Structural aspects of fungal allergens
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Despite the increasing number of solved crystal structures of allergens, the key question why some proteins are allergenic and the vast majority is not remains unanswered. The situation is not different for fungal allergens which cover a wide variety of proteins with different chemical properties and biological functions. They cover enzymes, cell wall, secreted, and intracellular proteins which, except cross-reactive allergens, does not show any evidence for structural similarities at least at the three-dimensional level. However, from a diagnostic point of view, pure allergens biotechnologically produced by recombinant technology can provide us, in contrast to fungal extracts which are hardly producible as standardized reagents, with highly pure perfectly standardized diagnostic reagents.
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Use of purified recombinant A. fumigatus allergens has the potential to substantially increase the specificity and sensitivity of diagnosis of A. fumigatus-related diseases, including ABPA.
“Use of purified recombinant A. fumigatus allergens (see the allergome database www.allergome.org for the recombinant A. fumigatus allergens, developed by R. Crameri [52, 53]) has the potential to substantially increase the specificity and sensitivity of diagnosis of A. fumigatus-related diseases, including ABPA.”
From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [53]
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- Authors
- Crameri, R.
- Affiliations
- University of Zurich (CH)
- Corresponding author
- Crameri, Reto
- Venue
- Seminars in Immunopathology
- Published
- 2014-11-21
- Volume
- 37
- Issue
- 2
- Pages
- 117-121
- ISSN
- 1863-2297 (ISSN-L)
- 1863-2300
- OpenAlex
- W2087328855
- Cited by
- 10
- References
- 58
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.zora.uzh.ch
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Seminars in Immunopathology (publishedVersion)
- PubMed (publishedVersion)
- reroDoc Digital Library (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- fungal allergens, allergenicity, protein structure, crystal structure, cross-reactive allergens, recombinant allergens, fungal extracts, allergen diagnosis
- MeSH terms
- Allergens, Antigens, Fungal, Cross Reactions, Fungi, Humans, Hypersensitivity, Models, Molecular, Molecular Structure
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