The link between metabolic abnormalities and endothelial dysfunction in type 2 diabetes: An update

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

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Inflammation, stress, and diabetes

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Adipose tissue dysfunction in obesity, diabetes, and vascular diseases

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Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications

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Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

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Endothelial dysfunction and vascular disease

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Inflammatory mechanisms in the regulation of insulin resistance

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Roles for Insulin Receptor, PI3-Kinase, and <i>Akt</i> in Insulin-Signaling Pathways Related to Production of Nitric Oxide in Human Vascular Endothelial Cells

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Vascular complications in diabetes mellitus: the role of endothelial dysfunction

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Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo

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Endothelial dysfunction in diabetes mellitus: Molecular mechanisms and clinical implications

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Hyperglycemia-Induced Reactive Oxygen Species Increase Expression of the Receptor for Advanced Glycation End Products (RAGE) and RAGE Ligands

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Diabetes Mellitus Enhances Vascular Matrix Metalloproteinase Activity

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The Polyol Pathway as a Mechanism for Diabetic Retinopathy: Attractive, Elusive, and Resilient

Lorenzi, M. (2007) · Journal of Diabetes Research · doi:10.1155/2007/61038 · Cited by 472 · see citing works

Is oxidative stress a therapeutic target in cardiovascular disease?

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Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy

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Endothelium‐mediated control of vascular tone: COX‐1 and COX‐2 products

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The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

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Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation

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Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity

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EDHF: an update

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Inhibition of Phosphatidylinositol 3-Kinase Enhances Mitogenic Actions of Insulin in Endothelial Cells

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The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action

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Free Fatty Acid Impairment of Nitric Oxide Production in Endothelial Cells Is Mediated by IKKβ

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Loss of Insulin Signaling in Vascular Endothelial Cells Accelerates Atherosclerosis in Apolipoprotein E Null Mice

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Endothelial Dysfunction in Diabetes: From Mechanisms to Therapeutic Targets

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Endothelial glycocalyx and coronary vascular permeability: the fringe benefit

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Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions

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Tumor Necrosis Factor-α Induces Endothelial Dysfunction in Lepr db Mice

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Insulin Receptor Substrate-1 and Phosphoinositide-Dependent Kinase-1 Are Required for Insulin-Stimulated Production of Nitric Oxide in Endothelial Cells

Montagnani, M., Ravichandran, L. V., Chen, H., Esposito, D. L., & Quon, M. J. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0074 · Cited by 235 · see citing works

Activation of NF-E2–Related Factor-2 Reverses Biochemical Dysfunction of Endothelial Cells Induced by Hyperglycemia Linked to Vascular Disease

Xue, M., Qian, Q., Adaikalakoteswari, A., Rabbani, N., Babaei‐Jadidi, R., & Thornalley, P. J. (2008) · Diabetes · doi:10.2337/db06-1003 · Cited by 235 · see citing works

Free Fatty Acids Inhibit Insulin Signaling–Stimulated Endothelial Nitric Oxide Synthase Activation Through Upregulating PTEN or Inhibiting Akt Kinase

Wang, X. L., Zhang, L., Youker, K. A., Zhang, M., Wang, J., LeMaire, S. A., Coselli, J. S., & Shen, Y. H. (2006) · Diabetes · doi:10.2337/db05-1574 · Cited by 228 · see citing works

Contribution of Insulin and Akt1 Signaling to Endothelial Nitric Oxide Synthase in the Regulation of Endothelial Function and Blood Pressure

Symons, J. D., McMillin, S. L., Riehle, C., Tanner, J. M., Palionyte, M., Hillas, E., Jones, D., Cooksey, R. C., Birnbaum, M. J., McClain, D. A., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.189316 · Cited by 212 · see citing works

Resveratrol Improves Endothelial Function

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Endothelial dysfunction as a potential contributor in diabetic nephropathy

Nakagawa, T., Tanabe, K., Croker, B. P., Johnson, R. J., Grant, M. B., Kosugi, T., & Li, Q. (2010) · Nature Reviews Nephrology · doi:10.1038/nrneph.2010.152 · Cited by 194 · see citing works

Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress

Brouwers, O., Niessen, P. M. G., Haenen, G. R. M. M., Miyata, T., Brownlee, M., Stehouwer, C. D. A., Mey, J. G. R. D., & Schalkwijk, C. (2010) · Diabetologia · doi:10.1007/s00125-010-1677-0 · Cited by 192 · see citing works

Vascular Lipotoxicity: Endothelial Dysfunction via Fatty-Acid-Induced Reactive Oxygen Species Overproduction in Obese Zucker Diabetic Fatty Rats

Chinen, I., Shimabukuro, M., Yamakawa, K., Higa, N., Matsuzaki, T., Noguchi, K., Ueda, S., Sakanashi, M., & Takasu, N. (2006) · Endocrinology · doi:10.1210/en.2006-1132 · Cited by 187 · see citing works

Effect of Endothelium-Specific Insulin Resistance on Endothelial Function In Vivo

Duncan, E. R., Crossey, P. A., Walker, S., Anilkumar, N. P., Poston, L., Douglas, G., Ezzat, V., Wheatcroft, S. B., Shah, A. M., & Kearney, M. T. (2008) · Diabetes · doi:10.2337/db07-1111 · Cited by 179 · see citing works

Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db−/−) mice: role of decreased tetrahydrobiopterin bioavailability

Pannirselvam, M., Verma, S., Anderson, T. J., & Triggle, C. R. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704683 · Cited by 177 · see citing works

Insulin-induced vasodilatation and endothelial function in obesity/insulin resistance. Effects of troglitazone

Tack, C. J. J., Ong, M. K. E., Lutterman, J. A., & Smits, P. (1998) · Diabetologia · doi:10.1007/s001250050948 · Cited by 177 · see citing works

AGE/RAGE produces endothelial dysfunction in coronary arterioles in Type 2 diabetic mice

Gao, X. J., Zhang, H., Schmidt, A. M., & Zhang, C. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00464.2008 · Cited by 174 · see citing works

Insulin says NO to cardiovascular disease

Yu, Q., Gao, F., & Ma, X. L. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq349 · Cited by 172 · see citing works

Endothelium‐dependent contractions: when a good guy turns bad!

Vanhoutte, P. M., & Tang, E. H. C. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.161430 · Cited by 163 · see citing works

Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction

Murdoch, C. E., Alom-Ruiz, S. P., Wang, M., Zhang, M., Walker, S., Yu, B., Brewer, A. C., & Shah, A. M. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0179-7 · Cited by 152 · see citing works

Advanced Glycation End-Product of Low Density Lipoprotein Activates the Toll-Like 4 Receptor Pathway Implications for Diabetic Atherosclerosis

Hodgkinson, C. P., Laxton, R. C., Patel, K. P., & Ye, S. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.175992 · Cited by 149 · see citing works

Endothelin-1 and diabetic complications: focus on the vasculature

Ergul, A. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.01.012 · Cited by 144 · see citing works

Elevated plasma free fatty acids increase cardiovascular risk by inducing plasma biomarkers of endothelial activation, myeloperoxidase and PAI-1 in healthy subjects

Mathew, M., Tay, E., & Cusi, K. J. (2010) · Cardiovascular Diabetology · doi:10.1186/1475-2840-9-9 · Cited by 144 · see citing works

Saturated, but Not Unsaturated, Fatty Acids Induce Apoptosis of Human Coronary Artery Endothelial Cells via Nuclear Factor-κB Activation

Staiger, K., Staiger, H., Weigert, C., Haas, C., Häring, H., & Kellerer, M. (2006) · Diabetes · doi:10.2337/db06-0188 · Cited by 139 · see citing works

Metabolic consequences of hyperglycemia and insulin resistance

Jellinger, P. S. (2007) · Clinical cornerstone · doi:10.1016/s1098-3597(07)80019-6 · Cited by 121 · see citing works

Increased MAPK Activation and Impaired Insulin Signaling in Subcutaneous Microvascular Endothelial Cells in Type 2 Diabetes: The Role of Endothelin-1

Gogg, S., Smith, U., & Jansson, P. (2009) · Diabetes · doi:10.2337/db08-0961 · Cited by 108 · see citing works

Paradoxical Activation of Endothelial Nitric Oxide Synthase by NADPH Oxidase

Zhang, Q., Malik, P., Pandey, D., Gupta, S. A., Jagnandan, D., de Chantemèle, E. J. B., Bánfi, B., Marrero, M. B., Rudic, R. D., Stepp, D. W., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.168278 · Cited by 106 · see citing works

COX-mediated endothelium-dependent contractions: from the past to recent discoveries

Wong, M. S. K., & Vanhoutte, P. M. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.127 · Cited by 105 · see citing works

The potential effects of anti-diabetic medications on myocardial ischemia–reperfusion injury

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CB1 receptor inhibition leads to decreased vascular AT1 receptor expression, inhibition of oxidative stress and improved endothelial function

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Glycated albumin, a precursor of advanced glycation end‐products, up‐regulates NADPH oxidase and enhances oxidative stress in human endothelial cells: molecular correlate of diabetic vasculopathy

Rodiño‐Janeiro, B. K., González‐Peteiro, M., Ucieda‐Somoza, R., González‐Juanatey, J. R., & Álvarez, E. (2010) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1117 · Cited by 95 · see citing works

Does reversal of oxidative stress and inflammation provide vascular protection?

Koh, K. K., Oh, P. C., & Quon, M. J. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn354 · Cited by 89 · see citing works

Role of EDHF in type 2 diabetes-induced endothelial dysfunction

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Effect of apocynin on NADPH oxidase-mediated oxidative stress-LOX-1-eNOS pathway in human endothelial cells exposed to high glucose

Taye, A., Saad, A., Kumar, A. H. S., & Morawietz, H. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.10.045 · Cited by 84 · see citing works

Free Fatty Acids Induce Insulin Resistance in Both Cardiac and Skeletal Muscle Microvasculature in Humans

Liu, J., Jahn, L. A., Fowler, D. E., Barrett, E. J., Cao, W., & Liu, Z. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1174 · Cited by 83 · see citing works

Dose-Dependent Modulatory Effects of Insulin on Glucose-Induced Endothelial Senescence In Vitro and In Vivo: A Relationship between Telomeres and Nitric Oxide

Matsui‐Hirai, H., Hayashi, T., Yamamoto, S., Ina, K., Maeda, M., Kotani, H., Iguchi, A., Ignarro, L. J., & Hattori, Y. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.177584 · Cited by 79 · see citing works

Bariatric Surgery Reduces Visceral Adipose Inflammation and Improves Endothelial Function in Type 2 Diabetic Mice

Zhang, H., Wang, Y., Zhang, J., Potter, B. J., Sowers, J. R., & Zhang, C. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.225870 · Cited by 76 · see citing works

Inhibition of the Renin-Angiotensin System Prevents Free Fatty Acid–Induced Acute Endothelial Dysfunction in Humans

Watanabe, S., Tagawa, T., Yamakawa, K., Shimabukuro, M., & Ueda, S. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000187465.55507.85 · Cited by 75 · see citing works

Coronary arterioles in type 2 diabetic (db/db) mice undergo a distinct pattern of remodeling associated with decreased vessel stiffness

Katz, P. S., Trask, A. J., Souza‐Smith, F. M., Hutchinson, K. R., Galantowicz, M. L., Lord, K. C., Stewart, J. A., Cismowski, M. J., Varner, K. J., & Lucchesi, P. A. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0201-0 · Cited by 73 · see citing works

Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension

Zhang, L.-N., Vincelette, J., Chen, D., Gless, R. D., Anandan, S., Rubanyi, G. M., Webb, H. K., MacIntyre, D. E., & Wang, Y. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.12.016 · Cited by 71 · see citing works

Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice

Cheang, W. S., Wong, W. T., Tian, X. Y., Yang, Q., Lee, H. K., He, G., Yao, X., & Huang, Y. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr233 · Cited by 70 · see citing works

Elevated concentrations of nonesterified fatty acids increase monocyte expression of CD11b and adhesion to endothelial cells.

Zhang, W.-Y., Schwartz, E., Wang, Y., Attrep, J., Li, Z., & Reaven, P. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000200226.53994.09 · Cited by 70 · cited 1× · see citing works

Intravenous Intralipid-Induced Blood Pressure Elevation and Endothelial Dysfunction in Obese African-Americans with Type 2 Diabetes

Umpierrez, G. E., Smiley, D. D., Robalino, G., Peng, L., Kitabchi, A. E., Khan, B. V., Le, A., Quyyumi, A. A., Brown, V., & Phillips, L. S. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1590 · Cited by 69 · see citing works

Reactive oxygen‐derived free radicals are key to the endothelial dysfunction of diabetes

Shi, Y., & Vanhoutte, P. M. (2009) · Journal of Diabetes · doi:10.1111/j.1753-0407.2009.00030.x · Cited by 68 · see citing works

C-peptide reduces high-glucose-induced apoptosis of endothelial cells and decreases NAD(P)H-oxidase reactive oxygen species generation in human aortic endothelial cells

Cifarelli, V., Geng, X., Styche, A. J., Lakomy, R. A., Trucco, M., & Luppi, P. (2011) · Diabetologia · doi:10.1007/s00125-011-2251-0 · Cited by 68 · see citing works

Prolonged deterioration of endothelial dysfunction in response to postprandial lipaemia is attenuated by vitamin C in Type 2 diabetes

Anderson, R. A., Evans, M., Ellis, G. R., Khan, N., Morris, K., Jackson, S. K., Rees, A., LEWIS, M. J., & Frenneaux, M. P. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2005.01767.x · Cited by 68 · see citing works

p38 Mitogen-Activated Protein Kinase Mediates Palmitate-Induced Apoptosis But Not Inhibitor of Nuclear Factor-κB Degradation in Human Coronary Artery Endothelial Cells

Chai, W., & Liu, Z. (2007) · Endocrinology · doi:10.1210/en.2006-1068 · Cited by 67 · see citing works

Direct relationship between levels of TNF-α expression and endothelial dysfunction in reperfusion injury

Zhang, C., Wu, J., Xu, X., Potter, B. J., & Gao, X. J. (2010) · Basic Research in Cardiology · doi:10.1007/s00395-010-0083-6 · Cited by 67 · see citing works

Free Fatty Acid Causes Leukocyte Activation and Resultant Endothelial Dysfunction Through Enhanced Angiotensin II Production in Mononuclear and Polymorphonuclear Cells

Azekoshi, Y., Yasu, T., Watanabe, S., Tagawa, T., Abe, S., Yamakawa, K., Uehara, Y., Momomura, S., Urata, H., & Ueda, S. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.153056 · Cited by 65 · see citing works

Effect of PAR2 in regulating TNF-α and NAD(P)H oxidase in coronary arterioles in type 2 diabetic mice

Park, Y., Yang, J.-Y., Zhang, H., Chen, X., & Zhang, C. (2010) · Basic Research in Cardiology · doi:10.1007/s00395-010-0129-9 · Cited by 64 · see citing works

APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice

Wang, Y., Cheng, K. K. Y., Lam, K. S. L., Wu, D., Wang, Y., Huang, Y., Vanhoutte, P. M., Sweeney, G., Li, Y., & Xu, A. (2011) · Diabetes · doi:10.2337/db11-0666 · Cited by 64 · see citing works

Unsaturated Fatty Acids Drive Disintegrin and Metalloproteinase (ADAM)-dependent Cell Adhesion, Proliferation, and Migration by Modulating Membrane Fluidity

Reiß, K., Cornelsen, I., Husmann, M., Gimpl, G., & Bhakdi, S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.243485 · Cited by 63 · see citing works

Role of NADPH Oxidase in Retinal Microvascular Permeability Increase by RAGE Activation

Warboys, C. M., Toh, H.-B., & Fraser, P. A. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2730 · Cited by 61 · see citing works

Role of MCP-1 in tumor necrosis factor-α-induced endothelial dysfunction in type 2 diabetic mice

Yang, J., Park, Y., Zhang, H., Gao, X. J., Wilson, E., Zimmer, W. E., Abbott, L. C., & Zhang, C. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00396.2009 · Cited by 59 · see citing works

Influence of obesity and metabolic dysfunction on the endothelial control in the coronary circulation

de Chantemèle, E. J. B., & Stepp, D. W. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.08.018 · Cited by 54 · see citing works

Adipose “Talks” to Distant Organs to Regulate Insulin Sensitivity and Vascular Function

Zhang, H., & Zhang, C. (2010) · Obesity · doi:10.1038/oby.2010.91 · Cited by 49 · see citing works

Mesenteric Resistance Arteries in Type 2 Diabetic db/db Mice Undergo Outward Remodeling

Souza‐Smith, F. M., Katz, P. S., Trask, A. J., Stewart, J. A., Lord, K. C., Varner, K. J., Vassallo, D. V., & Lucchesi, P. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023337 · Cited by 48 · see citing works

Regulation of Microvascular Function by Adipose Tissue in Obesity and Type 2 Diabetes: Evidence of an Adipose-Vascular

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Different mechanisms of saturated versus polyunsaturated FFA-induced apoptosis in human endothelial cells

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Direct apoptotic effects of free fatty acids on human endothelial cells

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Increased vascular thromboxane generation impairs dilation of skeletal muscle arterioles of obese Zucker rats with reduced oxygen tension

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Rosiglitazone Prevents Free Fatty Acid-Induced Vascular Endothelial Dysfunction

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Protein Kinase C inhibition ameliorates functional endothelial insulin resistance and Vascular Smooth Muscle Cell hypersensitivity to insulin in diabetic hypertensive rats

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Glucose-induced endothelin-1 expression is regulated by ERK5 in the endothelial cells and retina of diabetic ratsThis article is one of a selection of papers published in the two-part special issue entitled 20 Years of Endothelin Research.

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Glucose Control and Cardiovascular Disease

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Mechanisms of Vascular Insulin Resistance

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Polyol Formation in Cell Lines of Rat Retinal Capillary Pericytes and Endothelial Cells (TR-rPCT and TR-iBRB)

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High FFA-induced proliferation and apoptosis in human umbilical vein endothelial cell partly through Wnt/β-catenin signal pathway

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Obesity and Inflammatory Vasculopathy

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Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I

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Endothelial dysfunction — A major mediator of diabetic vascular disease

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Inflammatory Links Between High Fat Diets and Diseases

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High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications

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AMPK, Mitochondrial Function, and Cardiovascular Disease

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Frank, N., & Tadros, E. M. (2013) · Equine Veterinary Journal · doi:10.1111/evj.12169 · Cited by 248 · see citing works

Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nitrative stresses

Zhu, D., Wang, H., Zhang, J., Zhang, X., Xin, C., Zhang, F., Lee, Y., Zhang, L., Lian, K., Yan, W., et al. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.07.015 · Cited by 212 · see citing works

Post-Prandial Protein Handling: You Are What You Just Ate

Groen, B. B. L., Horstman, A. M. H., Hamer, H. M., de Haan, M. W., van Kranenburg, J. M. X., Bierau, J., Poeze, M., Wodzig, W. K. W. H., Rasmussen, B. B., & van Loon, L. J. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141582 · Cited by 150 · see citing works

Plasma Adropin Levels Predict Endothelial Dysfunction Like Flow-Mediated Dilatation in Patients With Type 2 Diabetes Mellitus

Topuz, M., Çelik, A., Aslantas, T., Demir, A. K., Aydın, S., & Aydın, S. (2013) · Journal of Investigative Medicine · doi:10.2310/jim.0000000000000003 · Cited by 125 · see citing works

Reversibility of endothelial dysfunction in diabetes: role of polyphenols

Suganya, N., Bhakkiyalakshmi, E., Sarada, D. V. L., & Ramkumar, K. M. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516001884 · Cited by 111 · see citing works

Relation Between Serum Free Fatty Acids and Adiposity, Insulin Resistance, and Cardiovascular Risk Factors From Adolescence to Adulthood

Frohnert, B. I., Jacobs, D. R., Steinberger, J., Moran, A., Steffen, L. M., & Sinaiko, A. R. (2013) · Diabetes · doi:10.2337/db12-1122 · Cited by 98 · see citing works

Anti-diabetic effects of the Indian indigenous fruit Emblica officinalis Gaertn: active constituents and modes of action

D'souza, J. J., D'souza, P., Fazal, F., Kumar, A., Bhat, H. P., & Baliga, M. S. (2014) · Food & Function · doi:10.1039/c3fo60366k · Cited by 97 · see citing works

Endothelial microparticles prevent lipid‐induced endothelial damage via Akt/eNOS signaling and reduced oxidative stress

Mahmoud, A. M., Wilkinson, F. L., McCarthy, E. M., Moreno-Martínez, D., Langford-Smith, A., Romero, M., Duarte, J., & Alexander, M. Y. (2017) · The FASEB Journal · doi:10.1096/fj.201601244rr · Cited by 96 · see citing works

A review of recent advances and current hypotheses on the pathogenesis of acute laminitis

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The vascular smooth muscle cell: a therapeutic target in Type 2 diabetes?

Porter, K. E., & Riches‐Suman, K. (2013) · Clinical Science · doi:10.1042/cs20120413 · Cited by 85 · see citing works

Endoplasmic Reticulum Stress and Obesity

Yılmaz, E. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_11 · Cited by 83 · see citing works

Overlapped Metabolic and Therapeutic Links between Alzheimer and Diabetes

Ahmad, W. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8352-z · Cited by 80 · see citing works

The effects of equal caloric high fat and western diet on metabolic syndrome, oxidative stress and vascular endothelial function in mice

HEINONEN, I. H. A., Rinne, P., Ruohonen, S., Ruohonen, S., Ahotupa, M. O., & Savontaus, E. (2014) · Acta Physiologica · doi:10.1111/apha.12253 · Cited by 76 · see citing works

Coronary endothelial dysfunction and mitochondrial reactive oxygen species in type 2 diabetic mice

Cho, Y.-E., Basu, A., Dai, A., Heldak, M., & Makino, A. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00234.2013 · Cited by 76 · see citing works

Blood Pressure Regulation in Stress: Focus on Nitric Oxide-Dependent Mechanisms

Púzserová, A., & Bernátová, I. (2016) · Physiological Research · doi:10.33549/physiolres.933442 · Cited by 73 · see citing works

A novel role for small molecule glycomimetics in the protection against lipid-induced endothelial dysfunction: Involvement of Akt/eNOS and Nrf2/ARE signaling

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Endoplasmic reticulum stress in insulin resistance and diabetes

Guerrero-Hernández, A., León-Aparicio, D., Chávez‐Reyes, J., Olivares-Reyes, J. A., & DeJesus, S. (2014) · Cell Calcium · doi:10.1016/j.ceca.2014.08.006 · Cited by 68 · see citing works

The ATP Receptors P2X7 and P2X4 Modulate High Glucose and Palmitate-Induced Inflammatory Responses in Endothelial Cells

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Tripping on TRIB3 at the junction of health, metabolic dysfunction and cancer

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Derivatization Methods for LC–MS Analysis of Endogenous Compounds

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Diabetes and Stroke Prevention: A Review

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Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells

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Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells

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Palmitate induces apoptosis in mouse aortic endothelial cells and endothelial dysfunction in mice fed high-calorie and high-cholesterol diets

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Interventional strategies to combat muscle disuse atrophy in humans: focus on neuromuscular electrical stimulation and dietary protein

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Impaired cardiometabolic responses to glucagon-like peptide 1 in obesity and type 2 diabetes mellitus

Moberly, S. P., Mather, K. J., Berwick, Z. C., Owen, M. K., Goodwill, A. G., Casalini, E. D., Hutchins, G. D., Green, M. A., Ng, Y., Considine, R. V., et al. (2013) · Basic Research in Cardiology · doi:10.1007/s00395-013-0365-x · Cited by 51 · see citing works

Comparison of placental findings in type 1 and type 2 diabetic pregnancies

Starikov, R. S., Inman, K. W., Chen, K., Lopes, V., Coviello, E., Pınar, H., & He, M. (2014) · Placenta · doi:10.1016/j.placenta.2014.10.008 · Cited by 49 · see citing works

Clusterin ameliorates endothelial dysfunction in diabetes by suppressing mitochondrial fragmentation

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Synthesis and preliminary therapeutic evaluation of copper nanoparticles against diabetes mellitus and -induced micro- (renal) and macro-vascular (vascular endothelial and cardiovascular) abnormalities in rats

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Endothelial dysfunction: from the particular to the general. Return to the «Old Paradigm»?

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Microvascular dysfunction and efficacy of PDE5 inhibitors in BPH–LUTS

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Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease

Nikdoust, F., Pazoki, M., Mohammadtaghizadeh, M., Aghaali, M. K., & Amrovani, M. (2021) · Cardiovascular Toxicology · doi:10.1007/s12012-021-09700-y · Cited by 41 · see citing works

Blood glucose management in the patient undergoing cardiac surgery: A review

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Dehydroepiandrosterone prevents linoleic acid-induced endothelial cell senescence by increasing autophagy

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The role of diabetes in the onset and development of endothelial dysfunction

Popyhova, E. B., Stepanova, T., Lagutina, D. D., Kiriyazi, T. S., & Иванов, А. Н. (2020) · Problems of Endocrinology · doi:10.14341/probl12212 · Cited by 39 · see citing works

Stevioside Attenuates Insulin Resistance in Skeletal Muscle by Facilitating IR/IRS-1/Akt/GLUT 4 Signaling Pathways: An In Vivo and In Silico Approach

Deenadayalan, A., Subramanian, V., Paramasivan, V., Veeraraghavan, V. P., Rengasamy, G., Janaki, C. S., Rajagopal, P., & Jayaraman, S. (2021) · Molecules · doi:10.3390/molecules26247689 · Cited by 39 · see citing works

Navigating the intersection: Diabetes and Alzheimer's intertwined relationship

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Sesamol intervention ameliorates obesity-associated metabolic disorders by regulating hepatic lipid metabolism in high-fat diet-induced obese mice

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Chronic treatment with long acting phosphodiesterase-5 inhibitor tadalafil alters proteomic changes associated with cytoskeletal rearrangement and redox regulation in Type 2 diabetic hearts

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Analysis of non-esterified fatty acids in human samples by solid-phase-extraction and gas chromatography/mass spectrometry

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Icariin Attenuates High Glucose-Induced Apoptosis, Oxidative Stress, and Inflammation in Human Umbilical Venous Endothelial Cells

Sun, S., Liu, L., Tian, X., Guo, Y., Cao, Y., Mei, Y., & Wang, C. (2019) · Planta Medica · doi:10.1055/a-0837-0975 · Cited by 32 · see citing works

Depletion of NAD pool contributes to impairment of endothelial progenitor cell mobilization in diabetes

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The effect of chronic exposure to high palmitic acid concentrations on the aerobic metabolism of human endothelial EA.hy926 cells

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The role of estrogen receptors in intracellular estrogen signaling pathways, an overview

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C1q/TNF-related protein 5 contributes to diabetic vascular endothelium dysfunction through promoting Nox-1 signaling

Liu, J., Meng, Z., Gan, L., Guo, R., Gao, J., Liu, C., Zhu, D., Liu, D., Zhang, L., Zhang, Z., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101476 · Cited by 31 · see citing works

Pharmacological management of vascular endothelial dysfunction in diabetes: TCM and western medicine compared based on biomarkers and biochemical parameters

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Comprehensive treatment of diabetic endothelial dysfunction based on pathophysiological mechanism

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Portulaca Oleracea L. (Purslane) Extract Protects Endothelial Function by Reducing Endoplasmic Reticulum Stress and Oxidative Stress through AMPK Activation in Diabetic Obese Mice

Miao, L., Zhou, C., Zhang, H., Cheong, M. S., Tan, Y., Wang, Y., Zhang, X., Yu, H., & Cheang, W. S. (2023) · Antioxidants · doi:10.3390/antiox12122132 · Cited by 26 · see citing works

Self‐reported Racial Discrimination and Endothelial Reactivity to Acute Stress in Women

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The effect of exercise on flow-mediated dilation in people with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials

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Macrophage polarization in diabetic vascular complications: mechanistic insights and therapeutic targets

Cao, L., Ding, L., Xia, Q., Zhang, Z., Li, M., Song, S., Yin, K., Li, Z., Li, X., Wang, Z., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07075-0 · Cited by 26 · see citing works

Management of Dyslipidemias in the Presence of the Metabolic Syndrome or Type 2 Diabetes

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Microembolization and myonecrosis during elective percutaneous coronary interventions in diabetic patients: an intracoronary Doppler ultrasound study with 2-year clinical follow-up

Otto, S., Seeber, M., Fujita, B., Kretzschmar, D., Ferrari, M. W., Goebel, B., Figulla, H. R., & Poerner, T. C. (2012) · Basic Research in Cardiology · doi:10.1007/s00395-012-0289-x · Cited by 24 · see citing works

d ‐Chiro inositol ameliorates endothelial dysfunction via inhibition of oxidative stress and mitochondrial fission

Zhang, B., Guo, X., Li, Y., Peng, Q., Gao, J., Liu, B., & Wang, M. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600710 · Cited by 24 · see citing works

Features Analysis of Lower Extremity Arterial Lesions in 162 Diabetes Patients

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Coronary heart disease in Type 2 diabetes: mechanisms and comprehensive prevention strategies

Wang, Y., Yu, Q., Fan, D., & Cao, F. (2012) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.12.52 · Cited by 23 · see citing works

Unripe Rubus coreanus Miquel Extract Containing Ellagic Acid Promotes Lipolysis and Thermogenesis In Vitro and In Vivo

Kim, K. J., Jeong, E.-S., Lee, K. H., Na, J.-R., Park, S., Kim, J. S., Na, C.-S., Kim, Y. R., & Kim, S. (2020) · Molecules · doi:10.3390/molecules25245954 · Cited by 23 · see citing works

Review article: vascular effects of PPARs in the context of NASH

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MicroRNA profiling of diabetic atherosclerosis in a rat model

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Treatment of NASH with Antioxidant Therapy: Beneficial Effect of Red Cabbage on Type 2 Diabetic Rats

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Effect of the PPARγ C161T Gene Variant on Serum Lipids in Ischemic Stroke Patients with and Without Type 2 Diabetes Mellitus

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Endothelial Metabolic Reprogramming Links Diabetes to Atherosclerosis

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Oxidative Stress, Inflammation and Endothelial Dysfunction: The Link Between Obstructive Sleep Apnoea and Vascular Disease in Type 2 Diabetes

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Inhibition of Endoplasmic Reticulum Stress Improves Acetylcholine-Mediated Relaxation in the Aorta of Type-2 Diabetic Rats

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The Transition of Cardiovascular Disease Risks from NAFLD to MAFLD

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Green Tea Catechol (−)-Epigallocatechin Gallate (EGCG) Conjugated with Phenylalanine Shows Enhanced Autophagy Stimulating Activity in Human Aortic Endothelial Cells

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HIV sero-positivity and risk factors for ischaemic and haemorrhagic stroke in hospitalised patients in Uganda: A prospective-case-control study

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Microvascular Parameters Help to Predict Stroke Risk in the Asian Diabetic Population in Taiwan: A Population Based Case-Control Study

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