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Cited by 209Ion channel regulation and functionIon Transport and Channel RegulationCardiac electrophysiology and arrhythmias

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Role of Voltage-gated Potassium Channels in Cancer

Pardo, L.A., Contreras-Jurado, C., Zientkowska, M., Alves, F., Stühmer, W.·2005·The Journal of Membrane Biology
DOI 10.1007/s00232-005-0776-1
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Abstract

Ion channels are being associated with a growing number of diseases including cancer. This overview summarizes data on voltage-gated potassium channels (VGKCs) that exhibit oncogenic properties: ether-à-go-go type 1 (Eag1). Normally, Eag1 is expressed almost exclusively in tissue of neural origin, but its ectopic expression leads to uncontrolled proliferation, while inhibition of Eag1 expression produces a concomitant reduction in proliferation. Specific monoclonal antibodies against Eag1 recognize an epitope in over 80% of human tumors of diverse origins, endowing it with diagnostic and therapeutic potential. Eag1 also possesses unique electrophysiological properties that simplify its identification. This is particularly important, as specific blockers of Eag1 currents are not available. Molecular imaging of Eag1 in live tumor models has been accomplished with dye-tagged antibodies using 3-D imaging techniques in the near-infrared spectral range.

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  • Ether à go-go (EAG) K+ channels may serve as biomarkers for cancer.

    “Increasing evidence suggests that Ether à go-go (EAG) K+ channels may serve as biomarkers for cancer (Ouadid-Ahidouch et al., 2001; Farias et al., 2004; Pardo et al., 2005; Hemmerlein et al., 2006; Ousingsawat et al., 2007; Ortiz et al., 2011; Rodriguez-Rasgado et al., 2012).”

    From Membrane potential and cancer progression (2013) · cites this paper as Pardo et al., 2005

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Metadata

Authors
Pardo, L. A., Contreras-Jurado, C., Zientkowska, M., Alves, F., & Stühmer, W.
Affiliations
  • Max Planck Society (DE)
  • Universitätsmedizin Göttingen (DE)
Corresponding author
Pardo, L.A.
ORCID
Venue
The Journal of Membrane Biology
Publisher
Springer Science and Business Media LLC
Published
2005-06
Volume
205
Issue
3
Pages
115-124
ISSN
  • 0022-2631 (ISSN-L)
  • 1432-1424
DOI
10.1007/s00232-005-0776-1
OpenAlex
W2006305093
Cited by
209
References
1
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FWCI
5.54
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The Journal of Membrane Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
voltage-gated potassium channels, Eag1, tumor cell proliferation, monoclonal antibodies, molecular imaging, cancer diagnosis, cancer therapy
MeSH terms
Animals, Humans, Membrane Potentials, Neoplasms, Potassium Channels, Voltage-Gated, Potassium Channel Blockers, Cell Size, Cell Proliferation, Ether-A-Go-Go Potassium Channels

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