Adipose tissue compartments, muscle mass, muscle fat infiltration, and coronary calcium in institutionalized frail nonagenarians
Abstract
Objective to compare the different adipose tissue (AT) compartments, muscle mass, muscle fat infiltration, coronary calcium, as well as associations among changes in different AT compartments between frail and robust nonagenarians.Materials and methods Forty-two elderly subjects took part in this study: 29 institutionalized frail elderly (92.0 ± 8 years) and 13 robust elderly (88.2 ± 4.1 years). All patients underwent helical thoracic, abdominal and thigh computed tomography (CT). In addition, a non-enhanced prospectively ECG-triggered cardiac CT was performed to quantify the amount of coronary artery calcification and measure pericardial AT.Results The robust group presented significantly greater pericardial and abdominal AT volume, as well as greater axial and appendicular muscle size and high-density muscle tissue (greater muscle quality) than the frail group (P < 0.001), whereas no differences between groups were observed in coronary calcium. There were positive correlations between pericardial AT with visceral and subcutaneous AT values, as well as between pericardial AT and quadriceps, hamstrings, psoas and paravertebral low-density muscle tissues in the frail and robust groups (r = 0.57 to 0.91,P < 0.05).Conclusions Robust group presented greater muscle size and quality in the axial and appendicular muscles, as well as pericardial and abdominal AT area than the frail group.Key points • Robust nonagenarians presented more pericardial and abdominal AT volume than frail. • Frailty is associated with lower muscle size and high-density muscle tissue. • Muscle-fat infiltration shares analogous pattern of visceral and pericardial AT distribution.
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In nonagenarians, muscle fat infiltration is positively correlated with the area of pericardial and visceral adipose tissue, although visceral fat mass becomes protective against frailty in this age group.
“Interestingly, a major geriatric study of nonagenarians indicated that, muscle fat infiltration is still positively correlated with the area of pericardial and visceral adipose tissue in these oldest old individuals, although visceral fat mass strangely become protective against frailty in this age group (part of a phenomenon known as the obesity paradox, which we will address in a later section).”
From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [10]
Fat redistribution is a hallmark of modern ageing that has been validated amongst nonagenarians as well.
“Fat redistribution is a hallmark of modern ageing that has been validated amongst nonagenarians as well.[ 10 ]”
From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [10]
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Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review
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- Authors
- Idoate, F., Cadore, E. L., Casas-Herrero, A., Zambom-Ferraresi, F., Marcellán, T., de Gordoa, A. R., Rodriguez-Mañas, L., Bastarrika, G., Marques, M. C., Martínez-Velilla, N., Vicente-Campos, D., & Izquierdo, M.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- Sunnybrook Health Science Centre (CA)
- University of Beira Interior (PT)
- Universidad Francisco de Vitoria (ES)
- Venue
- European Radiology
- Published
- 2014-12-16
- Volume
- 25
- Issue
- 7
- Pages
- 2163-2175
- ISSN
- 0938-7994 (ISSN-L)
- 1432-1084
- OpenAlex
- W1981109681
- Cited by
- 56
- References
- 46
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 8 · 2016: 6 · 2015: 3
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Radiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- frailty, nonagenarians, adipose tissue compartments, pericardial adipose tissue, abdominal fat, visceral adipose tissue, subcutaneous adipose tissue, muscle mass, muscle fat infiltration, coronary artery calcification, institutionalized elderly, sarcopenia
- MeSH terms
- Adipose Tissue, Aged, Coronary Artery Disease, Cross-Sectional Studies, Female, Heart, Humans, Institutionalization, Male, Muscular Diseases, Pericardium, Retrospective Studies, Thigh, Tomography, X-Ray Computed, Frail Elderly, Muscle, Skeletal, Abdominal Fat, Vascular Calcification
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