11C-Metomidate PET imaging of adrenocortical cancer
Abstract
The diagnostic potential of positron emission tomography (PET) with carbon-11 metomidate in patients with adrenocortical cancer (ACC) was evaluated. Thirteen PET examinations were performed in 11 patients with CT-detected primary tumours or recurrence and/or metastases from a previously histopathologically proven ACC. The findings at PET were compared with those at CT and verified by histopathology. Six studies (group A) were performed in patients who at the time of imaging were free of medication that could interfere with 11beta-hydroxylase activity and thereby tracer uptake at PET, such as adrenal steroid inhibitors or chemotherapy. The remaining seven studies (group B) were carried out in patients who were monitored during treatment with one or a combination of these drugs. PET visualised all viable tumours with high tracer uptake, and revealed two more lesions than were seen on CT. Three necrotic tumours were detected as false negative observations, as confirmed at surgery and histopathological examination. A true negative observation was obtained at PET in the case of a suspected liver metastasis on CT that was found to have fat vacuolation at histopathological examination of an ultrasonically guided core biopsy specimen. Group A showed apparently higher uptake in normal tissues than group B (adrenal, P=0.03; liver, P=0.01). The metomidate uptake was increased in tumour lesions as compared with normal tissues (adrenal, P=0.02; liver, P=0.005). ACC could be clearly visualised with (11)C-metomidate PET except when the tumour was necrotic. Medication with adrenal steroid inhibitors and chemotherapy decreased the tracer uptake.
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[11C]MTO PET cannot distinguish benign from malignant adrenocortical lesions.
“It cannot, however, distinguish benign from malignant adrenocortical lesions.”
From Adrenocortical carcinoma (2014) · cites this paper as [113]
[11C]MTO PET can distinguish tumors of adrenocortical origin from noncortical lesions.
“[11C]MTO PET can distinguish tumors of adrenocortical origin from noncortical lesions (113).”
From Adrenocortical carcinoma (2014) · cites this paper as [113]
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- Authors
- Khan, T. S., Sundin, A., Juhlin, C., Långström, B., Bergström, M., & Eriksson, B.
- Affiliations
- Uppsala University Hospital (SE)
- Uppsala University (SE)
- Corresponding author
- Eriksson, Barbro
- Venue
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2003-03
- Volume
- 30
- Issue
- 3
- Pages
- 403-410
- ISSN
- 1619-7070 (ISSN-L)
- 1619-7089
- OpenAlex
- W2008345499
- Cited by
- 107
- References
- 17
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 7 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 6 · 2014: 3 · 2013: 7 · 2012: 7
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Nuclear Medicine and Molecular Imaging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
- Keywords
- adrenocortical carcinoma, positron emission tomography, tumor necrosis, liver metastasis, cancer detection
- MeSH terms
- Adrenal Cortex Neoplasms, Adult, Aged, Antineoplastic Agents, Carbon Radioisotopes, Etomidate, Female, Humans, Male, Metabolic Clearance Rate, Middle Aged, Organ Specificity, Sensitivity and Specificity, Tissue Distribution, Tomography, Emission-Computed, Reproducibility of Results, Radiopharmaceuticals
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