Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial
Abstract
Background/objectives In spite of the much evidence for the beneficial effects of probiotics, their anti-obesity effects have not been well examined. We evaluated the effects of the probiotic Lactobacillus gasseri SBT2055 (LG2055) on abdominal adiposity, body weight and other body measures in adults with obese tendencies.Subjects/methods We conducted a multicenter, double-blind, randomized, placebo-controlled intervention trial. Subjects (n=87) with higher body mass index (BMI) (24.2-30.7 kg/m(2)) and abdominal visceral fat area (81.2-178.5 cm(2)) were randomly assigned to receive either fermented milk (FM) containing LG2055 (active FM; n=43) or FM without LG2055 (control FM; n=44), and were asked to consume 200 g/day of FM for 12 weeks. Abdominal fat area was determined by computed tomography.Results In the active FM group, abdominal visceral and subcutaneous fat areas significantly (P<0.01) decreased from baseline by an average of 4.6% (mean (confidence interval): -5.8 (-10.0, -1.7) cm(2)) and 3.3% (-7.4 (-11.6, -3.1) cm(2)), respectively. Body weight and other measures also decreased significantly (P<0.001) as follows: body weight, 1.4% (-1.1 (-1.5, -0.7) kg); BMI, 1.5% (-0.4 (-0.5, -0.2) kg/m(2)); waist, 1.8% (-1.7 (-2.1, -1.4) cm); hip, 1.5% (-1.5 (-1.8, -1.1) cm). In the control group, by contrast, none of these parameters decreased significantly. High-molecular weight adiponectin in serum increased significantly (P<0.01) in the active and control groups by 12.7% (0.17 (0.07, 0.26) microg/ml) and 13.6% (0.23 (0.07, 0.38) microg/ml), respectively.Conclusion The probiotic LG2055 showed lowering effects on abdominal adiposity, body weight and other measures, suggesting its beneficial influence on metabolic disorders.
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Some clinical interventions have found a beneficial effect of probiotics in body weight management and glycemic control.
“The impact of probiotics on appetite control has been less studied, yet some clinical interventions have found a beneficial effect in body weight management and glycemic control [85,86].”
From Homeostatic and Circadian Control of Food Intake: Clinical Strategies to Prevent Overconsumption (2013) · cites this paper as [86]
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- Authors
- Kadooka, Y., Sato, M., Imaizumi, K., Ogawa, A., Ikuyama, K., Akai, Y., Okano, M., Kagoshima, M., & Tsuchida, T.
- Affiliations
- Megmilk Snow Brand (Japan) (JP)
- Kyushu University (JP)
- Saitama Prefectural Industrial Technology Center (JP)
- IRYO Sosei University (JP)
- Corresponding author
- Kadooka, Y
- ORCID
- Sato, M
- Venue
- European Journal of Clinical Nutrition
- Published
- 2010-03-10
- Volume
- 64
- Issue
- 6
- Pages
- 636-643
- ISSN
- 0954-3007 (ISSN-L)
- 1476-5640
- OpenAlex
- W2069973024
- Cited by
- 700
- References
- 38
- Citations by year
- 2026: 24 · 2025: 25 · 2024: 37 · 2023: 27 · 2022: 55 · 2021: 52 · 2020: 58 · 2019: 58 · 2018: 65 · 2017: 43 · 2016: 45 · 2015: 59 · 2014: 44 · 2013: 45 · 2012: 29
- FWCI
- 51.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- probiotics, abdominal fat, visceral fat, subcutaneous adipose tissue, body weight, body mass index, fermented milk, high molecular weight adiponectin, obesity prevention, prebiotics, dietary fiber, dietary fat, dietary protein, dietary fiber to fat ratio
- MeSH terms
- Adult, Body Weight, Double-Blind Method, Female, Hip, Humans, Lactobacillus, Male, Middle Aged, Obesity, Body Mass Index, Probiotics, Intra-Abdominal Fat, Abdominal Fat, Subcutaneous Fat, Abdominal, Adiponectin, Waist Circumference, Obesity, Abdominal
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