The DOI matches its Crossref record; 239 of the 241 references it cites were found in a registry or an index.
The clinical implications of ageing for rational drug therapy
Abstract
Introduction The proportion of the elderly is constantly increasing and by the year 2025 20% of the population will be above 65 years of age. With advanced age, subjects will develop multiple diseases and often need to take several drugs.Discussion This polypharmacy increases the risk for drug interactions and adverse effects. In addition, age-related physiological changes affect different biological systems and can contribute to alterations in pharmacokinetics and pharmacodynamics in older patients, which are more often seen in the frail than in the fit elderly. These features will complicate drug therapy in the elderly, and a careful dose titration is advisable. Furthermore, inappropriate drug prescription and non-adherence to medication represent common therapeutic challenges in elderly subjects. To date, there is no evidence of any effective antiageing agent.Conclusion This review summarizes present knowledge of age-related problems in drug action and their clinical implications for an increasingly important population.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Older adults show greater sensitivity to drugs acting upon the central nervous system and their side effects [11, 12].”
From Stakeholders' views on the use of psychotropic medication in older people: a systematic review (2022) · cites this paper as [11]
Citations
Cites
1 retracted
Interventions for promoting adherence to tuberculosis management
Volmink, J. A., & Garner, P. (2000) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000010 · Cited by 54
RetractedOxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
Osterberg, L., & Blaschke, T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050100 · Cited by 7,974
Fried, L. P., Ferrucci, L., Darer, J., Williamson, J. D., & Anderson, G. (2004) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/59.3.m255 · Cited by 4,032
Kirk, J. M. W., MacDonald, A., Lavender, P., Dean, J. M., & Rubin, G. (2017) · Biomedicine Hub · doi:10.1159/000480347 · Cited by 3,902
Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients
Pirmohamed, M., James, S., Meakin, S., Green, C. A., SCOTT, A. K., Walley, T. J., Farrar, K., Park, B. K., & Breckenridge, A. M. (2004) · BMJ · doi:10.1136/bmj.329.7456.15 · Cited by 3,236
Shimada, T., Yamazaki, H., Mimura, M., Inui, Y., & Guengerich, F. P. (1994) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22379-5 · Cited by 2,785
Fick, D. M., Cooper, J. W., Wade, W. E., Waller, J. L., Maclean, J. R., & Beers, M. H. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.22.2716 · Cited by 2,389
Prevalence, Expenditures, and Complications of Multiple Chronic Conditions in the Elderly
Wolff, J. L., Starfield, B. H., & Anderson, G. F. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.20.2269 · Cited by 2,237
Liu, Y., Zhou, Z., Chen, K.-L., Zhou, B., Yang, L., Yan, H., & Li, Y. (2012) · Hepatogastroenterology · doi:10.5754/hge12281 · Cited by 2,097
Research works printed but not linked: 4
- Kennerfalk A, Ruigómez A, Wallander MA, Wilhelmsen L, Johansson S (2002) Geriatric drug therapy and healthcare utilization in the United Kingdom. Ann Pharmacother 36:797–803 · DOI · Paper page
- Doucet J, Queneau P (2005) Adverse drug reactions in the elderly. Bull Acad Natl Med 189:1693–1707; discussion 1708–1709
- Björkman IK, Fastbom J, Schmidt IK, Bernsten CB; Pharmaceutical Care of the Elderly in Europe Research (PEER) Group (2002) Drug-drug interactions in the elderly. Ann Pharmacother 36:1675–1681 · DOI · Paper page
- González-Juanatey JR, Rivera J, Gabriel Sánchez R, Reviriego Almohalla B, Casimiro C (2006) Effects of NSAID on blood pressure among hypertensive patients with a high cardiovascular risk. An Med Intern 23:420–427
Cited by
Sorted by citations
Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations
Fisher, M., Feuerstein, G., Howells, D. W., Hurn, P. D., Kent, T. A., Savitz, S. I., & Lo, E. H. (2009) · Stroke · doi:10.1161/strokeaha.108.541128 · Cited by 1,352
Pharmacokinetics and drug metabolism in the elderly
Klotz, U. (2009) · Drug Metabolism Reviews · doi:10.1080/03602530902722679 · Cited by 826
Self-citationPotentially Inappropriate Medications in the Elderly
Holt-Noreiks, S., Schmiedl, S., & Thürmann, P. (2010) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2010.0543 · Cited by 795
Age-Related Pharmacokinetic and Pharmacodynamic Changes and Related Risk of Adverse Drug Reactions
Corsonello, A., Pedone, C., & Incalzi, R. A. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710790416326 · Cited by 402
The epidemiology of polypharmacy in older adults: register-based prospective cohort study
Morin, L., Johnell, K., Laroche, M., Fastbom, J., & Wastesson, J. W. (2018) · Clinical Epidemiology · doi:10.2147/clep.s153458 · Cited by 390
Metadata
- Authors
- Shi, S., Mörike, K., & Klotz, U.
- Affiliations
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (DE)
- University of Tübingen (DE)
- Corresponding author
- Klotz, Ulrich
- ORCID
- Klotz, Ulrich
- Venue
- European Journal of Clinical Pharmacology
- Published
- 2008-01-05
- Volume
- 64
- Issue
- 2
- Pages
- 183-199
- ISSN
- 0031-6970 (ISSN-L)
- 1432-1041
- OpenAlex
- W2027764308
- Cited by
- 244
- References
- 241
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 11 · 2023: 9 · 2022: 10 · 2021: 13 · 2020: 14 · 2019: 15 · 2018: 14 · 2017: 12 · 2016: 15 · 2015: 23 · 2014: 15 · 2013: 21 · 2012: 18
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Clinical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Robert Bosch Stiftung
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- aging, older adults, polypharmacy, drug interactions, adverse drug reactions, age-related physiological changes, pharmacokinetics, pharmacodynamics, frail elderly, dose titration, inappropriate prescribing, medication non-adherence
- MeSH terms
- Aged, Aging, Drug Therapy, Humans, Pharmacokinetics, Practice Patterns, Physicians', Risk Factors, Comorbidity, Treatment Refusal, Frail Elderly, Polypharmacy, Drug-Related Side Effects and Adverse Reactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
