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Cited by 244Pharmaceutical Practices and Patient OutcomesPharmaceutical studies and practicesNutrition and Health in Aging

The DOI matches its Crossref record; 239 of the 241 references it cites were found in a registry or an index.

The clinical implications of ageing for rational drug therapy

Shi, Shaojun, Mörike, Klaus, Klotz, Ulrich·2008·European Journal of Clinical Pharmacology
DOI 10.1007/s00228-007-0422-1
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Abstract

Introduction The proportion of the elderly is constantly increasing and by the year 2025 20% of the population will be above 65 years of age. With advanced age, subjects will develop multiple diseases and often need to take several drugs.Discussion This polypharmacy increases the risk for drug interactions and adverse effects. In addition, age-related physiological changes affect different biological systems and can contribute to alterations in pharmacokinetics and pharmacodynamics in older patients, which are more often seen in the frail than in the fit elderly. These features will complicate drug therapy in the elderly, and a careful dose titration is advisable. Furthermore, inappropriate drug prescription and non-adherence to medication represent common therapeutic challenges in elderly subjects. To date, there is no evidence of any effective antiageing agent.Conclusion This review summarizes present knowledge of age-related problems in drug action and their clinical implications for an increasingly important population.

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Crossref · 10.1007/s00228-007-0422-1

Cites

239 of 239 references verified0 citation errors · 0 not checkable

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2 of the 241 references couldn’t be matched to a known paper.

Research works printed but not linked: 4

  1. Kennerfalk A, Ruigómez A, Wallander MA, Wilhelmsen L, Johansson S (2002) Geriatric drug therapy and healthcare utilization in the United Kingdom. Ann Pharmacother 36:797–803 · DOI · Paper page
  2. Doucet J, Queneau P (2005) Adverse drug reactions in the elderly. Bull Acad Natl Med 189:1693–1707; discussion 1708–1709
  3. Björkman IK, Fastbom J, Schmidt IK, Bernsten CB; Pharmaceutical Care of the Elderly in Europe Research (PEER) Group (2002) Drug-drug interactions in the elderly. Ann Pharmacother 36:1675–1681 · DOI · Paper page
  4. González-Juanatey JR, Rivera J, Gabriel Sánchez R, Reviriego Almohalla B, Casimiro C (2006) Effects of NSAID on blood pressure among hypertensive patients with a high cardiovascular risk. An Med Intern 23:420–427

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Metadata

Authors
Shi, S., Mörike, K., & Klotz, U.
Affiliations
  • Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (DE)
  • University of Tübingen (DE)
Corresponding author
Klotz, Ulrich
ORCID
Klotz, Ulrich
Venue
European Journal of Clinical Pharmacology
Publisher
Springer Science and Business Media LLC
Published
2008-01-05
Volume
64
Issue
2
Pages
183-199
ISSN
  • 0031-6970 (ISSN-L)
  • 1432-1041
DOI
10.1007/s00228-007-0422-1
OpenAlex
W2027764308
Cited by
244
References
241
Citations by year
2026: 6 · 2025: 5 · 2024: 11 · 2023: 9 · 2022: 10 · 2021: 13 · 2020: 14 · 2019: 15 · 2018: 14 · 2017: 12 · 2016: 15 · 2015: 23 · 2014: 15 · 2013: 21 · 2012: 18
FWCI
1.20
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • European Journal of Clinical Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Robert Bosch Stiftung
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Keywords
aging, older adults, polypharmacy, drug interactions, adverse drug reactions, age-related physiological changes, pharmacokinetics, pharmacodynamics, frail elderly, dose titration, inappropriate prescribing, medication non-adherence
MeSH terms
Aged, Aging, Drug Therapy, Humans, Pharmacokinetics, Practice Patterns, Physicians', Risk Factors, Comorbidity, Treatment Refusal, Frail Elderly, Polypharmacy, Drug-Related Side Effects and Adverse Reactions

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