Impact of dietary supplementation with resistant dextrin (NUTRIOSE®) on satiety, glycaemia, and related endpoints, in healthy adults
Open accessAbstract
Purpose: Resistant dextrin (RD) supplementation has been shown to alter satiety, glycaemia, and body weight, in overweight Chinese men; however, there are limited data on its effects in other demographic groups. Here, we investigated the effects of RD on satiety in healthy adults living in the United Kingdom. Methods: 20 normal weight and 16 overweight adults completed this randomised controlled cross-over study. Either RD (14 g/day NUTRIOSE® FB06) or maltodextrin control was consumed in mid-morning and mid-afternoon preload beverages over a 28-day treatment period with crossover after a 28-day washout. During 10-h study visits (on days 1, 14, and 28 of each treatment period), satietogenic, glycaemic and anorectic hormonal responses to provided meals were assessed. Results: Chronic supplementation with RD was associated with higher fasted satiety scores at day 14 (P = 0.006) and day 28 (P = 0.040), compared to control. RD also increased satiety after the mid-morning intervention drink, but it was associated with a reduction in post-meal satiety following both the lunch and evening meals (P < 0.01). The glycaemic response to the mid-morning intervention drink (0–30 min) was attenuated following RD supplementation (P < 0.01). Whilst not a primary endpoint we also observed lower systolic blood pressure at day 14 (P = 0.035) and 28 (P = 0.030), compared to day 1, following RD supplementation in the normal weight group. Energy intake and anthropometrics were unaffected. Conclusions: RD supplementation modified satiety and glycaemic responses in this cohort, further studies are required to determine longer-term effects on body weight control and metabolic markers. Clinicaltrials.gov registration: NCT02041975 (22/01/2014)
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Comparable studies examining postprandial glucose dynamics observed favorable responses with prebiotic beverages independent of available CHO content.
“Thus, it is worthwhile to note that comparable studies examining postprandial glucose dynamics observed favorable responses with prebiotic beverages independent of available CHO content (21,22).”
From Prebiotic soda lowers postprandial glucose compared to traditional soda pop: a randomized controlled trial (2025) · cites this paper as [21]
The Results (Blood metabolites) report lower postprandial glucose after the resistant-dextrin drink than after the maltodextrin control. But the Discussion says the drinks differed in carbohydrate and sugar content and that the glucose difference could reflect the maltodextrin’s greater immediate sugar bioavailability. The study therefore does not establish that the favorable response was independent of available carbohydrate content. (LLM, conf=0.88)
Experimental — accuracy not yet measuredRoutine prebiotic (resistant dextrin) beverage consumption (≥14 days) lowered blood glucose AUC and improved perceived satiety in the 0-2 h postprandial period compared to an isocaloric and available CHO-matched beverage in generally healthy adults with normal-to-overweight BMI.
“Moreover, routine prebiotic (resistant dextrin) beverage consumption (≥14 days) lowered blood glucose AUC and improved perceived satiety in the 0-2 h postprandial period compared to an isocaloric and available CHO-matched beverage in generally healthy adults with normal-tooverweight BMI (21).”
From Prebiotic soda lowers postprandial glucose compared to traditional soda pop: a randomized controlled trial (2025) · cites this paper as [21]
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredThe lack of effect of prebiotics on hunger in individuals with overweight or obese BMI may be a mere consequence of dose, whereby the beneficial effects of fiber intake may be relative to body weight.
“The lack of effect of prebiotics on hunger in individuals with overweight or obese BMI, like in our cohort and others (21), may be a mere consequence of dose, whereby the beneficial effects of fiber intake may be relative to body weight.”
From Prebiotic soda lowers postprandial glucose compared to traditional soda pop: a randomized controlled trial (2025) · cites this paper as [21]
The Results (Satiety ratings) report no effect on hunger and no observed satiety benefit in overweight participants. The Discussion suggests that 14 g/day of resistant dextrin may have been insufficient to alter satiety in that group. But the study did not include participants with obesity, did not establish that the effective dose scales with body weight, and also raises a possible microbiome-related explanation. (LLM, conf=0.86)
Experimental — accuracy not yet measuredPrebiotic beverage supplementation has previously been shown to improve fasting and postprandial satiety, but significant differences were only observed after ≥14 days of twice daily prebiotic beverage consumption.
“Prebiotic beverage supplementation has previously been shown to improve fasting and postprandial satiety, but significant differences were only observed after ≥14 days of twice daily prebiotic beverage consumption (21).”
From Prebiotic soda lowers postprandial glucose compared to traditional soda pop: a randomized controlled trial (2025) · cites this paper as [21]
Methods > Treatments reports twice-daily resistant-dextrin beverages. Results > Satiety ratings reports higher fasting satiety at days 14 and 28, and higher satiety after the morning drink at day 28. But it also reports lower satiety after lunch and the evening meal at day 28, so the broad claim that postprandial satiety improved is not supported. Page numbers are unavailable in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredBMI stratification identified that these satiety adaptations were exclusive to individuals with a normal BMI.
“However, BMI stratification identified that these satiety adaptations were exclusive to individuals with a normal BMI (21).”
From Prebiotic soda lowers postprandial glucose compared to traditional soda pop: a randomized controlled trial (2025) · cites this paper as [21]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Sugar-Sweetened Beverages, Obesity, Type 2 Diabetes Mellitus, and Cardiovascular Disease Risk
Malik, V. S., Popkin, B. M., Bray, G. A., Després, J.-P., & Hu, F. B. (2010) · Circulation · doi:10.1161/circulationaha.109.876185 · Cited by 1,641 · see citing works
Flagged first, then by citations
Research works printed but not linked: 25
- [1]Bäckhed F Ding H Wang T Hooper LV Koh GY Nagy A Semenkovich CF Gordon JI The gut microbiota as an environmental factor that regulates fat storage Proc Natl Acad Sci USA 2004 101 44 15718 15723 10.1073/pnas.0407076101 15505215 PMC524219 · DOI · Paper page
- [2]Roberfroid M Gibson GR Hoyles L McCartney AL Rastall R Rowland I Wolvers D Watzl B Szajewska H Stahl B Guarner F Respondek F Whelan K Coxam V Davicco MJ Léotoing L Wittrant Y Delzenne NM Cani PD Neyrinck AM Meheust A Prebiotic effects: metabolic and health benefits Br J Nutr 2010 104 Suppl 2 S1 63 10.1017/s0007114510003363 20920376 · DOI
- [3]Nøhr MK Gille A Egerod KL Engelstoft MS Offermanns S Schwartz TW GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes Endocrinology 2013 154 10 3552 3564 10.1210/en.2013-1142 23885020 · DOI
- [4]Beserra BT Fernandes R do Rosario VA, Mocellin MC, Kuntz MG, Trindade EB, A systematic review and meta-analysis of the prebiotics and synbiotics effects on glycaemia, insulin concentrations and lipid parameters in adult patients with overweight or obesity Clin Nutr (Edinburgh, Scotland) 2015 34 5 845 858 10.1016/j.clnu.2014.10.004 25456608 · DOI
- [5]John GK Wang L Nanavati J Twose C Singh R Mullin G Dietary alteration of the gut microbiome and its impact on weight and fat mass: a systematic review and meta-analysis Genes 2018 10.3390/genes9030167 29547587 PMC5867888 · DOI
- [6]Lefranc-Millot C Guérin-Deremaux L Wils D Neut C Miller LE Saniez-Degrave MH Impact of a resistant dextrin on intestinal ecology: how altering the digestive ecosystem with NUTRIOSE®, a soluble fibre with prebiotic properties, may be beneficial for health J Int Med Res 2012 40 1 211 224 10.1177/147323001204000122 22429361 · DOI
- [7]Guerin-Deremaux L Ringard F Desailly F Wils D Effects of a soluble dietary fibre NUTRIOSE® on colonic fermentation and excretion rates in rats Nurs Res Pract 2010 4 6 470 476 10.4162/nrp.2010.4.6.470 PMC3029787 21286404 · DOI
- [8]Hobden MR Martin-Morales A Guérin-Deremaux L Wils D Costabile A Walton GE Rowland I Kennedy OB Gibson GR In vitro fermentation of NUTRIOSE(®) FB06, a wheat dextrin soluble fibre, in a continuous culture human colonic model system PLoS ONE 2013 8 10 e77128 10.1371/journal.pone.0077128 24204753 PMC3811981 · DOI
- [9]Guérin-Deremaux L Pochat M Reifer C Wils D Cho S Miller LE The soluble fiber NUTRIOSE induces a dose-dependent beneficial impact on satiety over time in humans Nutr Res (New York, NY) 2011 31 9 665 672 10.1016/j.nutres.2011.09.004 22024490 · DOI
- [10]Guerin-Deremaux L Li S Pochat M Wils D Mubasher M Reifer C Miller LE Effects of NUTRIOSE® dietary fiber supplementation on body weight, body composition, energy intake, and hunger in overweight men Int J Food Sci Nutr 2011 62 6 628 635 10.3109/09637486.2011.569492 21591985 · DOI
- [11]Li S Guerin-Deremaux L Pochat M Wils D Reifer C Miller LE NUTRIOSE dietary fiber supplementation improves insulin resistance and determinants of metabolic syndrome in overweight men: a double-blind, randomized, placebo-controlled study Appl Physiol Nutr Metab Physiologie appliquee, nutrition et metabolisme 2010 35 6 773 782 10.1139/h10-074 21164548 · DOI
- [12]Aliasgharzadeh A Dehghan P Gargari BP Asghari-Jafarabadi M Resistant dextrin, as a prebiotic, improves insulin resistance and inflammation in women with type 2 diabetes: a randomised controlled clinical trial Br J Nutr 2015 113 2 321 330 10.1017/s0007114514003675 27028002 · DOI
- [13]Tillin T Hughes AD Mayet J Whincup P Sattar N Forouhi NG McKeigue PM Chaturvedi N The relationship between metabolic risk factors and incident cardiovascular disease in Europeans, South Asians, and African Caribbeans: SABRE (Southall and Brent Revisited) – a prospective population-based study J Am Coll Cardiol 2013 61 17 1777 1786 10.1016/j.jacc.2012.12.046 23500273 PMC3677086 · DOI
- [15]Stunkard AJ Messick S The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger J Psychosom Res 1985 29 1 71 83 10.1016/0022-3999(85)90010-8 3981480 · DOI · Paper page
- [17]Flint A Raben A Blundell JE Astrup A Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies Int J Obes Relat Metab Disord 2000 24 1 38 48 10.1038/sj.ijo.0801083 10702749 · DOI · Paper page
- [18]Hobden MR Guérin-Deremaux L Commane DM Rowland I Gibson GR Kennedy OB A pilot investigation to optimise methods for a future satiety preload study Pilot Feasibility Stud 2017 3 61 10.1186/s40814-017-0208-x 29177071 PMC5693544 · DOI
- [19]Blundell J de Graaf C Hulshof T Jebb S Livingstone B Lluch A Mela D Salah S Schuring E van der Knaap H Westerterp M Appetite control: methodological aspects of the evaluation of foods Obes Rev 2010 11 3 251 270 10.1111/j.1467-789X.2010.00714.x 20122136 PMC3609405 · DOI
- [20]Goswami C Iwasaki Y Yada T Short-chain fatty acids suppress food intake by activating vagal afferent neurons J Nutr Biochem 2018 57 130 135 10.1016/j.jnutbio.2018.03.009 29702431 · DOI
- [21]Byrne CS Chambers ES Preston T Tedford C Brignardello J Garcia-Perez I Holmes E Wallis GA Morrison DJ Frost GS Effects of inulin propionate ester incorporated into palatable food products on appetite and resting energy expenditure: a randomised crossover study Nutrients 2019 10.3390/nu11040861 30995824 PMC6520886 · DOI
- [22]Beck B Villaume C Debry G Clinical aspects of GIP secretion Acta Diabetol Lat 1982 19 1 1 11 10.1007/bf02581180 6280423 · DOI
- [23]Georg Jensen M Kristensen M Belza A Knudsen JC Astrup A Acute effect of alginate-based preload on satiety feelings, energy intake, and gastric emptying rate in healthy subjects Obesity (Silver Spring, Md.) 2012 20 9 1851 1858 10.1038/oby.2011.232 21779093 · DOI
- [25]Sarbini SR Kolida S Naeye T Einerhand A Brison Y Remaud-Simeon M Monsan P Gibson GR Rastall RA In vitro fermentation of linear and alpha-1,2-branched dextrans by the human fecal microbiota Appl Environ Microbiol 2011 77 15 5307 5315 10.1128/aem.02568-10 21666027 PMC3147461 · DOI
- [26]Ley RE Turnbaugh PJ Klein S Gordon JI Microbial ecology: human gut microbes associated with obesity Nature 2006 444 7122 1022 1023 10.1038/4441022a 17183309 · DOI · Paper page
- [27]Yeo SK Ooi LG Lim TJ Liong MT Antihypertensive properties of plant-based prebiotics Int J Mol Sci 2009 10 8 3517 3530 10.3390/ijms10083517 20111692 PMC2812835 · DOI
- [28]Cook NR Cohen J Hebert PR Taylor JO Hennekens CH Implications of small reductions in diastolic blood pressure for primary prevention Arch Intern Med 1995 155 7 701 709 10.1001/archinte.1995.00430070053006 7695458 · DOI
Cited by
Sorted by citations
McKenna, C. F., Voreades, N., Weiser, M. J., McCormick, C., Valdes, A. M., Blonquist, T., Kaden, V., Mah, E., & Cook, C. (2025) · doi:10.1101/2025.04.18.25326077
- Authors
- Hobden, M. R., Commane, D. M., Guérin-Deremaux, L., Wils, D., Thabuis, C., Martin-Morales, A., Wolfram, S., Dìaz, A., Collins, S., Morais, I., Rowland, I. R., Gibson, G. R., & Kennedy, O. B.
- Affiliations
- University of Reading (GB)
- Northumbria University (GB)
- Roquette Frères (France) (FR)
- Corresponding author
- Commane, Daniel M.
- Venue
- European Journal of Nutrition
- Published
- 2021-06-25
- Volume
- 60
- Issue
- 8
- Pages
- 4635-4643
- ISSN
- 1436-6207 (ISSN-L)
- 1436-6215
- PMC
- PMC8572182
- OpenAlex
- W3175034163
- Cited by
- 25
- References
- 1
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 1
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Update notices
- correction (2021-08-25)
- Open access
- hybrid
- doi.org
- Locations
- European Journal of Nutrition (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Northumbria Research Link (Northumbria University) (acceptedVersion)
- CentAUR (University of Reading) (acceptedVersion)
- Funders
- University of Reading
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Keywords
- resistant dextrin, dietary supplementation, satiety, glycemic response, maltodextrin, systolic blood pressure, energy intake, weight management, healthy adults
- MeSH terms
- Adult, Blood Glucose, Energy Intake, Dextrins, Humans, Male, Satiation, Satiety Response, Cross-Over Studies, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
