[18F]AV-1451 tau-PET uptake does correlate with quantitatively measured 4R-tau burden in autopsy-confirmed corticobasal degeneration.
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Studies comparing antemortem tau positron emission tomography imaging with autopsy have begun assessing the ability of flortaucipir to detect underlying neurofibrillary tangles in Alzheimer disease and non-Alzheimer disease dementias.
“Studies comparing antemortem tau PET imaging with autopsy have begun assessing the ability of flortaucipir to detect underlying NFTs in AD and non-AD dementias.25,26,27,28,29,30,31,32,33”
From Positron Emission Tomography Imaging With [ <sup>18</sup> F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes (2020) · cites this paper as [26]
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Criteria for the diagnosis of corticobasal degeneration
Armstrong, M. J., Litvan, I., Lang, A. E., Bak, T. H., Bhatia, K. P., Borroni, B., Boxer, A. L., Dickson, D. W., Grossman, M., Hallett, M., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e31827f0fd1 · Cited by 1,904 · see citing works
Self-citationOffice of Rare Diseases Neuropathologic Criteria for Corticobasal Degeneration
Dickson, D. W., Bergeron, C., Chin, S. S., Duyckaerts, C., Horoupian, D., Ikeda, K., Jellinger, K., Lantos, P. L., Lippa, C. F., Mirra, S. S., et al. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.11.935 · Cited by 724 · see citing works
Self-citationEarly Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808
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Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807
Chien, D. T., Bahri, S., Szardenings, A. K., Walsh, J. C., Mu, F., Su, M.-Y., Shankle, W. R., Elizarov, A., & Kolb, H. C. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-122059 · Cited by 651 · cited 1× · see citing works
“One such ligand, [18F]AV-1451, has been shown to bind to abnormal 3R + 4R tau in diseases such as Alzheimer’s disease [2].”
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An autoradiographic evaluation of AV-1451 Tau PET in dementia
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Self-citationβ‐amyloid burden is not associated with rates of brain atrophy
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Self-citationSander, K., Lashley, T., Gami, P., Gendron, T., Lythgoe, M. F., Rohrer, J. D., Schott, J. M., Revesz, T., Fox, N. C., & Årstad, E. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.01.003 · Cited by 187 · see citing works
Smith, R., Puschmann, A., Schöll, M., Ohlsson, T., van Swieten, J., Honer, M., Englund, E., & Hansson, O. (2016) · Brain · doi:10.1093/brain/aww163 · Cited by 168 · see citing works
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Ghirelli, A., Tosakulwong, N., Weigand, S. D., Clark, H. M., Ali, F., Botha, H., Duffy, J. R., Utianski, R. L., Buciuc, M., Murray, M. E., et al. (2020) · Annals of Neurology · doi:10.1002/ana.25893 · Cited by 59 · see citing works
Self-citationMartersteck, A., Ayala, I., Ohm, D. T., Spencer, C., Coventry, C., Weintraub, S., Bigio, E. H., Mesulam, M. M., Geula, C., & Rogalski, E. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01412-w · Cited by 9 · see citing works
- Authors
- Josephs, K. A., Whitwell, J. L., Tacik, P., Duffy, J. R., Senjem, M. L., Tosakulwong, N., Jack, C. R., Lowe, V., Dickson, D. W., & Murray, M. E.
- Affiliations
- Mayo Clinic (US)
- Mayo Clinic in Florida (US)
- Corresponding author
- Josephs, Keith A.
- ORCID
- Venue
- Acta Neuropathologica
- Published
- 2016-09-19
- Volume
- 132
- Issue
- 6
- Pages
- 931-933
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- PMC
- PMC5107140
- OpenAlex
- W2521285559
- Cited by
- 127
- References
- 10
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 13 · 2020: 15 · 2019: 24 · 2018: 24 · 2017: 22 · 2016: 3
- FWCI
- 19.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Deafness and Other Communication Disorders (R01-DC12519)
- National Institute of Neurological Disorders and Stroke (R01-NS89757)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- 18F-AV-1451, tau PET, 4R tau, corticobasal degeneration, tau burden, amyloid PET, neurodegeneration imaging
- MeSH terms
- Aniline Compounds, Autopsy, Basal Ganglia, Carbolines, Cerebral Cortex, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Thiazoles, tau Proteins, Neurodegenerative Diseases, Positron-Emission Tomography
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