Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons
Open accessAbstract
Transactivating DNA-binding protein-43 (TDP-43) deposits represent a typical finding in almost all ALS patients, more than half of FTLD patients and patients with several other neurodegenerative disorders. It appears that perturbation of nucleo-cytoplasmic transport is an important event in these conditions but the mechanistic role and the fate of TDP-43 during neuronal degeneration remain elusive. We have developed an experimental system for visualising the perturbed nucleocytoplasmic transport of neuronal TDP-43 at the single-cell level in vivo using zebrafish spinal cord. This approach enabled us to image TDP-43-expressing motor neurons before and after experimental initiation of cell death. We report the formation of mobile TDP-43 deposits within degenerating motor neurons, which are normally phagocytosed by microglia. However, when microglial cells were depleted, injury-induced motor neuron degeneration follows a characteristic process that includes TDP-43 redistribution into the cytoplasm, axon and extracellular space. This is the first demonstration of perturbed TDP-43 nucleocytoplasmic transport in vivo, and suggests that impairment in microglial phagocytosis of dying neurons may contribute towards the formation of pathological TDP-43 presentations in ALS and FTLD.
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The activation of microglia by protein aggregates creates a feed-forward vicious cycle that aggravates neurodegeneration as activated microglia contribute to the propagation of tau, Aβ, α-synuclein, and TDP-43 into unaffected brain regions.
“Ultimately, the activation of microglia by these protein aggregates creates a feed-forward vicious cycle that aggravates neurodegeneration as activated microglia contribute to the propagation of tau, Aβ, α-synuclein, and TDP-43 into unaffected brain regions.159–164”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [164]
Microglia could phagocytize mobile TDP-43 deposits within degenerating motor neurons.
“Microglia could phagocytize mobile TDP-43 deposits within degenerating motor neurons.341”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [341]
Microglia could phagocytize pathological protein deposits such as TDP-43, and interaction of TDP-43 with microglial TREM2 promotes phagocytosis and clearance of TDP-43 by microglia.
“Overall, microglia could phagocytize pathological protein deposits such as TDP-43, and the interaction of TDP-43 with microglial TREM2 promotes the phagocytosis and clearance of TDP-43 by microglia.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [341]
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- Authors
- Svahn, A. J., Don, E. K., Badrock, A. P., Cole, N. J., Graeber, M. B., Yerbury, J. J., Chung, R., & Morsch, M.
- Affiliations
- Macquarie University (AU)
- University of Manchester (GB)
- The University of Sydney (AU)
- University of Wollongong (AU)
- Corresponding author
- Chung, Roger
- Morsch, Marco
- ORCID
- Venue
- Acta Neuropathologica
- Published
- 2018-06-25
- Volume
- 136
- Issue
- 3
- Pages
- 445-459
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- PMC
- PMC6096729
- OpenAlex
- W2810948711
- Cited by
- 87
- References
- 74
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 6 · 2023: 14 · 2022: 7 · 2021: 20 · 2020: 9 · 2019: 7 · 2018: 5
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Acta Neuropathologica (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, cc-by)
- Research Online (University of Wollongong) (submittedVersion)
- Figshare (submittedVersion)
- Funders
- Motor Neurone Disease Research Institute of Australia (GI1638, GI1838)
- Australian Research Council (DP150104472)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- TDP-43, nuclear transport, microglia, motor neuron degeneration, microglial phagocytosis, neurodegeneration, amyotrophic lateral sclerosis, frontotemporal lobar degeneration, cell death
- MeSH terms
- Animals, Axons, DNA-Binding Proteins, Motor Neurons, Nerve Degeneration, Zebrafish, Microglia, Protein Transport, Zebrafish Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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