Zinc deficiency as a mediator of toxic effects of alcohol abuse

Skalny, Anatoly V.; Skalnaya, Margarita G.; Grabeklis, Andrei R.; Skalnaya, Anastasia A.; Tinkov, Alexey A.

doi:10.1007/s00394-017-1584-y

Cited by 60Trace Elements in HealthAlcohol Consumption and Health EffectsHeavy Metal Exposure and Toxicity

Zinc deficiency as a mediator of toxic effects of alcohol abuse

Skalny, Anatoly V., Skalnaya, Margarita G., Grabeklis, Andrei R., Skalnaya, Anastasia A., Tinkov, Alexey A.·2018·European Journal of Nutrition

DOI 10.1007/s00394-017-1584-y

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Abstract

Objective To review data on the role of ethanol-induced alteration of Zn homeostasis in mediation of adverse effects of alcohol abuse.Methods The scholarly published articles on the association between Zn metabolism and alcohol-associated disorders (liver, brain, lung, gut dysfunction, and fetal alcohol syndrome) have been reviewed.Results It is demonstrated that alcohol-induced modulation of zinc transporters results in decreased Zn levels in lungs, liver, gut, and brain. Zn deficiency in the gut results in increased gut permeability, ultimately leading to endotoxemia and systemic inflammation. Similarly, Zn deficiency in lung epithelia and alveolar macrophages decreases lung barrier function resulting in respiratory distress syndrome. In turn, increased endotoxemia significantly contributes to proinflammatory state in alcoholic liver disease. Finally, impaired gut and liver functions may play a significant role in alcoholic brain damage, being associated with both increased proinflammatory signaling and accumulation of neurotoxic metabolites. It is also hypothesized that ethanol-induced Zn deficiency may interfere with neurotransmission. Similar changes may take place in the fetus as a result of impaired placental zinc transfer, maternal zinc deficiency, or maternal Zn sequestration, resulting in fetal alcoholic syndrome. Therefore, alcoholic Zn deficiency not only mediates the adverse effects of ethanol exposure, but also provides an additional link between different alcohol-induced disorders.Conclusions Generally, current findings suggest that assessment of Zn status could be used as a diagnostic marker of metabolic disturbances in alcohol abuse, whereas modulation of Zn metabolism may be a potential tool in the treatment of alcohol-associated disorders.

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Zinc deficiency is suspected to be a mediator of toxic effects of alcohol abuse, including at the brain level, and zinc status is generally low in alcoholic patients.
“Zinc deficiency is suspected to be a mediator of toxic effects of alcohol abuse, including at the brain level, and zinc status is generally low in alcoholic patients [193].”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [193]

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Authors: Skalny, A. V., Skalnaya, M. G., Grabeklis, A. R., Skalnaya, A. A., & Tinkov, A. A.
Affiliations: Peoples' Friendship University of Russia (RU)
Lomonosov Moscow State University (RU)
Corresponding author: Tinkov, Alexey A.
ORCID: Skalny, Anatoly V.
Grabeklis, Andrei R.
Skalnaya, Anastasia A.
Tinkov, Alexey A.
Venue: European Journal of Nutrition
Publisher: Springer Science and Business Media LLC
Published: 2017-11-24
Volume: 57
Issue: 7
Pages: 2313-2322
ISSN: 1436-6207 (ISSN-L)
1436-6215
DOI: 10.1007/s00394-017-1584-y
OpenAlex: W2770275161
Semantic Scholar: f2e28667a582c907d813235d96351258b8e2372d
Cited by: 60
References: 123
Citations by year: 2026: 9 · 2025: 3 · 2024: 10 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 10 · 2019: 7 · 2018: 1
FWCI: 0.51
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: European Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: Russian Foundation for Basic Research (RU) (15-04-08621)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords: zinc deficiency, alcohol abuse, ethanol, zinc homeostasis, zinc transporters, intestinal permeability, endotoxemia, systemic inflammation, alcoholic liver disease, alcoholic brain damage, respiratory distress syndrome, fetal alcohol syndrome, neuroinflammation
MeSH terms: Ethanol, Alcoholism, Female, Humans, Liver Diseases, Alcoholic, Pregnancy, Zinc

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Zinc deficiency as a mediator of toxic effects of alcohol abuse

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