The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Role of the Gut in Multiple Organ Failure: Bacterial Translocation and Permeability Changes
Abstract
It is clear that increased gut permeability and bacterial translocation play a role in multiple organ failure (MOF). Failure of the gut barrier remains central to the hypothesis that toxins escaping from the gut lumen contribute to activation of the host’s immune inflammatory defense mechanisms, subsequently leading to the autointoxication and tissue destruction seen in the septic response characteristic of MOF. However, the role of the gut is more than that of a sieve, which simply allows passage of bacteria and endotoxin from the gut lumen to the portal or systemic circulation. It appears, in addition, that the translocation of bacteria and endotoxin may lead to local activation of the immune inflammatory system and the local production of cytokines and other immune inflammatory mediators. These intestinally derived mediators may then exacerbate the systemic inflammatory response and potentially lead to a further increase in gut permeability. A vicious cycle of increased intestinal permeability, leading to toxic mediator release, resulting in a further increase in gut permeability is generated. Additionally, the systemic and local inflammatory cells that become activated in the gut contribute to the systemic response characteristic of the sepsis syndrome and MOF. Thus even if the immune inflammatory system, rather than the gut, is the “motor of” MOF, the gut remains one of the major pistons that turns the motor.
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Citations
Cites
Multiple Organ Failure Pathophysiology and Potential Future Therapy
DEITCH, E. A. (1992) · Annals of Surgery · doi:10.1097/00000658-199208000-00002 · Cited by 1,380
Self-citationMultiple-Organ Failure: Generalized Autodestructive Inflammation?
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Ischemic injury in the cat small intestine: Role of superoxide radicals
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Multiple System Organ Failure: The Role of Uncontrolled Infection
Fry, D. E. (1980) · Archives of Surgery · doi:10.1001/archsurg.1980.01380020006003 · Cited by 735
Gut Bacterial Translocation via the Portal Vein: A Clinical Perspective with Major Torso Trauma
MOORE, F. A., MOORE, E. E., POGGETTI, R., McANENA, O. J., PETERSON, V. M., ABERNATHY, C. M., & PARSONS, P. E. (1991) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199105000-00006 · Cited by 491 · cited 1×
“clinical relevance of gut-origin septic states [43, 44]: In neither”
BackgroundAssessment of Splanchnic Oxygenation by Gastric Tonometry in Patients With Acute Circulatory Failure
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Mechanism of Prevention of Postburn Hypermetabolism and Catabolism by Early Enteral Feeding
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Endotoxin and Bacteria in Portal Blood
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Endotoxemia and Bacteremia During Hemorrhagic Shock The Link Between Trauma and Sepsis?
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Cited by
McClave, S. A., Taylor, B. E., Martindale, R. G., Warren, M. M., Johnson, D. R., Braunschweig, C., McCarthy, M. S., Davanos, E., Rice, T. W., Cresci, G. A., et al. (2016) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607115621863 · Cited by 3,982
Intestinal permeability – a new target for disease prevention and therapy
Bischoff, S. C., Barbara, G., Buurman, W., Ockhuizen, T., Schulzke, J.-D., Serino, M., Tilg, H., Watson, A., & Wells, J. M. (2014) · BMC Gastroenterology · doi:10.1186/s12876-014-0189-7 · Cited by 1,755
Taylor, B. E., McClave, S. A., Martindale, R. G., Warren, M. M., Johnson, D. R., Braunschweig, C., McCarthy, M. S., Davanos, E., Rice, T. W., Cresci, G. A., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001525 · Cited by 1,476
Kalogeris, T., Baines, C. P., Krenz, M., & Korthuis, R. J. (2016) · Comprehensive Physiology · doi:10.1002/cphy.c160006 · Cited by 718
Michielan, A., & D’Incà, R. (2015) · Mediators of Inflammation · doi:10.1155/2015/628157 · Cited by 709
Metadata
- Authors
- Swank, G. M., & Deitch, E. A.
- Venue
- World Journal of Surgery
- Publisher
- Wiley
- Published
- 1996-05
- Volume
- 20
- Issue
- 4
- Pages
- 411-417
- ISSN
- 0364-2313 (ISSN-L)
- 1432-2323
- OpenAlex
- W2079555223
- Cited by
- 566
- References
- 38
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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