Cited by 244Pharmaceutical Practices and Patient OutcomesPharmaceutical studies and practicesNutrition and Health in Aging

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The clinical implications of ageing for rational drug therapy

Shi, Shaojun, Mörike, Klaus, Klotz, Ulrich·2008·European Journal of Clinical Pharmacology

DOI 10.1007/s00228-007-0422-1

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Abstract

Introduction The proportion of the elderly is constantly increasing and by the year 2025 20% of the population will be above 65 years of age. With advanced age, subjects will develop multiple diseases and often need to take several drugs.Discussion This polypharmacy increases the risk for drug interactions and adverse effects. In addition, age-related physiological changes affect different biological systems and can contribute to alterations in pharmacokinetics and pharmacodynamics in older patients, which are more often seen in the frail than in the fit elderly. These features will complicate drug therapy in the elderly, and a careful dose titration is advisable. Furthermore, inappropriate drug prescription and non-adherence to medication represent common therapeutic challenges in elderly subjects. To date, there is no evidence of any effective antiageing agent.Conclusion This review summarizes present knowledge of age-related problems in drug action and their clinical implications for an increasingly important population.

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Authors: Shi, S., Mörike, K., & Klotz, U.
Affiliations: Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (DE)
University of Tübingen (DE)
Corresponding author: Klotz, Ulrich
ORCID: Klotz, Ulrich
Venue: European Journal of Clinical Pharmacology
Publisher: Springer Science and Business Media LLC
Published: 2008-01-05
Volume: 64
Issue: 2
Pages: 183-199
ISSN: 0031-6970 (ISSN-L)
1432-1041
DOI: 10.1007/s00228-007-0422-1
OpenAlex: W2027764308
Cited by: 244
References: 241
Citations by year: 2026: 6 · 2025: 5 · 2024: 11 · 2023: 9 · 2022: 10 · 2021: 13 · 2020: 14 · 2019: 15 · 2018: 14 · 2017: 12 · 2016: 15 · 2015: 23 · 2014: 15 · 2013: 21 · 2012: 18
FWCI: 1.20
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: European Journal of Clinical Pharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Robert Bosch Stiftung
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Keywords: aging, older adults, polypharmacy, drug interactions, adverse drug reactions, age-related physiological changes, pharmacokinetics, pharmacodynamics, frail elderly, dose titration, inappropriate prescribing, medication non-adherence
MeSH terms: Aged, Aging, Drug Therapy, Humans, Pharmacokinetics, Practice Patterns, Physicians', Risk Factors, Comorbidity, Treatment Refusal, Frail Elderly, Polypharmacy, Drug-Related Side Effects and Adverse Reactions

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The clinical implications of ageing for rational drug therapy

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