Alcohol and the risk of myocardial infarction
Abstract
Epidemiological studies have repeatedly demonstrated a beneficial effect of moderate alcohol consumption on the incidence of coronary heart disease, myocardial infarction and overall mortality. The latter increases with excessive alcohol consumption. Although most epidemiological studies demonstrate a beneficial effect of alcohol consumption independent from the specific kind of alcoholic beverage, there is increasing evidence that wine and in particular red wine might contain pharmacological substances, which prevent atherosclerosis and myocardial infarction independent from the wine ethanol. Pathophysiological mechanisms mediating these beneficial effects include effects of wine phenols and tannins on LDL-cholesterol oxidation status, thrombocyte aggregation, endothelial function and smooth muscle cell proliferation. Identification and characterization of the pharmacologically active substances might provide the stage for the development of new substances to be used in the prevention of coronary artery disease and myocardial infarction.
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- Authors
- Flesch, M., Rosenkranz, S., Erdmann, E., & Böhm, M.
- Affiliations
- University of Cologne (DE)
- Venue
- Basic Research in Cardiology
- Published
- 2001-03-01
- Volume
- 96
- Issue
- 2
- Pages
- 128-135
- ISSN
- 0003-9217 (ISSN-L)
- 0300-8428
- 1435-1803
- OpenAlex
- W2043957904
- Cited by
- 87
- References
- 40
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 8
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Basic Research in Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- alcohol consumption, myocardial infarction, coronary artery disease, red wine, tannins, LDL oxidation, platelet aggregation, endothelial function, smooth muscle cell proliferation, atherosclerosis, coronary heart disease prevention, excessive alcohol consumption, mortality
- MeSH terms
- Alcohol Drinking, Humans, Myocardial Infarction, Risk Factors, Wine
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