOCTURNAL MELATONIN SECRETION IN WOMEN WITH FUNCTIONAL HYPOTHALAMIC AMENORRHEA
Berga, S. L., Mortola, J. F., & Yen, S. S. C. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-1-242 · Cited by 181 · see citing works
Direct Effect of Melatonin on Syrian Hamster Testes: Melatonin Subtype 1a Receptors, Inhibition of Androgen Production, and Interaction with the Local Corticotropin-Releasing Hormone System
Frungieri, M. B., Mayerhofer, A., Zitta, K., Pignataro, O. P., Calandra, R. S., & González-Calvar, S. I. (2004) · Endocrinology · doi:10.1210/en.2004-0990 · Cited by 173 · see citing works
Monozygotic twins with Alzheimer's disease treated with melatonin: Case report
Brusco, L. I., Márquez, M., & Cardinali, D. P. (1998) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1998.tb00396.x · Cited by 172 · see citing works
Self-citation
Melatonin for the Treatment of Sleep Disturbances in Major Depressive Disorder
Dolberg, O. T., Hirschmann, S., & Grunhaus, L. J. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.8.1119 · Cited by 169 · see citing works
Melatonin alleviates behavioral deficits associated with apoptosis and cholinergic system dysfunction in the APP 695 transgenic mouse model of Alzheimer's disease
Zheng, F., Chang, Y. S., Cheng, Y., Zhang, B. W., Qu, Z., Qin, C., & Zhang, J. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00144.x · Cited by 169 · see citing works
Antioxidant properties of melatonin: a pulse radiolysis study
Mahal, H. S., Sharma, H. S., & Mukherjee, T. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00226-3 · Cited by 167 · see citing works
Nitrosation of melatonin by nitric oxide and peroxynitrite
Blanchard, B., Pompon, D., & Ducrocq, C. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.290308.x · Cited by 167 · see citing works
Overview: clinical and physiological comparison of meditation with other self-control strategies
Shapiro, D. H. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.3.267 · Cited by 162 · see citing works
Melatonin activates Th1 lymphocytes by increasing IL-12 production
García‐Mauriño, S., Pozo, D., Carrillo‐Vico, A., Calvo, J. R., & Guerrero, J. M. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00479-8 · Cited by 161 · see citing works
Melatonin as a hydroxyl radical scavenger
Stasica, P., Ulański, P., & Rosiak, J. M. (1998) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1998.tb00387.x · Cited by 161 · see citing works
Melatonin and cancer risk: does light at night compromise physiologic cancer protection by lowering serum melatonin levels?
Schernhammer, E. S., & Schulmeister, K. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601626 · Cited by 161 · see citing works
Melatonin advances the circadian timing of EEG sleep and directly facilitates sleep without altering its duration in extended sleep opportunities in humans
Rajaratnam, S. M. W., Middleton, B., Stone, B. M., Arendt, J., & Dijk, D. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.073742 · Cited by 160 · see citing works
A Randomized, Double-Blind, Placebo-Controlled Crossover Study of the Effect of Exogenous Melatonin on Delayed Sleep Phase Syndrome
Kayumov, L., Brown, G. M., Jindal, R. D., Buttoo, K., & Shapiro, C. M. (2001) · Psychosomatic Medicine · doi:10.1097/00006842-200101000-00005 · Cited by 160 · see citing works
Melatonin for treatment of sundowning in elderly persons with dementia – a preliminary study
Cohen‐Mansfield, J., Garfinkel, D., & Lipson, S. (2000) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(00)00068-6 · Cited by 159 · see citing works
Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer's disease
Zheng, F., Qin, C., Chang, Y. S., & Zhang, J. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.014 · Cited by 156 · see citing works
Anticarcinogenic actions of melatonin which involve antioxidative processes: comparison with other antioxidants
Karbownik‐Lewińska, M. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00059-0 · Cited by 156 · see citing works
Serum melatonin and urinary 6-sulfatoxymelatonin in major depression
Crasson, M., Kjiri, S., Colin, A., Kjiri, K., L’Hermite‐Balériaux, M., Ansseau, M., & Legros, J. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00123-3 · Cited by 154 · see citing works
Melatonin Reverses the Profibrillogenic Activity of Apolipoprotein E4 on the Alzheimer Amyloid Aβ Peptide
Pöeggeler, B., Miravalle, L., Zagorski, M. G., Wısnıewskı, T., Chyan, Y., Zhang, Y., Shao, H., Bryant‐Thomas, T., Vidal, R., Frangione, B., et al. (2001) · Biochemistry · doi:10.1021/bi0114269 · Cited by 154 · see citing works
Senescence, sleep, and circadian rhythms
Pandi-Perumal, S. R., Seils, L. K., Kayumov, L., Ralph, M. R., Lowe, A. D., Moller, H. J., & Swaab, D. F. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00014-4 · Cited by 154 · see citing works
Self-citation
GLUCOCORTICOID-INDUCED OSTEOPOROSIS
Lukert, B. P., & Raisz, L. G. (1994) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(21)00353-7 · Cited by 153 · see citing works
Acute increases in night-time plasma melatonin levels following a period of meditation
Tooley, G. A., Armstrong, S. M., Norman, T. R., & Sali, A. (2000) · Biological Psychology · doi:10.1016/s0301-0511(00)00035-1 · Cited by 152 · see citing works
How to Trick Mother Nature into Letting You Fly Around or Stay Up All Night
Revell, V. L., & Eastman, C. I. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730405277233 · Cited by 151 · see citing works
Chronobiotics—drugs that shift rhythms
Dawson, D. E., & Armstrong, S. M. (1996) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)02020-9 · Cited by 150 · see citing works
Ubiquitous melatonin-presence and effects in unicells, plants and animals
Hardeland, R., & Fuhrberg, B. (1996) · Cited by 147 · see citing works
Self-citation
Improvement of sleep quality by melatonin
Wurtman, R. J., & Zhdanova, I. V. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92509-0 · Cited by 146 · see citing works
The chronobiotic properties of melatonin
Pévet, P., Bothorel, B., Slotten, H. A., & Saboureau, M. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0584-1 · Cited by 146 · see citing works
Melatonin Receptor Activation Regulates GnRH Gene Expression and Secretion in GT1–7 GnRH Neurons
Roy, D., & Belsham, D. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108890200 · Cited by 145 · see citing works
Melatonin
Reiter, R. J., & Tan, D. X. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02938.x · Cited by 145 · see citing works
Mitochondrial regulation by melatonin And its metabolites
Acuña-Castroviejo, D., Escames, G., León, J., Carazo, Á., & Khaldy, H. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0135-0_63 · Cited by 144 · see citing works
Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and Apoptosis in Alzheimer’s Disease
Takuma, K., Yan, S. S., Stern, D. M., & Yamada, K. (2005) · Journal of Pharmacological Sciences · doi:10.1254/jphs.cpj04006x · Cited by 143 · see citing works
DNA oxidatively damaged by chromium(III) and H2O2 is protected by the antioxidants melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine, resveratrol and uric acid
Burkhardt, S. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00052-8 · Cited by 142 · see citing works
Melatonin treatment stabilizes chronobiologic and cognitive symptoms in Alzheimer's disease.
Brusco, L. I., Márquez, M., & Cardinali, D. P. (2000) · PubMed · Cited by 140 · see citing works
Self-citation
Expression of membrane and nuclear melatonin receptor mRNA and protein in the mouse immune system
Carrillo‐Vico, A., Garc�a-Perga�eda, A., Naji, L., Calvo, J. R., Romero, M., & Guerrero, J. M. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3207-4 · Cited by 139 · see citing works
Melatonin desensitizes endogenous MT 2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin
Gerdin, M. J., Masana, M. I., Rivera-Bermudez, M. A., Hudson, R. L., Earnest, D. J., Gillette, M. U., & Dubocovich, M. L. (2004) · The FASEB Journal · doi:10.1096/fj.03-1339com · Cited by 137 · see citing works
Melatonin, Sleep, and Shift Work Adaptation
Burch, J. B., Yost, M. G., Johnson, W., & Allen, E. (2005) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000177336.21147.9f · Cited by 135 · see citing works
Gene Regulation by Melatonin
Carlberg, C. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05403.x · Cited by 134 · see citing works
Some Effects of Melatonin and the Control of its Secretion in Humans
Arendt, J., Bojkowski, C. J., Folkard, S., Franey, C. S., Marks, V., Minors, D. S., Waterhouse, J. M., Wever, R. A., Wildgruber, C. M., & Wright, J. (1985) · Novartis Foundation symposium · doi:10.1002/9780470720981.ch16 · Cited by 131 · see citing works
Serum Melatonin in Central Precocious Puberty Is Lower than in Age-Matched Prepubertal Children*
Waldhauser, F., Boepple, P. A., SCHEMPER, M., Mansfield, M. J., & Crowley, W. F. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-4-793 · Cited by 130 · see citing works
Meditation, melatonin and breast/prostate cancer: Hypothesis and preliminary data
Massion, A. O., Teas, J., Hébert, J. R., Wertheimer, M. D., & Kabat‐Zinn, J. (1995) · Medical Hypotheses · doi:10.1016/0306-9877(95)90299-6 · Cited by 126 · see citing works
The pineal, a tranquillizing organ?
Romijn, H. J. (1978) · Life Sciences · doi:10.1016/0024-3205(78)90191-1 · Cited by 125 · see citing works
Melatonin receptor (MT1) knockout mice display depression-like behaviors and deficits in sensorimotor gating
Weil, Z. M., Hotchkiss, A. K., Gatien, M. L., Pieke-Dahl, S., & Nelson, R. J. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.09.016 · Cited by 125 · see citing works
The 2004 Aschoff/Pittendrigh Lecture: Theory of the Origin of the Pineal Gland— A Tale of Conflict and Resolution
Klein, D. C. (2004) · Journal of Biological Rhythms · doi:10.1177/0748730404267340 · Cited by 123 · see citing works
Melatonin inhibits estrogen receptor transactivation and cAMP levels in breast cancer cells
Kiefer, T. L., Ram, P. T., Yuan, L., & Hill, S. M. (2002) · Breast Cancer Research and Treatment · doi:10.1023/a:1013301408464 · Cited by 122 · see citing works
Neuroendocrine Aspects of Primary Endogenous Depression
Rubín, R. T. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820070052008 · Cited by 121 · see citing works
Pinealectomy induces malformation of the spine and reduces the mechanical strength of the vertebrae in Atlantic salmon, Salmo salar
Fjelldal, P. G., Grotmol, S., Kryvi, H., Gjerdet, N. R., Taranger, G. L., Hansen, T., Porter, M. J. R., & Totland, G. K. (2004) · Journal of Pineal Research · doi:10.1046/j.1600-079x.2003.00109.x · Cited by 120 · see citing works
Origin of cerebrospinal fluid melatonin and possible function in the integration of photoperiod
Tricoire-Leignel, H., Møller, M., Chemineau, P., & Malpaux, B. (2019) · Bioscientifica Proceedings · doi:10.1530/biosciprocs.5.023 · Cited by 118 · see citing works
Reactions of the melatonin metabolite AMK (N1‐acetyl‐5‐methoxykynuramine) with reactive nitrogen species: Formation of novel compounds, 3‐acetamidomethyl‐6‐methoxycinnolinone and 3‐nitro‐AMK
Guenther, A. L., Schmidt, S. I., Laatsch, H., Fotso, S., Ness, H., Ressmeyer, A., Pöeggeler, B., & Hardeland, R. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00242.x · Cited by 115 · see citing works
Self-citation
Acute effects of melatonin administration on cardiovascular autonomic regulation in healthy men
Nishiyama, K., Yasue, H., Moriyama, Y., Tsunoda, R., Ogawa, H., Yoshimura, M., & Kugiyama, K. (2001) · American Heart Journal · doi:10.1067/mhj.2001.114368 · Cited by 113 · see citing works
Melatonin and colon carcinogenesis: I. Inhibitory effect of melatonin on development of intestinal tumors induced by 1,2-dimethylhydrazine in rats
Anisimov, V. V. (1997) · Carcinogenesis · doi:10.1093/carcin/18.8.1549 · Cited by 113 · see citing works
The pineal gland and reproduction
Aleandri, V. (1996) · Human Reproduction Update · doi:10.1093/humupd/2.3.225 · Cited by 110 · see citing works
Melatonin in elderly patients with insomnia.
Rikkert, M. G. M. O., & Rigaud, A. (2001) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s003910170025 · Cited by 109 · see citing works
SUPPLEMENTARY ADMINISTRATION OF ARTIFICIAL BRIGHT LIGHT AND MELATONIN AS POTENT TREATMENT FOR DISORGANIZED CIRCADIAN REST-ACTIVITY AND DYSFUNCTIONAL AUTONOMIC AND NEUROENDOCRINE SYSTEMS IN INSTITUTIONALIZED DEMENTED ELDERLY PERSONS
Mishima, K., Okawa, M., Hozumi, S., & Hishikawa, Y. (2000) · Chronobiology International · doi:10.1081/cbi-100101055 · Cited by 108 · see citing works
Localization of Aa-nat mRNA in the rat retina by fluorescence in situ hybridization and laser capture microdissection
Liu, C., Fukuhara, C., Wessel, J. H., Iuvone, P. M., & Tosini, G. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0822-1 · Cited by 107 · see citing works
Pro-oxidant activity of aluminum in the rat hippocampus: gene expression of antioxidant enzymes after melatonin administration
Gómez, M., Esparza, J. L., Nogués, M. R., Giralt, M., Cabré, M., & Domingo, J. L. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.10.009 · Cited by 103 · see citing works
Colony-stimulating activity and hematopoietic rescue from cancer chemotherapy compounds are induced by melatonin via endogenous interleukin 4.
Maestroni, G. J. M., Conti, A., & Lissoni, P. (1994) · PubMed · Cited by 102 · see citing works
Self-citation
The oncostatic action of melatonin in an ovarian carcinoma cell line
Petranka, J. G., Baldwin, W. S., Biermann, J., Jayadev, S., Barrett, J. C., & Murphy, E. (1999) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1999.tb00574.x · Cited by 101 · see citing works
Metabolism of serotonin by the rat retina in vitro
Cardinali, D. P., & Rosner, J. M. (1971) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1971.tb03752.x · Cited by 100 · see citing works
Self-citation
Influences of melatonin administration on the circulation of women
Cagnacci, A., Arangino, S., Angiolucci, M., Maschio, E., & Melis, G. B. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.2.r335 · Cited by 100 · see citing works
Melatonin increases oestradiol‐induced bone formation in ovariectomized rats
Ladizesky, M. G., Boggio, V., Albornoz, L. E., Castrillón, P. O., Mautalén, C., & Cardinali, D. P. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00021.x · Cited by 99 · see citing works
Self-citation
High‐affinity binding of melatonin by human circulating T lymphocytes (CD4 + )
González-Haba, M. G., García‐Mauriño, S., Calvo, J. R., Goberna, R., & Guerrero, J. M. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.13.7557023 · Cited by 98 · see citing works
The Reaction of Melatonin with Peroxynitrite: Formation of Melatonin Radical Cation and Absence of Stable Nitrated Products
Zhang, H., Squadrito, G. L., & Pryor, W. A. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9426 · Cited by 97 · see citing works
Melatonin and enterochromaffine cells
Райхлин, Н. Т., & Kvetnoy, I. M. (1976) · Acta Histochemica · doi:10.1016/s0065-1281(76)80092-x · Cited by 97 · see citing works
Contrary to other non-photic cues, acute melatonin injection does not induce immediate changes of clock gene mrna expression in the rat suprachiasmatic nuclei
Poirel, V., Boggio, V., Dardente, H., Pévet, P., Masson‐Pévet, M., & Gauer, F. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00344-0 · Cited by 96 · see citing works
Melatonin Treatment of Day-Night Rhythm Disturbances and Sundowning in Alzheimer Disease
Mahlberg, R., Kunz, D., Sutej, I., Kühl, K.-P., & Hellweg, R. (2004) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000132443.12607.fd · Cited by 96 · see citing works
Molecular evidence that melatonin is enzymatically oxidized in a different manner than tryptophan: investigations with both indoleamine 2,3-dioxygenase and myeloperoxidase.
Ferry, G., Ubeaud, C., Lambert, P., Bertin, S., Cogé, F., Chomarat, P., Delagrange, P., Serkiz, B., Bouchet, J., Truscott, R., et al. (2005) · Biochemical Journal · doi:10.1042/bj20042075 · Cited by 95 · see citing works
Seasonal, menstrual and circadian secretions of melatonin, gonadotropins and prolactin in women
Kivelä, A., Kauppila, A., Ylöstalo, P., Vakkuri, O., & Leppäluoto, J. (1988) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1988.tb08335.x · Cited by 95 · see citing works
Melatonin protects against MPTP/MPP + ‐induced mitochondrial DNA oxidative damage in vivo and in vitro
Chen, L., Gao, Y., Li, X., Shen, D., & Sun, F. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00209.x · Cited by 92 · see citing works
Decreased nocturnal synthesis of melatonin in patients with coronary artery disease
Yaprak, M., Altun, A., Vardar, S. A., Aktöz, M., Çiftçi, Ş., & Özbay, G. (2003) · International Journal of Cardiology · doi:10.1016/s0167-5273(02)00461-8 · Cited by 91 · see citing works
Differential growth inhibitory effect of melatonin on two endometrial cancer cell lines
香西, 洋., Kobayashi, Y., Noda, S., Ishizuka, B., & Saito, K. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.280405.x · Cited by 87 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

Hardeland R, Poeggeler B, Behrmann G & Fuhrberg B (1996) Enzymatic and non-enzymatic metabolism of methoxyindoles. In Metabolism and Cellular Dynamics of Indoles (Hardeland R, ed.), pp. 6-22. University of Goettingen, Goettingen.

Sorted by citations

Melatonin as an antioxidant: under promises but over delivers
Reiter, R. J., Mayo, J. C., Tan, D. X., Sainz, R. M., Alatorre-Jiménez, M. A., & Qin, L. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12360 · Cited by 1,741 · see citing works
Melatonin as a natural ally against oxidative stress: a physicochemical examination
Galano, A., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00916.x · Cited by 1,154 · see citing works
Melatonin—A pleiotropic, orchestrating regulator molecule
Hardeland, R., Cardinali, D. P., Srinivasan, V., Spence, D. W., Brown, G. M., & Pandi-Perumal, S. R. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.12.004 · Cited by 843 · see citing works
Self-citation
Melatonin: Pharmacology, Functions and Therapeutic Benefits
Tordjman, S., Sylvie Chokron, A., Delorme, R., Charrier, A., Bellissant, É., Jaafari, N., & Fougerou, C. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666161228122115 · Cited by 836 · see citing works
Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways
Pandi-Perumal, S. R., Trakht, I. N., SRINIVASAN, V., SPENCE, D., Maestroni, G. J. M., Zisapel, N., & Cardinali, D. P. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.04.001 · Cited by 799 · see citing works
Self-citation
Amide Bond Bioisosteres: Strategies, Synthesis, and Successes
Kumari, S., Carmona, A. V., Tiwari, A. K., & Trippier, P. C. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00530 · Cited by 692 · see citing works
Circadian genes, rhythms and the biology of mood disorders
McClung, C. A. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.02.003 · Cited by 666 · see citing works
Agomelatine, the first melatonergic antidepressant: discovery, characterization and development
de Bodinat, C., Lemaître, B. J., Mocaër, E., Renard, P., Muñoz, C., & Millan, M. J. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3140 · Cited by 595 · see citing works
Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin's Neuroendocrine System
Slominski, A. T., Zmijewski, M. A., Skobowiat, C., Zbytek, B., Slominski, R. M., & Steketee, J. D. (2012) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-642-19683-6 · Cited by 502 · see citing works
Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin
Reiter, R. J., Paredes, S. D., Manchester, L. C., & Tan, D.-X. (2009) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230903044914 · Cited by 477 · see citing works
Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines
Hardeland, R., Tan, D., & Reiter, R. J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00701.x · Cited by 474 · see citing works
Self-citation
The Glymphatic System: A Novel Component of Fundamental Neurobiology
Hablitz, L. M., & Nedergaard, M. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0619-21.2021 · Cited by 480 · see citing works
Involvement of ROS in BBB dysfunction
Pun, P. B. L., Lu, J., & Moochhala, S. (2009) · Free Radical Research · doi:10.1080/10715760902751902 · Cited by 457 · see citing works
Melatonin and inflammation-Story of a double-edged blade
Hardeland, R. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12525 · Cited by 455 · see citing works
Self-citation
Melatonin, sleep disturbance and cancer risk
Blask, D. E. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2008.07.007 · Cited by 452 · see citing works
Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling
Hardeland, R., Madrid, J. A., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00934.x · Cited by 449 · see citing works
Self-citation
The changing biological roles of melatonin during evolution: from an antioxidant to signals of darkness, sexual selection and fitness
Tan, D. X., Hardeland, R., Manchester, L. C., Paredes, S. D., Korkmaz, A., Sainz, R. M., Mayo, J. C., Fuentes‐Broto, L., & Reiter, R. J. (2009) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2009.00118.x · Cited by 365 · see citing works
Self-citation
Aging, melatonin, and the pro- and anti-inflammatory networks
Hardeland, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051223 · Cited by 337 · see citing works
Self-citation
Melatonin in the skin: synthesis, metabolism and functions
Slominski, A. T., Tobin, D. J., Zmijewski, M. A., Wortsman, J., & Paus, R. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2007.10.007 · Cited by 331 · see citing works
Clarifying the role of sleep in depression: A narrative review
Pandi-Perumal, S. R., Monti, J. M., Burman, D., Ramanujam, K., BaHammam, A. S., Spence, D. W., Brown, G. M., & Narashimhan, M. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.113239 · Cited by 335 · see citing works
Self-citation
Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes
Pandi-Perumal, S. R., BaHammam, A. S., Brown, G. M., Spence, D. W., Bharti, V. K., Kaur, C., Hardeland, R., & Cardinali, D. P. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9337-4 · Cited by 320 · see citing works
Self-citation
Circadian photoreception: ageing and the eye's important role in systemic health
Turner, P. L., & Mainster, M. A. (2008) · British Journal of Ophthalmology · doi:10.1136/bjo.2008.141747 · Cited by 315 · see citing works
Thidiazuron: A multi-dimensional plant growth regulator
Guo, B., Abbasi, B. H., Amir, Z., L, L. X., & Y, H. W. (2011) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb11.636 · Cited by 302 · see citing works
Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care
Tarocco, A., Caroccia, N., Morciano, G., Wieckowski, M. R., Ancora, G., Garani, G., & Pinton, P. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1556-7 · Cited by 307 · see citing works
Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions
Slominski, A. T., Hardeland, R., Zmijewski, M. A., Slominski, R. M., Reiter, R. J., & Paus, R. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.10.025 · Cited by 293 · see citing works
Self-citation
Oxidative Stress and BPA Toxicity: An Antioxidant Approach for Male and Female Reproductive Dysfunction
Meli, R., Monnolo, A., Annunziata, C., Pirozzi, C., & Ferrante, M. C. (2020) · Antioxidants · doi:10.3390/antiox9050405 · Cited by 301 · see citing works
Circadian rhythms and memory formation
Gerstner, J. R., & Yin, J. C. P. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2881 · Cited by 253 · see citing works
Melatonin, hormone of darkness and more – occurrence, control mechanisms, actions and bioactive metabolites
Hardeland, R. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8001-x · Cited by 253 · see citing works
Self-citation
The Uniqueness of Tryptophan in Biology: Properties, Metabolism, Interactions and Localization in Proteins
Barik, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228776 · Cited by 233 · see citing works
Melatonin as an anti-inflammatory agent modulating inflammasome activation
Favero, G., Franceschetti, L., Bonomini, F., Rodella, L. F., & Rezzani, R. (2017) · International Journal of Endocrinology · doi:10.1155/2017/1835195 · Cited by 233 · see citing works
Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer
Jung-Hynes, B. D., Reiter, R. J., & Ahmad, N. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00729.x · Cited by 234 · see citing works
Melatonin: Signaling mechanisms of a pleiotropic agent
Hardeland, R. (2009) · BioFactors · doi:10.1002/biof.23 · Cited by 227 · see citing works
Self-citation
Melatonin Mitigates Salt Stress in Wheat Seedlings by Modulating Polyamine Metabolism
Ke, Q., Ye, J., Wang, B., Ren, J., Yin, L., Deng, X., & Wang, S. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.00914 · Cited by 228 · see citing works
Neonatal hypoxic ischemic encephalopathy: an update on disease pathogenesis and treatment
Yıldız, E. P., Ekici, B., & Tatlı, B. (2016) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1259567 · Cited by 220 · see citing works
Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else?
Paus, R., Schallreuter, K. U., Bahadoran, P., Picardo, M., Slominski, A. T., Elassiuty, Y. E., Kemp, E. H., Giachino, C., Liu, J. B., Luiten, R. M., et al. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2007.00666_1.x · Cited by 213 · see citing works
Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
Talib, W. H., Alsayed, A. R., Abuawad, A., Daoud, S., & Mahmod, A. I. (2021) · Molecules · doi:10.3390/molecules26092506 · Cited by 223 · see citing works
Therapeutic Actions of Melatonin in Cancer: Possible Mechanisms
Srinivasan, V., Spence, D. W., Pandi-Perumal, S. R., Trakht, I., & Cardinali, D. P. (2008) · Integrative Cancer Therapies · doi:10.1177/1534735408322846 · Cited by 208 · see citing works
Self-citation
Melatonin: functions and ligands
Singh, M., & Jadhav, H. R. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.04.014 · Cited by 206 · see citing works
Melatonin in aging and disease -multiple consequences of reduced secretion, options and limits of treatment.
Hardeland, R. (2012) · Europe PMC (PubMed Central) · Cited by 202 · see citing works
Self-citation
Implications of circadian clocks for the rhythmic delivery of cancer therapeutics
Lévi, F., Focan, C., Karaboué, A., de la Valette, V., Focan-Henrard, D., Baron, B., Kreutz, F., & Giacchetti, S. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.11.001 · Cited by 199 · see citing works
The chronotherapeutic treatment of bipolar disorders: A systematic review and practice recommendations from the ISBD task force on chronotherapy and chronobiology
Gottlieb, J. F., Benedetti, F., Geoffroy, P. A., Henriksen, T. E. G., Lam, R. W., Murray, G., Phelps, J., Sit, D., Swartz, H. A., Crowe, M., et al. (2019) · Bipolar Disorders · doi:10.1111/bdi.12847 · Cited by 196 · see citing works
Role of CYP1B1 in Glaucoma
Vasiliou, V., & Gonzalez, F. J. (2007) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.48.061807.154729 · Cited by 193 · see citing works
Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair
Fischer, T. W., Slominski, A. T., Zmijewski, M. A., Reiter, R. J., & Paus, R. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00767.x · Cited by 187 · see citing works
The role of environmental light in sleep and health: Effects of ocular aging and cataract surgery
Turner, P. L., Someren, E. J. W. V., & Mainster, M. A. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.11.002 · Cited by 187 · see citing works
Melatonin in macrophage biology: Current understanding and future perspectives
Xia, Y., Chen, S., Zeng, S., Zhao, Y., Zhu, C., Deng, B., Zhu, G., Yin, Y., Wang, W., Hardeland, R., et al. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12547 · Cited by 188 · see citing works
Self-citation
Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part
Talaz, O., Gülçın, İ., Göksu, S., & Saraçoğlu, N. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.07.077 · Cited by 180 · see citing works
Circadian Rhythms and Hormonal Homeostasis: Pathophysiological Implications
Gnocchi, D., & Bruscalupi, G. (2017) · Biology · doi:10.3390/biology6010010 · Cited by 184 · see citing works
Role of the Melatonin System in the Control of Sleep
Pandi-Perumal, S. R., Srinivasan, V., Spence, D. W., & Cardinali, D. P. (2007) · CNS Drugs · doi:10.2165/00023210-200721120-00004 · Cited by 178 · see citing works
Self-citation
Melatonin in Medicinal and Food Plants: Occurrence, Bioavailability, and Health Potential for Humans
Salehi, B., Sharopov, F. S., Fokou, P. V. T., Kobylińska, A., de Jonge, L., Tadio, K., Sharifi‐Rad, J., Posmyk, M. M., Martorell, M., Martins, N. A., et al. (2019) · Cells · doi:10.3390/cells8070681 · Cited by 189 · see citing works
MT1 and MT2 Melatonin Receptors: Ligands, Models, Oligomers, and Therapeutic Potential
Zlotos, D. P., Jockers, R., Cecon, E., Rivara, S., & Witt‐Enderby, P. A. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm401343c · Cited by 178 · see citing works
Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements
Minich, D. M., Henning, M., Darley, C., Fahoum, M., Schuler, C. B., & Frame, J. (2022) · Nutrients · doi:10.3390/nu14193934 · Cited by 176 · see citing works
“Production gradually declines as people age, starting in the late twenties to the fifties, with production leveling at approximately 30 pg/mL [4,11] (see Figure 1).”
BackgroundInfluential
Urban-like night illumination reduces melatonin release in European blackbirds (Turdus merula): implications of city life for biological time-keeping of songbirds
Dominoni, D. M., Goymann, W., Helm, B., & Partecke, J. (2013) · Frontiers in Zoology · doi:10.1186/1742-9994-10-60 · Cited by 177 · see citing works
Neurobiology, Pathophysiology, and Treatment of Melatonin Deficiency and Dysfunction
Hardeland, R. (2012) · The Scientific World Journal · doi:10.1100/2012/640389 · Cited by 173 · see citing works
Self-citation
Dim light at night provokes depression-like behaviors and reduces CA1 dendritic spine density in female hamsters
Bedrosian, T. A., Fonken, L. K., Walton, J. C., Haim, A., & Nelson, R. J. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.01.004 · Cited by 167 · see citing works
Melatonin Attenuates Potato Late Blight by Disrupting Cell Growth, Stress Tolerance, Fungicide Susceptibility and Homeostasis of Gene Expression in Phytophthora infestans
Zhang, S., Zheng, X., Reiter, R. J., Feng, S., Wang, Y., Liu, S., Liang, J. H., Li, Z., Datla, R. S. S., & Ren, M. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01993 · Cited by 167 · see citing works
Genetics of circadian rhythms and mood spectrum disorders
Étain, B., Milhiet, V., Bellivier, F., & Leboyer, M. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.07.007 · Cited by 162 · see citing works
Melatonin protects from the long‐term consequences of a neonatal hypoxic‐ischemic brain injury in rats
Carloni, S., Perrone, S., Buonocore, G., Longini, M., Proietti, F., & Balduini, W. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00503.x · Cited by 161 · see citing works
Melatonin and Melatonergic Drugs on Sleep: Possible Mechanisms of Action
Srinivasan, V., Pandi-Perumal, S. R., Trahkt, I., Spence, D. W., Pöeggeler, B., Hardeland, R., & Cardinali, D. P. (2009) · International Journal of Neuroscience · doi:10.1080/00207450802328607 · Cited by 160 · see citing works
Self-citation
Tacrine–Melatonin Hybrids as Multifunctional Agents for Alzheimer's Disease, with Cholinergic, Antioxidant, and Neuroprotective Properties
Fernández‐Bachiller, M. I., Pérez, C., Campillo, N. E., Paez, J. A., González-Muñoz, G. C., Usán, P., García‐Palomero, E., López, M. G., Villarroya, M., Garcı́a, A. G., et al. (2009) · ChemMedChem · doi:10.1002/cmdc.200800414 · Cited by 160 · see citing works
New perspectives in melatonin uses
Carpentieri, A. R., de Barboza, G. D., Areco, V. A., López, M. P., & de Talamoni, N. T. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.01.003 · Cited by 158 · see citing works
New targets for rapid antidepressant action
Machado‐Vieira, R., Henter, I. D., & Zarate, C. A. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.12.001 · Cited by 156 · see citing works
Environmental effects on asexual reproduction rates of the scyphozoan Aurelia labiata
Purcell, J. (2007) · Marine Ecology Progress Series · doi:10.3354/meps07056 · Cited by 153 · see citing works
Melatonin in fruit production and postharvest preservation: A review
Wang, S., Shi, X., Wang, R., Wang, H., Liu, F., & Laborda, P. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.126642 · Cited by 151 · see citing works
Antioxidant Activities of Synthetic Indole Derivatives and Possible Activity Mechanisms
Süzen, S. (2007) · Springer eBooks · doi:10.1007/7081_2007_074 · Cited by 151 · see citing works
Chronic melatonin consumption prevents obesity‐related metabolic abnormalities and protects the heart against myocardial ischemia and reperfusion injury in a prediabetic model of diet‐induced obesity
Nduhirabandi, F., Toit, E. F. D., Blackhurst, D., MARAIS, D. P., & Lochner, A. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00826.x · Cited by 144 · see citing works
Associations between Melatonin, Neuroinflammation, and Brain Alterations in Depression
Won, E., Na, K., & Kim, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010305 · Cited by 146 · see citing works
Melatonin induces apoptotic death in LNCaP cells via p38 and JNK pathways: therapeutic implications for prostate cancer
Joo, S. S., & Yoo, Y. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00682.x · Cited by 141 · see citing works
Melatonin increases cleavage rate of porcine preimplantation embryos in vitro
Rodríguez‐Osorio, N., Kim, I. J., Wang, H., Kaya, A., & Memili, E. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00475.x · Cited by 141 · see citing works
Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Depression
Salgado‐Delgado, R., Osorio, A. T., Saderi, N., & Escobar, C. (2011) · Depression Research and Treatment · doi:10.1155/2011/839743 · Cited by 144 · see citing works
The role of mitochondria in mood disorders: from physiology to pathophysiology and to treatment
Giménez-Palomo, A., Dodd, S., Anmella, G., Carvalho, A. F., Scaini, G., Quevedo, J., Pacchiarotti, I., Vieta, E., & Berk, M. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.546801 · Cited by 140 · see citing works
Antidepressant-like effects of melatonin in the mouse chronic mild stress model
Detanico, B. C., Piato, Â., de Freitas, J. J., Lhullier, F. L. R., Hidalgo, M. P. L., Caumo, W., & Elisabetsky, E. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.02.037 · Cited by 139 · see citing works
Melatonin Metabolism in the Central Nervous System
Hardeland, R. (2010) · Current Neuropharmacology · doi:10.2174/157015910792246164 · Cited by 138 · see citing works
Self-citation
Fielding a current idea: exploring the public health impact of electromagnetic radiation
Genuis, S. J. (2007) · Public Health · doi:10.1016/j.puhe.2007.04.008 · Cited by 137 · see citing works
A role for the circadian genes in drug addiction
Falcón, E., & McClung, C. A. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.054 · Cited by 135 · see citing works
Melatonin in Children with Autism Spectrum Disorders: Endogenous and Pharmacokinetic Profiles in Relation to Sleep
Goldman, S. E., Adkins, K. W., Calcutt, M. W., Carter, M. D., Goodpaster, R. L., Wang, L., Shi, Y., Burgess, H. J., Hachey, D. L., & Malow, B. A. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-014-2123-9 · Cited by 133 · see citing works
Melatonin controlled apoptosis and protected the testes and sperm quality against bisphenol A-induced oxidative toxicity
Othman, A. I., Edrees, G., El-Missiry, M. A., Ali, D. A., Abouel-Nour, M. F., & Dabdoub, B. R. (2014) · Toxicology and Industrial Health · doi:10.1177/0748233714561286 · Cited by 132 · see citing works
Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs
Srinivasan, V., Singh, J., Pandi-Perumal, S. R., Brown, G. M., Spence, D. W., & Cardinali, D. P. (2010) · Advances in Therapy · doi:10.1007/s12325-010-0065-y · Cited by 129 · see citing works
Self-citation
Biological rhythms and chronotherapeutics in depression
Geoffroy, P. A., & Palagini, L. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110158 · Cited by 127 · see citing works
Melatonin the "light of night" in human biology and adolescent idiopathic scoliosis
Grivas, T. B., & Savvidou, O. D. (2007) · Scoliosis · doi:10.1186/1748-7161-2-6 · Cited by 126 · see citing works
Stress and Its Effects on Glucose Metabolism and 11-HSD Activities in Rats Fed on a Combination of High-Fat and High-Sucrose Diet with Glycyrrhizic Acid
Fernando, H. A., Chin, H.-F., Ton, S. H., & Kadir, K. A. (2013) · Journal of Diabetes Research · doi:10.1155/2013/190395 · Cited by 125 · see citing works
Age-related changes in melatonin synthesis in rat extrapineal tissues
Sánchéz‐Hidalgo, M., Alarcón‐de‐la‐Lastra, C., Carrascosa-Salmoral, M. P., Naranjo, M. C., Gómez-Corvera, A., Caballero, B., & Guerrero, J. M. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.02.002 · Cited by 125 · see citing works
Antioxidant Properties of Melatonin and its Potential Action in Diseases
Karaaslan, Ç., & Süzen, S. (2015) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666150220120946 · Cited by 125 · see citing works
Melatonin in Antinociception: Its Therapeutic Applications
Srinivasan, V., Lauterbach, E. C., Ho, K. Y., Acuña-Castroviejo, D., Zakaria, R., & Brzezinski, A. (2012) · Current Neuropharmacology · doi:10.2174/157015912800604489 · Cited by 123 · see citing works
Self-citation
Evidence for the Benefits of Melatonin in Cardiovascular Disease
Tobeiha, M., Jafari, A., Fadaei, S., Mirazimi, S. M. A., Dashti, F., Amiri, A., Khan, H. Z., Asemi, Z., Reiter, R. J., Hamblin, M. R., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.888319 · Cited by 126 · see citing works
Melatonin and breast cancer: Evidences from preclinical and human studies
Kubatka, P., Žúbor, P., Büsselberg, D., Kwon, T. K., Adamek, M., Petrovič, D., Opatřilová, R., Gazdíková, K., Čaprnda, M., Rodrigo, L., et al. (2017) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.12.018 · Cited by 122 · see citing works
Positive Effect of Daylight Exposure on Nocturnal Urinary Melatonin Excretion in the Elderly: A Cross-Sectional Analysis of the HEIJO-KYO Study
Obayashi, K., Saeki, K., Iwamoto, J., Okamoto, N., Tomioka, K., Nezu, S., Ikada, Y., & Kurumatani, N. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1873 · Cited by 120 · see citing works
Melatonin attenuates antipsychotic metabolic effects: an eight‐week randomized, double‐blind, parallel‐group, placebo‐controlled clinical trial
Romo‐Nava, F., Álvarez-Icaza, D., Fresán, A., Saracco-Álvarez, R. A., Becerra‐Palars, C., Moreno, J., Uribe, M. P. O., Berlanga, C., Heinze, G., & Buijs, R. M. (2014) · Bipolar Disorders · doi:10.1111/bdi.12196 · Cited by 119 · see citing works
Agomelatine: A novel mechanism of antidepressant action involving the melatonergic and the serotonergic system
San, L., & Arranz, B. (2008) · European Psychiatry · doi:10.1016/j.eurpsy.2008.04.002 · Cited by 117 · see citing works
Plasma melatonin is reduced in Huntington's disease
Kalliolia, E., Silajdžić, E., Nambron, R., Hill, N. R., Doshi, A., Frost, C. D., Watt, H., Hindmarsh, P. C., Björkqvist, M., & Warner, T. T. (2014) · Movement Disorders · doi:10.1002/mds.26003 · Cited by 118 · see citing works
Melatonin and the metabolic syndrome: a tool for effective therapy in obesity‐associated abnormalities?
Nduhirabandi, F., Toit, E. F. D., & Lochner, A. (2012) · Acta Physiologica · doi:10.1111/j.1748-1716.2012.02410.x · Cited by 116 · see citing works
Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism
Gnocchi, D., Pedrelli, M., Hurt-Camejo, E., & Parini, P. (2015) · Biology · doi:10.3390/biology4010104 · Cited by 115 · see citing works
Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis
Morvaridzadeh, M., Sadeghi, E., Agah, S., Nachvak, S. M., Fazelian, S., Moradi, F., Persad, E., & Heshmati, J. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105210 · Cited by 115 · see citing works
Melatonin in Arabidopsis thaliana acts as plant growth regulator at low concentrations and preserves seed viability at high concentrations
Hernández, I. G., Gómez, F. J. V., Cerutti, S. E., Arana, M. V., & Silva, M. F. (2015) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2015.06.011 · Cited by 115 · see citing works
Therapeutic potential of melatonin and its analogs in Parkinson’s disease: focus on sleep and neuroprotection
Srinivasan, V., Cardinali, D. P., Srinivasan, U. S., Kaur, C., Brown, G. M., Spence, D. W., Hardeland, R., & Pandi-Perumal, S. R. (2011) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285611406166 · Cited by 113 · see citing works
Self-citation
Placental melatonin system is present throughout pregnancy and regulates villous trophoblast differentiation
Soliman, A., Lacasse, A., Lanoix, D., Sagrillo‐Fagundes, L., Boulard, V., & Vaillancourt, C. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12236 · Cited by 114 · see citing works
The Melatonin Conformer Space: Benchmark and Assessment of Wave Function and DFT Methods for a Paradigmatic Biological and Pharmacological Molecule
Fogueri, U. R., Kozuch, S., Karton, A., & Martin, J. M. L. (2013) · The Journal of Physical Chemistry A · doi:10.1021/jp312644t · Cited by 113 · see citing works
Melatonin and human reproduction: Shedding light on the darkness hormone
Srinivasan, V., Spence, W., Pandi-Perumal, S. R., Zakharia, R., Bhatnagar, K. P., & Brzezinski, A. (2009) · Gynecological Endocrinology · doi:10.3109/09513590903159649 · Cited by 114 · see citing works
Self-citation
Melatonin, Immune Function and Cancer
Srinivasan, V., Pandi-Perumal, S. R., Brzezinski, A., Bhatnagar, K. P., & Cardinali, D. P. (2011) · Recent Patents on Endocrine Metabolic & Immune Drug Discovery · doi:10.2174/187221411799015408 · Cited by 109 · see citing works
Self-citation
HPLC‐F analysis of melatonin and resveratrol isomers in wine using an SPE procedure
Mercolini, L., Saracino, M. A., Bugamelli, F., Ferranti, A., Malaguti, M., Hrelia, S., & Raggi, M. A. (2008) · Journal of Separation Science · doi:10.1002/jssc.200700458 · Cited by 108 · see citing works
Reciprocal interactions between sleep, circadian rhythms and Alzheimer's disease: Focus on the role of hypocretin and melatonin
Slats, D., Claassen, J. A. H. R., Verbeek, M. M., & Overeem, S. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.04.003 · Cited by 109 · see citing works

Authors: Pandi‐Perumal, S. R., Srinivasan, V., Maestroni, G. J. M., Cardinali, D. P., Poeggeler, B., & Hardeland, R.
Affiliations: Universiti Sains Malaysia (MY)
Istituto Cantonale di Patologia (CH)
Universidad de Buenos Aires (AR)
University of Göttingen (DE)
ORCID: Cardinali, D. P.
Hardeland, R.
Venue: The FEBS Journal
Publisher: Wiley
Published: 2006-06-15
Volume: 273
Issue: 13
Pages: 2813-2838
ISSN: 1742-464X (ISSN-L)
1742-4658
DOI: 10.1111/j.1742-4658.2006.05322.x
OpenAlex: W2049985521
Cited by: 875
References: 293
Citations by year: 2026: 15 · 2025: 29 · 2024: 33 · 2023: 33 · 2022: 42 · 2021: 56 · 2020: 47 · 2019: 49 · 2018: 42 · 2017: 45 · 2016: 34 · 2015: 38 · 2014: 53 · 2013: 53 · 2012: 51
FWCI: 5.54
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: FEBS Journal (publishedVersion)
PubMed (publishedVersion)
GRO (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
Keywords: melatonin, pineal gland, suprachiasmatic nucleus, circadian rhythm, sleep regulation, antioxidant activity, anti-apoptotic signaling, neuroprotection, neurodegenerative diseases, immunomodulation, circadian rhythm sleep disorders, jet lag, shift work disorder, insomnia, agomelatine, photoperiodism, seasonal reproduction, melatonin analogues
MeSH terms: Animals, Antioxidants, Chronobiology Phenomena, Depression, Humans, Melatonin, Models, Chemical, Plant Proteins, Sleep, Signal Transduction, Free Radical Scavengers, Apoptosis, Receptors, Melatonin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Melatonin: Nature’s most versatile biological signal?

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks