Difference in nitroglycerin dose-response in the venous and arterial beds

Imhof, P. R.; Ott, B.; Frankhauser, P.; Chu, L. -C.; Hodler, J.

doi:10.1007/bf00874655

Cited by 160Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionBlood Pressure and Hypertension Studies

Difference in nitroglycerin dose-response in the venous and arterial beds

Imhof, P. R., Ott, B., Frankhauser, P., Chu, L. -C., Hodler, J.·1980·European Journal of Clinical Pharmacology

DOI 10.1007/bf00874655

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Abstract

In twelve healthy volunteers given nitroglycerin sublingually (1.6 mg) or epicutaneously (12 mg), venous distensibility was found to be maximal, even at low plasma concentrations (less than 0.2 ng/ml); there was no further change with increasing concentrations. Peripheral arterial resistance, on the other hand, decreased progressively with rising plasma concentrations and no distinct plateau was demonstrable, even at the highest plasma concentration measured (greater than 2.0 ng/ml).

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Arteriolar and venular components of the cardiovascular system have differing sensitivities to glyceryl trinitrate.
“arteriolar and venular components of the cardiovascular system have differing sensitivities to GTN, with venous distension maximal at very low nitrate concentrations whilst arterial resistance shows lower sensitivities to GTN (Imhof et al. 1980).”
From Oral nitrate and citrulline decrease blood pressure and increase vascular conductance in young adults: a potential therapy for heart failure (2016) · cites this paper as Imhof et al. 1980

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Authors: Imhof, P. R., Ott, B., Frankhauser, P., Chu, L. C., & Hodler, J.
Affiliations: Novartis (Switzerland) (CH)
ORCID: Hodler, J.
Venue: European Journal of Clinical Pharmacology
Publisher: Springer Science and Business Media LLC
Published: 1980
Volume: 18
Issue: 6
Pages: 455-460
ISSN: 0031-6970 (ISSN-L)
1432-1041
DOI: 10.1007/bf00874655
OpenAlex: W2032181779
Cited by: 160
References: 13
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 3 · 2016: 1 · 2014: 4 · 2013: 4 · 2012: 3
FWCI: 4.16
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: European Journal of Clinical Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords: nitroglycerin, dose-response relationship, venous distensibility, peripheral arterial resistance, sublingual administration, plasma drug concentration, vasorelaxation
MeSH terms: Adult, Arteries, Dose-Response Relationship, Drug, Nitroglycerin, Humans, Male, Mathematics, Vascular Resistance, Veins

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Difference in nitroglycerin dose-response in the venous and arterial beds

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