The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Low-density granulocytes: a distinct class of neutrophils in systemic autoimmunity
Open accessAbstract
Recent studies have renewed the interest on the potential role that neutrophils play in the development of systemic lupus erythematosus (SLE) and other autoimmune conditions. A distinct subset of proinflammatory, low-density granulocytes (LDGs) isolated from the peripheral blood mononuclear cell fractions of patients with SLE has been described. While the origin and role of LDGs needs to be fully characterized, there is evidence that these cells may contribute to lupus pathogenesis and to the development of end-organ damage through heightened proinflammatory responses, altered phagocytic capacity, enhanced ability to synthesize type I interferons, and to kill endothelial cells. Furthermore, these cells readily form neutrophil extracellular traps, a phenomenon that may promote autoantigen externalization and organ damage. This review examines the biology and potential origin of LDGs, describes the ultrastructural characteristics of these cells, and discusses their putative pathogenic role in systemic autoimmune diseases.
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1 retracted
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RetractedNeutrophil Extracellular Traps Kill Bacteria
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Novel cell death program leads to neutrophil extracellular traps
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Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?
Rosales, C. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00113 · Cited by 1,334
Neutrophil migration in infection and wound repair: going forward in reverse
de Oliveira, S., Rosowski, E. E., & Huttenlocher, A. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.49 · Cited by 1,058
Selders, G. S., Fetz, A. E., Radic, M. Z., & Bowlin, G. L. (2017) · Regenerative Biomaterials · doi:10.1093/rb/rbw041 · Cited by 538
Neutrophil extracellular traps — the dark side of neutrophils
Sørensen, O. E., & Borregaard, N. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84538 · Cited by 528
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531
Metadata
- Authors
- Carmona-Rivera, C., & Kaplan, M. J.
- Venue
- Seminars in Immunopathology
- Published
- 2013-04-04
- Volume
- 35
- Issue
- 4
- Pages
- 455-463
- ISSN
- 1863-2297 (ISSN-L)
- 1863-2300
- OpenAlex
- W1973511155
- Cited by
- 342
- References
- 56
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- green
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