MDCT-findings in patients with non-occlusive mesenteric ischemia (NOMI): Influence of vasoconstrictor agents
Open accessAbstract
OBJECTIVES: To evaluate the influence of vasoconstrictor agents (VCAs) on signs of vasoconstriction and bowel ischemia on MDCT detected in patients with non-occlusive mesenteric ischemia (NOMI). METHODS: This 8-year single-center retrospective study consecutively included all patients with histopathologically proven NOMI who underwent MDCT ≤ 48 h prior to surgical bowel resection. Two blinded radiologists jointly reviewed each examination for signs of bowel ischemia, abdominal organ infarct, mesenteric vessel size and regularity, and ancillary vascular findings. VCA administration (length and dosage), clinical and biochemical data, risk factors, and outcomes were retrieved from patients' medical records. Subgroup comparisons were performed. RESULTS: Ninety patients were included (59 males, mean age 65 years); 40 (44.4%) had received VCAs before MDCT. Overall mortality was 32% (n = 29), with no significant difference between the two groups. In patients treated with VCAs, the calibre of the superior mesenteric artery (SMA) was smaller (p = 0.032), and vasoconstriction of its branches tended to be more important (p = 0.096) than in patients not treated with VCAs. The presence and extent of bowel ischemia did not significantly correlate with VCA administration, but abdominal organ infarcts tended to be more frequent (p = 0.005) and involved more organs (p = 0.088). The VCA group had lower mean arterial pressure (p = 0.006) and lower hemoglobin levels (p < 0.001). Several biomarkers of organ failure and inflammation, differed significantly with VCA use, proving worse clinical condition. CONCLUSIONS: MDCT demonstrates more severe SMA vasoconstriction and tends to show increased abdominal organ infarcts after VCA administration in NOMI patients compared to NOMI patients not treated with VCAs. KEY POINTS: • In critically ill patients with NOMI, MDCT demonstrates VCA support via increased vasoconstriction of the main SMA and its branches. • VCA administration in NOMI patients tends to contribute to the development of organ infarcts, as shown on MDCT. • An important degree of vasoconstriction in NOMI patients may indicate insufficient resuscitation and, thus, help clinicians in further patient management.
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In critically ill patients with non-obstructive mesenteric ischemia, vasoconstricting agents can increase superior mesenteric artery vasoconstriction, potentially contributing to organ infarcts.
“Furthermore, critically ill patients with non-obstructive mesenteric ischemia prescribed vasoconstricting agents can increase superior mesenteric artery vasoconstriction, potentially contributing to organ infarcts [17].”
From Revascularization Strategies for Acute and Chronic Mesenteric Ischemia: A Narrative Review (2024) · cites this paper as [17]
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Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
von Elm, E., Altman, D. G., Egger, M., Pocock, S. J., Gøtzsche, P. C., & Vandenbroucke, J. P. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61602-x · Cited by 21,320 · see citing works
Non-occlusive mesenteric ischemia: etiology, diagnosis, and interventional therapy
Trompeter, M., Brazda, T., Remy, C. T., Vestring, T., & Reimer, P. (2002) · European Radiology · doi:10.1007/s00330-001-1220-2 · Cited by 378 · see citing works
Epidemiology of Mesenteric Vascular Disease: Clinical Implications
Acosta, S. (2010) · Seminars in Vascular Surgery · doi:10.1053/j.semvascsurg.2009.12.001 · Cited by 340 · see citing works
Unchanged high mortality rates from acute occlusive intestinal ischemia: six year review
Kassahun, W. T., Schulz, T., Richter, O., & Hauss, J. (2008) · Langenbeck's Archives of Surgery · doi:10.1007/s00423-007-0263-5 · Cited by 262 · see citing works
Angiographic Diagnosis of Mesenteric Arterial Vasoconstriction
Siegelman, S. S., Sprayregen, S., & Boley, S. J. (1974) · Radiology · doi:10.1148/112.3.533 · Cited by 190 · see citing works
Lock, G. (2001) · Best Practice & Research Clinical Gastroenterology · doi:10.1053/bega.2000.0157 · Cited by 148 · see citing works
Woodhams, R., Nishimaki, H., Fujii, K., Kakita, S., & Hayakawa, K. (2009) · European Journal of Radiology · doi:10.1016/j.ejrad.2009.05.012 · Cited by 103 · see citing works
Diagnosis of non-occlusive acute mesenteric ischemia in the intensive care unit
Bourcier, S., Oudjit, A., Goudard, G., Charpentier, J., Leblanc, S., Coriat, R., Gouya, H., Dousset, B., Mira, J.-P., & Pène, F. (2016) · Annals of Intensive Care · doi:10.1186/s13613-016-0213-x · Cited by 90 · see citing works
Pérez-García, C., de Miguel Campos, E., Fernández Gonzalo, A., Malfaz, C., Martín Pinacho, J. J., Fernández Álvarez, C., & Herranz Pérez, R. (2018) · The British Journal of Radiology · doi:10.1259/bjr.20170492 · Cited by 81 · see citing works
Multidetector CT Features of Mesenteric Vein Thrombosis
Durán, R., Denys, A. L., Letovanec, I., Meuli, R. A., & Schmidt, S. (2012) · Radiographics · doi:10.1148/rg.325115100 · Cited by 71 · see citing works
Self-citationSepsis and the Obesity Paradox: Size Matters in More Than One Way
Jagan, N., Morrow, L. E., Walters, R. W., et al. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004459 · Cited by 64 · see citing works
Treyaud, M.-O., Durán, R., Zins, M., Knebel, J., Meuli, R. A., & Schmidt, S. (2016) · European Radiology · doi:10.1007/s00330-016-4348-9 · Cited by 60 · see citing works
Self-citationNonocclusive mesenteric ischaemia: think about it
Mazzei, M. A., & Volterrani, L. (2014) · La radiologia medica · doi:10.1007/s11547-014-0460-6 · Cited by 57 · see citing works
Blachar, A., Barnes, S., Adam, S. Z., Levy, G., Weinstein, I., Precel, R., Federle, M. P., & Sosna, J. (2011) · Emergency Radiology · doi:10.1007/s10140-011-0965-4 · Cited by 51 · see citing works
Stahl, K., Busch, M., Maschke, S. K., Schneider, A. S., Manns, M. P., Fuge, J., Wiesner, O., Meyer, B., Hoeper, M. M., Hinrichs, J. B., et al. (2019) · Journal of Intensive Care Medicine · doi:10.1177/0885066619837911 · Cited by 50 · see citing works
Catecholamine Use is Associated With Enterocyte Damage in Critically Ill Patients
Piton, G., Cypriani, B., Regnard, J., Patry, C., Puyraveau, M., & Capellier, G. (2015) · Shock · doi:10.1097/shk.0000000000000327 · Cited by 48 · see citing works
Revelly, J., Liaudet, L., Frascarolo, P., et al. (2000) · Critical Care Medicine · doi:10.1097/00003246-200007000-00052 · Cited by 47 · see citing works
Self-citationNakamura, Y., Urashima, M., Toyota, N., Ono, C., Iida, M., Fukumoto, W., Kaichi, Y., Tani, C., Honda, Y., Komoto, D., et al. (2013) · Japanese Journal of Radiology · doi:10.1007/s11604-013-0245-1 · Cited by 45 · see citing works
Barrett, T., Upponi, S. S., Benaglia, T., & Tasker, A. D. (2013) · British Journal of Radiology · doi:10.1259/bjr.20130277 · Cited by 42 · see citing works
Mazzei, M. A., Guerrini, S., Squitieri, N. C., Vindigni, C., Imbriaco, G., Gentili, F., Berritto, D., Mazzei, F. G., Grassi, R., & Volterrani, L. (2016) · British Journal of Radiology · doi:10.1259/bjr.20150956 · Cited by 41 · see citing works
Kammerer, S., Schülke, C., Berkemeyer, S., Velasco, A., Heindel, W. L., Koehler, M., & Buerke, B. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193698 · Cited by 34 · see citing works
Portomesenteric venous gas: Is gas distribution linked to etiology and outcome?
Heye, T. J., Bernhard, M., Mehrabi, A., et al. (2012) · European Journal of Radiology · doi:10.1016/j.ejrad.2012.07.017 · Cited by 26 · see citing works
Sepsis in cirrhosis: emerging concepts in pathogenesis, diagnosis and management
Philips, C. A., & Sarin, S. K. (2016) · Hepatology International · doi:10.1007/s12072-016-9753-2 · Cited by 25 · see citing works
Comparison of Vasopressor Duration in Septic Shock Patients With and Without Cirrhosis
Durst, M. M., Eitzen, E. A., & Benken, S. T. (2020) · Annals of Pharmacotherapy · doi:10.1177/1060028020980727 · Cited by 8 · see citing works
Relationship Between Body Mass Index and Survival Among Critically Ill Patients With Cirrhosis.
Choi, C., Lennon, R. J., Choi, D. H., et al. (2022) · PubMed · doi:10.1177/08850666211029827 · Cited by 1 · see citing works
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Revascularization Strategies for Acute and Chronic Mesenteric Ischemia: A Narrative Review
Gries, J. J., Sakamoto, T., Chen, B., Virk, H. U. H., Alam, M., & Krittanawong, C. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13051217 · Cited by 19 · see citing works
“Plain abdominal radiographs can rule out intra-abdominal free air indicative of bowel perforation but are considered nonspecific for intestinal ischemia [1,25].”
Background
- Authors
- Topolsky, A., Pantet, O., Liaudet, L., Sempoux, C., Denys, A., Knebel, J.-F., & Schmidt, S.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- Corresponding author
- Schmidt, Sabine
- ORCID
- Venue
- European Radiology
- Published
- 2023-01-24
- Volume
- 33
- Issue
- 5
- Pages
- 3627-3637
- ISSN
- 0938-7994 (ISSN-L)
- 1432-1084
- PMC
- PMC10121529
- OpenAlex
- W4317869811
- Cited by
- 13
- References
- 26
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 5 · 2023: 1
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- European Radiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (submittedVersion, cc-by)
- IRIS (submittedVersion, cc-by)
- Funders
- University of Lausanne
- Topics
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
- Health Sciences › Medicine › Emergency Medicine › Appendicitis Diagnosis and Management
- Keywords
- nonocclusive mesenteric ischemia, vasoconstrictors, multidetector computed tomography, intestinal ischemia, critically ill patients, mortality, hemodynamic instability, mean arterial pressure
- MeSH terms
- Aged, Humans, Infarction, Ischemia, Male, Retrospective Studies, Tomography, X-Ray Computed, Vasoconstrictor Agents, Mesenteric Ischemia
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