Probiotics during weaning: a follow-up study on effects on body composition and metabolic markers at school age
Abstract
Purpose An aberrant gut microbiome has been suggested to contribute to the worldwide epidemic of obesity. In animal models, the probiotic Lactobacillus paracasei ssp. paracasei F19 (LF19) induced upregulation of genes involved in energy homoeostasis, reduced body fat and altered the serum (S) lipoprotein profile. In our previous report, feeding LF19 to infants during weaning impacted the global plasma metabolome. LF19 lowered palmitoleic acid, a monounsaturated fatty acid associated with hypertriglyceridemia and increased visceral adiposity. Therefore, we assessed if feeding LF19 from 4 to 13 months of age would have long-term effects on body composition, growth and metabolic markers.Methods Of 179 children included in our baseline study, 120 entered the follow-up at 8-9 years of age, n = 58 in the probiotic and n = 62 in the placebo group. Body composition was measured using dual energy X-ray absorptiometry. Anthropometrics of the child and accompanying parent(s) were assessed. S-lipids, insulin, glucose and transaminases were determined after overnight fasting.Results LF19 did not affect body mass index z-score, sagittal abdominal diameter, fat-free mass, fat mass index, truncal fat %, android or gynoid fat % and had no long-term impact on any of the assessed metabolic markers (p > 0.05).Conclusion Feeding LF19 during infancy did not modulate body composition, growth or any of the assessed metabolic markers at school age. The steady increase in probiotic products targeting infants and children calls for long-term follow-up of initiated probiotic intervention studies.
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Studies evaluating rates of childhood obesity following probiotic therapy in the perinatal and infant period have not reported any adverse events with respect to body mass index.
“Importantly, studies evaluating rates of childhood obesity following probiotic therapy in the perinatal and infant period have not reported any AEs with respect to body mass index.133, ,134”
From Emerging issues in probiotic safety: 2023 perspectives (2023) · cites this paper as [133]
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Emerging issues in probiotic safety: 2023 perspectives
Merenstein, D., Pot, B., Leyer, G., Ouwehand, A. C., Preidis, G. A., Elkins, C. A., Hill, C., Lewis, Z. T., Shane, A. L., Zmora, N., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2185034 · Cited by 481 · see citing works
- Authors
- Karlsson Videhult, F., Öhlund, I., Stenlund, H., Hernell, O., & West, C. E.
- Affiliations
- Umeå University (SE)
- Corresponding author
- West, Christina E.
- Venue
- European Journal of Nutrition
- Published
- 2014-05-17
- Volume
- 54
- Issue
- 3
- Pages
- 355-363
- ISSN
- 1436-6207 (ISSN-L)
- 1436-6215
- OpenAlex
- W1977037397
- Cited by
- 49
- References
- 48
- Citations by year
- 2026: 1 · 2025: 5 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 5 · 2015: 5 · 2014: 2
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Västerbotten Läns Landsting
- Umeå Universitet
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- probiotics, infant weaning, body composition, childhood obesity, long-term follow-up, metabolic biomarkers, serum lipids, insulin, growth, gut microbiota, palmitoleic acid, visceral fat
- MeSH terms
- Body Composition, Body Weight, Energy Intake, Child, Demography, Double-Blind Method, Female, Follow-Up Studies, Humans, Infant, Lactobacillus, Male, Motor Activity, Weaning, Biomarkers, Absorptiometry, Photon, Body Mass Index, Probiotics
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