Oxytocin nasal spray in fibromyalgic patients
Abstract
Fibromyalgia is a pain disorder associated with frequent comorbid mood, anxiety, and sleep disorders. Despite the frequent use of a complex, poly-drug pharmacotherapy, treatment for fibromyalgia is of limited efficacy. Oxytocin has been reported to reduce the severity of pain, anxiety, and depression, and improve the quality of sleep, suggesting that it may be useful to treat fibromyalgia. To evaluate this hypothesis, 14 women affected by fibromyalgia and comorbid disorders, assuming a complex pharmacotherapy, were enrolled in a double-blind, crossover, randomized trial to receive oxytocin and placebo nasal spray daily for 3 weeks for each treatment. Order of treatment (placebo-oxytocin or oxytocin-placebo) was randomly assigned. Patients were visited once a week. At each visit, the following instruments were administered: an adverse drug reaction record card, Visual Analog Scale of Pain Intensity, Spielberger State Anxiety Inventory, Zung Self-rating Depression Scale, and SF-12. Women self-registered painkiller assumption, pain severity, and quality of sleep in a diary. Unlikely, oxytocin nasal spray (80 IU a day) did not induce positive therapeutic effects but resulted to be safe, devoid of toxicity, and easy to handle.
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Other studies administering intranasal oxytocin daily from 3 to 13 weeks in patients with chronic syndromes did not show any analgesic effects.
“However, other studies administering intranasal oxytocin daily from 3 to 13 weeks in patients with chronic syndromes did not show any analgesic effects 21, 22.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [21]
Double-blind, placebo-controlled studies have produced mixed results regarding the analgesic role of oxytocin in humans.
“However, double‐blind, placebo‐controlled studies have produced mixed results.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [21]
Cites
(1970) · Cited by 24,983 · see citing works
WARE, J. E., KOSINSKI, M., & KELLER, S. D. (1996) · Medical Care · doi:10.1097/00005650-199603000-00003 · Cited by 17,392 · see citing works
A self-rating depression scale
ZUNG, W. W. K. (1965) · Archives of General Psychiatry · doi:10.1001/archpsyc.1965.01720310065008 · Cited by 9,813 · see citing works
The american college of rheumatology 1990 criteria for the classification of fibromyalgia
Wolfe, F., Smythe, H. A., Yunus, M. B., Bennett, R. M., Bombardier, C., Goldenberg, D. L., Tugwell, P., Campbell, S. M., Abeles, M., Clark, P., et al. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330203 · Cited by 9,563 · see citing works
Pain Measurement and Assessment
Melzack, R. (1983) · Medical Entomology and Zoology · Cited by 575 · see citing works
Oxytocin can hinder trust and cooperation in borderline personality disorder
Bartz, J., Simeon, D., Hamilton, H., Kim, S., Crystal, S., Braun, A., Vicens, V., & Hollander, E. (2011) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq085 · Cited by 452 · see citing works
Guastella, A. J., Howard, A. L., Dadds, M. R., Mitchell, P., & Carson, D. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.01.005 · Cited by 366 · see citing works
Pain measurement and assessment
Pearce, S. A. (1984) · Pain · doi:10.1016/0304-3959(84)90089-7 · Cited by 360 · see citing works
Guastella, A. J., Hickie, I. B., McGuinness, M. M., Otis, M., Woods, E. A., Disinger, H. M., Chan, H.-K., Chen, T. F., & Banati, R. B. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.11.019 · Cited by 357 · see citing works
Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients
Feifel, D., Macdonald, K., Nguyen, A., Cobb, P., Warlan, H., Galangue, B., Minassian, A., Becker, O., Cooper, J., Perry, W., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.039 · Cited by 308 · see citing works
Improving the Recognition and Diagnosis of Fibromyalgia
Arnold, L. M., Clauw, D. J., & McCarberg, B. H. (2011) · Mayo Clinic Proceedings · doi:10.4065/mcp.2010.0738 · Cited by 226 · see citing works
Oxytocin and Pain: A Systematic Review and Synthesis of Findings
Rash, J. A., Aguirre-Camacho, A., & Campbell, T. S. (2014) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e31829f57df · Cited by 175 · see citing works
Yang, J. (1994) · Spine · doi:10.1097/00007632-199404150-00001 · Cited by 157 · see citing works
Intranasal oxytocin modulates EEG mu/alpha and beta rhythms during perception of biological motion
Perry, A., Bentin, S., Shalev, I., Israel, S., Uzefovsky, F., Bar-On, D., & Ebstein, R. P. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.04.011 · Cited by 143 · see citing works
Elevated salivary levels of oxytocin persist more than 7 h after intranasal administration
van IJzendoorn, M. H., Bhandari, R., van der Veen, R., Grewen, K. M., & Bakermans-Kranenburg, M. J. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00174 · Cited by 137 · see citing works
Melis, M. R., & Argiolas, A. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.014 · Cited by 129 · see citing works
Self-citation長南達也 (1992) · 呼吸 · Cited by 112 · see citing works
Plasma oxytocin levels in female fibromyalgia syndrome patients
Anderberg, U. M., & Uvnäs‐Moberg, K. (2000) · Zeitschrift für Rheumatologie · doi:10.1007/s003930070045 · Cited by 111 · see citing works
Madrazo, I., Franco-Bourland, R. E., León-Meza, V. M., & Mena, I. X. (1987) · Stereotactic and Functional Neurosurgery · doi:10.1159/000100753 · Cited by 98 · see citing works
Pharmacotherapy of fibromyalgia
Mease, P. J., Dundon, K. M. W., & Sarzi‐Puttini, P. (2011) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2011.01.015 · Cited by 72 · see citing works
Condés‐Lara, M., Maie, I. A. S., & Dickenson, A. H. (2005) · Brain Research · doi:10.1016/j.brainres.2005.03.020 · Cited by 71 · see citing works
The impact of mood, anxiety, and sleep disorders on fibromyalgia
Consoli, G., Marazziti, D., Ciapparelli, A., Bazzichi, L. M., Massimetti, G., Giacomelli, C., Rossi, A., Bombardieri, S., & Dell’Osso, L. (2012) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2012.03.008 · Cited by 70 · see citing works
Oxytocin in the periaqueductal grey regulates nociception in the rat
Yang, J., Li, P., Liang, J., Pan, Y.-J., Yan, X.-Q., Yan, F., Hao, F., Zhang, X.-Y., Zhang, J., Qiu, P.-Y., et al. (2011) · Regulatory Peptides · doi:10.1016/j.regpep.2011.04.007 · Cited by 47 · see citing works
Intranasal Oxytocin as an Adjunct to Escitalopram in Major Depression
Scantamburlo, G., Ansseau, M., Geenen, V. G., & Legros, J. (2011) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.23.2.e5 · Cited by 35 · see citing works
Oxytocin and Behavior: Evidence for Effects in the Brain
Stevens, F. L., Wiesman, O., Feldman, R., Hurley, R. A., & Taber, K. H. (2013) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.13030061 · Cited by 35 · see citing works
Intranasal delivery could be used to administer drugs directly to the brain
Lawrence, D. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08601-4 · Cited by 29 · see citing works
Carta, M. G., Ruggiero, V., Sancassiani, F., Cutrano, F., Manca, A., Peri, M., Fais, A., & Cacace, E. (2013) · Clinical Practice and Epidemiology in Mental Health · doi:10.2174/1745017901309010120 · Cited by 19 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Walker, S. C., Trotter, P. D., Swaney, W. T., Marshall, A. G., & McGlone, F. P. (2017) · Neuropeptides · doi:10.1016/j.npep.2017.01.001 · Cited by 193 · see citing works
Oxytocin and Pain Perception: From Animal Models to Human Research
Boll, S., de Minas, A. C. A., Raftogianni, A., Herpertz, S. C., & Grinevich, V. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.09.041 · Cited by 137 · see citing works
Oxytocin Signaling in Pain: Cellular, Circuit, System, and Behavioral Levels
Poisbeau, P., Grinevich, V., & Charlet, A. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_14 · Cited by 92 · see citing works
Oxytocin and the modulation of pain experience: Implications for chronic pain management
Tracy, L. M., Georgiou‐Karistianis, N., Gibson, S. J., & Giummarra, M. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.013 · Cited by 89 · see citing works
The analgesic effects of oxytocin in the peripheral and central nervous system
Xin, Q., Bai, B., & Liu, W. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2016.12.021 · Cited by 81 · see citing works
Multimodale Therapie des Fibromyalgiesyndroms
Schiltenwolf, M., Eidmann, U., Köllner, V., Kuhn, T. E., Offenbächer, M., Petzke, F. W., Sarholz, M., Weigl, M. B., Wolf, B., & Häuser, W. (2017) · Der Schmerz · doi:10.1007/s00482-017-0205-2 · Cited by 71 · see citing works
Horta, M., Kaylor, K., Feifel, D., & Ebner, N. C. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.012 · Cited by 62 · see citing works
Paloyelis, Y., Krahé, C., Maltezos, S., Williams, S. C., Howard, M. A., & Fotopoulou, A. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12347 · Cited by 61 · see citing works
Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances
Melis, M. R., & Argiolas, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910376 · Cited by 44 · see citing works
Self-citationZunhammer, M., Geis, S., Busch, V., Greenlee, M. W., & Eichhammer, P. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000142 · Cited by 42 · see citing works
Medikamentöse Therapie des Fibromyalgiesyndroms
Sommer, C., Alten, R., Bär, K., Bernateck, M., Brückle, W., Friedel, E., Henningsen, P., Petzke, F. W., Tölle, T. R., Üçeyler, N., et al. (2017) · Der Schmerz · doi:10.1007/s00482-017-0207-0 · Cited by 41 · see citing works
Nishimura, H., Kawasaki, M., Suzuki, H., Matsuura, T., Motojima, Y., Ohnishi, H., Yamanaka, Y., Yoshimura, M., Maruyama, T., Saito, R., et al. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.02.027 · Cited by 31 · see citing works
Skvortsova, A., Veldhuijzen, D. S., van Middendorp, H., Colloca, L., & Evers, A. W. M. (2019) · Journal of Pain · doi:10.1016/j.jpain.2019.08.010 · Cited by 28 · see citing works
Enhancing Placebo Effects in Somatic Symptoms Through Oxytocin
Skvortsova, A., Veldhuijzen, D. S., van Middendorp, H., den Bergh, O. V., & Evers, A. W. M. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000571 · Cited by 27 · see citing works
Nielsen, E. I., Al-Saqi, S. H., Jonasson, A. F., & Uvnäs‐Moberg, K. (2017) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.961 · Cited by 26 · see citing works
Oxytocin and positive couple interaction affect the perception of wound pain in everyday life
Pfeifer, A.-C., Schröder‐Pfeifer, P., Schneider, E., Schick, M., Heinrichs, M., Bodenmann, G., Ehlert, U., Herpertz, S. C., Läuchli, S., Eckstein, M., et al. (2020) · Molecular Pain · doi:10.1177/1744806920918692 · Cited by 23 · see citing works
Flynn, M. J., Campbell, T. S., Robert, M., Nasr‐Esfahani, M., & Rash, J. A. (2020) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.13441 · Cited by 23 · see citing works
Raymond, J. S., Rehn, S., Hoyos, C. M., & Bowen, M. T. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.016 · Cited by 21 · see citing works
Tracy, L. M., Labuschagne, I., Georgiou‐Karistianis, N., Gibson, S. J., & Giummarra, M. J. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.05.028 · Cited by 21 · see citing works
Lussier, D., Cruz‐Almeida, Y., & Ebner, N. C. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00338 · Cited by 20 · see citing works
Mekhael, A. A., Bent, J. E., Fawcett, J. M., Campbell, T. S., Aguirre‐Camacho, A., Farrell, A., & Rash, J. A. (2023) · Canadian Journal of Pain · doi:10.1080/24740527.2023.2191114 · Cited by 19 · see citing works
Boada, M. D., Gutierrez, S., & Eisenach, J. C. (2019) · Pain · doi:10.1097/j.pain.0000000000001495 · Cited by 19 · see citing works
Lopes, S., & Osório, F. D. L. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105282 · Cited by 19 · see citing works
Riem, M. M. E., Kunst, L. E., & Kop, W. J. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.09.057 · Cited by 14 · see citing works
Gamal‐Eltrabily, M., & Manzano-García, A. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0068 · Cited by 14 · see citing works
Martı́nez-Martos, J. M., Correa‐Rodríguez, M., Rus, A., Molina, F., Ramı́rez-Expósito, M. J., & Aguilar‐Ferrándiz, M. E. (2019) · Biological Research For Nursing · doi:10.1177/1099800419854207 · Cited by 13 · see citing works
Hudson, J., Imamura, M., Robertson, C., Whibley, D., Aucott, L. S., Gillies, K., Manson, P. D., Dulake, D., Abhishek, A., Tang, N. K. Y., et al. (2025) · Arthritis Care & Research · doi:10.1002/acr.25505 · Cited by 11 · see citing works
Ikeda, N., Kawasaki, M., Baba, K., Nishimura, H., Fujitani, T., Suzuki, H., Matsuura, T., Ohnishi, H., Shimizu, M., Sanada, K., et al. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.07.028 · Cited by 10 · see citing works
Agabio, R., & Farci, A. M. G. (2016) · Clinical Pharmacology & Biopharmaceutics · doi:10.4172/2167-065x.1000155 · Cited by 10 · see citing works
Self-citationNovel pharmaceutical options for treating fibromyalgia
Gerardi, M. C., Batticciotto, A., Talotta, R., Franco, M. D., Atzeni, F., & Sarzi‐Puttini, P. (2016) · Expert Review of Clinical Pharmacology · doi:10.1586/17512433.2016.1145052 · Cited by 10 · see citing works
Zayas‐González, H., González‐Hernández, A., Manzano‐García, A., Hernández‐Rivero, D., García‐Cuevas, M. A., Granados‐Mortera, J. C., Aguirre, L. V., Flores‐Fierro, S., Martı́nez-Lorenzana, G., & Condés‐Lara, M. (2019) · European Journal of Pain · doi:10.1002/ejp.1427 · Cited by 9 · see citing works
Bruti, G., & Foggetti, P. (2024) · Biomedicines · doi:10.3390/biomedicines12081744 · Cited by 8 · see citing works
Rash, J. A., Toivonen, K., Robert, M., Nasr‐Esfahani, M., Jarrell, J. F., & Campbell, T. S. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-014909 · Cited by 8 · see citing works
Good daily habits during the early stages of life determine success throughout life
Kohyama, J. (2016) · Sleep Science · doi:10.1016/j.slsci.2016.09.002 · Cited by 8 · see citing works
Placebo Effects in the Neuroendocrine System: Conditioning of the Oxytocin Responses
Skvortsova, A., Veldhuijzen, D. S., Pacheco‐López, G., Bakermans‐Kranenburg, M. J., van IJzendoorn, M. H., Smeets, M. A. M., Wilderjans, T. F., Dahan, A., den Bergh, O. V., Chavannes, N. H., et al. (2019) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000759 · Cited by 8 · see citing works
Future directions for the investigation of intranasal oxytocin and pain
Rash, J. A., & Campbell, T. S. (2014) · Rheumatology International · doi:10.1007/s00296-014-3070-7 · Cited by 8 · see citing works
Silva, K., Castro, L., Santos, C., Lourenço, A., & Lima, M. (2020) · Pain Medicine · doi:10.1093/pm/pnaa438 · Cited by 7 · see citing works
Association of Interindividual Variation in Plasma Oxytocin With Postcesarean Incisional Pain
Ende, H. B., Soens, M., Nandi, M., Strichartz, G. R., & Schreiber, K. L. (2018) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000003567 · Cited by 7 · see citing works
Wirkung von Oxytocin auf das menschliche Schmerzerleben
Pfeifer, A.-C., Ditzen, B., Neubauer, E., & Schiltenwolf, M. (2016) · Der Schmerz · doi:10.1007/s00482-016-0164-z · Cited by 7 · see citing works
Usami, N., Maegawa, H., Hayashi, M., Kudo, C., & Niwa, H. (2024) · PLoS ONE · doi:10.1371/journal.pone.0300081 · Cited by 6 · see citing works
Oxytocin nasal spray in fibromyalgic patients: additional information
Agabio, R., Mameli, S., Sardo, S., Minerba, L., & Melis, M. R. (2014) · Rheumatology International · doi:10.1007/s00296-014-3101-4 · Cited by 6 · see citing works
Self-citationRash, J. A., Campbell, T. S., Cooper, L., Flusk, D., MacInnes, A. I., Nasr‐Esfahani, M., Mekhael, A. A., Poulin, P. A., Robert, M., & Yi, Y. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-055039 · Cited by 4 · see citing works
Subcutaneous Oxytocin Injection Reduces Heat Pain: A Randomized-Controlled Trial
Albinni, B., Zimmerman, M. S., Ross, J., Ozdoyuran, L., Alasha, V. J., Schuster, N. M., Said, E. T., & Case, L. K. (2024) · Journal of Pain · doi:10.1016/j.jpain.2024.104547 · Cited by 4 · see citing works
Intranasal oxytocin and NSAIDs
Kwong, K. K., & Chan, S. (2014) · Rheumatology International · doi:10.1007/s00296-014-3163-3 · Cited by 4 · see citing works
Oxytocin Receptor Polymorphism Is Associated With Sleep Apnea Symptoms
Goto, H., Yamamoto, Y., Tsujiguchi, H., Sato, T. K., Yamamoto, R., Takeshita, Y., Nakano, Y., Kannon, T., Hosomichi, K., Suzuki, K., et al. (2024) · Journal of the Endocrine Society · doi:10.1210/jendso/bvae198 · Cited by 2 · see citing works
Imamura, M., Robertson, C., Hudson, J., Whibley, D., Aucott, L. S., Gillies, K., Beasley, M., Stevens, M., Manson, P. D., Dulake, D., et al. (2025) · Health Technology Assessment · doi:10.3310/gtbr7561 · Cited by 2 · see citing works
The lack of efficacy of oxytocin and NSAIDs
Agabio, R., Mameli, S., & Melis, M. R. (2015) · Rheumatology International · doi:10.1007/s00296-014-3200-2
Self-citationChortis, V., & Boelaert, K. (2015) · Side effects of drugs annual · doi:10.1016/bs.seda.2015.07.004
Oxytocin and chronic pain in humans
Palacios‐Espinosa, X., Gómez-Carvajal, A.-M., Botero-Meneses, J. S., & Sánchez, L. P. (2018) · Revista de la Sociedad Española del Dolor · doi:10.20986/resed.2018.3664/2018
Desamparo em pacientes com dor lombar crônica: estudo psicanalítico e neurocientífico
de Almeida, N. A. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.47.2018.tde-14112018-101323
Kalcev, G., Testa, G., Manconi, M., Bacchetta, G., Scano, A., Orrù, G., Deidda, M. C., Finco, G., & Carta, M. G. (2020) · Biointerface Research in Applied Chemistry · doi:10.33263/briac113.99289938
Self-citation横山, 圭. (1992) · 全国大会講演論文集
Oxytocin in chronic pain: From analgesic to biopsychosocial adjuvant - An opinion paper
Moerkerke, M., Coppieters, I., Timmers, I., & Oosterwijck, J. V. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106586
The oxytocinergic descending control of pain and its modulation by neonatal maternal separation
Melchior, M. (2018) · theses.fr (ABES) · doi:10.70675/368c73c0ze731z4b57zb52cz8f31049fb33c
- Authors
- Mameli, S., Pisanu, G. M., Sardo, S., Marchi, A., Pili, A., Carboni, M., Minerba, L., Trincas, G., Carta, M. G., Melis, M. R., & Agabio, R.
- Affiliations
- University of Cagliari (IT)
- Corresponding author
- Agabio, R.
- Venue
- Rheumatology International
- Published
- 2014-02-08
- Volume
- 34
- Issue
- 8
- Pages
- 1047-1052
- ISSN
- 0172-8172 (ISSN-L)
- 1437-160X
- OpenAlex
- W2126391111
- Cited by
- 54
- References
- 27
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 8 · 2018: 5 · 2017: 10 · 2016: 4 · 2015: 5 · 2014: 3
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Rheumatology International (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- fibromyalgia, oxytocin, nasal spray, pain intensity, anxiety, depression, sleep quality, comorbid mood disorders, drug safety, women
- MeSH terms
- Administration, Intranasal, Aerosols, Anxiety, Depression, Double-Blind Method, Female, Fibromyalgia, Humans, Middle Aged, Oxytocin, Pain Measurement, Psychiatric Status Rating Scales, Quality of Life, Surveys and Questionnaires, Sleep, Time Factors, Comorbidity, Treatment Outcome, Cross-Over Studies, Musculoskeletal Pain
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