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Cited by 78Adrenal and Paraganglionic TumorsAdvanced X-ray and CT ImagingMedical Imaging Techniques and Applications

Diagnostic accuracy of virtual non-contrast enhanced dual-energy CT for diagnosis of adrenal adenoma: a systematic review and meta-analysis

Connolly, Michael J., McInnes, Matthew D. F., El-Khodary, Mohamed, McGrath, Trevor A., Schieda, Nicola·2017·European Radiology
DOI 10.1007/s00330-017-4785-0
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Abstract

Objective To compare the diagnostic accuracy of dual-energy (DE) virtual non-contrast computed tomography (vNCT) to non-contrast CT (NCT) for the diagnosis of adrenal adenomas.Methods Search of multiple databases and grey literature was performed. Two reviewers independently applied inclusion criteria and extracted data. Risk of bias was assessed using QUADAS-2. Summary estimates of diagnostic accuracy were generated and sources of heterogeneity were assessed.Results Five studies (170 patients; 192 adrenal masses) were included for diagnostic accuracy assessment; all used dual-source dual-energy CT. Pooled sensitivity for adrenal adenoma on vNCT was 54% (95% CI: 47-62%). Pooled sensitivity for NCT was 57% (95% CI: 45-69%). Pooling of specificity was not performed since no false positives were reported. There was a trend for overestimation of HU density on vNCT as compared to NCT which appeared related to contrast timing. Potential sources of bias were seen regarding the index test and reference standard for the included studies. Potential sources of heterogeneity between studies were seen in adenoma prevalence and intravenous contrast timing.Conclusions vNCT images generated from dual-energy CT demonstrated comparable sensitivity to NCT for the diagnosis of adenomas; however the included studies are heterogeneous and at high risk for some types of bias.Key points • Similar sensitivity of vNCT to NCT for diagnosis of adenoma • Heterogeneity could be related to vNCT from early (<=60 sec) CECT studies • Could not pool specificity as there were no false positives • Small number of heterogeneous studies at high risk of bias.

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Crossref · 10.1007/s00330-017-4785-0

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  • Virtual non-contrast CT images from dual-energy CT demonstrate comparable sensitivity with standard noncontrast CT for diagnosis of lipid-rich adenomas, but data limited.

    “A recent systematic review and meta-analysis reported that virtual non-contrast CT images generated from dual-energy CT demonstrate comparable sensitivity with standard noncontrast CT for diagnosis of lipid-rich adenomas, but data were only available from a small number of heterogeneous studies at high risk of bias (306).”

    From Adrenal incidentaloma (2020) · cites this paper as [306]

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Authors
Connolly, M. J., McInnes, M. D. F., El-Khodary, M., McGrath, T. A., & Schieda, N.
Affiliations
University of Ottawa (CA)
Corresponding author
McInnes, Matthew D. F.
ORCID
Venue
European Radiology
Publisher
Springer Science and Business Media LLC
Published
2017-03-13
Volume
27
Issue
10
Pages
4324-4335
ISSN
  • 0938-7994 (ISSN-L)
  • 1432-1084
DOI
10.1007/s00330-017-4785-0
OpenAlex
W2595538986
Cited by
78
References
33
Citations by year
2026: 5 · 2025: 7 · 2024: 8 · 2023: 12 · 2022: 13 · 2021: 5 · 2020: 13 · 2019: 8 · 2018: 4 · 2017: 3
FWCI
1.62
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (unspecified)
Locations
  • European Radiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Physical Sciences › Engineering › Biomedical Engineering › Advanced X-ray and CT Imaging
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Keywords
adrenal adenoma, virtual non-contrast CT, dual-energy CT, non-contrast CT, diagnostic accuracy, sensitivity, adrenal mass, dual-source CT
MeSH terms
Adrenal Cortex Neoplasms, Contrast Media, Humans, Sensitivity and Specificity, Tomography, X-Ray Computed, Adrenocortical Adenoma

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