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Cited by 538Neutrophil, Myeloperoxidase and Oxidative MechanismsWound Healing and TreatmentsInflammation biomarkers and pathways

An overview of the role of neutrophils in innate immunity, inflammation and host-biomaterial integration

Open access
Selders, Gretchen S., Fetz, Allison E., Radic, Marko Z., Bowlin, Gary L.·2017·Regenerative Biomaterials
DOI 10.1093/rb/rbw041PMC PMC5274707
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Abstract

Despite considerable recent progress in defining neutrophil functions and behaviors in tissue repair, much remains to be determined with regards to its overall role in the tissue integration of biomaterials. This article provides an overview of the neutrophil's numerous, important roles in both inflammation and resolution, and subsequently, their role in biomaterial integration. Neutrophils function in three primary capacities: generation of oxidative bursts, release of granules and formation of neutrophil extracellular traps (NETs); these combined functions enable neutrophil involvement in inflammation, macrophage recruitment, M2 macrophage differentiation, resolution of inflammation, angiogenesis, tumor formation and immune system activation. Neutrophils exhibit great flexibility to adjust to the prevalent microenvironmental conditions in the tissue; thus, the biomaterial composition and fabrication will potentially influence neutrophil behavior following confrontation. This review serves to highlight the neutrophil's plasticity, reiterating that neutrophils are not just simple suicidal killers, but the true maestros of resolution and regeneration.

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  • Inflammatory responses are strongly linked to MMP-mediated degradation of scaffolds.

    “Upon transplantation, inflammatory responses are strongly linked to the MMP-mediated degradation of the scaffolds.”

    From Bioengineered liver crosslinked with nano-graphene oxide enables efficient liver regeneration via MMP suppression and immunomodulation (2023) · cites this paper as [14]

    In “Neutrophils in inflammation” (page unavailable), the paper says inflammatory mediators upregulate MMP production and implicates MMP-9, alongside other agents, in accelerated biomaterial degradation. It limits that degradation to excessive amounts of these agents, especially in the presence of neutrophils; it does not establish the claimed strong, general link between post-transplant inflammation and MMP-mediated scaffold degradation. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Xenograft-derived dECM scaffolds are recognized as foreign bodies by host immune system, immune cells infiltrate and release proteases to degrade scaffolds.

    “As xenograft-derived dECM scaffolds are recognized as foreign bodies by the host immune system, immune cells infiltrate into the transplants and release proteases to degrade the scaffolds14,16.”

    From Bioengineered liver crosslinked with nano-graphene oxide enables efficient liver regeneration via MMP suppression and immunomodulation (2023) · cites this paper as [14]

    The “Neutrophils and macrophages: the crucial pairing” section (page not provided) reports macrophage infiltration into decellularized tissue constructs and MMP-9 release by M2 macrophages. It does not establish that xenograft-derived dECM scaffolds are recognized as foreign bodies or that infiltrating cells release proteases to degrade those scaffolds. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Neutrophils are first responders taking part in phagocytosis and degranulation after infiltration into implanted biomaterials.

    “neutrophils are the first responders taking part in phagocytosis and degranulation after infiltration into implanted biomaterials13,14.”

    From Bioengineered liver crosslinked with nano-graphene oxide enables efficient liver regeneration via MMP suppression and immunomodulation (2023) · cites this paper as [14]

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Authors
Selders, G. S., Fetz, A. E., Radic, M. Z., & Bowlin, G. L.
Affiliations
  • University of Memphis (US)
  • University of Tennessee Health Science Center (US)
Corresponding author
Bowlin, Gary L.
ORCID
Venue
Regenerative Biomaterials
Publisher
Oxford University Press (OUP)
Published
2017-01-29
Volume
4
Issue
1
Pages
55-68
ISSN
  • 2056-3418 (ISSN-L)
  • 2056-3426
DOI
10.1093/rb/rbw041
PMC
PMC5274707
OpenAlex
W2580188336
Cited by
538
References
9
Citations by year
2026: 31 · 2025: 63 · 2024: 66 · 2023: 57 · 2022: 59 · 2021: 79 · 2020: 71 · 2019: 62 · 2018: 40 · 2017: 10
FWCI
5.14
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Regenerative Biomaterials (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords
neutrophils, innate immunity, inflammation, inflammation resolution, neutrophil extracellular traps, respiratory burst, granule release, M2 macrophage differentiation, macrophage recruitment, angiogenesis, tissue regeneration

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