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The clinical implications of ageing for rational drug therapy
Abstract
Introduction The proportion of the elderly is constantly increasing and by the year 2025 20% of the population will be above 65 years of age. With advanced age, subjects will develop multiple diseases and often need to take several drugs.Discussion This polypharmacy increases the risk for drug interactions and adverse effects. In addition, age-related physiological changes affect different biological systems and can contribute to alterations in pharmacokinetics and pharmacodynamics in older patients, which are more often seen in the frail than in the fit elderly. These features will complicate drug therapy in the elderly, and a careful dose titration is advisable. Furthermore, inappropriate drug prescription and non-adherence to medication represent common therapeutic challenges in elderly subjects. To date, there is no evidence of any effective antiageing agent.Conclusion This review summarizes present knowledge of age-related problems in drug action and their clinical implications for an increasingly important population.
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“Older adults show greater sensitivity to drugs acting upon the central nervous system and their side effects [11, 12].”
From Stakeholders' views on the use of psychotropic medication in older people: a systematic review (2022) · cites this paper as [11]
Citations
Cites
1 retracted
Interventions for promoting adherence to tuberculosis management
Volmink, J. A., & Garner, P. (2000) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000010 · Cited by 54
RetractedOxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
Osterberg, L., & Blaschke, T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050100 · Cited by 7,974
Fried, L. P., Ferrucci, L., Darer, J., Williamson, J. D., & Anderson, G. (2004) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/59.3.m255 · Cited by 4,032
Kirk, J. M. W., MacDonald, A., Lavender, P., Dean, J. M., & Rubin, G. (2017) · Biomedicine Hub · doi:10.1159/000480347 · Cited by 3,902
Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients
Pirmohamed, M., James, S., Meakin, S., Green, C. A., SCOTT, A. K., Walley, T. J., Farrar, K., Park, B. K., & Breckenridge, A. M. (2004) · BMJ · doi:10.1136/bmj.329.7456.15 · Cited by 3,236
Shimada, T., Yamazaki, H., Mimura, M., Inui, Y., & Guengerich, F. P. (1994) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22379-5 · Cited by 2,785
Fick, D. M., Cooper, J. W., Wade, W. E., Waller, J. L., Maclean, J. R., & Beers, M. H. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.22.2716 · Cited by 2,389
Prevalence, Expenditures, and Complications of Multiple Chronic Conditions in the Elderly
Wolff, J. L., Starfield, B. H., & Anderson, G. F. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.20.2269 · Cited by 2,237
Liu, Y., Zhou, Z., Chen, K.-L., Zhou, B., Yang, L., Yan, H., & Li, Y. (2012) · Hepatogastroenterology · doi:10.5754/hge12281 · Cited by 2,097
Research works printed but not linked: 4
- Kennerfalk A, Ruigómez A, Wallander MA, Wilhelmsen L, Johansson S (2002) Geriatric drug therapy and healthcare utilization in the United Kingdom. Ann Pharmacother 36:797–803 · DOI · Paper page
- Doucet J, Queneau P (2005) Adverse drug reactions in the elderly. Bull Acad Natl Med 189:1693–1707; discussion 1708–1709
- Björkman IK, Fastbom J, Schmidt IK, Bernsten CB; Pharmaceutical Care of the Elderly in Europe Research (PEER) Group (2002) Drug-drug interactions in the elderly. Ann Pharmacother 36:1675–1681 · DOI · Paper page
- González-Juanatey JR, Rivera J, Gabriel Sánchez R, Reviriego Almohalla B, Casimiro C (2006) Effects of NSAID on blood pressure among hypertensive patients with a high cardiovascular risk. An Med Intern 23:420–427
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“Drug interactions are more likely with each drug taken [58] and are more likely to be harmful in older patients [59].”
BackgroundHerr, M., Robine, J., Pinot, J., Arvieu, J., & Ankri, J. (2015) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3772 · Cited by 216
Dimitrow, M. S., Airaksinen, M. S. A., Kivelä, S., Lyles, A., & Leikola, S. N. S. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03497.x · Cited by 203
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Sera, L., & McPherson, M. L. (2012) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2012.01.007 · Cited by 166
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Gnjidic, D., Cumming, R. G., Couteur, D. G. L., Handelsman, D. J., Naganathan, V., Abernethy, D. R., & Hilmer, S. N. (2009) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2009.03411.x · Cited by 166
Review on Pharmacokinetics and Pharmacodynamics and the Aging Kidney
Aymanns, C., Keller, F., Maus, S., Hartmann, B., & Czock, D. (2010) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03960609 · Cited by 159
Nymberg, V. M., Rekman, E., Bondesson, Å., Eriksson, T., Jakobsson, U., Westerlund, T., & Midlöv, P. (2013) · Drugs & Aging · doi:10.1007/s40266-013-0057-0 · Cited by 153
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Shi, S., & Klotz, U. E. (2012) · Clinical Pharmacokinetics · doi:10.2165/11597910-000000000-00000 · Cited by 147
Self-citationChiatti, C., Bustacchini, S., Furneri, G., Mantovani, L. G., Cristiani, M., Misuraca, C., & Lattanzio, F. (2012) · Drug Safety · doi:10.1007/bf03319105 · Cited by 143
Psychotropic drugs and the risk of fall injuries, hospitalisations and mortality among older adults
Johnell, K., Jonasdottir Bergman, G., Fastbom, J., Danielsson, B., Borg, N., & Salmi, P. (2017) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4483 · Cited by 130
Underprescription of Beneficial Medicines in Older People
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Cornu, P., Steurbaut, S., Leysen, T., Baere, E. D., Ligneel, C., Mets, T. F., & Dupont, A. G. (2012) · Annals of Pharmacotherapy · doi:10.1345/aph.1q594 · Cited by 119
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Reeve, E., Wiese, M. D., & Mangoni, A. A. (2015) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2015.1004310 · Cited by 124
Pedrós, C., Formiga, F., Corbella, X., & Arnau, J. M. (2015) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-015-1974-0 · Cited by 112
Steurbaut, S., Leemans, L., Leysen, T., Baere, E. D., Cornu, P., Mets, T. F., & Dupont, A. G. (2010) · Annals of Pharmacotherapy · doi:10.1345/aph.1p192 · Cited by 108
Novaes, P. H., da Cruz, D. T., Lucchetti, A. L. G., Leite, I. C. G., & Lucchetti, G. (2017) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-017-0470-2 · Cited by 97
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Maanen, A. C. D., van Marum, R. J., Knol, W., van der Linden, C. M. J., & Jansen, P. A. F. (2009) · Drugs & Aging · doi:10.2165/11316400-000000000-00000 · Cited by 97
Sköldunger, A., Fastbom, J., Wimo, A. B., Fratiglioni, L., & Johnell, K. (2015) · Drugs & Aging · doi:10.1007/s40266-015-0287-4 · Cited by 91
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Meulendijk, M. C., Spruit, M. R., Maanen, A. C. D., Numans, M. E., Brinkkemper, S., Jansen, P. A. F., & Knol, W. (2015) · Drugs & Aging · doi:10.1007/s40266-015-0270-0 · Cited by 84
Maio, V., Canale, S. D., Abouzaid, S., & GAP Investigators (2009) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.2009.01094.x · Cited by 82
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Gallelli, L., Colosimo, M., Tolotta, G. A., Falcone, D., Luberto, L., Curto, L. S., Rende, P., Mazzei, F. A., Marigliano, N. M., Sarro, G. D., et al. (2009) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-009-0751-3 · Cited by 58
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Goh, C. W., Aw, C. C., Lee, J. H., Chen, C., & Browne, E. R. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.035964 · Cited by 53
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Tajiri, N., Dailey, T., Metcalf, C., Mosley, Y. I., Lau, T., Staples, M., van Loveren, H., Kim, S. U., Yamashima, T., Yasuhara, T., et al. (2013) · Translational Stroke Research · doi:10.1007/s12975-012-0241-2 · Cited by 45
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Jönsson, K. M., Wieloch, M., Sterner, G., Nyman, U., Elmståhl, S., Engström, G., & Svensson, P. J. (2011) · Thrombosis Research · doi:10.1016/j.thromres.2011.04.022 · Cited by 28
Margolese, H. C., Wolf, Y., Desmarais, J. E., & Beauclair, L. (2010) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e328337910b · Cited by 28
Ernst, R., Fischer, K., Molino, C. D. G. R. C., Orav, E., Theiler, R., Meyer, U., Fischler, M., Gagesch, M., Ambühl, P., Freystätter, G., et al. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2019.07.007 · Cited by 23
Lesén, E., Petzold, M., Sundell, K. A., & Carlsten, A. (2009) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-009-0623-x · Cited by 28
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Metadata
- Authors
- Shi, S., Mörike, K., & Klotz, U.
- Affiliations
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (DE)
- University of Tübingen (DE)
- Corresponding author
- Klotz, Ulrich
- ORCID
- Klotz, Ulrich
- Venue
- European Journal of Clinical Pharmacology
- Published
- 2008-01-05
- Volume
- 64
- Issue
- 2
- Pages
- 183-199
- ISSN
- 0031-6970 (ISSN-L)
- 1432-1041
- OpenAlex
- W2027764308
- Cited by
- 244
- References
- 241
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 11 · 2023: 9 · 2022: 10 · 2021: 13 · 2020: 14 · 2019: 15 · 2018: 14 · 2017: 12 · 2016: 15 · 2015: 23 · 2014: 15 · 2013: 21 · 2012: 18
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Clinical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Robert Bosch Stiftung
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- aging, older adults, polypharmacy, drug interactions, adverse drug reactions, age-related physiological changes, pharmacokinetics, pharmacodynamics, frail elderly, dose titration, inappropriate prescribing, medication non-adherence
- MeSH terms
- Aged, Aging, Drug Therapy, Humans, Pharmacokinetics, Practice Patterns, Physicians', Risk Factors, Comorbidity, Treatment Refusal, Frail Elderly, Polypharmacy, Drug-Related Side Effects and Adverse Reactions
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