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Cited by 96Adrenal and Paraganglionic TumorsRenal cell carcinoma treatmentNeuroendocrine Tumor Research Advances

Re-evaluation of pheochromocytomas on delayed contrast-enhanced CT: washout enhancement and other imaging features

Park, Byung Kwan, Kim, Chan Kyo, Kwon, Ghee Young, Kim, Jung Han·2007·European Radiology
DOI 10.1007/s00330-007-0695-x
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Abstract

The purpose of this study was to retrospectively evaluate the enhancement washout and other imaging features of pheochromocytomas on delayed contrast-enhanced CT. Twenty-four patients with 31 pathologically confirmed pheochromocytomas were examined using unenhanced, early and delayed contrast-enhanced CT. The range of their APEW (absolute percentage of enhancement washout) or RPEW (relative PEW) values was analyzed. The other CT features including cystic or necrotic change, calcification, and hemorrhage were also determined by a pathologic correlation. Of the 31 pheochromocytomas, 10 (32%) had APEW values of 60% or less and RPEW values of 40% or less. Fourteen (45%) had APEW values >60% and RPEW values >40%. CT showed cystic or necrotic changes in 11 pheochromocytomas (35%) and calcification (10%) in 3. Nineteen pheochromocytomas showed cystic or necrotic changes on early contrast-enhanced CT, but eight of these lesions showed late enhancement on delayed contrast-enhanced CT, which pathologically corresponded to myxoid degeneration. The unenhanced CT showed hemorrhage in 23 pheochromocytomas, but the pathology examinations showed hemorrhage in 15 lesions. Many pheochromocytomas can be misdiagnosed as adenomas on CT due to the high enhancement washout values. Delayed contrast-enhanced CT can detect myxoid degeneration with late enhancement, which is seen as a cystic or necrotic change on early contrast-enhanced CT.

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Crossref · 10.1007/s00330-007-0695-x

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15 of 15 references verified0 citation errors · 0 not checkable

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  • Pheochromocytomas usually show slow contrast washout, but occasionally can mimic benign lipid-poor adenomas by showing rapid washout.

    “Caution is also required because whilst pheochromocytomas usually show slow contrast washout, occasionally they can mimic benign lipid-poor adenomas by showing rapid washout (302).”

    From Adrenal incidentaloma (2020) · cites this paper as [302]

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Authors
Park, B. K., Kim, C. K., Kwon, G. Y., & Kim, J. H.
Affiliations
Samsung Medical Center (KR)
Corresponding author
Park, Byung Kwan
ORCID
Venue
European Radiology
Publisher
Springer Science and Business Media LLC
Published
2007-06-05
Volume
17
Issue
11
Pages
2804-2809
ISSN
  • 0938-7994 (ISSN-L)
  • 1432-1084
DOI
10.1007/s00330-007-0695-x
OpenAlex
W2085973397
Cited by
96
References
15
Citations by year
2026: 5 · 2025: 6 · 2024: 13 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 9 · 2015: 9 · 2014: 7 · 2013: 5 · 2012: 4
FWCI
1.33
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • European Radiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal cell carcinoma treatment
  • Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
Keywords
pheochromocytoma, myxoid degeneration, late enhancement, calcification, hemorrhage
MeSH terms
Adrenal Gland Neoplasms, Adrenal Glands, Adult, Aged, Contrast Media, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Pheochromocytoma, Radiographic Image Enhancement, Retrospective Studies, Tomography, X-Ray Computed

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