Cited by 87Alcohol Consumption and Health EffectsCardiovascular Health and Risk FactorsNutritional Studies and Diet

Alcohol and the risk of myocardial infarction

Flesch, Markus, Rosenkranz, Stephan, Erdmann, Erland, Böhm, Michael·2001·Basic Research in Cardiology

Abstract

Epidemiological studies have repeatedly demonstrated a beneficial effect of moderate alcohol consumption on the incidence of coronary heart disease, myocardial infarction and overall mortality. The latter increases with excessive alcohol consumption. Although most epidemiological studies demonstrate a beneficial effect of alcohol consumption independent from the specific kind of alcoholic beverage, there is increasing evidence that wine and in particular red wine might contain pharmacological substances, which prevent atherosclerosis and myocardial infarction independent from the wine ethanol. Pathophysiological mechanisms mediating these beneficial effects include effects of wine phenols and tannins on LDL-cholesterol oxidation status, thrombocyte aggregation, endothelial function and smooth muscle cell proliferation. Identification and characterization of the pharmacologically active substances might provide the stage for the development of new substances to be used in the prevention of coronary artery disease and myocardial infarction.

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Crossref · 10.1007/s003950170062

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Authors
Flesch, M., Rosenkranz, S., Erdmann, E., & Böhm, M.
Affiliations
University of Cologne (DE)
Venue
Basic Research in Cardiology
Published
2001-03-01
Volume
96
Issue
2
Pages
128-135
ISSN
  • 0003-9217 (ISSN-L)
  • 0300-8428
  • 1435-1803
OpenAlex
W2043957904
Cited by
87
References
40
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 8
FWCI
3.53
Type
journal article
Language
en
Open access
closed
Locations
  • Basic Research in Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
alcohol consumption, myocardial infarction, coronary artery disease, red wine, tannins, LDL oxidation, platelet aggregation, endothelial function, smooth muscle cell proliferation, atherosclerosis, coronary heart disease prevention, excessive alcohol consumption, mortality
MeSH terms
Alcohol Drinking, Humans, Myocardial Infarction, Risk Factors, Wine

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