Effects of carvedilol and atenolol on arterial pulse curves (plethysmography) and finger temperature after hand cooling
Abstract
Objective In a double-blind, parallel study, the effects of 25 mg carvedilol and 50 mg atenolol on peripheral finger circulation and arterial pulse curve configuration were compared.Methods Healthy volunteers (n = 17) were examined at baseline and for 15 min after 60 s of hand cooling in ice-water. Finger temperature and digital plethysmography were recorded each minute from the cooled and the control hands. Measurements were also made before and 2 h after drug administration.Results Blood pressure declined from 120/86 to 108/74 mm Hg after atenolol (n = 9), and from 122/88 to 108/73 mm Hg after carvedilol (n = 8). In both groups, baseline finger temperature increased slightly after drug, and a more rapid rise in finger temperature was observed after cooling. There was no group difference in the drug effect on finger temperature, except in the first few minutes after cooling, when temperature recovery was greater after carvedilol. Carvedilol reduced the vasoconstrictor response to local cooling (digital plethysmography), compared both to the value before drug and after atenolol. At rest, carvedilol changed the pulse curves (control hand) towards vasodilatation and high compliance, expressed as a mean change in the relative height of the dicrotic notch of -10.3% versus 0.0% after atenolol.Conclusion Future studies should clarify whether the vasoactive profile of carvedilol may translate into reduced occurrence of cold hands and feet amongst patients treated for hypertension.
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The position of the dicrotic notch in the peripheral blood flow signal, estimated as PAR, reflected the general vascular tone in young adults.
“The position of the dicrotic notch in the peripheral blood flow signal, estimated as PAR, reflected the general vascular tone in young adults (Klemsdal et al. 1996).”
From Oral nitrate and citrulline decrease blood pressure and increase vascular conductance in young adults: a potential therapy for heart failure (2016) · cites this paper as Klemsdal et al. 1996
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- Authors
- Klemsdal, T. O., Mundal, H. H., & Gjesdal, K.
- Affiliations
- Oslo University Hospital (NO)
- Venue
- European Journal of Clinical Pharmacology
- Published
- 1996-07-30
- Volume
- 50
- Issue
- 6
- Pages
- 483-489
- ISSN
- 0031-6970 (ISSN-L)
- 1432-1041
- OpenAlex
- W2067086594
- Cited by
- 10
- References
- 21
- Citations by year
- 2016: 1 · 2012: 1
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Clinical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
- Keywords
- carvedilol, atenolol, beta-blockers, peripheral circulation, finger temperature, hand cooling, digital plethysmography, vasoconstriction, vasodilation, cold hands and feet, hypertension, blood pressure
- MeSH terms
- Carvedilol, Adrenergic beta-Antagonists, Adult, Atenolol, Blood Circulation, Body Temperature, Carbazoles, Fingers, Hemodynamics, Humans, Hypothermia, Male, Plethysmography, Propanolamines
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